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This paper summarized the treatment and nursing experience of a patient with insomnia of disharmony between spleen and stomach type. Based on the routine nursing care, meridian massage combined with five-element music therapy was carried out to improve the sleep quality of the patient. The Pittsburgh Sleep Quality Index score (PSQI) decreased after treatment, and the insomnia-related symptoms were relieved。 (本文总结1例脾胃不和型失眠患者的治疗和护理经验。在加强常规护理的基础上, 通过实施经穴推拿联合五音疗法, 有效降低患者匹兹堡睡眠质量指数量表(PSQI)评分, 改善失眠症状。)

Background: Triple-negative breast cancer (TNBC) represents a highly aggressive subset of breast malignancies characterized by its challenging clinical management and unfavorable prognosis. While TFAP2A, a member of the AP-2 transcription factor family, has been implicated in maintaining the basal phenotype of breast cancer, its precise regulatory role in TNBC remains undefined. Methods: In vitro assessments of TNBC cell growth and migratory potential were conducted using MTS, colony formation, and EdU assays. Quantitative PCR was employed to analyze mRNA expression levels, while Western blot was utilized to evaluate protein expression and phosphorylation status of AKT and ERK. The post-transcriptional regulation of TFAP2A by miR-8072 and the transcriptional activation of SNAI1 by TFAP2A were investigated through luciferase reporter assays. A xenograft mouse model was employed to assess the in vivo growth capacity of TNBC cells. Results: Selective silencing of TFAP2A significantly impeded the proliferation and migration of TNBC cells, with elevated TFAP2A expression observed in breast cancer tissues. Notably, TNBC patients exhibiting heightened TFAP2A levels experienced abbreviated overall survival. Mechanistically, TFAP2A was identified as a transcriptional activator of SNAI1, a crucial regulator of epithelial-mesenchymal transition (EMT) and cellular proliferation, thereby augmenting the oncogenic properties of TFAP2A in TNBC. Moreover, miR-8072 was unveiled as a negative regulator of TFAP2A, exerting potent inhibitory effects on TNBC cell growth and migration. Importantly, the tumor-suppressive actions mediated by the miR-8072/TFAP2A axis were intricately associated with the attenuation of AKT/ERK signaling cascades and the blockade of EMT processes. Conclusions: Our findings unravel the role and underlying molecular mechanism of TFAP2A in driving tumorigenesis of TNBC. Targeting the TFAP2A/SNAI1 pathway and utilizing miR-8072 as a suppressor represent promising therapeutic strategies for treating TNBC. [ABSTRACT FROM AUTHOR]

Objective: The objective of this study was to determine the role of body fat percentage (BFP) changes in diabetes remission (DR) and the association between baseline body composition and its changes after bariatric surgery. Methods: We analyzed 203 patients with type 2 diabetes who underwent Roux‐en‐Y gastric bypass. Body composition was measured using a gold‐standard‐derived predictive equation and magnetic resonance imaging. Body composition changes were calculated as 100 × (baseline value – follow‐up value)/baseline value. We verified the results in a laparoscopic sleeve gastrectomy cohort with 311 patients. Results: Compared with non‐remission patients in the Roux‐en‐Y gastric bypass cohort, those who achieved DR showed a higher baseline fat‐free mass index (FFMI) and experienced the most significant changes in BFP (p < 0.001). In comparative analyses, BFP changes were significantly better than BMI changes in identifying short‐ and long‐term DR. Linear regression analysis identified FFMI as the most significant baseline variable correlated with BFP changes (p < 0.001). Baseline BMI was positively correlated with changes in BFP but negatively correlated with changes in FFMI. These findings were replicated in the laparoscopic sleeve gastrectomy cohort. Conclusions: BFP changes determine DR after bariatric surgery, and baseline FFMI is crucial for BFP changes. A low initial BMI is associated with a smaller BFP reduction and greater FFMI loss after bariatric surgery. [ABSTRACT FROM AUTHOR]

In situ surface wind observation is a critical meteorological data source for various research fields. However, data quality is affected by factors such as surface friction changes, station relocations and anemometer updates. Previous methods to address discontinuities have been insufficient, and processing methods have not always adhered to World Meteorological Organization (WMO) World Climate Programme guidelines. We analyzed data discontinuity caused by anemometer changes and station relocations in China's daily in situ near-surface (∼ 10 m) wind speed observations and the impact of the processing methods on wind speed trends. By comparing the wind speed discontinuities with the recorded location changes, we identified 90 stations that showed abnormally increasing wind speeds due to relocation. After removing those stations, we followed a standard quality control method recommended by the World Meteorological Organization to improve the data reliability and applied Thiessen polygons to calculate the area-weighted average wind speed. The result shows that China's recent reversal of wind speed was reduced by 41 % after removing the problematic stations, with an increasing trend of 0.017 m s -1 yr -1 (R2 = 0.64, P < 0.05), emphasizing the importance of robust quality control and homogenization protocols in wind trend assessments. [ABSTRACT FROM AUTHOR]

In this paper, a new approach involving the use of a mobile manipulator to assist humans with mobility impairments to walk is proposed. First, in order to achieve flexible interaction between humans and mobile manipulators, we propose a variable admittance controller that can adaptively regulate the virtual mass and damping parameters based on the interaction forces and the human motion intention predicted using the fuzzy theory. Moreover, a feedforward velocity compensator based on a designed state observer is proposed to decrease the inertia resistance of the manipulator, effectively enhancing the compliance of the human–robot interaction. Then, the configuration of the mobile manipulator is optimized based on a null-space approach by considering the singularity, force capacity, and deformation induced by gravity. Finally, the proposed assisted walking approach for the mobile manipulator is implemented using the human–robot interaction controller and the null-space controller. The validity of the proposed controllers and the feasibility of assisted human walking are verified by conducting a set of tests involving different human volunteers. [ABSTRACT FROM AUTHOR]

Research Findings: Online Teaching Video Cases (OTVCs) are an increasingly utilized digital learning resource for training pre-service preschool teachers (PPTs). This study employed an integrated framework integrating the Technology Acceptance Model (TAM) and the Expectation Confirmation Model (ECM) to examine the factors that influence PPTs' perceived learning performance and satisfaction, as well as the interactive relationships among these factors. Survey participants (N = 269) were randomly sampled from seven normal universities and colleges in Shandong province (China). A partial least squares structural equation modeling approach was used to test the study's hypotheses. The findings of this study demonstrate that the actual usage of OTVCs significantly affects PPTs' learning performance and subsequent learning satisfaction, which in turn is directly influenced by expectation confirmation and learning performance. Practice or Policy: As such, this study highlights the potential of OTVCs as an effective digital learning resource for PPTs. The proposed framework combining TAM and ECM can largely explain PPTs' learning satisfaction with OTVCs. Teacher educators are encouraged to provide PPTs with applicable video-based instructional cases to optimize their learning experiences. [ABSTRACT FROM AUTHOR]