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9. Vector-Borne Infections

Author

Hojjatie, Sara L., Yeh, Steven, Shantha, Jessica G., Teixeira, Lucileia, Johnson, John L., Singh, Arun D., Series Editor, Lowder, Careen Y., editor, Shrestha, Nabin, editor, and Venkat, Arthi, editor

Published
2023
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12. Operationalization of Retinopathy of Prematurity Screening by the Application of the Essential Public Health Services Framework

Author

Sobhy, Myrna, Cole, Emily, Jabbehdari, Sayena, Valikodath, Nita G., Al-Khaled, Tala, Kalinoski, Lauren, Chervinko, Margaret, Cherwek, David Hunter, Chuluunkhuu, Chimgee, Shah, Parag K., K.C., Sagun, Jonas, Karyn E., Scanzera, Angel, Yap, Vivien L., Yeh, Steven, Kalpathy-Cramer, Jayashree, Chiang, Michael F., Campbell, John Peter, and Chan, R.V. Paul

Published
2023
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15. Vector-Borne Infections

Author

Hojjatie, Sara L., primary, Yeh, Steven, additional, Shantha, Jessica G., additional, Teixeira, Lucileia, additional, and Johnson, John L., additional

Published
2023
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16. Endogenous Endophthalmitis

Author

Berry, Duncan, Yeh, Steven, Sobrin, Lucia, Section editor, Albert, Daniel M., editor, Miller, Joan W., editor, Azar, Dimitri T., editor, and Young, Lucy H., editor

Published
2022
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21. Visual Morbidity and Outcomes of Scleritis Associated with Intraocular Inflammation Compared to Isolated Scleritis.

Author

Liao, Albert, Fajoles-Vasseneix, Caroline, Rali, Aditya, Ward, Laura, Fernandes, Alcides, Patel, Purnima S., O'Keefe, Ghazala, Shantha, Jessica G., and Yeh, Steven

Subjects
EYE inflammation, SCLERITIS, VISUAL acuity, OCULAR manifestations of general diseases, THERAPEUTIC complications
Abstract

To compare visual outcomes, ocular complications and therapies for patients with scleritis-associated intraocular inflammation (SAI) and patients with isolated scleritis (IS). A total of 52 patients (36 with SAI and 16 with IS) were reviewed. Mean age (standard deviation) at presentation was 48.4 years old (± 15.4) in the SAI group and 53 years old (± 17.1) in the IS group (p =.37). Visual acuity was worse at presentation and last visit for patients with SAI compared to IS (p =.04). Patients in the SAI group developed greater posterior segment complications than in the IS group (p =.002). Scleritis with intraocular inflammation was associated with a higher rate of visual morbidity compared to isolated scleritis. More aggressive management strategies may be needed for patients who present with scleritis associated with inflammation. [ABSTRACT FROM AUTHOR]

Published
2024
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23. Childhood vision impairment and blindness in West Africa: public health measures and implications for systemic health

Author

Yeh, Caleb, primary, Huang, Crystal, additional, Huang, Ye, additional, Hartley, Caleb D., additional, Fashina, Tolulope, additional, Ashby, Nathaniel, additional, Miller, Chase, additional, Shantha, Jessica G., additional, Justin, Grant A., additional, Chan, R. V. Paul, additional, Mattia, John G., additional, Vandy, Matthew J., additional, Harrison-Williams, Lloyd, additional, Mustapha, Jalikatu, additional, Mwanza, Jean-Claude, additional, and Yeh, Steven, additional

Published
2024
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25. 3 Things You Should Know About Managing Noninfectious UME

Author

Yeh, Steven

Subjects
Continuing medical education, Medical colleges, Adalimumab, Medical care -- Quality management, Company business management, Health
Abstract

Learning Objectives Upon successful completion of this activity, you should be better prepared to: * Describe factors associated with the etiology and pathogenesis of uveitic macular edema (UME) * Apply [...]

Published
2022

26. Comprehensive Assessment of Quality of Life, Functioning, and Mental Health in Children With Juvenile Idiopathic Arthritis and Noninfectious Uveitis

Author

McDonald, Joseph, Cassedy, Amy, Altaye, Mekibib, Andringa, Jennifer, Cooper, Ashley M., Drews‐Botsch, Carolyn, Engelhard, George, Jr, Hennard, Theresa, Holland, Gary N., Jenkins, Kirsten, Lambert, Scott R., Lipscomb, Jessi, McCracken, Courtney, McCurdy, Deborah K., Mwase, Najima, Prahalad, Sampath, Shantha, Jessica, Stahl, Erin, Utz, Virginia Miraldi, Walker, A. Adrienne, Yeh, Steven, and Angeles‐Han, Sheila T.

Published
2022
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27. Molecular Diagnostics for Infectious Uveitis: Current Practice and Future Directions.

Author

Fashina, Tolulope, Hariprasad, Seenu M., and Yeh, Steven

Subjects
MOLECULAR diagnosis, UVEITIS, POLYMERASE chain reaction, PATHOGENIC microorganisms, DRUG resistance
Abstract

The article focuses on the use of molecular diagnostics for identifying infectious uveitis and outlines current practices and future directions. Topics include the limitations of traditional diagnostic methods, the advantages of polymerase chain reaction (PCR) and real-time PCR for detecting specific pathogens, and the potential of next-generation sequencing (NGS) for comprehensive pathogen identification and drug resistance analysis.

Published
2024
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28. Ocular Ischemic Events and Vision Loss Associated with COVID-19 Acute Hypoxic Respiratory Failure.

Author

Blyden, K'Mani K., Fashina, Tolulope, Randleman, Casey, Pearce, William, Wells, Jill, Yeh, Steven, and Shantha, Jessica G.

Subjects
COVID-19 pandemic, SARS-CoV-2, MEDICAL care, MEDICAL personnel, RETINAL vein occlusion
Abstract

Coronavirus disease 2019 (COVID-19) is associated with increased risk of microvascular complications; however, reports of ophthalmic manifestations associated with retinal vascular occlusion associated with COVID-19 are limited. In this report, we describe two middle-aged female patients who were admitted for acute hypoxic respiratory failure secondary to COVID-19-induced pneumonia. Following prolonged intensive care unit admission requiring mechanical ventilation and critical care interventions, both patients reported substantially reduced vision upon regaining consciousness. Dilated funduscopic exam showed multiple blot hemorrhages in all quadrants of the posterior pole, bilateral retinal hemorrhage, macular edema, and retinal vascular tortuosity. Both patients were diagnosed with retinal ischemic events owing to bilateral ophthalmic artery occlusion in the first patient, and bilateral central retinal vein occlusion (CRVO) in the second individual. While uncommon, retinal microvascular complications associated with COVID-19 leading to vision loss require prompt evaluation and referral given their potential long-term impact following acute illness. [ABSTRACT FROM AUTHOR]

Published
2024
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32. Dissociations of the Fluocinolone Acetonide Implant: The Multicenter Uveitis Steroid Treatment (MUST) Trial and Follow-up Study

Author

Holbrook, Janet T, Sugar, Elizabeth A, Burke, Alyce E, Vitale, Albert T, Thorne, Jennifer E, Davis, Janet L, Jabs, Douglas A, Jaffe, Glenn J, Branchaud, Brenda, Hahn, Paul, Koreen, Larry, Lad, Eleonora M, Lin, Phoebe, Martel, Joseph Nissim, Serrano, Neha, Skalak, Cindy, Vajzovic, Lejla, Baer, Claxton, Bryant, Joyce, Chavala, Sai, Cusick, Michael, Day, Shelley, Dayani, Pouya, Ehlers, Justis, Kesen, Muge, Lee, Annie, Melamud, Alex, Qureshi, Jawad A, Scott, Adrienne Williams, See, Robert F, Shuler, Robert K, Wood, Megan, Yeh, Steven, Fernandes, Alcides, Gibbs, Deborah, Leef, Donna, Martin, Daniel F, Srivastava, Sunil, Dunn, James P, Begum, Hosne, Boring, Jeff, Brotherson, Kristen L, Burkholder, Bryn, Butler, Nicholas J, Cain, Dennis, Cook, Mary A, Emmert, David, Graul, Janis R, Herring, Mark, Laing, Ashley, Leung, Theresa G, Mahon, Michael C, Moradi, Ahmafreza, Nwankwo, Antonia, Ostheimer, Trucian L, Reed, Terry, Arnold, Ellen, Barnabie, Patricia M, Belair, Marie-Lynn, Bolton, Stephen G, Brodine, Joseph B, Brown, Diane M, Brune, Lisa M, Galor, Anat, Gan, Theresa, Jacobowitz, Adam, Kapoor, Meera, Kedhar, Sanjay, Kim, Stephen, Leder, Henry A, Livingston, Alison G, Morton, Yavette, Nolan, Kisten, Peters, George B, Soto, Priscilla, Stevenson, Ricardo, Tarver-Carr, Michelle, Wang, Yue, Foster, C Stephen, Anesi, Stephen D, Bruner, Linda, Ceron, Olga, Hinkle, David M, Persons, Nancy, Wentworth, Bailey, Acevedo, Sarah, Anzaar, Fahd, Cesca, Tom, Contero, Angelica, Fitzpatrick, Kayleigh, Goronga, Faith, Johnson, Jyothir, Lebron, Karina Q, Marvell, Danielle, Morgan, Chandra, Patel, Nita, Pinto, Jennifer, Siddique, Sana S, Sprague, Janet, and Yilmaz, Taygan

Subjects
Clinical Trials and Supportive Activities, Brain Disorders, Eye Disease and Disorders of Vision, Bioengineering, Clinical Research, Prevention, Neurosciences, Eye, Adolescent, Adult, Aged, Aged, 80 and over, Drug Implants, Equipment Failure, Female, Fluocinolone Acetonide, Follow-Up Studies, Foreign-Body Migration, Glucocorticoids, Humans, Intravitreal Injections, Male, Middle Aged, Postoperative Complications, Reoperation, Risk Factors, Time Factors, Uveitis, Visual Acuity, Multicenter Uveitis Steroid Treatment (MUST) Trial Research Group, Clinical Sciences, Opthalmology and Optometry, Public Health and Health Services, Ophthalmology & Optometry
Abstract

PurposeTo describe fluocinolone acetonide implant dissociations in the Multicenter Uveitis Steroid Treatment (MUST) Trial.DesignRandomized clinical trial with extended follow-up.MethodsReview of data collected on the first implant in the eye(s) of participants. Dissociation was defined as the drug pellet no longer being affixed to the strut and categorized as spontaneous or surgically related.ResultsA total of 250 eyes (146 patients) had at least 1 implant placed. Median follow-up time after implant placement was 6 years (range 0.5-9.2 years). Thirty-four dissociations were reported in 30 participants. There were 22 spontaneous events in 22 participants; 6-year cumulative risk of a spontaneous dissociation was 4.8% (95% confidence interval [CI]: 2.4%-9.1%). The earliest event occurred 4.8 years after placement. Nine of 22 eyes with data had a decline in visual acuity ≥5 letters temporally related to the dissociation. Thirty-nine implant removal surgeries were performed, 33 with replacement. Twelve dissociations were noted during implant removal surgeries in 10 participants (26%, 95% CI 15%-48%); 5 of these eyes had a decline in visual acuity ≥5 letters after surgery. The time from implant placement to removal surgery was longer for the surgeries at which dissociated implants were identified than for those without one (5.7 vs 3.7 years, P < .001). Overall, visual acuity declined 15 or more letters from pre-implant values in 22% of affected eyes; declines were frequently associated with complications of uveitis or its treatment.ConclusionThere is an increasing risk of dissociation of Retisert implants during follow-up; the risk is greater with removal/exchange surgeries, but the risk of both spontaneous and surgically related events increases with longevity of the implants. In 22% of affected eyes visual acuity declined by 15 letters. In the context of eyes with moderate to severe uveitis for years, this rate is not unexpected.

Published
2016

35. 3 Things You Should Know About Diagnosing and Managing Uveitic Macular Edema

Author

Yeh, Steven

Subjects
Corticosteroids, Dropsy -- Development and progression, Fluocinolone acetonide, Edema -- Development and progression, Fluocinolone, Company business management, Health
Abstract

Complications of uveitic macular edema (UME) account for 20% of cases of legal blindness and are the fifth-leading cause of visual impairment in developed nations. (1) Targeted approaches to corticosteroid [...]

Published
2022

36. Factors Predicting Visual Acuity Outcome in Intermediate, Posterior, and Panuveitis: The Multicenter Uveitis Steroid Treatment (MUST) Trial

Author

Kempen, John H, Van Natta, Mark L, Altaweel, Michael M, Dunn, James P, Jabs, Douglas A, Lightman, Susan L, Thorne, Jennifer E, Holbrook, Janet T, Jaffe, Glenn J, Branchaud, Brenda, Hahn, Paul, Koreen, Larry, Lad, Eleonora M, Lin, Phoebe, Martel, Joseph Nissim, Serrano, Neha, Skalak, Cindy, Vajzovic, Lejla, Baer, Claxton, Bryant, Joyce, Chavala, Sai, Cusick, Michael, Day, Shelley, Dayani, Pouya, Ehlers, Justis, Kesen, Muge, Lee, Annie, Melamud, Alex, Qureshi, Jawad A, Scott, Adrienne Williams, See, Robert F, Shuler, Robert K, Wood, Megan, Yeh, Steven, Fernandes, Alcides, Gibbs, Deborah, Leef, Donna, Martin, Daniel F, Srivastava, Sunil, Begum, Hosne, Boring, Jeff, Brotherson, Kristen L, Burkholder, Bryn, Butler, Nicholas J, Cain, Dennis, Cook, Mary A, Emmert, David, Graul, Janis R, Herring, Mark, Laing, Ashley, Leung, Theresa G, Mahon, Michael C, Moradi, Ahmafreza, Nwankwo, Antonia, Ostheimer, Trucian L, Reed, Terry, Arnold, Ellen, Barnabie, Patricia M, Belair, Marie-Lynn, Bolton, Stephen G, Brodine, Joseph B, Brown, Diane M, Brune, Lisa M, Galor, Anat, Gan, Theresa, Jacobowitz, Adam, Kapoor, Meera, Kedhar, Sanjay, Kim, Stephen, Leder, Henry A, Livingston, Alison G, Morton, Yavette, Nolan, Kisten, Peters, George B, Soto, Priscilla, Stevenson, Ricardo, Tarver-Carr, Michelle, Wang, Yue, Foster, C Stephen, Anesi, Stephen D, Bruner, Linda, Ceron, Olga, Hinkle, David M, Persons, Nancy, Wentworth, Bailey, Acevedo, Sarah, Anzaar, Fahd, Cesca, Tom, Contero, Angelica, Fitzpatrick, Kayleigh, Goronga, Faith, Johnson, Jyothir, Lebron, Karina Q, Marvell, Danielle, Morgan, Chandra, Patel, Nita, Pinto, Jennifer, Siddique, Sana S, and Sprague, Janet

Subjects
Clinical Trials and Supportive Activities, Clinical Research, Eye Disease and Disorders of Vision, 6.1 Pharmaceuticals, Evaluation of treatments and therapeutic interventions, Eye, Aged, Drug Implants, Female, Follow-Up Studies, Glucocorticoids, Humans, Male, Middle Aged, Panuveitis, Time Factors, Tomography, Optical Coherence, Treatment Outcome, Visual Acuity, Multicenter Uveitis Steroid Treatment (MUST) Trial Research Group, Clinical Sciences, Opthalmology and Optometry, Public Health and Health Services, Ophthalmology & Optometry
Abstract

PurposeTo identify factors associated with best-corrected visual acuity (BCVA) presentation and 2-year outcome in 479 intermediate, posterior, and panuveitic eyes.DesignCohort study using randomized controlled trial data.MethodsMulticenter Uveitis Steroid Treatment (MUST) Trial masked BCVA measurements at baseline and at 2 years follow-up used gold-standard methods. Twenty-three clinical centers documented characteristics per protocol, which were evaluated as potential predictive factors for baseline BCVA and 2-year change in BCVA.ResultsBaseline factors significantly associated with reduced BCVA included age ≥50 vs 10 vs grade 0; cataract; macular thickening; and exudative retinal detachment. Over 2 years, eyes better than 20/50 and 20/50 or worse at baseline improved, on average, by 1 letter (P = .52) and 10 letters (P < .001), respectively. Both treatment groups and all sites of uveitis improved similarly. Factors associated with improved BCVA included resolution of active AC cells, resolution of macular thickening, and cataract surgery in an initially cataractous eye. Factors associated with worsening BCVA included longer duration of uveitis (6-10 or >10 vs

Published
2015

41. Approach to Cataract Surgery in an Ebola Virus Disease Survivor with Prior Ocular Viral Persistence

Author

Wells, Jill R., Crazier, Ian, Kraft, Colleen S., Sexton, Mary Elizabeth, Hill, Charles E., Ribner, Bruce S., Bavari, Sina, Palacios, Gustavo, Pearce, William A., Van Gelder, Russell, Grossniklaus, Hans, Cazares, Lisa, Zeng, Xiankung, Shantha, Jessica G., and Yeh, Steven

Subjects
Ebola hemorrhagic fever -- Prevention, Ebola virus -- Health aspects, Genitalia -- Health aspects, Mental health -- Health aspects, Medical research -- Health aspects, Cataracts -- Prevention, Cataract extraction -- Health aspects, Difluprednate -- Health aspects, Health
Abstract

The 2013-2016 Ebola virus disease (EVD) outbreak in western Africa was unprecedented in magnitude, leading to the largest cohort of EVD survivors in history (1). Thousands of survivors were at [...]

Published
2020
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43. 3 Things You Should Know About Uveitic Macular Edema

Author

Yeh, Steven

Subjects
Dropsy -- Care and treatment, Continuing medical education, Fluocinolone acetonide, Edema -- Care and treatment, Fluocinolone, Adalimumab, Medical care -- Quality management, Health
Abstract

Learning Objectives Upon successful completion of this activity, you should be better prepared to: * Characterize treatable targets involved in the pathophysiology of uveitic macular edema (UME) * Identify unmet [...]

Published
2022

44. Coxsackievirus A24 causing acute conjunctivitis in a 2023 outbreak in Vietnam

Author

Prajna, Lalitha, Prajna, N. Venkatesh, Gunasekaran, Ramesh, Sharma, Sankalp Singh, Teja, Vishnu, Chaudhary, Meenu, Sitaula, Sanjeeta, Sié, Ali, Coulibaly, Boubacar, Bountogo, Mamadou, Somkijrungroj, Thanapong, Satitpitakul, Vannarut, Tran, Huy, Mai, Linh Hoàng, Xuân, Thảo Hạ, Tran, Yen, Urzua, Cristhian A., Vega, Fabian, Salgado, Felipe, Cuitino, Loreto, Pérez, Fernando Pérez, Martínez, Jaime Macías, Lansingh, Van Charles, Thanapaisal, Sukhumal, Laovirojjanakul, Wipada, McKie, George, Chavez, Kenia, Redd, Travis, Chamberlain, Winston, Cheng, Angel, Tham, Vivien, Sansanayudh, Wiwan, Yakoura, Abba Kaka Hajia, Amza, Abdou, Souley, Abdoul Salam Youssoufou, Diori, Adam Nouhou, Nassirou, Beido, Kadri, Boubacar, Mariama, Boubacar, Ibrahim, Cissé Mamadou, Roufaye, Lamyne Aboubacar, Boulhassane, Ramatou, Ali, Saley, Abdou, Zakou, Goren, Lee, Bahar, Irit, Sella, Ruti, Kelliher, Clare, Green, Laura, Ong, Hon Shing, Mehta, Jod, Liu, Yu-Chi, Pinsky, Benjamin A., Hwang, De-Kuang, Fan, Nai-Wen, Chiong, Hong Sheng, Lacorzana, Javier, Cabrera-Aguas, Maria, Watson, Stephanie, Tsui, Edmund, Cherian, Nina M., Feit-Leichman, Rachel, Hughes, Reginald E., Jr, Onclinx, Tania, Privratsky, Joseph K, Yu, Carol, McClean, Esmeralda, Molina, Iliana, Hinterwirth, Armin, Chen, Cindi, Yu, Danny, Liu, David, Lebas, Elodie, Colby, Emily, Seitzman, Gerami, Ruder, Kevin, Zhong, Lina, Deiner, Michael, Abraham, Thomas, Lietman, Thomas, Doan, Thuy, Porco, Travis, McLeod, Stephen, Kanai, Kuniyoshi, Whiteside, Meredith, Yeh, Steven, Fashina, Tolulope, Chodosh, James, Tarkap, Bridgit, Garap, Jambi N., Mangot, Magdalene, Amel, Edwin, Taleo, Fasihah, Kasso, Johnson, Willie, Kalbule, Nanu, Madopule, Rymill, Prudence, Solomon, Anthony W., Ha, Thao, Hoang, Linh, Liu, YuHeng, Porco, Travis C., Lietman, Thomas M., and Seitzman, Gerami D.

Published
2024
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45. Ebola Uveitis

Author

Lindeke-Myers, Aaron, primary, Yeh, Steven, additional, and Shantha, Jessica G., additional

Published
2021
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46. List of Contributors

Author

Aleman, Tomas S., primary, Arepalli, Sruthi, additional, Belfort, Rubens, additional, Blodi, Frederick R., additional, Bodaghi, Bahram, additional, Chan, Weilin, additional, Chang, Peter Yuwei, additional, Chorfi, Sarah, additional, Conrady, Christopher, additional, Eliott, Dean, additional, Foster, C. Stephen, additional, Trief, Danielle, additional, Hassan, Muhammad, additional, Kaliki, Swathi, additional, Kaplan, Henry J., additional, Karadzic, Jelena, additional, Kerley, Madison E., additional, Levison, Ashleigh L., additional, Lindeke-Myers, Aaron, additional, Magrath, George, additional, Maguire, Albert M., additional, Minkus, Caroline L., additional, Modjtahedi, Bobeck S., additional, Mohay, Judith, additional, Moussa, Kareem, additional, Munk, Marion Ronit, additional, Nguyen, Quan Dong, additional, Onghanseng, Neil, additional, Papaliodis, George N., additional, Pepple, Kathryn, additional, Radosavljevic, Aleksandra, additional, Ramasubramanian, Aparna, additional, Rathinam, Sivakumar R., additional, Sadiq, Mohammad Ali, additional, Sandhu, Harpal S., additional, Shantha, Jessica G., additional, Shields, Ryan A., additional, Sobrin, Lucia, additional, Stanescu, Dinu, additional, Strässle, Kim Anne, additional, Suhler, Eric, additional, Thanos, Aristomenis, additional, Touhami, Sara, additional, Toutee, Adelaide, additional, Uchiyama, Eduardo, additional, Gelder, Russell Neil Van, additional, Ventura, Camila V., additional, Ventura, Liana O., additional, Vitale, Albert, additional, Yeh, Steven, additional, and Zierhut, Manfred, additional

Published
2021
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47. Suprachoroidal Drug Delivery for Macular Edema Associated With Noninfectious Uveitis

Author

Huang, Ye, Choo, Charlene, Hancock, Shelley, Ciulla, Thomas A., Wykoff, Charles C., Shantha, Jessica G., and Yeh, Steven

Abstract

Purpose:To evaluate clinical trials in the literature that focus on suprachoroidal drug delivery for the treatment of noninfectious uveitis and other posterior segment diseases. Methods:A synthesis of the literature was performed. Results:In 2021, suprachoroidal space triamcinolone acetonide, a corticosteroid delivery system used for the treatment of uveitic macular edema (ME), was approved by the US Food and Drug Administration. The drug-delivery system targets the suprachoroidal space using a microneedle-based device and has a favorable pharmacokinetic profile. Suprachoroidally administered investigational therapies have also been assessed in clinical trials for other posterior segment diseases, including diabetic ME, retinal vein occlusion, age-related macular degeneration, and choroidal melanoma. Conclusions:The safety and efficacy of suprachoroidal corticosteroid injections to treat uveitic ME have been shown in recent phase III clinical trials. Multiple programs are also investigating this modality of drug delivery for use in many other retinal and choroidal pathologies.

Published
2024
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50. Clinical characteristics and Aetiology of Uveitis in a Viral Haemorrhagic Fever Zone

Author

Balendra, Shiama, primary, Williams, Lloyd, additional, Mustapha, Jalikatu, additional, Koroma, Zikan, additional, Kamara, Alicious, additional, Conteh, Osman, additional, Kanu, Theophilus, additional, Saradugu, Bangi, additional, Kamara, Santigie, additional, Ward, Laura, additional, Wang, Huachun, additional, Fashina, Tolulope, additional, Koroma, Sheku, additional, Shantha, Jessica, additional, Yeh, Steven, additional, and Kennedy, Alasdair, additional

Published
2023
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