5,843 results on '"YAO, Yang"'
Search Results
2. Exploring the Potential of Large Language Models in Graph Generation
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Yao, Yang, Wang, Xin, Zhang, Zeyang, Qin, Yijian, Zhang, Ziwei, Chu, Xu, Yang, Yuekui, Zhu, Wenwu, and Mei, Hong
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Computer Science - Machine Learning ,Computer Science - Artificial Intelligence ,Quantitative Biology - Biomolecules - Abstract
Large language models (LLMs) have achieved great success in many fields, and recent works have studied exploring LLMs for graph discriminative tasks such as node classification. However, the abilities of LLMs for graph generation remain unexplored in the literature. Graph generation requires the LLM to generate graphs with given properties, which has valuable real-world applications such as drug discovery, while tends to be more challenging. In this paper, we propose LLM4GraphGen to explore the ability of LLMs for graph generation with systematical task designs and extensive experiments. Specifically, we propose several tasks tailored with comprehensive experiments to address key questions regarding LLMs' understanding of different graph structure rules, their ability to capture structural type distributions, and their utilization of domain knowledge for property-based graph generation. Our evaluations demonstrate that LLMs, particularly GPT-4, exhibit preliminary abilities in graph generation tasks, including rule-based and distribution-based generation. We also observe that popular prompting methods, such as few-shot and chain-of-thought prompting, do not consistently enhance performance. Besides, LLMs show potential in generating molecules with specific properties. These findings may serve as foundations for designing good LLMs based models for graph generation and provide valuable insights and further research.
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- 2024
3. Rolling V-groove microstructures on glass using a modified PDMS mold
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Hsu, Ming-Huai, Tsai, Yao-Yang, Gao, Jhao-Hong, and Yang, Sen-Yeu
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- 2024
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4. Qwen Technical Report
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Bai, Jinze, Bai, Shuai, Chu, Yunfei, Cui, Zeyu, Dang, Kai, Deng, Xiaodong, Fan, Yang, Ge, Wenbin, Han, Yu, Huang, Fei, Hui, Binyuan, Ji, Luo, Li, Mei, Lin, Junyang, Lin, Runji, Liu, Dayiheng, Liu, Gao, Lu, Chengqiang, Lu, Keming, Ma, Jianxin, Men, Rui, Ren, Xingzhang, Ren, Xuancheng, Tan, Chuanqi, Tan, Sinan, Tu, Jianhong, Wang, Peng, Wang, Shijie, Wang, Wei, Wu, Shengguang, Xu, Benfeng, Xu, Jin, Yang, An, Yang, Hao, Yang, Jian, Yang, Shusheng, Yao, Yang, Yu, Bowen, Yuan, Hongyi, Yuan, Zheng, Zhang, Jianwei, Zhang, Xingxuan, Zhang, Yichang, Zhang, Zhenru, Zhou, Chang, Zhou, Jingren, Zhou, Xiaohuan, and Zhu, Tianhang
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Computer Science - Computation and Language - Abstract
Large language models (LLMs) have revolutionized the field of artificial intelligence, enabling natural language processing tasks that were previously thought to be exclusive to humans. In this work, we introduce Qwen, the first installment of our large language model series. Qwen is a comprehensive language model series that encompasses distinct models with varying parameter counts. It includes Qwen, the base pretrained language models, and Qwen-Chat, the chat models finetuned with human alignment techniques. The base language models consistently demonstrate superior performance across a multitude of downstream tasks, and the chat models, particularly those trained using Reinforcement Learning from Human Feedback (RLHF), are highly competitive. The chat models possess advanced tool-use and planning capabilities for creating agent applications, showcasing impressive performance even when compared to bigger models on complex tasks like utilizing a code interpreter. Furthermore, we have developed coding-specialized models, Code-Qwen and Code-Qwen-Chat, as well as mathematics-focused models, Math-Qwen-Chat, which are built upon base language models. These models demonstrate significantly improved performance in comparison with open-source models, and slightly fall behind the proprietary models., Comment: 59 pages, 5 figures
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- 2023
5. The Relationship between Mathematics Self-Efficacy and Mathematics Achievement: Multilevel Analysis with NAEP 2019
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Yao Yang, Yukiko Maeda, and Marcia Gentry
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Background: This empirical study aims to investigate the association between mathematics self-efficacy and mathematics achievement gaps among students in Grades 4, 8, and 12, utilizing data from the 2019 National Assessment of Educational Progress (NAEP). The study also considers student-level (e.g., mathematics self-efficacy, gender, race/ethnicity) and school-level (e.g., school location, proportion of underrepresented students) demographics to provide a comprehensive analysis of the factors contributing to mathematics achievement gaps. Methods: A two-level cross-sectional multilevel modeling approach was employed to analyze the variance in mathematics achievement, partitioning it into within- and between-school components. This approach allowed for an examination of association between mathematics self-efficacy and achievement gaps while considering various student and school characteristics. The rationale behind this methodology lies in its ability to capture the hierarchical nature of educational data and provide a nuanced understanding of the factors associated with mathematics achievement. Results: The analysis of the NAEP data revealed substantial variability in mathematics achievement across schools in the United States at all grade levels. Furthermore, mathematics self-efficacy emerged as a robust predictor of students' mathematics achievement, exhibiting significant effect sizes for Grades 4, 8, and 12. Remarkably, when students' mathematics self-efficacy was held constant, the mathematics achievement gaps among different student subgroups by gender, race/ethnicity, ELL, IEP, NSLP status narrowed, highlighting the importance of self-efficacy in addressing these disparities. The study also identified the presence of significant school contextual effects, further emphasizing the role of the educational environment in shaping mathematics achievement. Conclusions: This study underscores the critical role of mathematics self-efficacy in influencing mathematics achievement gaps among students. By acknowledging the association between self-efficacy beliefs and mathematics achievement, policymakers and educators can develop targeted interventions to enhance students' confidence and motivation in mathematics, ultimately promoting equitable educational outcomes. The findings also emphasize the significance of school-level factors, calling for comprehensive approaches that consider both individual and contextual factors in narrowing achievement gaps. The implications of adopting a self-efficacy perspective to address mathematics achievement gaps extend to educational policy, curriculum development, and instructional practices, ultimately fostering more inclusive and effective mathematics education for all students.
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- 2024
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6. The UTUH model: a time-dependent unified hardening constitutive model for unsaturated soils
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Zhao, Runkang, Zhou, Annan, and Yao, Yang-Ping
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- 2024
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7. Survival of advanced/recurrent gastrointestinal stromal tumors treated with tyrosine kinase inhibitors in Taiwan: a nationwide registry study
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Hui-Jen Tsai, Yan-Shen Shan, Ching-Yao Yang, Chin-Fu Hsiao, Chung-Hsin Tsai, Chuan-Cheng Wang, Ming-Tsan Lin, Chun-Fu Ting, De-Chuan Chan, Te-Hung Chen, Chueh-Chuan Yen, Yen-Yang Chen, Hsuan-Yu Lin, Ta-Sen Yeh, Ching-Liang Ho, Tze-Yu Shieh, Li-Yaun Bai, Jun-Te Hsu, I-Shu Chen, Li-Tzong Chen, Chun-Nan Yeh, and Taiwan Cooperative Oncology Group (TCOG) GIST Study Group
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Gastrointestinal stromal tumor ,Metastatic ,Recurrent ,Tyrosine kinase inhibitor ,Registry study ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Background Most gastrointestinal stromal tumors (GISTs) harbor c-KIT or PDGFRA mutations. Administration of tyrosine kinase inhibitors (TKIs) has significantly improved the survival of patients with GISTs. We aimed to evaluate the clinical outcome of advanced or recurrent GIST patients in Taiwan. Methods Patients diagnosed between 2010 and 2020 were enrolled. The collected data included baseline characteristics, treatment pattern, treatment outcome, genetic aberrations and survival status. Progression-free survival (PFS) and overall survival (OS) were analyzed and plotted with the Kaplan–Meier method. Cox regression analysis was used to analyze the prognostic factors of survival. Results A total of 224 patients with advanced or recurrent GISTs treated with TKIs were enrolled. All patients received imatinib treatment. Ninety-three and 42 patients received sunitinib and regorafenib treatment, respectively. The 48-month PFS and OS rates for patients treated with imatinib were 50.5% and 79.5%, respectively. c-KIT exon 9 and PDGFRA mutations were prognostic factors for a poor PFS and PDGFRA mutation was a prognostic factor for a poor OS in patients treated with imatinib in multivariate Cox regression analysis. The median PFS of patients who received sunitinib treatment was 12.76 months (95% confidence interval (CI), 11.01–14.52). Patients with c-KIT exon 9 mutations had a longer PFS than those with other genetic aberrations. The median PFS of patients treated with regorafenib was 7.14 months (95% CI, 3.39–10.89). Conclusions We present real-world clinical outcomes for advanced GIST patients treated with TKIs and identify mutational status as an independent prognostic factor for patient survival.
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- 2024
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8. Circ_0004851 regulates the molecular mechanism of miR-296-3p/FGF11 in the influence of high iodine on PTC
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Jing-jing Li, Zi-xuan Ru, Xu Yang, Jing-xue Sun, Yan-mei-zhi Wu, Xiao-yao Yang, Bo-yu Hou, Bing Xue, Chao Ding, and Hong Qiao
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Iodine ,PTC ,Circ_0004851 ,miR-296-3p ,FGF11 ,Tumor development ,Medicine - Abstract
Abstract The prevalence of papillary thyroid cancer (PTC) has been rising in recent years. Despite its relatively low mortality, PTC frequently metastasizes to lymph nodes and often recurs, posing significant health and economic burdens. The role of iodine in the pathogenesis and advancement of thyroid cancer remains poorly understood. Circular RNAs (circRNAs) are recognized to function as competing endogenous RNAs (ceRNAs) that modulate gene expression and play a role in various cancer stages. Consequently, this research aimed to elucidate the mechanism by which circRNA influences the impact of iodine on PTC. Our research indicates that high iodine levels can exacerbate the malignancy of PTC via the circ_0004851/miR-296-3p/FGF11 axis. These insights into iodine’s biological role in PTC and the association of circRNA with the disease could pave the way for novel biomarkers and potentially effective therapeutic strategies to mitigate PTC progression.
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- 2024
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9. Project case of taurine production wastewater treatment
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PENG Jiwei, CHEN Hao, XIAO Lei, HE Jinfeng, and YAO Yang
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taurine production wastewater ,rear anoxia tank ,sulphide ,ammonia nitrogen ,tapered aeration ,Environmental technology. Sanitary engineering ,TD1-1066 - Abstract
With the wastewater treatment project of a taurine production enterprise in Hubei as a case study, this paper analyzed the production process and wastewater quality characteristics of the enterprise, the targeted treatment process of “hydrolysis acidification+pre anoxic+aerobic biochemistry+post anoxic+secondary sedimentation” was adopted. When the average influent COD, ammonia nitrogen, and total nitrogen were 956.8, 50.6, 99.1 mg/L, respectively, the average effluent COD, ammonia nitrogen, and TN were 73.6, 1.6, 12.2 mg/L, respectively, with the average removal rates could reach 92.3%, 96.9%, and 87.7%, respectively. The effluent water quality was stable and meet the limits of water pollutants for newly built enterprises in the Chemical Synthesis Pharmaceutical Industry Water Pollutant Discharge Standard(GB 21904-2008). By adopting tapered aeration and fan frequency conversion control, energy consumption was significantly reduced, and the operating cost was 1.60 CNY/m3.
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- 2024
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10. DEAD-box helicase 17 (DDX17) protects cardiac function by promoting mitochondrial homeostasis in heart failure
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Mingjing Yan, Junpeng Gao, Ming Lan, Que Wang, Yuan Cao, Yuxuan Zheng, Yao Yang, Wenlin Li, Xiaoxue Yu, Xiuqing Huang, Lin Dou, Bing Liu, Junmeng Liu, Hongqiang Cheng, Kunfu Ouyang, Kun Xu, Shenghui Sun, Jin Liu, Weiqing Tang, Xiyue Zhang, Yong Man, Liang Sun, Jianping Cai, Qing He, Fuchou Tang, Jian Li, and Tao Shen
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Medicine ,Biology (General) ,QH301-705.5 - Abstract
Abstract DEAD-box helicase 17 (DDX17) is a typical member of the DEAD-box family with transcriptional cofactor activity. Although DDX17 is abundantly expressed in the myocardium, its role in heart is not fully understood. We generated cardiomyocyte-specific Ddx17-knockout mice (Ddx17-cKO), cardiomyocyte-specific Ddx17 transgenic mice (Ddx17-Tg), and various models of cardiomyocyte injury and heart failure (HF). DDX17 is downregulated in the myocardium of mouse models of heart failure and cardiomyocyte injury. Cardiomyocyte-specific knockout of Ddx17 promotes autophagic flux blockage and cardiomyocyte apoptosis, leading to progressive cardiac dysfunction, maladaptive remodeling and progression to heart failure. Restoration of DDX17 expression in cardiomyocytes protects cardiac function under pathological conditions. Further studies showed that DDX17 can bind to the transcriptional repressor B-cell lymphoma 6 (BCL6) and inhibit the expression of dynamin-related protein 1 (DRP1). When DDX17 expression is reduced, transcriptional repression of BCL6 is attenuated, leading to increased DRP1 expression and mitochondrial fission, which in turn leads to impaired mitochondrial homeostasis and heart failure. We also investigated the correlation of DDX17 expression with cardiac function and DRP1 expression in myocardial biopsy samples from patients with heart failure. These findings suggest that DDX17 protects cardiac function by promoting mitochondrial homeostasis through the BCL6-DRP1 pathway in heart failure.
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- 2024
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11. Infinite series involving harmonic numbers and reciprocal of binomial coefficients
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Kwang-Wu Chen and Fu-Yao Yang
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multiple zeta values ,harmonic numbers ,binomial coefficients ,yamamoto's integral ,2-poset ,Mathematics ,QA1-939 - Abstract
Yamamoto's integral was the integral associated with 2-posets, which was first introduced by Yamamoto. In this paper, we obtained the values of infinite series involving harmonic numbers and reciprocal of binomial coefficients by using some techniques of Yamamoto's integral. We determine the value of infinite series of the form: $ \sum\limits_{m_1,\ldots,m_n,\ell_1,\ldots,\ell_k\geq 1}\frac{H_{m_1}^{(a_1)}\cdots H_{m_n}^{(a_n)}} {m_1^{b_1}\cdots m_n^{b_n}\ell_1^{c_1}\cdots\ell_k^{c_k} \binom{m_1+\cdots+m_n+\ell_1+\cdots+\ell_k}{\ell_k}}, $ in terms of a finite sum of multiple zeta values, for positive integers $ a_1, \ldots, a_n, b_1, \ldots, b_n, c_1, \ldots, c_k $.
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- 2024
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12. AODiMP‐TIR: Anti‐occlusion thermal infrared targets tracker based on SuperDiMP
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Shaoyang Ma, Yao Yang, and Gang Chen
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infrared imaging ,Kalman filters ,object tracking ,Photography ,TR1-1050 ,Computer software ,QA76.75-76.765 - Abstract
Abstract To address the issue of tracking drift and failures in thermal infrared (TIR) tracking tasks caused by target occlusion, this study proposes an anti‐occlusion TIR target tracker named AODiMP‐TIR. This approach involves an anti‐occlusion strategy that relies on target occlusion status determination and trajectory prediction. This enables the prediction of the target's current position when it is identified as occluded, ensuring swift recapture upon reappearance. A criterion is introduced for occlusion status determination based on the classification response map of SuperDiMP. Additionally, a trajectory mapping module designed to decouple target motion from camera motion is presented, enhancing the precision of trajectory prediction. Comparative experiments with other state‐of‐the‐art trackers are conducted on the large‐scale high‐diversity thermal infrared object tracking benchmark (LSOTB‐TIR), LSOTB‐TIR100, and thermal infrared pedestrian tracking benchmark (PTB‐TIR) datasets. The results indicate that the AODiMP‐TIR performs well across all three datasets, particularly exhibiting outstanding performance in occlusion sequences. Furthermore, ablation study experiments confirm the effectiveness of the anti‐occlusion strategy, occlusion determination criterion and trajectory mapping module.
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- 2024
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13. The relationship between mathematics self-efficacy and mathematics achievement: multilevel analysis with NAEP 2019
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Yao Yang, Yukiko Maeda, and Marcia Gentry
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NAEP ,Mathematics self-efficacy ,Mathematics achievement ,Achievement gap ,Education (General) ,L7-991 - Abstract
Abstract Background This empirical study aims to investigate the association between mathematics self-efficacy and mathematics achievement gaps among students in Grades 4, 8, and 12, utilizing data from the 2019 National Assessment of Educational Progress (NAEP). The study also considers student-level (e.g., mathematics self-efficacy, gender, race/ethnicity) and school-level (e.g., school location, proportion of underrepresented students) demographics to provide a comprehensive analysis of the factors contributing to mathematics achievement gaps. Methods A two-level cross-sectional multilevel modeling approach was employed to analyze the variance in mathematics achievement, partitioning it into within- and between-school components. This approach allowed for an examination of association between mathematics self-efficacy and achievement gaps while considering various student and school characteristics. The rationale behind this methodology lies in its ability to capture the hierarchical nature of educational data and provide a nuanced understanding of the factors associated with mathematics achievement. Results The analysis of the NAEP data revealed substantial variability in mathematics achievement across schools in the United States at all grade levels. Furthermore, mathematics self-efficacy emerged as a robust predictor of students' mathematics achievement, exhibiting significant effect sizes for Grades 4, 8, and 12. Remarkably, when students' mathematics self-efficacy was held constant, the mathematics achievement gaps among different student subgroups by gender, race/ethnicity, ELL, IEP, NSLP status narrowed, highlighting the importance of self-efficacy in addressing these disparities. The study also identified the presence of significant school contextual effects, further emphasizing the role of the educational environment in shaping mathematics achievement. Conclusions This study underscores the critical role of mathematics self-efficacy in influencing mathematics achievement gaps among students. By acknowledging the association between self-efficacy beliefs and mathematics achievement, policymakers and educators can develop targeted interventions to enhance students' confidence and motivation in mathematics, ultimately promoting equitable educational outcomes. The findings also emphasize the significance of school-level factors, calling for comprehensive approaches that consider both individual and contextual factors in narrowing achievement gaps. The implications of adopting a self-efficacy perspective to address mathematics achievement gaps extend to educational policy, curriculum development, and instructional practices, ultimately fostering more inclusive and effective mathematics education for all students.
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- 2024
- Full Text
- View/download PDF
14. Antiviral and anti-inflammatory activities of chemical constituents from twigs of Mosla chinensis Maxim
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Shi-Yan Feng, Na Jiang, Jia-Ying Yang, Lin-Yao Yang, Jiang-Chao Du, Xuan-Qin Chen, Dan Liu, Rong-Tao Li, and Jin-Dong Zhong
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Mosla chinensis Maxim ,Flavonoids ,Phenolic structure ,Anti-H1N1 virus activity ,Anti-inflammatory activity ,Botany ,QK1-989 - Abstract
Abstract Seven undescribed compounds, including three flavones (1–3), one phenylpropanoid (19), three monoaromatic hydrocarbons (27–29), were isolated from the twigs of Mosla chinensis Maxim together with twenty-eight known compounds. The structures were characterized by HRESIMS, 1D and 2D NMR, and ECD spectroscopic techniques. Compound 20 displayed the most significant activity against A/WSN/33/2009 (H1N1) virus (IC50 = 20.47 μM) compared to the positive control oseltamivir (IC50 = 6.85 µM). Further research on the anti-influenza mechanism showed that compound 20 could bind to H1N1 virus surface antigen HA1 and inhibit the early attachment stage of the virus. Furthermore, compounds 9, 22, 23, and 25 displayed moderate inhibitory effects on the NO expression in LPS inducing Raw 264.7 cells with IC50 values of 22.78, 20.47, 27.66, and 30.14 µM, respectively. Graphical Abstract
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- 2024
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15. Adaptive Meta-Learning Probabilistic Inference Framework for Long Sequence Prediction.
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Jianping Zhu, Xin Guo, Yang Chen, Yao Yang, Wenbo Li, Bo Jin, and Fei Wu
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- 2024
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16. A double-sided PDMS mold for double-sided embossing by rollers
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Hsu, Ming-Huai, Tsai, Yao-Yang, He, Jyun-Wei, and Yang, Sen-Yeu
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- 2024
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17. Measurement of Critical Temperatures, Critical Pressures and Densities of Acetone–Water Solutions for Simulation
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Chen, Zhirong, Yao, Yang, Yuan, Shenfeng, and Yin, Hong
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- 2023
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18. A Systematic Workflow of Data Mining Confirms Widespread Occurrence of Antibiotic Contamination in Freshwater Reservoirs
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Guo, Zhao-Feng, Boeing, Wiebke J., Xu, Yao-Yang, Borgomeo, Edoardo, Liu, Dong, and Zhu, Yong-Guan
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- 2023
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19. A Chinese Way of Democratisation?
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Yao, Yang
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- 2010
20. Influence of vaccination on critical COVID-19 patients with acute respiratory failure: a retrospective cohort study
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Hsiao-Chin Shen, Jhong-Ru Huang, Chuan-Yen Sun, Ying-Ting Liao, Hung-Jui Ko, Chih-Jung Chang, Jia-Yih Feng, Yuh-Min Chen, Wei-Chih Chen, and Kuang-Yao Yang
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Acute Respiratory Failure ,Acute Respiratory Distress Syndrome ,Coronavirus Disease 2019 (COVID-19) ,COVID-19 Vaccines ,Virus Shedding ,Medicine - Abstract
Abstract Background Despite vaccines’ effectiveness in reducing COVID-19 infection rates and disease severity, their impact on critical patients presenting with acute respiratory failure is elusive. The aim of this study was to further investigate the influence of vaccination on mortality rates among severely ill COVID-19 patients experiencing acute respiratory failure. Methods This retrospective cohort study was carried out at a tertiary medical center in Taiwan. From April to September 2022, patients who tested positive for the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) through reverse transcription polymerase chain reaction (RT-PCR) and subsequently experienced acute respiratory failure were included in the study. Baseline characteristics, including vaccination history, along with information regarding critical illness and clinical outcomes, were gathered and compared between patients who received the vaccine and those who did not. Results A total of 215 patients with COVID-19 exhibiting acute respiratory failure, as confirmed via RT‒PCR, were included in the analysis. Of this cohort, sixty-six (30.7%) patients died within 28 days. Neither administration of the vaccine nor achievement of primary series vaccination status had a significantly different effect on 28 day mortality, number of viral shedding events, acute respiratory distress syndrome (ARDS) incidence or other clinical outcomes. Patients who received the booster vaccine and completed the primary series showed a tendency of increased 28 days of ventilator-free status, though this difference was not statistically significant (p = 0.815). Conclusions Vaccination status did not significantly influence mortality rates, the occurrence of ARDS, or the viral shedding duration in COVID-19 patients with acute respiratory failure.
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- 2024
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21. Study on the preservation effects of the amputated forelimb by machine perfusion at physiological temperature
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Sheng-Feng Chen, Bo-Yao Yang, Tie-Yuan Zhang, Xiang-Yu Song, Zhi-Bo Jia, Lei-Jia Chen, Meng-Yi Cui, Wen-Jing Xu, and Jiang Peng
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Traumatic amputation ,Machine perfusion ,Static cold storage ,Limb replantation ,Medicine (General) ,R5-920 - Abstract
Purpose: Ischemia and hypoxia are the main factors limiting limb replantation and transplantation. Static cold storage (SCS), a common preservation method for tissues and organs, can only prolong limb ischemia time to 4 – 6 h. The normothermic machine perfusion (NMP) is a promising method for the preservation of tissues and organs, which can extend the preservation time in vitro by providing continuous oxygen and nutrients. This study aimed to evaluate the difference in the efficacy of the 2 limb preservation methods. Methods: The 6 forelimbs from beagle dogs were divided into 2 groups. In the SCS group (n = 3), the limbs were preserved in a sterile refrigerator at 4 °C for 24 h, and in the NMP group (n = 3), the perfusate prepared with autologous blood was used for the oxygenated machine perfusion at physiological temperature for 24 h, and the solution was changed every 6 h. The effects of limb storage were evaluated by weight gain, perfusate biochemical analysis, enzyme-linked immunosorbent assay, and histological analysis. All statistical analyses and graphs were performed using GraphPad Prism 9.0 one-way or two-way analysis of variance. The p value of less than 0.05 was considered to indicate statistical significance. Results: In the NMP group, the weight gained percentage was 11.72% ± 4.06%; the hypoxia-inducible factor-1α contents showed no significant changes; the shape of muscle fibers was normal; the gap between muscle fibers slightly increased, showing the intercellular distance of (30.19 ± 2.83) μm; and the vascular α-smooth muscle actin (α-SMA) contents were lower than those in the normal blood vessels. The creatine kinase level in the perfusate of the NMP group increased from the beginning of perfusion, decreased after each perfusate change, and remained stable at the end of perfusion showing a peak level of 4097.6 U/L. The lactate dehydrogenase level of the NMP group increased near the end of perfusion and reached the peak level of 374.4 U/L. In the SCS group, the percentage of weight gain was 0.18% ± 0.10%, and the contents of hypoxia-inducible factor-1α increased gradually and reached the maximum level of (164.85 ± 20.75) pg/mL at the end of the experiment. The muscle fibers lost their normal shape and the gap between muscle fibers increased, showing an intercellular distance of (41.66 ± 5.38) μm. The contents of vascular α-SMA were much lower in the SCS group as compared to normal blood vessels. Conclusions: NMP caused lesser muscle damage and contained more vascular α-SMA as compared to SCS. This study demonstrated that NMP of the amputated limb with perfusate solution based on autologous blood could maintain the physiological activities of the limb for at least 24 h.
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- 2024
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22. Quantitative characteristics and influencing factors of Tibetan Buddhist religious space with monasteries as the carrier: a case study of U-Tsang, China
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Subin Fang, Yaolong Zhao, Xinxin Liu, and Yao Yang
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Tibetan Buddhist Monasteries ,Spatial distribution ,Religious space ,Influencing factors ,Tibetan regions ,Fine Arts ,Analytical chemistry ,QD71-142 - Abstract
Abstract Tibetan Buddhism has an inseparable connection with the spatial characteristics, development process, and human-natural environment of the Tibetan Plateau. This paper takes monasteries as carriers of Tibetan Buddhist culture in U-Tsang region which is one of the traditional geographical units of Tibet. Using geospatial analysis methods, this study explores the spatial quantification characteristics of Tibetan Buddhist monasteries and qualitatively and quantitatively analyzes the factors that influence the spatial distribution of monasteries. The results indicate that: (1) Political activities of human society influence the pattern of political power. Under the unique context of Tibetan theocracy system, the scope of political authority has a significant influence and affects the religious spatial pattern in the U-Tsang region throughout history. The distribution of monasteries in the U-Tsang region shows significant spatial differences at three sub-regional scales. (2) The religious spatial pattern in the U-Tsang is the result of the diverse interaction of human-natural factors. The results indirectly endorse that religious space is an inevitable product of the interaction between humans and the environment. (3) The religious spatial distribution patterns in the three major Tibetan regions have distinct characteristics, closely related to the superior conditions of their respective historical and geographical environments.
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- 2024
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23. Physiological responses to drought stress of three pine species and comparative transcriptome analysis of Pinus yunnanensis var. pygmaea
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Feng Xiao, Yang Zhao, Xiurong Wang, Xueyan Jian, and Yao Yang
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Pinus yunnanensis var. pygmaea ,Drought stress ,Rehydration ,PacBio ,Transcriptome ,WGCNA ,Biotechnology ,TP248.13-248.65 ,Genetics ,QH426-470 - Abstract
Abstract Drought stress can significantly affect plant growth, development, and yield. Fewer comparative studies have been conducted between different species of pines, particularly involving Pinus yunnanensis var. pygmaea (P. pygmaea). In this study, the physiological indices, photosynthetic pigment and related antioxidant enzyme changes in needles from P. pygmaea, P. elliottii and P. massoniana under drought at 0, 7, 14, 21, 28 and 35 d, as well as 7 days after rehydration, were measured. The PacBio single-molecule real-time (SMRT) and Illumina RNA sequencing were used to uncover the gene expression differences in P. pygmaea under drought and rehydration conditions. The results showed that the total antioxidant capacity (TAOC) of P. pygmaea was significantly higher than P. massoniana and P. elliottii. TAOC showed a continuous increase trend across all species. Soluble sugar (SS), starch content and non-structural carbohydrate (NSC) of all three pines displayed a "W" pattern, declining initially, increasing, and then decreasing again. P. pygmaea exhibits stronger drought tolerance and greater recovery ability under prolonged drought conditions. Through the PacBio SMRT-seq, a total of 50,979 high-quality transcripts were generated, and 6,521 SSR and 5,561 long non-coding RNAs (LncRNAs) were identified. A total of 2310, 1849, 5271, 5947, 7710, and 6854 differentially expressed genes (DEGs) were identified compared to the control (Pp0D) in six pair-wise comparisons of treatment versus control. bHLH, NAC, ERF, MYB_related, C3H transcription factors (TFs) play an important role in drought tolerance of P. pygmaea. KEGG enrichment analysis and Gene set enrichment analysis (GSEA) analysis showed that P. pygmaea may respond to drought by enhancing metabolic processes such as ABA signaling pathway, alpha-linolenic acid. Weighted gene co-expression network analysis (WGCNA) revealed GST, CAT, LEC14B, SEC23 were associated with antioxidant enzyme activity and TAOC. This study provides a basis for further research on drought tolerance differences among coniferous species.
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- 2024
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24. Mechanical behaviors of backfill-rock composites: Physical shear test and back-analysis
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Jie Xin, Quan Jiang, Fengqiang Gong, Lang Liu, Chang Liu, Qiang Liu, Yao Yang, and Pengfei Chen
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Physical simulation ,Backfill-rock composites ,Shear failure ,Cracking ,Shear constitutive model ,Engineering geology. Rock mechanics. Soil mechanics. Underground construction ,TA703-712 - Abstract
The shear behavior of backfill-rock composites is crucial for mine safety and the management of surface subsidence. For exposing the shear failure mechanism of backfill-rock composites, we conducted shear tests on backfill-rock composites under three constant normal loads, compared with the unfilled rock. To investigate the macro- and meso-failure characteristics of the samples in the shear tests, the cracking behavior of samples was recorded by a high-speed camera and acoustic emission monitoring. In parallel with the experimental test, the numerical models of backfill-rock composites and unfilled rock were established using the discrete element method to analyze the continuous-discontinuous shearing process. Based on the damage mechanics and statistics, a novel shear constitutive model was proposed to describe mechanical behavior. The results show that backfill-rock composites had a special bimodal phenomenon of shearing load-deformation curve, i.e. the first shearing peak corresponded to rock break and the second shearing peak induced by the broken of aeolian sand-cement/fly ash paste backfill. Moreover, the shearing characteristic curves of the backfill-rock composites could be roughly divided into four stages, i.e. the shear failure of the specimens experienced: stage I: stress concentration; stage II: crack propagation; stage III: crack coalescence; stage IV: shearing friction. The numerical simulation shows that the existence of aeolian sand-cement/fly ash paste backfill inevitably altered the coalescence type and failure mode of the specimens and had a strengthening effect on the shear strength of backfill-rock composites. Based on damage mechanics and statistics, a shear constitutive model was proposed to describe the shear fracture characteristics of specimens, especially the bimodal phenomenon. Finally, the micro- and meso-mechanisms of shear failure were discussed by combining the micro-test and numerical results. The research can advance the better understanding of the shear behavior of backfill-rock composites and contribute to the safety of mining engineering.
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- 2024
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25. Assessment of the (Pro)renin Receptor Protein Expression in Organs
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Teng-Yao Yang, Pey-Jium Chang, Yu-Shien Ko, Siou-Ru Shen, and Shun-Fu Chang
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cardiovascular disease ,M8.9 fragment ,(pro)renin receptor ,renin-angiotensin system ,s(P)RR ,Biology (General) ,QH301-705.5 - Abstract
The (pro)renin receptor ((P)RR) is an essential component of the renin–angiotensin system (RAS) as a specific single-pass transmembrane receptor for prorenin and renin and has now emerged as a multifunctional protein implicated in a wide variety of developmental and physio-pathological processes and pathways. The (P)RR may be of pathological significance in metabolic syndrome. The (P)RR has received much consideration; substantial efforts have been made to understand the localization, regulation, and function of the (P)RR at both a molecular and system level. (P)RR regulation of cell function depends on whether it is intact or cleaved into its constituent forms. Therefore, the present chapter describes immunohistochemical approaches to examine the expression of (P)RR in various organs. It was shown that different molecular forms of (P)RR could be present in different tissue compartments in almost all organs. Among them, the liver has high PRR activity. Our findings could elucidate more detailed distribution of different (P)RR molecular forms in different organs, which could provide useful information to further investigate the pathophysiological mechanisms of the development of various diseases in the future.
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- 2024
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26. Research Progress on Food 3D Printing Based on Starch
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ZHU Yingying, WU Huajun, ZHU Jiawen, SHI Zhenxing, ZOU Liang, SHEN Ruiling, YAO Yang
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starch materials ,extrusion-based 3d printing ,physicochemical properties ,printing characteristics ,starch modification ,Food processing and manufacture ,TP368-456 - Abstract
Three-dimensional (3D) printing, also known as additive manufacturing, is an emerging manufacturing technology that enables personalized product design and precise modeling through digital control. In recent years, 3D printing technology has gained significant attention in the food industry due to its potential advantages, especially in the field of customized food processing. Starch is an important component of human diet, especially in the eastern diet structure primarily based on plant-based foods. Most starches possess excellent rheological, hydration, and gel properties, making them have natural advantages in outflow nozzle and printing molding and thus have great application potential in food 3D printing. In this article, recent progress in starch-based 3D printing is reviewed with respect to printing equipment types commonly used in starch-based 3D printing, printing technology using common starches as raw materials, the correlation between starch physicochemical properties and printing performance, starch modification for quality improvement of 3D printed products, the post-processing of starch-based 3D printed products and the influence of printing on starch structure. Furthermore, future prospects in the 3D printing field are presented.
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- 2024
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27. Macular hole following scleral buckling for rhegmatogenous retinal detachment: a case series
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Fangyu Wang, Zhongqiao Zhu, Hong Yan, Yao Yang, Laxiao Niu, and Jing Liu
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Macular hole ,Scleral buckling ,Rhegmatogenous retinal detachment ,Case series ,Clinical study ,Ophthalmology ,RE1-994 - Abstract
Abstract Background Macular hole (MH) development following scleral buckling (SB) surgery for rhegmatogenous retinal detachment (RRD) repair is rare. This study presents both full-thickness MH (FTMH) and lamellar MH (LMH) cases following SB for the treatment of RRD. Methods Clinical records of patients undergoing SB surgery for treatment of RRD at the Xi’an People’s Hospital (Xi’an Fourth Hospital) from January 2016 to December 2021 were reviewed, and cases with postoperative MH were selected. Clinical features and follow-up data were summarised, and possible causes were analysed. Results Among 483 identified cases (483 eyes), four eyes (three male patients, one female patient) had postoperative MH, with prevalence, mean age, and mean axial length of 0.83%, 43.5 ± 10.66 years, and 29.13 ± 3.80 mm, respectively. All patients did not undergo subretinal fluid (SRF) drainage. The mean time for detecting MH was 26 ± 15.5 days postoperatively. Macula-off RRD with high myopia and FTMH combined with retinal re-detachment were diagnosed in three patients. One patient had macula-on RRD with outer LMH. The average follow-up duration was 7.25 ± 1.5 months. The FTMH closed successfully after reoperation, while the outer LMH closed without intervention. Visual acuity insignificantly improved or slightly decreased in all patients. Conclusions Patients with high myopia combined with macula-off RRD might be more susceptible to FTMH, causing MH related retinal detachment. Additionally, LMH following SB was noted in patients with macula-on RRD. Therefore, we should raise awareness of MH following SB for RRD repair.
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- 2024
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28. Evaluation of a novel vaginal cells self‐sampling device for human papillomavirus testing in cervical cancer screening: A clinical trial assessing reliability and acceptability
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Chung‐Yao Yang, Ting‐Chang Chang, Hung‐Hsueh Chou, Angel Chao, Shih‐Tien Hsu, Yu‐Hsiang Shih, Huei‐Jean Huang, Cheng‐Tao Lin, Min‐Yu Chen, Lou Sun, Kuan‐Gen Huang, Kai‐Yun Wu, Wu‐Chiao Hsieh, Yi‐Ting Huang, Liang‐Hsuan Chen, Chien‐Hsing Lu, Hao Lin, and Chao‐Min Cheng
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acceptability ,cervical cancer screening ,HPV testing ,reliability ,self‐sampling ,Chemical engineering ,TP155-156 ,Biotechnology ,TP248.13-248.65 ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Abstract Cervical cancer is a significant public health concern, particularly in low‐ and middle‐income countries where resources for prevention and treatment are limited. Routine screening, such as the Papanicolaou test (Pap smears) and human papillomavirus (HPV) testing, plays a crucial role in the early detection and prevention of cervical cancer. However, the participation rate in cervical cancer screening programs remains below optimal levels due to various factors. This study aimed to evaluate the reliability and acceptability of the HygeiaTouch Self Sampling Kit for Women in collecting vaginal samples for HPV typing, comparing the results with samples collected by physicians. The study included 1210 women aged 21–65 from three medical centers in Taiwan. The findings indicated that the self‐sampling kit was as effective as physician‐collected specimens in terms of obtaining valid samples and identifying HPV. The agreement between the two methods was 88%, with a κ value of 0.75. Furthermore, the study assessed the mechanical characteristics of the self‐sampling applicator through tensile, bending, and torque tests, and determined that it was safe for intravaginal use. Additionally, the study evaluated the safety and satisfaction of self‐sampling and found a low rate of adverse events (0.7%) and high levels of satisfaction (over 90%) among participants. Overall, we demonstrated that the HygeiaTouch Self Sampling Kit for Women is a reliable and acceptable device for HPV testing and cervical screening, providing a convenient, safe, and effective alternative for women.
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- 2024
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29. Metabolic syndrome and risk of subclinical hypothyroidism: a systematic review and meta-analysis
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Lei Zhong, Shuo Liu, Yao Yang, Tong Xie, Jifeng Liu, Huahui Zhao, and Guang Tan
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subclinical hypothyroidism ,thyroid ,metabolic syndrome ,metabolic component ,meta-analysis ,Diseases of the endocrine glands. Clinical endocrinology ,RC648-665 - Abstract
BackgroundSubclinical hypothyroidism (SCH) is a common endocrine subclinical disorder, the main adverse consequences of which are the development of clinical hypothyroidism and the promotion of ischemic heart disease. Metabolic syndrome (MetS) is a collection of metabolic problems. The goal of this meta-analysis was to evaluate the relationship between MetS and SCH.MethodsSuitable publications were identified using PubMed, Embase, and the Cochrane Library. The meta-analysis included only studies in English that reported odds ratio (OR) data for MetS and SCH. Two researchers combined data using a random-effects model. OR and 95% confidence intervals (CIs) were used to present the results.ResultsMetS was associated with an elevated risk of developing SCH (OR 2.56, 95% CI 1.44–4.55). However, the individual components of MetS were not associated with the risk of SCH. Subgroup analysis revealed that different definitions of MetS had varying effects on SCH. Sensitivity analysis confirmed that our results were robust.ConclusionsThis meta-analysis indicates that patients with MetS have an increased risk of SCH, while there is no significant association between the five individual components of MetS and the risk of SCH.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO/, identifier CRD42023454415.
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- 2024
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30. Toripalimab plus cetuximab combined with radiotherapy in a locally advanced platinum-based chemotherapy-insensitive nasopharyngeal carcinoma patient: a case report
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Ying Piao, Yao Yang, Shihai Wu, and Ling Han
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nasopharyngeal carcinoma ,toripalimab ,cetuximab ,radiotherapy ,platinum-insensitive ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
BackgroundLocoregionally advanced nasopharyngeal carcinoma (NPC) is an epithelial malignancy that primarily occurs in East and Southeast Asia, and it is associated with relatively poor overall survival (OS). Currently, there is no reliably effective standard treatment for NPC that progresses after first-line therapy with platinum-based chemotherapy.Case reportA 55-year-old woman diagnosed with stage IVa NPC received two cycles of platinum-based chemotherapy but encountered an increase in the size of cervical lymph nodes and suffered from adverse events. The patient was then switched to toripalimab plus cetuximab combined with radical radiotherapy and had a complete clinical response within 2 months following the completion of radiotherapy without severe treatment-related adverse events.ConclusionThis case report showed that toripalimab plus cetuximab combined with radiotherapy for the treatment of patients with locoregionally advanced nasopharyngeal carcinoma may result in a fast and durable response with a manageable safety profile.
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- 2024
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31. Characterising global antimicrobial resistance research explains why One Health solutions are slow in development: An application of AI-based gap analysis
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Cai Chen, Shu-Le Li, Yao-Yang Xu, Jue Liu, David W. Graham, and Yong-Guan Zhu
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Antimicrobial resistance ,One Health ,Natural language processing ,Artificial intelligence ,Methods harmonization ,Environmental sciences ,GE1-350 - Abstract
The global health crisis posed by increasing antimicrobial resistance (AMR) implicitly requires solutions based a One Health approach, yet multisectoral, multidisciplinary research on AMR is rare and huge knowledge gaps exist to guide integrated action. This is partly because a comprehensive survey of past research activity has never performed due to the massive scale and diversity of published information. Here we compiled 254,738 articles on AMR using Artificial Intelligence (AI; i.e., Natural Language Processing, NLP) methods to create a database and information retrieval system for knowledge extraction on research perfomed over the last 20 years. Global maps were created that describe regional, methodological, and sectoral AMR research activities that confirm limited intersectoral research has been performed, which is key to guiding science-informed policy solutions to AMR, especially in low-income countries (LICs). Further, we show greater harmonisation in research methods across sectors and regions is urgently needed. For example, differences in analytical methods used among sectors in AMR research, such as employing culture-based versus genomic methods, results in poor communication between sectors and partially explains why One Health-based solutions are not ensuing. Therefore, our analysis suggest that performing culture-based and genomic AMR analysis in tandem in all sectors is crucial for data integration and holistic One Health solutions. Finally, increased investment in capacity development in LICs should be prioritised as they are places where the AMR burden is often greatest. Our open-access database and AI methodology can be used to further develop, disseminate, and create new tools and practices for AMR knowledge and information sharing.
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- 2024
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32. Energy Consumption Optimization of UAV-Assisted Traffic Monitoring Scheme With Tiny Reinforcement Learning.
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Xiangjie Kong 0001, Chen-hao Ni, Gaohui Duan, Guojiang Shen, Yao Yang, and Sajal K. Das 0001
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- 2024
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33. Research on Noise Reduction Method for Leakage Signal of Water Supply Pipeline.
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Zhu Jiang, Yuchen Wang, Yao Yang, Jun Zhou, and Liang Shi
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- 2024
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34. Deep Isotonic Embedding Network: A flexible Monotonic Neural Network.
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Jiachi Zhao, Hongwen Zhang 0007, Yue Wang, Yiteng Zhai, and Yao Yang
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- 2024
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35. SecureReID: Privacy-Preserving Anonymization for Person Re-Identification.
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Mang Ye, Wei Shen, Junwu Zhang, Yao Yang, and Bo Du 0001
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- 2024
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36. Effects of single and multiple imputation strategies on addressing over-fitting issues caused by imbalanced data from various scenarios.
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Jiaxi Yang, Yihan Wang, Ye Yang, Kai Ding, Chongning Na, and Yao Yang
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- 2024
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37. Identification of cancer-keeping genes as therapeutic targets by finding network control hubs
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Zhang, Xizhe, Pan, Chunyu, Wei, Xinru, Yu, Meng, Liu, Shuangjie, An, Jun, Yang, Jieping, Wei, Baojun, Hao, Wenjun, Yao, Yang, Zhu, Yuyan, and Zhang, Weixiong
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Quantitative Biology - Molecular Networks ,Electrical Engineering and Systems Science - Systems and Control - Abstract
Finding cancer driver genes has been a focal theme of cancer research and clinical studies. One of the recent approaches is based on network structural controllability that focuses on finding a control scheme and driver genes that can steer the cell from an arbitrary state to a designated state. While theoretically sound, this approach is impractical for many reasons, e.g., the control scheme is often not unique and half of the nodes may be driver genes for the cell. We developed a novel approach that transcends structural controllability. Instead of considering driver genes for one control scheme, we considered control hub genes that reside in the middle of a control path of every control scheme. Control hubs are the most vulnerable spots for controlling the cell and exogenous stimuli on them may render the cell uncontrollable. We adopted control hubs as cancer-keep genes (CKGs) and applied them to a gene regulatory network of bladder cancer (BLCA). All the genes on the cell cycle and p53 singling pathways in BLCA are CKGs, confirming the importance of these genes and the two pathways in cancer. A smaller set of 35 sensitive CKGs (sCKGs) for BLCA was identified by removing network links. Six sCKGs (RPS6KA3, FGFR3, N-cadherin (CDH2), EP300, caspase-1, and FN1) were subjected to small-interferencing-RNA knockdown in four cell lines to validate their effects on the proliferation or migration of cancer cells. Knocking down RPS6KA3 in a mouse model of BLCA significantly inhibited the growth of tumor xenografts in the mouse model. Combined, our results demonstrated the value of CKGs as therapeutic targets for cancer therapy and the potential of CKGs as an effective means for studying and characterizing cancer etiology., Comment: Contact the corresponding authors for supplementary material
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- 2022
38. A visuo-haptic mixed reality manual milling training simulator
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Chuang, Tung-Jui, Tsai, Yao-Yang, and Smith, Shana
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- 2023
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39. Cohort Profile: The China Severe Trauma Cohort (CSTC)
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Yao Yang, Minlan Yuan, Yu Zeng, Yuanjing Xie, Yueyao Xu, Dengbin Liao, Yongmei Chen, Meiru Chen, Yuanyuan Qu, Yao Hu, Wei Zhang, and Huan Song
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cohort ,physical trauma ,post-trauma stress reaction ,psychopathology ,genetics ,Medicine (General) ,R5-920 - Abstract
Background: We sought to establish a prospective hospital-based cohort, featuring detailed multidimensional data of trauma patients with active follow-ups, which can be a reliable data source for all studies focusing on the effects or underlying mechanistic pathways of environmental and biological factors on multiple interested trauma-related outcomes, particularly the incidence and trajectory of trauma-related psychopathology, in a Chinese population. Methods: The China Severe Trauma Cohort (CSTC) enrolled all traumatized individuals aged 12 to 80 years admitted to the Trauma Center of West China Hospital between March 1st, 2020 and July 8th, 2022. The bio-sample and detailed questionnaire data were collected at recruitment, and phone/internet follow-ups were scheduled at 1, 3, 6, and 12 months after the baseline. Long-term health outcomes are planned to be obtained from administrative databases through data linkage. Results: A total of 2,500 trauma patients were enrolled (response rate = 87.1%) with an average age of 46.01 years, and most of the participants were males (62.6%). The proportions of participants with blood and fecal sample collected at baseline were 93.8% and 66.3%, respectively. As of August 31st, 2022, the follow-up rate was 90.0%, 77.0%, 76.5%, and 89.0% for 1-, 3-, 6-, and 12-month follow-ups, respectively. Fall/wrench (47.6%) and traffic accident (26.2%) were the top causes of current trauma. The most common psychopathology at recruitment was sleep disturbance (39.4%), followed by depression (22.6%), anxiety (18.2%), and acute stress reaction (7.8%), all of which showed recovering trajectories during the follow-up period, particularly the first 3 months after baseline. Conclusion: CSTC provides a platform with multidimensional data to study both short-term and long-term trauma-related health consequences, prompting early identification and intervention for individuals with high risk of health decline after trauma exposures.
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- 2024
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40. Risk factors for prolonged mechanical ventilation in critically ill patients with influenza-related acute respiratory distress syndrome
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Pai-Chi Hsu, Yi-Tsung Lin, Kuo-Chin Kao, Chung-Kan Peng, Chau-Chyun Sheu, Shinn-Jye Liang, Ming-Cheng Chan, Hao-Chien Wang, Yu-Mu Chen, Wei-Chih Chen, Kuang-Yao Yang, and TSIRC (Taiwan Severe Influenza Research Consortium)
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Diseases of the respiratory system ,RC705-779 - Abstract
Abstract Background Patients with influenza-related acute respiratory distress syndrome (ARDS) are critically ill and require mechanical ventilation (MV) support. Prolonged mechanical ventilation (PMV) is often seen in these cases and the optimal management strategy is not established. This study aimed to investigate risk factors for PMV and factors related to weaning failure in these patients. Methods This retrospective cohort study was conducted by eight medical centers in Taiwan. All patients in the intensive care unit with virology-proven influenza-related ARDS requiring invasive MV from January 1 to March 31, 2016, were included. Demographic data, critical illness data and clinical outcomes were collected and analyzed. PMV is defined as mechanical ventilation use for more than 21 days. Results There were 263 patients with influenza-related ARDS requiring invasive MV enrolled during the study period. Seventy-eight patients had PMV. The final weaning rate was 68.8% during 60 days of observation. The mortality rate in PMV group was 39.7%. Risk factors for PMV were body mass index (BMI) > 25 (kg/m2) [odds ratio (OR) 2.087; 95% confidence interval (CI) 1.006–4.329], extracorporeal membrane oxygenation (ECMO) use (OR 6.181; 95% CI 2.338–16.336), combined bacterial pneumonia (OR 4.115; 95% CI 2.002–8.456) and neuromuscular blockade use over 48 h (OR 2.8; 95% CI 1.334–5.879). In addition, risk factors for weaning failure in PMV patients were ECMO (OR 5.05; 95% CI 1.75–14.58) use and bacteremia (OR 3.91; 95% CI 1.20–12.69). Conclusions Patients with influenza-related ARDS and PMV have a high mortality rate. Risk factors for PMV include BMI > 25, ECMO use, combined bacterial pneumonia and neuromuscular blockade use over 48 h. In addition, ECMO use and bacteremia predict unsuccessful weaning in PMV patients.
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- 2024
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41. Non-Cooperative Game Based Optimal Dispatch Model for Integrated Energy Systems
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Jiandong Duan, Qian Sun, Chen Wu, Yao Yang, and Siyu Tu
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Integrated energy system ,multi-energy complimentarily ,non-cooperative game theory ,Technology ,Physics ,QC1-999 - Abstract
In order to improve the efficiency of energy utilization, the integrated energy system (IES) has emerged. The IES typically acts as a whole system during operations, the subsystems are separated, and the interests of each system are independent. In this paper, considering the relationship between the various energy systems, non-cooperative game theory is used to establish the optimal dispatch model. The proposed model mainly relies on the relationship between the cooperation and competition among various subsystems to obtain the maximum benefit they can accept. Furthermore, the basic definition is combined with the particle swarm optimization algorithm to solve the problem. The results show that the optimization strategy proposed in this paper can operate safely and reliably, and effectively distribute the benefits of each energy system.
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- 2024
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42. Clinical characteristics and outcomes among critically ill patients with cancer and COVID-19-related acute respiratory failure
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Ying-Ting Liao, Hsiao-Chin Shen, Jhong-Ru Huang, Chuan-Yen Sun, Hung-Jui Ko, Chih-Jung Chang, Yuh-Min Chen, Jia-Yih Feng, Wei-Chih Chen, and Kuang-Yao Yang
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Acute respiratory failure ,Coronavirus disease 2019 (COVID-19) ,Malignancy ,Vasopressor ,Inflammatory marker ,Diseases of the respiratory system ,RC705-779 - Abstract
Abstract Background Coronavirus disease 2019 (COVID-19) has affected individuals worldwide, and patients with cancer are particularly vulnerable to COVID-19-related severe illness, respiratory failure, and mortality. The relationship between COVID-19 and cancer remains a critical concern, and a comprehensive investigation of the factors affecting survival among patients with cancer who develop COVID-19-related respiratory failure is warranted. We aim to compare the characteristics and outcomes of COVID-19-related acute respiratory failure in patients with and without underlying cancer, while analyzing factors affecting in-hospital survival among cancer patients. Methods We conducted a retrospective observational study at Taipei Veterans General Hospital in Taiwan from May to September 2022, a period during which the omicron variant of the severe acute respiratory syndrome coronavirus 2 was circulating. Eligible patients had COVID-19 and acute respiratory failure. Clinical data, demographic information, disease severity markers, treatment details, and outcomes were collected and analyzed. Results Of the 215 enrolled critically ill patients with COVID-19, 65 had cancer. The patients with cancer were younger and had lower absolute lymphocyte counts, higher ferritin and lactate dehydrogenase (LDH) concentrations, and increased vasopressor use compared with those without cancer. The patients with cancer also received more COVID-19 specific treatments but had higher in-hospital mortality rate (61.5% vs 36%, P = 0.002) and longer viral shedding (13 vs 10 days, P = 0.007) than those without cancer did. Smoking [odds ratio (OR): 5.804, 95% confidence interval (CI): 1.847–39.746], elevated LDH (OR: 1.004, 95% CI: 1.001–1.012), vasopressor use (OR: 5.437, 95% CI: 1.202–24.593), and new renal replacement therapy (OR: 3.523, 95% CI: 1.203–61.108) were independent predictors of in-hospital mortality among patients with cancer and respiratory failure. Conclusion Critically ill patients with cancer experiencing COVID-19-related acute respiratory failure present unique clinical features and worse clinical outcomes compared with those without cancer. Smoking, elevated LDH, vasopressor use, and new renal replacement therapy were risk factors for in-hospital mortality in these patients.
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- 2024
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43. Efficacy and Safety of Neoadjuvant, Adjuvant, and Perioperative Immune Checkpoint Inhibitors Single Agent or with Chemotherapy in Resectable NSCLC: Indirect Comparison and Clinicopathological Impact
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Meng, Yunchang, primary, Zhang, Qingfeng, additional, Wu, Ranpu, additional, Wang, Zhaofeng, additional, Li, Huijuan, additional, Yao, Yang, additional, Li, Xinjing, additional, Gong, Yanzhuo, additional, Chen, Zhangxuan, additional, and Liu, Hongbing, additional
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- 2024
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44. The landscape of patellofemoral arthroplasty research: a bibliometric analysis
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Yao Yang, Yuan Chen, Yingjie Wang, Junjie Wang, Baoliang Lu, Wanbo Zhu, Ning Yang, Junchen Zhu, Chen Zhu, and Xianzuo Zhang
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Patellofemoral arthroplasty ,Osteoarthritis ,Knee ,Cooperative networks ,Bibliometric analysis ,Orthopedic surgery ,RD701-811 - Abstract
Abstract Purpose Patellofemoral arthroplasty (PFA) was shown to be a potentially effective surgical technique for isolated patellofemoral osteoarthritis but varying reports on PFA-related implant failure and complications have rendered the procedure controversial. This study aimed to identify impactful publications, research interests/efforts, and collaborative networks in the field of PFA research. Methods The study used the Web of Science Core Collection (WOSCC) database, Medline, Springer, BIOSIS Citation Index, and PubMed to retrieve relevant publications on PFA research published between 1950–2022. Statistical tests in R software were used for analysis while VOSviewer, Bibliometrix, and CiteSpace were employed for data visualization. Results Two hundred forty-one articles were analyzed with the number of published papers increasing over time. Knee was the most frequent journal and Clinical Orthopaedics and Related Research was the most cited journal. Clinical outcomes, such as prosthesis survival, revision, and complications, were researched most frequently as demonstrated by keyword analysis. The United States was the top contributor to cooperative networks, followed by the United Kingdom while Technical University Munich formed close ties among authors. Conclusion Publications on PFA research have witnessed a notable surge. They primarily came from a limited number of centers and were characterized by low-level evidence. The majority of studies primarily focused on the clinical outcomes of PFA, while revision of PFA and patient satisfaction have emerged as new research areas.
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- 2023
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45. Identification of the protein coding capability of coronavirus defective viral genomes by mass spectrometry
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Ching-Hung Lin, Feng-Cheng Hsieh, Chien-Chen Lai, Wei-Chen Wang, Cheng-Yu Kuo, Chun-Chun Yang, Hsuan-Wei Hsu, Hon-Man-Herman Tam, Cheng-Yao Yang, and Hung-Yi Wu
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Coronavirus ,Defective viral genome ,Protein coding ,Gene expression ,Pathogenesis ,Infectious and parasitic diseases ,RC109-216 - Abstract
Abstract During coronavirus infection, in addition to the well-known coronavirus genomes and subgenomic mRNAs, an abundance of defective viral genomes (DVGs) can also be synthesized. In this study, we aimed to examine whether DVGs can encode proteins in infected cells. Nanopore direct RNA sequencing and liquid chromatography-tandem mass spectrometry (LC–MS/MS) analysis were employed. With the protein databases generated by nanopore direct RNA sequencing and the cell lysates derived from the RNA–protein pull-down assay, six DVG-encoded proteins were identified by LC–MS/MS based on the featured fusion peptides caused by recombination during DVG synthesis. The results suggest that the coronavirus DVGs have the capability to encode proteins. Consequently, future studies determining the biological function of DVG-encoded proteins may contribute to the understanding of their roles in coronavirus pathogenesis and the development of antiviral strategies.
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- 2023
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46. Identification of A Novel Capsular Polysaccharide Cluster in Lactiplantibacillus plantarum YZH81
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Fang ZHAO, Lu HUANG, Hailin HUAN, Shuting HUANG, Wenjun ZHANG, Qingqing LIANG, and Yao YANG
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lactiplantibacillus plantarum ,exopolysaccharides (eps) ,capsular polysaccharide cluster (cps cluster) ,adhesion ,probiotics ,Food processing and manufacture ,TP368-456 - Abstract
In order to investigate the mechanism of extracellular polysaccharide (EPS) synthesis in Lactobacillus plantarum, a strain of Lactobacillus plantarum YZH81 with high EPS production was selected for the study of extracellular polysaccharide synthesis gene cluster (cps). After whole-genome sequencing, alignment and analysis, it was determined that the genome of YZH81 contained two cps gene clusters, one of which (cps1) had yet to be identified in terms of structure and function, while the other (cps2) was highly homologous to other reported Lactobacillus plantarum strains. The conclusions in this study, the cps1 gene cluster resulted 52.28% reduction in EPS production, accelerated self-aggregation, reduced adhesion and 32.42% reduction in the ability to generated 1,1-diphenyl-2-trinitrophenylhydrazine (DPPH·) in the YZH81∆cps1 strain compared to the wild-type YZH81 strain. The results suggested that the cps1 gene cluster of strain YZH81 was associated with EPS synthesis and established favorable conditions for further studies on the mechanism of EPS biosynthesis in this strain.
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- 2023
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47. Gelidocalamus albozonatus (Poaceae, Bambusoideae), a new species from the southeast of Chongqing, China, and analysis of the morphological diversity in the core group of Gelidocalamus
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Yong-Long Li, Rong Guo, Hong-Jing Zhang, Si-Rong Yi, Guang-Yao Yang, and Wen-Gen Zhang
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Botany ,QK1-989 - Abstract
Gelidocalamus albozonatus W. G. Zhang, S. R. Yi & Y. L. Li, a new species of Gelidocalamus, collected from Pengshui County of Chongqing City in China, was described and illustrated herein. In this study, key morphological characters were compared between the new species and other eight “gelido-” members of Gelidocalamus. By using scanning electron microscopy (SEM), its leaf epidermal characters were observed in comparison with those of another three Gelidocalamus representatives. Our results show that the new taxon has the typical characteristics of the genus Gelidocalamus, both macromorphologically and micromorphologically. Moreover, it was most similar to G. tessellatus, but differed by a ring of white tomenta below per node, culm sheath base with densely purple verrucous setae and foliage leaf blades mesophyll.
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- 2023
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48. Assessment of hyperspectral imaging and CycleGAN-simulated narrowband techniques to detect early esophageal cancer
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Kai-Yao Yang, Arvind Mukundan, Yu-Ming Tsao, Xian-Hong Shi, Chien-Wei Huang, and Hsiang-Chen Wang
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Medicine ,Science - Abstract
Abstract The clinical signs and symptoms of esophageal cancer (EC) are often not discernible until the intermediate or advanced phases. The detection of EC in advanced stages significantly decreases the survival rate to below 20%. This study conducts a comparative analysis of the efficacy of several imaging techniques, including white light image (WLI), narrowband imaging (NBI), cycle-consistent adversarial network simulated narrowband image (CNBI), and hyperspectral imaging simulated narrowband image (HNBI), in the early detection of esophageal cancer (EC). In conjunction with Kaohsiung Armed Forces General Hospital, a dataset consisting of 1000 EC pictures was used, including 500 images captured using WLI and 500 images captured using NBI. The CycleGAN model was used to generate the CNBI dataset. Additionally, a novel method for HSI imaging was created with the objective of generating HNBI pictures. The evaluation of the efficacy of these four picture types in early detection of EC was conducted using three indicators: CIEDE2000, entropy, and the structural similarity index measure (SSIM). Results of the CIEDE2000, entropy, and SSIM analyses suggest that using CycleGAN to generate CNBI images and HSI model for creating HNBI images is superior in detecting early esophageal cancer compared to the use of conventional WLI and NBI techniques.
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- 2023
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49. Targeting the conserved coronavirus octamer motif GGAAGAGC is a strategy for the development of coronavirus vaccine
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Ching-Hung Lin, Feng-Cheng Hsieh, Yu-Chia Chang, Cheng-Yao Yang, Hsuan-Wei Hsu, Chun-Chun Yang, Hon-Man-Herman Tam, and Hung-Yi Wu
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Coronavirus ,Coronavirus octamer ,Vaccine ,Translation ,Replication ,Infectious and parasitic diseases ,RC109-216 - Abstract
Abstract Background Coronaviruses are pathogens of humans and animals that cause widespread and costly diseases. The development of effective strategies to combat the threat of coronaviruses is therefore a top priority. The conserved coronavirus octamer motif 5’GGAAGAGC3’ exists in the 3’ untranslated region of all identified coronaviruses. In the current study, we aimed to examine whether targeting the coronavirus octamer motif GGAAGAGC is a promising approach to develop coronavirus vaccine. Methods Plaque assays were used to determine the titers of mouse hepatitis virus (MHV)-A59 octamer mutant (MHVoctm) and wild-type (wt) MHV-A59 (MHVwt). Western blotting was used for the determination of translation efficiency of MHVoctm and MHVwt. Plaque assays and RT-qPCR were employed to examine whether MHVoctm was more sensitive to interferon treatment than MHVwt. Weight loss, clinical signs, survival rate, viral RNA detection and histopathological examination were used to evaluate whether MHVoctm was a vaccine candidate against MHVwt infection in BALB/c mice. Results In this study, we showed that (i) the MHVoctm with mutation of coronavirus octamer was able to grow to high titers but attenuated in mice, (ii) with the reduced multiplicity of infection (MOI), the difference in gene expression between MHVoctm and MHVwt became more evident in cultured cells, (iii) MHVoctm was more sensitive to interferon treatment than MHVwt and (iv) mice inoculated with MHVoctm were protected from MHVwt infection. Conclusions Based on the results obtained from cultured cells, it was suggested that the synergistic effects of octamer mutation, multiplicity of infection and immune response may be a mechanism explaining the distinct phenotypes of octamer-mutated coronavirus in cell culture and mice. In addition, targeting the conserved coronavirus octamer motif is a strategy for development of coronavirus vaccine. Since the conserved octamer exists in all coronaviruses, this strategy of targeting the conserved octamer motif can also be applied to other human and animal coronaviruses for the development of coronavirus vaccines, especially the emergence of novel coronaviruses such as SARS-CoV-2, saving time and cost for vaccine development and disease control.
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- 2023
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50. Electrosynthesis of buckyballs with fused-ring systems from PCBM and its analogue
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Wang, Wei-Feng, Liu, Kai-Qing, Niu, Chuang, Wang, Yun-Shu, Yao, Yang-Rong, Yin, Zheng-Chun, Chen, Muqing, Ye, Shi-Qi, Yang, Shangfeng, and Wang, Guan-Wu
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- 2023
- Full Text
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