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Long-term outcome data from real-world studies on the implementation of a two-drug dolutegravir plus lamivudine (DTG+3TC) regimen for the treatment of human immunodeficiency virus (HIV) infection remain limited. This study evaluated the real-world effectiveness and safety of DTG+3TC in people living with HIV (PLHIV) in Southwestern China.This was an observational, single-center, retrospective study that enrolled antiretroviral therapy (ART)-naïve (n = 36) and ART-experienced patients with HIV (n = 86) between January 2019 and April 2021. The virological response to therapy and adverse events were documented. The primary endpoint was an HIV viral load (VL)50 copies/mL at week 48.The proportion of treatment-naïve and ART-experienced PLHIV with a VL50 copies/mL at 48 weeks was 97.2% and 97.7%, respectively. The CD4 count increased significantly by 80.2 cells/μL (P = 0.012) and 79.0 cells/μL (P = 0.021) in the ART-naïve and ART-experienced patients, respectively. No patients discontinued DTG+3TC by week 48 due to adverse events.Virologic suppression may be achieved with DTG+3TC, in ART-naïve patients with a high VL, and in ART-experienced patients with residual viremia. This study also demonstrated a low prevalence of drug-related side effects.

Background: Prospective studies examining long-term therapeutic outcomes of the BIC+FTC+TAF regimen in human immunodeficiency virus (HIV) infection remain limited. This study assessed the actual efficacy and safety of BIC+FTC+TAF in HIV-infected individuals in southwest China. Methods: This was a single-center, prospective study enrolling treatment-naïve (n=32) and treatment-experienced (n=177) HIV-infected patients administered BIC+FTC+TAF treatment between March 2022 and August 2022. The data were collected until February 28, 2023. Virological reactions and adverse events to the treatment were recorded, and patient subjective feelings in the form of ePRO were collected. The primary endpoint was the rate of patients with HIV viral load Results: At week 24, 87.5% and 95.5% of treatment-naïve and treatment-experienced HIV patients had a viral load P=0.002) and 55.0 cells/μL (P=0.022), respectively. By week 24, no patients had discontinued the BIC+FTC+TAF treatment due to adverse events. Based on ePRO data, treatment-naïve and treatment-experienced patients at week 24 had stable disease symptom burden, quality of life, and depression level after treatment with BIC+FTC+TAF. Conclusion: BIC+FTC+TAF reduces the viral load in treatment-naïve patients with high viral load as well as treatment-experienced patients with residual viremia. The patient's subjective experience was maintained stable after treatment with BIC+FTC+TAF. This study also revealed a very low incidence for BIC+FTC+TAF drug-related side effects.

Background To evaluate the therapeutic effect and tolerance of BIC/FTC/TAF used for 24-week in ART-naïve in China. Methods This single-center retrospective cohort study included ART-naïve who received BIC/FTC/TAF from July 2021 to April 2022. The proportion of patients with HIV RNA

Two lanthanide coordination polymers (CPs) {[Er(Hmtbd)(H2mtbd)(H2O)3]·2H2O}n (1) and [Yb(Hmtbd)(H2mtbd)(H2O)3]n (2) carrying an N-heterocyclic carboxylate ligand 5-(3-methylformate-1H-1,2,4-triazole-1-methyl)benzen-1,3-dicarboxylate (H3mtbd) were prepared under solvothermal conditions. The single-crystal X-ray diffraction data demonstrate that 1 and 2 are isostructural and display 1D chain structure. Alternating current (AC) impedance measurements illustrate that the highest proton conductivities of 1 and 2 can attain 5.09 × 10-3 and 3.09 × 10-3 S·cm-1 at 100 °C and 98% relative humidity (RH), respectively. The value of 1 exceeds those of most reported lanthanide-based crystalline materials and ranks second among the described Er-CPs under similar conditions, whereas the value for 2 is the highest proton conductivity among the previous Yb-CPs. Coupled with the structural analyses of the two CPs and H2O vapor adsorption, the calculated Ea values help to deduce their proton conductive mechanisms. Notably, the N-heterocyclic units (triazole), carboxyl, and hydrogen-bonding network all play key roles in the proton-transfer process. The prominent proton conductive abilities of both CPs show great promise as efficient proton conductors.

The relatively narrow electrochemical steady window and low ionic conductivity are two critical challenges for Li+ -conducting solid polymer electrolytes (SPE). Here, a family of poly-oxalate(POE) structures were prepared as SPE; among them, POEs composed from diols with an odd number of carbons show higher ionic conductivity than those composed from diols with an even number of carbons, and the POE composed from propanediol (C5-POE) has the highest Li+ conductivity. The HOMO (highest occupied molecular orbital) electrons of POE were found located on the terminal units. When using trifluoroacetate as the terminating unit (POE-F), not only does the HOMO become more negative, but also the HOMO electrons shift to the middle oxalate units, improving the antioxidative capability. Furthermore, the interfacial compatibility across the Li-metal/POE-F is also improved by the generation of a LiF-based solid-electrolyte-interlayer(SEI). With the trifluoroacetate-terminated C5-POE (C5-POE-F) as the electrolyte and Li+ -conducting binder in the cathode, the all-solid-state Li/LiNi0.8 Mn0.1 Co0.1 O2 (NMC811) cells showed significantly improved stability than the counterpart with poly-ether, providing a promising candidate for the forthcoming all-solid-state high-voltage Li-metal batteries.

Cloud computing, with the features of flexible resource assignment, timely on-demand service and transparent by-quantity pricing, has been widely applied recently. As a new business service model, cloud platform must be capable of satisfying user demand and enhancing quality of service. Therefore, an excellent resource scheduling scheme is requisite to improve the working efficiency of cloud platform and ensure its stability. To achieve the goal of meeting user demand and maximizing the benefit of cloud platform, a dynamic allocation model for cloud resource, which takes into account requirement of users and benefit of cloud platform, is proposed. On the one hand, the concept of user satisfaction is presented to meet the different requirements of different users on time and cost. And a dynamic pricing model is designed to realize the flexible conversion between time and cost, which can instead serve to ensure quality of service and win customer loyalty. On the other hand, genetic algorithm is employed to schedule cloud resources, which can reduce operating cost, shorten makespan, lessen energy consumption, and ensure load balancing, stability and fluency of cloud platform, in order to maximize the benefit of cloud platform as possible. Finally, the results of 5 comparative experiments show that the dynamic pricing model presented is reasonable and the dynamic resource assignment scheme proposed is feasible and efficient.

ObjectivesTo estimate anaemia prevalence and the associated factors among hospitalised people living with HIV (PLHIV) receiving antiretroviral therapy (ART).DesignA cross-sectional study.SettingPLHIV receiving ART and hospitalised in a specialised hospital for infectious disease in Guizhou Province, Southwest China, between 1 January 2018 and 31 March 2021.ParticipantsA total of 6959 hospitalised PLHIV aged ≥18 years and receiving ART were included in this study.Primary and secondary outcome measuresAnaemia was diagnosed as a haemoglobin concentration ResultsThe prevalence of anaemia was 27.5%, and that of mild, moderate and severe anaemia was 9.2%, 12.2% and 6.1%, respectively. Results from multivariate logistic regression showed that females had increased odds of anaemia (adjusted OR (aOR)=1.60, 95% CI: 1.42 to 1.81) compared with males. Widowed or divorced inpatients (anaemia: aOR=1.26, 95% CI: 1.08 to 1.47; severe anaemia: aOR=1.52, 95% CI: 1.16 to 1.97) and thrombocytopenia inpatients (anaemia: aOR=4.25, 95% CI: 3.54 to 5.10; severe anaemia: aOR=4.16, 95% CI: 3.24 to 5.35) had increased odds of anaemia and severe anaemia compared with their counterparts. Hepatitis C was associated with increased odds of severe anaemia (aOR=1.80, 95% CI: 1.11 to 2.92).ConclusionsAnaemia was prevalent among hospitalised PLHIV. Female sex, those widowed or divorced, and thrombocytopenia were associated with increased odds of anaemia, and those widowed or divorced, thrombocytopenia and hepatitis C were associated with increased odds of severe anaemia. Determination of anaemia predictors, early detection and timely management of anaemia are crucial to prevent anaemia progression.

There is great interest in the promising applications of proton-conductive metal-organic frameworks (MOFs) in the field of electrochemistry. Thus, seeking more types of MOFs with high proton conductivity is of great importance. Herein, we designed and prepared two substituted imidazoledicarboxylate-based MOFs, {[Cd( p-TIPhH

Timely and accurate grasp of land salinization status and its matching relationship with land use is the basis for scientific improvement of saline land and rational land use. The current land use types of Shouguang City on the south coast of the Bohai Sea were obtained based on Landsat 8 OLI multispectral images using supervised classification. And the spatial distribution map of land salinization was obtained by IDW interpolation. By superimposed analysis of the current land use types and the spatial distribution of salinization, the information of salinization degree was obtained. The matching relationship between salinization and land use was analyzed from both quantitative and spatial aspects. The results show that OLI multispectral image and filed survey can improve the extraction accuracy of land types and salinization degree information. The distribution of salinized land in Shouguang City has prominent regional characteristics, with non-saline, mild, moderate, severe, and saline soil distributed in a pattern of “large concentration and small insertion” from south to north. The spatial consistency of land use and salinization in Shouguang is remarkable, forming spatial characteristics of “vegetable in the south, grain and cotton in the middle, and fishery and salt in the north”. However, no matter from space or quantity, the land use and salinization in Shouguang City have the problem of “overall match, local mismatch”. It is suggested to take differentiated measures to regulate land use according to the current situation of distribution characteristics of land salinization and utilization.

In the quantitative estimation by spectra of soil organic matter (SOM), there are great difficulties in the extraction of characteristic spectral information. It is difficult to effectively improve the correlation with SOM by ordinary spectral transformations, and the spectral estimation models are not high in accuracy and applicability. The purpose of this paper is to explore a more accurate and more suitable non-destructive evaluation model for apple orchard soil. In this paper, an apple orchard in Shuangquan Town, Changqing District, Jinan City, was selected as the study area. The continuous wavelet transform (CWT) was used to process the original soil spectra at multiple scales, and the effect of the estimation model on the SOM correlation at different resolutions was investigated. The results showed that the CWT treatment significantly improved the degree of spectral response to SOM in the orchard. Compared with the original spectra, the prediction accuracy of the model constructed by CWT was higher. After wavelet algorithm processing, the prediction ability of the model tends to increase with the decrease of spectral resolution. The best prediction accuracy was found at the spectral resolution of 20 nm, with the coefficient of determination R2= 0.7547 and the root means square error RMSE=0.0042; the validation accuracy R2=0.8015 and the root mean square error RMSE=0.0039. The model achieved a more satisfactory prediction result at the spectral resolution of 5 nm also. The results show that the broad-band spectral data processed by CWT can be used for accurate monitoring of SOM in apple orchards.

It is of great significance to strengthen the research on the relationship between land use/cover and environmental sustainable development. Taking Hekou District in the Yellow River Delta as an example, based on “3S” technology, using the methods of field investigation, sampling test and statistical analysis, combining remote sensing classification with spatial interpolation, the land information is accurately extracted, and the land salinization and utilization characteristics and their matching relationship are analyzed. The spatial characteristics of land use in Hekou District are obvious. Cultivated land is concentrated in the southwest and southeast, a little in the middle. Aquaculture water surface and saline wasteland are concentrated in the northeast and northwest coastal area. Construction land is concentrated in the south, and salt pan fields are mainly distributed in the northwest. The spatial distribution of soil salinization in Hekou District increased from southwest to east and north in spring, showing strong variability. The spatial distribution and quantity of land use and salinization are in the relationship of "overall matching and partial mismatch". Land use should be adjusted according to the characteristics of salinization and land demand. Hekou District should strengthen the protection of cultivated land, develop characteristic gardens and animal husbandry, explore the multi-functional utilization of saline land resources, and promote regional ecological improvement and sustainable development.

As a significant type of crystalline solid proton conducting materials, metal–organic frameworks (MOFs) have been paid great attention and pursued by researchers. In this review, we will mainly summarize the proton conduction explorations of MOFs based on carboxylate ligands (including aliphatic carboxylate-based and aromatic carboxylate-based MOFs) from the aspects of synthetic strategies, stability, proton conductive properties and mechanism, application, etc. Finally, on the basis of summarization of literature and our own research on proton conduction, development prospects and challenges for such conductive materials in the future are highlighted.