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Objective A positive correlation is observed between the progression of renal impairment and the increasing risk of cardiovascular disease. Our aim was to examine the relationship between the renal resistive index (RRI) assessed by duplex sonography and the extent of atherosclerosis in patients without renal impairment undergoing vascular imaging studies. Methods The RRI was evaluated pre-procedurally among 106 outpatients with an estimated glomerular filtration rate (eGFR) ≥60 mL/min/1.73 m2 undergoing clinically-driven coronary computed tomography angiography (CCTA). In those subjects, a carotid artery ultrasound scan was also performed to evaluate carotid artery disease. We investigated the association between the RRI and the atherosclerotic extent, defined by the presence of coronary artery calcium (CAC)>0 and carotid intima-media thickness (cIMT)≥1.0 mm. Results Multi-site atherosclerosis (CAC>0 and cIMT≥1.0 mm) was found in 31 patients. The RRI was significantly increased with an increasing number of atherosclerotic vessels (absence of atherosclerosis: 0.65±0.04 vs. single-site atherosclerosis: 0.67±0.06 vs. multi-site atherosclerosis: 0.71±0.05, p0.70 [odds ratio (OR): 4.05, 95% confidence interval (CI), 1.37-12.0, p=0.01], cardio ankle vascular index (CAVI)≥9.0 (OR: 8.18, 95% CI: 2.47-27.1, p90 mL/min/1.73 m2 (OR: 5.89, 95% CI: 1.39-25.1, p=0.01) were associated with multi-site atherosclerosis. Conclusion The RRI, a sub-clinical renal parameter is an atherosclerotic marker in patients without renal impairment.

要 旨：過去にcoronary spastic angina(CSA)とcardio-ankle vascular index(CAVI)との関連についての報告はない。そこで今回2009年に心臓カテーテル検査で冠攣縮誘発試験を行った41例を冠攣縮陽性群と陰性群の2郡に群別し，その関連を検討した。評価項目は年齢・性別・喫煙・血圧・脂質代謝(T-Cho，TG，HDL，LDL，LDL/HDL比)・糖代謝(HbA1C)・ABI・CAVIとした。2群間で有意差が得られたのはCAVIのみであった(陽性群8.78±0.21，陰性群7.73±0.26，P=0.004)。血管内皮障害がCSAを惹起し，CAVIを上昇させたと考えられた。