253 results on '"Yoshiaki IMAMURA"'
Search Results
2. Follicular cholangitis mimicking a common bile duct cancer: a case report
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Kenji Koneri, Takanori Goi, Hokahiro Katayama, Noriyuki Tagai, Michiaki Shimada, Hidetaka Kurebayashi, Katsuji Sawai, Mitsuhiro Morikawa, Masato Tamaki, Yasuo Hirono, Satomi Hatta, Yoshiaki Imamura, and Makoto Murakami
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Follicular cholangitis ,Distal common bile duct ,Common bile duct cancer ,Case report ,Surgery ,RD1-811 - Abstract
Abstract Background Follicular cholangitis (FC) is a benign bile duct disease that was first reported 2003. Pathologically, it is characterized by lymphoplasmacytic infiltration with multiple lymphoid follicle formations under the mucosal layer of the biliary tract. However, as this disease is extremely rare, little is known about its etiology and pathogenesis. Case presentation A 77-year-old woman was diagnosed with middle bile duct stenosis and potential increases in alkaline phosphatase (ALP) and γ-glutamyl transpeptidase levels (γ-GTP). Carcinoembryonic antigen (CEA), carbohydrate antigen 19-9 (CA19-9) and IgG4 levels were all within the normal limits. Contrast-enhanced computed tomography (CE-CT) and magnetic resonance imaging (MRI) revealed bile duct dilation from intrahepatic to upper common bile duct and an irregular mass lesion in distal bile duct. Additionally, multiple overlapping leaf-like folds were detected. 18F-fluorodeoxyglucose positron emission tomography–computed tomography (18F-FDG-PET/CT) did not demonstrate fluorodeoxyglucose uptake. Subtotal stomach-preserving pancreaticoduodenectomy with regional lymph node dissection was performed because common bile duct cancer could not be ruled out. The resected specimen showed diffuse homogeneous middle bile duct wall thickening. Microscopically, the lesion exhibited thick fibrosis with several invaded lymphoplasmacytic cells, and lymphoid follicle formations were detected under the mucosal layer. Immunohistochemical staining (IHC) revealed positive for CD3, CD4, CD20 and CD79a, and these findings led to a final diagnosis of FC. The patient has not experienced recurrence to date (42 months postoperatively). Conclusions Currently, accurate preoperative diagnosis of FC is difficult. More cases must be accumulated to generate additional knowledge on its precise diagnosis and proper treatment.
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- 2023
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3. Primary Ewing's sarcoma/primitive neuroectodermal tumor of the kidney and its clinical features
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Shiori Saikawa, Minekatsu Taga, Yasushi Matsuda, Koji Suzuki, Aina Yamaguchi, Mana Fukushima, Yoshiaki Imamura, Hideaki Ito, and Osamu Yokoyama
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Ewing sarcoma ,primary renal ESFT ,secondary cancer ,Diseases of the genitourinary system. Urology ,RC870-923 - Abstract
Introduction Ewing sarcoma family tumor is a malignant tumor that is primarily of bone origin; it rarely occurs in the kidney. Case presentation A 22‐year‐old woman presented with hematuria. Computed tomography revealed a 6 × 6‐cm mass in the lower pole of the right kidney with invasion into the right renal vein. A right laparoscopic radical nephrectomy was performed. The tumor was completely encapsulated. Based on the small‐round‐cell histology, diffusely CD99‐positive tumor cells, and EWS (ex7)–FLi1 (ex6) fusion gene break point transcript, we diagnosed Ewing sarcoma/primitive neuroectodermal tumor of the kidney. After surgery, eight cycles of adjuvant chemotherapy including vincristine, doxorubicin (Adriamycin®), cyclophosphamide, ifosfamide, and etoposide were given. No evidence of recurrence has been observed 13 months from diagnosis. Conclusion This was a rare Ewing sarcoma family tumor in the kidney of a young female with no remarkable family medical history.
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- 2022
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4. Hepatocellular carcinoma progression promoted by 5-lipoxygenase activity in CD163(+) tumor-associated macrophages
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Takuto Nosaka, Yosuke Murata, Kazuto Takahashi, Tatsushi Naito, Kazuya Ofuji, Hidetaka Matsuda, Masahiro Ohtani, Katsushi Hiramatsu, Yoshiaki Imamura, Takanori Goi, and Yasunari Nakamoto
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5-lipoxygenase ,Tumor-associated macrophage ,Hepatocellular carcinoma ,Leukotriene ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Arachidonic acid 5-lipoxygenase (5-LOX), an enzyme that synthesizes leukotrienes (LTs), is involved in cancer development including proliferation, invasion, metastasis and drug resistance. However, the functional role of 5-LOX in hepatocellular carcinoma (HCC) remains to be elucidated. In this study, we analyzed the contribution of 5-LOX in HCC progression and investigated the potential of targeted therapy. Analysis of 86 resected HCC specimens and the clinical data of 362 cases of liver cancer from The Cancer Genome Atlas Liver Hepatocellular Carcinoma dataset, showed that 5-LOX expression was associated with postoperative survival. The cancer proliferative and stem cell potential were correlated with the levels of 5-LOX in CD163(+) tumor-associated macrophages (TAMs). In an HCC mouse model, CD163(+) TAMs expressed 5-LOX and produced LTB4 and LTC/D/E4; the 5-LOX inhibitor, zileuton, suppressed HCC progression. LTB4 and LTC/D/E4 promoted cancer proliferation and stem cell capacity via phosphorylation of extracellular signal-regulated kinase 1/2 and stem cell-associated genes. Taken together, we identified a novel mechanism of HCC progression in which CD163(+) TAMs express 5-LOX and produce LTB4 and LTC/D/E4, thereby enhancing the proliferative and stem cell potential of HCC cells. Furthermore, inhibition of 5-LOX activity regulates HCC progression, suggesting it has potential as a new therapeutic target.
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- 2023
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5. Heterotopic ossification in lymph node metastasis after rectal cancer resection: a case report and literature review
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Hideki Nagano, Tamotsu Togawa, Takeshi Watanabe, Kenji Ohnishi, Toshihisa Kimura, Atsushi Iida, Sakon Noriki, Yoshiaki Imamura, Yasunori Sato, and Takanori Goi
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Heterotopic ossification ,Rectal cancer ,Lymph node ,Epithelial-mesenchymal transition ,Osteoblast-like cell ,BMP-2 ,Surgery ,RD1-811 ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Background Heterotopic ossification (HO) is the formation of osseous tissue outside the skeleton. HO in malignant tumors of the digestive tract is extremely rare, as is ossification in metastatic lesions from HO-negative digestive tract tumors. Regarding the pathogenesis of HO, two theories have been proposed. The first is that the osteoblastic metaplasia of tumor cells (driven by the epithelial-mesenchymal transition, EMT) results in HO, and the second is that factors secreted by cancer cells lead to the metaplasia of stromal pluripotent cells into osteoblasts. However, the osteogenic mechanisms remain unclear. Case presentation An 83-year-old Japanese woman underwent low anterior rectal resection for rectal cancer before presentation at our institution, in June 2018. The final diagnosis was stage IIB rectal adenocarcinoma (T4aN0M0). Histological examination did not reveal HO in the primary tumor. Thirteen months after the operation, a solitary metastatic lesion in the brain 20 mm in size and a solitary metastatic lesion in a right axillary lymph node 20 mm in size were diagnosed. The patient was treated with gamma-knife therapy for the brain metastasis. One month later, she was referred to our institution. She underwent lymph node resection. Histological examination revealed that most portions of the affected lymph node were occupied by metastatic tumor cells and that central necrosis and four small ossified lesions without an osteoblast-like cell rim were present in the peripheral region. Immunohistochemical analysis showed tumor cells positive for BMP-2, osteonectin, osteocalcin, AE1/AE3, TGF-β1, Gli2, Smad2/3, and CDX2 and negative for nestin, CD56, and CK7. Conclusion This is the first English case report of HO in a metachronous metastatic lymph node after the curative resection of HO-negative rectal cancer. Unlike HO lesions in past reports, the HO lesion did not show peripheral osteoblast-like cells, and the immunohistochemical findings indicated that the present case resulted from the EMT.
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- 2021
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6. A typical case of resected pancreatic hamartoma: a case report and literature review on imaging and pathology
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Hokahiro Katayama, Kyohei Azuma, Kenji Koneri, Makoto Murakami, Yasuo Hirono, Satomi Hatta, Yoshiaki Imamura, and Takanori Goi
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Pancreatic hamartoma ,Characteristics ,Imaging ,Pathology ,Surgery ,RD1-811 - Abstract
Abstract Background Pancreatic hamartomas are rare entities and difficult to diagnose before resection. We report a case of resected pancreatic hamartoma and literature review of typical characteristics of the lesion. Case presentation A 78-year-old man presented with a mass in his pancreas, which was incidentally identified when he experienced pneumonia. No remarkable symptoms were observed, and laboratory tests showed no abnormalities, except a slight carcinoembryonic antigen elevation. Enhanced computed tomography and magnetic resonance imaging showed a well-demarcated solid mass with heterogeneous contrast that was 2 cm in size. A gradual enhancement pattern was also observed. The biopsy revealed no specific findings; therefore, surgical resection was necessitated to confirm the diagnosis. Histopathologically, ducts, acinar cells, and adipose cells without atypia were observed among abundant fibrous stroma, but islets of Langerhans and peripheral nerves were absent. An immunohistochemical examination demonstrated CD34 and c-kit positive staining in the stromal cells, S-100 positivity in the adipose cells, and a lack of elastic fibers in the duct walls. The lesion was diagnosed as a pancreatic hamartoma. Conclusion Asymptomatic pancreatic hamartomas can avoid resection. A careful consideration of imaging and appropriate immunohistochemistry of biopsy specimen may facilitate accurate diagnosis before resection. Therefore, sufficient recognition of the characteristics of pancreatic hamartomas is desirable.
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- 2020
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7. Case report: IgG4-related mass-forming thyroiditis accompanied by regional lymphadenopathy
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Yasuhiro Sakai and Yoshiaki Imamura
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IgG4-related disease ,Mass-forming thyroiditis ,Regional lymphadenopathy ,Pathology ,RB1-214 - Abstract
Abstract Background It has been recently accepted that IgG4-related thyroiditis is comparable to the Hashimoto and Riedel thyroiditis and Graves disease which are rich in IgG4-secreting plasma cells. Many physicians believe that in IgG4-related thyroiditis, the thyroid is entirely enlarged and diffusely affected, which is similar to conventional thyroiditis, but rarely ever accompanied by pseudoneoplastic mass formation as in IgG4-related disease in the other organs. This report introduces another pattern of IgG4-related thyroiditis as mass-forming thyroiditis and presents the occurrence of IgG4-related regional lymphadenopathy as an unusual accompanying symptom. Case presentation A 66-year-old woman presented with an approximately 2.5-cm mass in the right thyroidal lobe and regional lymph node swelling, which were preoperatively misinterpreted as thyroidal carcinoma. After lobectomy, histological examination was performed, revealing that the mass showed dense stromal fibrosis, lymphoplasmacytic infiltration, and effacement of thyroid follicles, while the background thyroidal tissue seemed to mimic lymphocytic thyroiditis without fibrosis. Immunohistochemistry revealed predominance of IgG4-secreting plasma cells among infiltrating lymphocytes independent of mass lesion or background tissue. In addition, the regional Delphian and paratracheal lymph nodes were swollen, histologically showing numerous IgG4-secreting plasma cell infiltrations in the interfollicular zone. Conclusions IgG4-related mass-forming thyroiditis, which may be an extremely rare but recognizable pattern of IgG4-related thyroiditis, may be distinguishable from Hashimoto and Riedel thyroiditis, Graves disease, and thyroidal carcinoma. In addition, the regional IgG4-related lymphadenopathy, also possibly misdiagnosed as metastatic thyroidal carcinoma, may be a newly recognized manifestation of IgG4-related thyroiditis.
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- 2018
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8. Duplication cyst of the ileum presenting with severe anemia detected by double-balloon endoscopy
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Yumi Takegawa, Katsushi Hiramatsu, Yosuke Murata, Yu Akazawa, Yasushi Saito, Yoshihiko Ozaki, Kazuto Takahashi, Tatsushi Naito, Kazuya Ofuji, Hidetaka Matsuda, Masahiro Ohtani, Tomoyuki Nemoto, Hiroyuki Suto, Takanori Goi, Yoshiaki Imamura, and Yasunari Nakamoto
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Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
Background and study aims Duplication cysts of the ileum are rare and present with non-specific clinical manifestations such as abdominal pain, vomiting, melena, and intussusception. Therefore, preoperative diagnosis is difficult. Here, we report a case of duplication cyst of the small intestine that was diagnosed preoperatively using double-balloon enteroscopy. A 19-year-old man presented with severe iron deficiency anemia, abdominal pain, and exertional dyspnea. Gastroscopy and colonoscopy revealed no remarkable findings. Abdominal computed tomography revealed a cystic structure in the ileum. Therefore, we performed double-balloon enteroscopy via the anal route. The intestinal tract was bifurcated, with one segment ending in a blind sac containing normal villi and an ulceration. Tc-99 m pertechnetate scintigraphy showed no accumulation in the lesion. Accordingly, we diagnosed a duplication cyst and suspected that this was the cause of severe anemia. Following small bowel resection with cyst excision and anastomosis, the anemia and presenting symptoms resolved. This report highlights the usefulness of double-balloon enteroscopy of the small intestine for preoperative diagnosis of the obscure gastrointestinal bleeding, including duplication cysts.
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- 2018
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9. High-Risk Neuroblastoma with Metastases to Bilateral Kidneys at Diagnosis
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Toshihide Yoshikawa, Akihiko Tanizawa, Koji Suzuki, Kazumi Ikeda, Eishi Nomura, Yumekichi Maeda, Nanae Tanaka, Kenta Yamada, Yasuhiro Sakai, Yoshiaki Imamura, and Yusei Ohshima
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Pediatrics ,RJ1-570 - Abstract
Renal metastasis at diagnosis with neuroblastoma is rare. We present a 14-month-old boy who was diagnosed with high-risk neuroblastoma with multiple metastases, including bilateral kidneys. He received five cycles of induction chemotherapy and high-dose chemotherapy with autologous peripheral blood stem cell transplantation. All of the lesions shrank, and magnetic resonance imaging indicated that some of the metastases had disappeared. However, there were residual masses in the bilateral kidneys, and histological examination revealed the presence of tumor cells. Therefore, the patient underwent unrelated cord blood stem cell transplantation, which involved killer-ligand incompatibility in the graft-versus-host direction, in addition to human leukocyte antigen C and DRB1 mismatches. Three months later, tumor progression occurred from the residual mass in the sacral canal and a new lesion in the pancreas. Although tumor progression could not be controlled by additional chemotherapy and local radiotherapy, the metastatic nodules in bilateral kidneys did not increase in size before his death. To the best of our knowledge, this is the first report of neuroblastoma with bilateral renal metastases in the English medical literature. In addition, this case suggests that the combination of chemotherapy and immunotherapy may inhibit the progression of the renal lesions under certain conditions.
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- 2017
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10. Preoperative diagnosis of cavernous hemangioma presenting with melena using wireless capsule endoscopy of the small intestine
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Yu Akazawa, Katsushi Hiramatsu, Takuto Nosaka, Yasushi Saito, Yoshihiko Ozaki, Kazuto Takahashi, Tatsushi Naito, Kazuya Ofuji, Hidetaka Matsuda, Masahiro Ohtani, Tomoyuki Nemoto, Hiroyuki Suto, Akio Yamaguchi, Yoshiaki Imamura, and Yasunari Nakamoto
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Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
Background and study aims: Primary neoplasms of the small intestine are relatively rare in all age groups, accounting for about 5 % of all gastrointestinal tumors 1. Cavernous hemangiomas of the small intestine are also rare, can cause gastrointestinal bleeding, and are extremely difficult to diagnose preoperatively 2. We present a patient who presented with melena and iron deficiency anemia, for whom wireless capsule endoscopy and single-balloon enteroscopy facilitated the diagnosis of cavernous hemangioma.
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- 2016
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11. Surgical Treatment of Adrenal Gland Metastasis Originating from Small Cell Carcinoma of the Urinary Bladder
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Minekatsu Taga, Hideaki Ito, Naoya Kusukawa, Yoshiji Miwa, Hironobu Akino, Yoshiaki Imamura, and Osamu Yokoyama
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Diseases of the genitourinary system. Urology ,RC870-923 - Published
- 2013
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12. Human T-cell Lymphotropic Virus Type-1-associated Bronchioloalveolar Disorder with Non-necrotizing Granulomas: A Case Report and Literature Review.
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Satomi Kimura, Yukihiro Umeda, Ryoko Egashira, Kazuhiro Tabata, Akifumi Muramoto, Mihoko Morita, Makiko Yamaguchi, Yuko Waseda, Yoshiaki Imamura, Takahiro Yamauchi, and Tamotsu Ishizuka
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- 2024
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13. Histology and cytokine levels in hepatic injury accompanying a case of non-severe COVID-19
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Hidetaka Matsuda, Takuto Nosaka, Katsushi Hiramatsu, Kazuto Takahashi, Tatsushi Naito, Kazuya Ofuji, Masahiro Ohtani, Yoshiaki Imamura, Hiromichi Iwasaki, and Yasunari Nakamoto
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Gastroenterology ,General Medicine - Published
- 2023
14. A fatal case of hemophagocytic lymphohistiocytosis associated with gestational psittacosis without symptoms of pneumonia
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Michinobu Yoshimura, Kanako Shimizu, Yukiko Nakura, Kazumi Kawahara, Harutaka Katano, Daisuke Motooka, Makoto Takeuchi, Kisaburo Nagamune, Yoshiaki Imamura, Shota Nakamura, Kiyoshi Yasukawa, Hideki Hasegawa, Yoshio Yoshida, and Itaru Yanagihara
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Obstetrics and Gynecology - Published
- 2022
15. A Case of Adenosquamous Carcinoma with an Adenoma Component in the Descending Colon
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Satoko Sakamoto, Mitsuhiro Morikawa, Nobuhiro Maegawa, Hidetaka Kurebayashi, Katsuji Sawai, Kenji Koneri, Masato Tamaki, Makoto Murakami, Yasuo Hirono, Yoshiaki Imamura, and Takanori Goi
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Gastroenterology ,Surgery - Published
- 2022
16. A rare case of eosinophilic gastritis induced by nivolumab therapy for metastatic melanoma
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Arisa Tsuji, Katsushi Hiramatsu, Shouichi Namikawa, Arisa Yamamoto, Yohei Midori, Yosuke Murata, Tomoko Tanaka, Takuto Nosaka, Tatsushi Naito, Kazuto Takahashi, Kazuya Ofuji, Hidetaka Matsuda, Masahiro Ohtani, Yoshiaki Imamura, Shiro Iino, Minoru Hasegawa, and Yasunari Nakamoto
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Skin Neoplasms ,Prednisolone ,Gastroenterology ,Nausea ,Neoplasms, Second Primary ,General Medicine ,Enteritis ,Antineoplastic Agents, Immunological ,Nivolumab ,Gastritis ,Eosinophilia ,Humans ,Female ,Immune Checkpoint Inhibitors ,Melanoma ,Aged - Abstract
Cancer immunotherapy using immune checkpoint inhibitors can cause immune reactions at various sites as a side effect called immune-related adverse events (irAEs). The gastrointestinal tract is susceptible to irAEs, however, the degree and presentation vary considerably from case to case. A 76-year-old woman was diagnosed with anal mucosal melanoma. She underwent radical surgery and received postoperative adjuvant therapy. However, because new metastases were also found in bilateral inguinal lymph nodes, immunotherapy with nivolumab was performed. Approximately 10 months after the initiation of nivolumab administration, she presented with epigastric discomfort and nausea, and her laboratory data showed severe eosinophilia (1938/mm
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- 2022
17. Perivascular epithelioid cell tumors (PEComas) of the bone and soft tissue: A Japanese Musculoskeletal Oncology Group (JMOG) multi-institutional study
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Yuya Izubuchi, Shunsuke Hamada, Yoshikazu Tanzawa, Ikuo Fujita, Jungo Imanishi, Hirotaka Koyanagi, Akiyoshi Shimatani, Tadashi Komatsubara, Takaaki Tanaka, Mana Fukushima, Yoshiaki Imamura, Takafumi Ueda, Hirotaka Kawano, and Akihiko Matsumine
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Purpose: Perivascular epithelioid cell tumors (PEComas) of the bone and soft tissues are rare mesenchymal neoplasms, some of which are malignant. However, their clinical and pathological characteristics remain unclear. This study was performed to investigate the clinical and pathological characteristics of PEComas in bone and soft tissues by leveraging information from the Japanese Musculoskeletal Oncology Group. Methods: Ten patients, including four male and six female patients with a median age of 49 years, were retrospectively reviewed. PEComas of the visceral organs, including the uterus and retroperitoneum, were excluded. Results: Nine tumors arose in the soft tissue and one in the bone, with a mean size of 9.3 cm. Four patients showed local recurrence or distant metastasis. The 1-year survival rate was 77%. Pathologically, eight tumors were classified as malignant and two as having uncertain malignancy potential. Half of the tumors showed high MIB-1 index values of >30%. Immunohistochemically, the melanocyte marker HMB45 was expressed in 90% cases, and muscle-specific markers were expressed only in 30–50% cases. Transcription factor binding to IGHM enhancer 3 (TFE3) expression was positive in 89% of the patients. Tumors with high expression of TFE3 were classified as PEComas with malignant potential according to Folpe’s classification. Conclusions: Bone and soft tissue PEComas may have a higher malignancy potential than other visceral PEComas and are more likely to develop as TFE3-rearranged PEComas.
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- 2023
18. Addition Reaction of Alcohol to Isocyanate Catalyzed by Copper Present in Tap Water: Robust Manufacturing Process of Naldemedine Tosylate
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Shinichi Oda, Yoshiyuki Masui, Sohei Omura, Yoshiaki Imamura, Yoshiyuki Takeuchi, and Masahiro Hosoya
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Organic Chemistry ,Physical and Theoretical Chemistry - Published
- 2022
19. Gastrointestinal AA amyloidosis secondary to chronic pyelonephritis presenting with refractory diarrhea and severe hypoalbuminemia
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Yoshiaki Imamura, Tomoko Tanaka, Yohei Midori, Hidetaka Matsuda, Hironobu Naiki, Masahiro Ohtani, Takuto Nosaka, Tatsushi Naito, Yasunari Nakamoto, Osamu Yokoyama, Kazuya Ofuji, Katsushi Hiramatsu, and Kazuto Takahashi
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Diarrhea ,medicine.medical_specialty ,Ileum ,Gastroenterology ,AA amyloidosis ,Submucosa ,Internal medicine ,Biopsy ,medicine ,Humans ,Hypoalbuminemia ,Aged ,Gastrointestinal tract ,Pyelonephritis ,medicine.diagnostic_test ,business.industry ,Amyloidosis ,General Medicine ,medicine.disease ,Gastrointestinal Tract ,medicine.anatomical_structure ,Female ,medicine.symptom ,Complication ,business - Abstract
Secondary amyloidosis is a rare complication of chronic inflammatory diseases, such as collagen diseases, and is often difficult to treat. In addition, the gastrointestinal tract is frequently involved in amyloid deposition that often results in various disorders and symptoms. A 70-year-old woman was admitted to our hospital with refractory diarrhea and hypoalbuminemia. Abdominal computed tomography demonstrated extensive edematous wall thickening of the small intestine and colon. Video capsule endoscopy revealed multiple ulcerations with a white mossy appearance of the ileum. Double-balloon endoscopy showed severe circumferential ulcers in the entire ileum. Histological examination of ileum biopsy samples revealed severe amyloid deposition in the lamina propria and perivascular areas of the submucosa. The patient was diagnosed with gastrointestinal AA amyloidosis. The cause of AA amyloid deposition was presumed to be chronic pyelonephritis due to ureteral stones that had been left untreated for 35 years. After treatment with ureteral drainage and antibiotics, the patient's symptoms and serological abnormalities improved dramatically. Here, we describe a case of severe gastrointestinal AA amyloidosis secondary to chronic pyelonephritis. Clinicians should thoroughly investigate the entire gastrointestinal tract in patients with refractory diarrhea and severe hypoalbuminemia considering the possibility of gastrointestinal amyloidosis.
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- 2021
20. Liquid-based cytology (LBC) with immunocytochemical staining improves fine-needle aspiration cytology (FNA) performance for salivary gland tumors
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Junya Kimura, Norihiko Narita, Yoshiaki Imamura, Takahiro Tokunaga, Masaki Mori, Haruka Matsukawa, Kazumi Furuichi, Yumi Ito, Yoshimasa Imoto, Tetsuji Takabayashi, and Shigeharu Fujieda
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Cell Biology ,Pathology and Forensic Medicine - Published
- 2023
21. Advanced primary adenosquamous carcinoma of the liver with a small cell carcinoma component: an autopsy case report
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Hidetaka Matsuda, Yasunari Nakamoto, Shouichi Namikawa, Takuto Nosaka, Kazuto Takahashi, Katsushi Hiramatsu, Kazuya Ofuji, Yoshiaki Imamura, Masahiro Ohtani, and Tatsushi Naito
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medicine.medical_specialty ,Pathology ,Liver tumor ,Adenosquamous carcinoma ,medicine.medical_treatment ,Small-cell carcinoma ,Carcinoma, Adenosquamous ,Internal medicine ,Biopsy ,medicine ,Humans ,Carcinoma, Small Cell ,Lymph node ,Chemotherapy ,medicine.diagnostic_test ,business.industry ,Gastroenterology ,General Medicine ,Middle Aged ,Hepatology ,medicine.disease ,Bile Ducts, Intrahepatic ,medicine.anatomical_structure ,Bile Duct Neoplasms ,Liver ,Adenocarcinoma ,Female ,Autopsy ,business - Abstract
Primary adenosquamous carcinoma (ASC) of the liver is a rare subtype of cholangiocarcinoma that comprises both adenocarcinoma and squamous cell carcinoma components. We report a 48-year-old woman with advanced primary ASC and small cell carcinoma of the liver who had extrahepatic metastasis and received multiple chemotherapy regimens. After first presenting with upper abdominal pain, imaging revealed a 10.2 × 9.5 cm mass in the right lobe of the liver with lymph node and lung metastases. A liver tumor biopsy revealed adenocarcinoma and squamous cell carcinoma components, leading to a diagnosis of advanced primary ASC of the liver. The tumor shrank with gemcitabine/cisplatin therapy; however, neuron-specific enolase (NSE) and CYFRA levels were increased and the tumor grew. Next, hepatic arterial infusion chemotherapy using 5-fluorouracil and cisplatin decreased NSE and CYFRA levels and suppressed tumor growth. However, due to tumor growth, she died 14 months post-initial diagnosis. Post-autopsy pathology revealed a mixture of CD56- and synaptophysin-positive small cell carcinoma component in addition to ASC. We report a rare advanced primary ASC with small cell carcinoma of the liver diagnosed at autopsy.
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- 2021
22. A case of immune checkpoint inhibitor-related colitis with a distinctive endoscopic finding of colonic pseudolipomatosis
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Hidetaka Matsuda, Takuto Nosaka, Kazuya Ofuji, Katsushi Hiramatsu, Kazuto Takahashi, Yasunari Nakamoto, Yoshiaki Imamura, Tamotsu Ishizuka, Masahiro Ohtani, and Tatsushi Naito
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Male ,medicine.medical_specialty ,Lung Neoplasms ,Rectum ,CD8-Positive T-Lymphocytes ,Gastroenterology ,03 medical and health sciences ,0302 clinical medicine ,Atezolizumab ,Carcinoma, Non-Small-Cell Lung ,Internal medicine ,medicine ,Humans ,Colitis ,Immune Checkpoint Inhibitors ,Aged ,medicine.diagnostic_test ,business.industry ,Endoscopy ,Sigmoidoscopy ,Common Terminology Criteria for Adverse Events ,General Medicine ,medicine.disease ,Immune checkpoint ,Hematochezia ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,Prednisolone ,030211 gastroenterology & hepatology ,medicine.symptom ,business ,medicine.drug - Abstract
A man in his 70s received anticancer chemotherapy with the anti-programmed cell death protein–ligand 1 antibody atezolizumab for non-small cell lung cancer. Ten days later, he developed diarrhea and skin rash, which were suspected to be due to immune-related adverse events, and was treated with prednisolone for 2 weeks. Five weeks after atezolizumab administration, he was admitted to our hospital for Common Terminology Criteria for Adverse Events Grade 3 diarrhea and hematochezia. Sigmoidoscopy revealed a dark red color in the mucosa of the transverse colon and multiple whitish mucosal plaques extending from the transverse colon to the rectum. Biopsy specimens revealed empty vacuoles in the lamina propria with infiltration of numerous inflammatory cells, including CD8+ T cells. Based on the findings of sigmoidoscopy and histology, the diagnosis was immune checkpoint inhibitor-related colitis with colonic pseudolipomatosis. The endoscopic findings and symptoms were markedly improved by prednisolone administration. We herein report the first case of immune checkpoint inhibitor-related colitis with characteristic endoscopic findings of colonic pseudolipomatosis. It is important to perform endoscopy and histological evaluation to determine the differential diagnosis and treatment strategy for patients treated with immune checkpoint inhibitors.
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- 2021
23. A case of idiopathic portal hypertension accompanying multiple hepatic nodular regenerative hyperplasia in a patient with systemic sclerosis
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Arisa Yamamoto, Kazuto Takahashi, Takuto Nosaka, Arisa Tsuji, Yoshiaki Imamura, Tomoko Tanaka, Katsushi Hiramatsu, Masahiro Ohtani, Tatsushi Naito, Gen Tohda, Yosuke Murata, Yohei Midori, Kazuya Ofuji, Yasunari Nakamoto, and Hidetaka Matsuda
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Liver Cirrhosis ,medicine.medical_specialty ,Pathology ,Pancytopenia ,Scleroderma ,Fibrosis ,Internal medicine ,Hypertension, Portal ,Ascites ,medicine ,Humans ,skin and connective tissue diseases ,Aged ,Hyperplasia ,Scleroderma, Systemic ,medicine.diagnostic_test ,business.industry ,Gastroenterology ,Magnetic resonance imaging ,Nodule (medicine) ,Idiopathic Noncirrhotic Portal Hypertension ,General Medicine ,Hepatology ,medicine.disease ,Liver ,Liver biopsy ,Splenomegaly ,Female ,medicine.symptom ,business ,Nodular regenerative hyperplasia - Abstract
Idiopathic portal hypertension (IPH) is one of the background diseases causing nodular regenerative hyperplasia (NRH). Furthermore, IPH patients accompanied with autoimmune diseases, such as systemic lupus erythematosus (SLE) and systemic sclerosis (SSc), are more likely to form NRH in the liver. A 76-year-old woman had been aware of the Raynaud's phenomenon and scleroderma for the past 30 years. In this case, she presented with abdominal fullness, and her imaging analysis revealed ascites and multiple liver nodules. On Gd-EOB-DTPA enhanced magnetic resonance imaging (EOB-MRI), donut-like uptake was observed in the nodules in the hepatobiliary phase. Liver biopsy of a nodule demonstrated that it was composed of hyperplastic hepatocytes without fibrous septa, and dilated sinusoids were observed beside the nodule. Conversely, background liver showed that peripheral portal veins appeared stenotic with dense fibrosis in the portal area. The final diagnosis was that multiple NRH of the liver developed in SSc patient accompanying IPH. This case suggests that NRH may be unexpectedly diagnosed in patients with autoimmune diseases accompanying IPH.
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- 2021
24. Metastatic invasive lobular breast cancer presenting as linitis plastica of the colon: Tumour characterization using [ 18 F]FES PET/MRI
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Hidehiko Okazawa, Tetsuya Tsujikawa, Takanori Goi, Akira Makino, Mizuho Takahashi, Yoshiaki Imamura, Yasushi Kiyono, Hiroyuki Maeda, and Tetsuya Mori
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Linitis plastica ,business.industry ,Estrogen receptor ,medicine.disease ,digestive system diseases ,body regions ,Breast cancer ,Oncology ,In vivo ,medicine ,Cancer research ,Radiology, Nuclear Medicine and imaging ,Colonic metastasis ,skin and connective tissue diseases ,business - Abstract
Metastatic invasive lobular breast cancer (ILC) to the colon is rare and usually ER-positive. We present an ER-negative case of metastatic ILC presenting as linitis plastica of the colon where [18 F]FES PET/MRI allowed the evaluation of the ER phenotypic transformation in the colonic metastasis from the ER-positive breast ILC in vivo.
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- 2021
25. A case of sarcomatoid urothelial carcinoma of the right ureter
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Satomi HATTA, Kazumi FURUICHI, Masaki MORI, Natsumi YONEMOTO, Tomomi ITO, Aina YAMAGUCHI, Shohei HIGUCHI, and Yoshiaki IMAMURA
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- 2021
26. A case of ameloblastic carcinoma of the maxilla
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Yoshiaki Imamura, Hayato Itoi, Hisato Yoshida, Keiichi Ohta, Satoshi Yamamoto, Shinpei Matsuda, Hitoshi Yoshimura, and Takashi Ryoke
- Subjects
Orthodontics ,Ameloblastic carcinoma ,business.industry ,Maxilla ,government.form_of_government ,government ,Medicine ,business - Published
- 2021
27. A case of intrathyroid thymic carcinoma accompanied by associated with papillary carcinoma
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Tomomi ITO, Kazumi FURUICHI, Masaki MORI, Satomi HATTA, Natsumi YONEMOTO, Aina YAMAGUCHI, Shohei HIGUCHI, and Yoshiaki IMAMURA
- Published
- 2021
28. Comparison of diagnostic accuracy between [18F]FDG PET/MRI and contrast-enhanced MRI in T staging for oral tongue cancer
- Author
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Norihiko Narita, Tetsuya Tsujikawa, Hidehiko Okazawa, Akira Makino, Yumi Ito, Masafumi Kanno, Yoshiaki Imamura, Shigeharu Fujieda, and Hirohiko Kimura
- Subjects
business.industry ,Gadolinium ,chemistry.chemical_element ,Cancer ,Diagnostic accuracy ,General Medicine ,medicine.disease ,Primary tumor ,Surgical pathology ,medicine.anatomical_structure ,chemistry ,Tongue ,medicine ,T-stage ,Radiology, Nuclear Medicine and imaging ,Nuclear medicine ,business ,Cancer staging - Abstract
Integrated PET/MRI with [18F]FDG is advantageous in that it enables simultaneous PET and MR imaging with higher soft-tissue contrast, multiplanar image acquisition, and functional imaging capability without using fat suppression and gadolinium-based contrast agents (GBCAs). The aims of this study were to demonstrate the feasibility of [18F]FDG PET/MRI for assessing the extent of the primary tumor (T) in oral tongue cancer (OTC) based on the 8th edition of American Joint Committee on Cancer (AJCC) cancer staging system, and to compare the diagnostic accuracy between [18F]FDG PET/MRI and contrast-enhanced MRI (ceMRI). 18 patients with biopsy-proven operable OTC underwent preoperative regional [18F]FDG PET/MRI and ceMRI within 2 weeks. For [18F]FDG PET/MRI, rainbow-colored PET images were overlaid on the corresponding MR images. Tumor size and the depth of invasion (DOI) were visually measured on [18F]FDG PET/MRI and ceMRI. The size, DOI, and clinical T stage were evaluated using the final surgical pathology as the reference. Of the 18 OTCs, one was not detected by ceMRI due to metal artifacts from an artificial denture, and another due to superficial type (pathological DOI = 0 mm). Tumor sizes measured by ceMRI and [18F]FDG PET/MRI had significant positive correlations with the pathological size (r = 0.80 and r = 0.90, respectively), and DOIs measured by ceMRI and [18F]FDG PET/MRI had significant positive correlations with the pathological DOI (r = 0.74 and r = 0.64, respectively). The means ± SD of size (mm) were 20.4 ± 9.1, 22.9 ± 10.9, and 26.2 ± 10.0, and those of DOI (mm) were 7.1 ± 2.5, 6.9 ± 2.2, and 5.8 ± 3.2 for ceMRI, [18F]FDG PET/MRI, and pathology, respectively. A significant difference was observed in tumor size between ceMRI and pathology (p
- Published
- 2020
29. A case of eosinophilic fasciitis without skin manifestations: a case report in a patient with lupus and literature review
- Author
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Masamichi Ikawa, Yuki Watanabe, Kazuhiro Itoh, Satomi Hatta, Ichizo Nishino, Hiromichi Iwasaki, Yoshiaki Imamura, Naoko Hosono, Kohei Asaoka, Tomohisa Yamaguchi, Tomoya Hirota, and Takahiro Yamauchi
- Subjects
Adult ,medicine.medical_specialty ,Erythema ,Prednisolone ,03 medical and health sciences ,0302 clinical medicine ,Rheumatology ,Internal medicine ,Edema ,Eosinophilia ,Biopsy ,medicine ,Humans ,030212 general & internal medicine ,Fasciitis ,Aged ,030203 arthritis & rheumatology ,Systemic lupus erythematosus ,medicine.diagnostic_test ,business.industry ,General Medicine ,Fascia ,medicine.disease ,Magnetic Resonance Imaging ,Dermatology ,Connective tissue disease ,Eosinophilic fasciitis ,medicine.anatomical_structure ,Female ,medicine.symptom ,business - Abstract
Eosinophilic fasciitis (EF) is a rare connective tissue disease that causes inflammation and fibrosis of the fascia, inducing pain and motor dysfunction. Characteristic skin manifestations, such as edema, erythema, induration, peau d'orange appearance, and the groove sign, are of diagnostic significance and observed in the majority of patients with EF. We herein report a case of EF without these characteristic skin manifestations. A 66-year-old Japanese woman developed progressive limb pain and motor dysfunction. No skin changes were observed. We diagnosed the patient with EF based on the clinical course, magnetic resonance imaging, and en bloc biopsy containing fascia and muscle. Oral prednisolone therapy markedly attenuated limb pain and motor dysfunctions. Through a systemic search of the medical literature, we retrieved 4 juvenile cases and 8 adult cases of EF without characteristic skin manifestations during the clinical course. We herein present a systemic review on EF without skin manifestations and discuss differences between the two proposed sets of diagnostic criteria of EF.
- Published
- 2020
30. Development of Manufacturing Processes for the Carboxylic Acid Key Intermediate of Lusutrombopag: One-Pot Reaction Process of Formylation and the Horner–Wadsworth–Emmons Reaction
- Author
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Makoto Kakinuma, Yutaka Nishino, Yusuke Sato, Tadafumi Komurasaki, Takaharu Matsuura, and Yoshiaki Imamura
- Subjects
chemistry.chemical_classification ,chemistry.chemical_compound ,chemistry ,Carboxylic acid ,Scientific method ,One pot reaction ,Organic Chemistry ,Horner–Wadsworth–Emmons reaction ,Organic chemistry ,Physical and Theoretical Chemistry ,Lusutrombopag ,Formylation ,Benzoic acid - Abstract
We describe the development of a one-pot preparation process of (E)-3,5-dichloro-4-(3-ethoxy-2-methyl-3-oxoprop-1-en-1-yl)benzoic acid (3), which is a key carboxylic acid intermediate of lusutrombo...
- Published
- 2020
31. Primary intradural extramedullary Ewing sarcoma: A case report and literature review
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Takayuki Nojima, Hideaki Nakajima, Kazuya Honjoh, Yoshiaki Imamura, Yuya Izubuchi, and Akihiko Matsumine
- Subjects
0301 basic medicine ,Cancer Research ,Pathology ,medicine.medical_specialty ,medicine.medical_treatment ,CD99 ,intradural tumor ,Lesion ,03 medical and health sciences ,0302 clinical medicine ,medicine ,radiotherapy ,meningeal seeding ,business.industry ,Cancer ,Cauda equina ,Articles ,Spinal cord ,medicine.disease ,adjuvant chemotherapy ,Radiation therapy ,030104 developmental biology ,medicine.anatomical_structure ,Oncology ,030220 oncology & carcinogenesis ,FLI1 ,Sarcoma ,medicine.symptom ,business ,cauda equina tumor ,Ewing sarcoma - Abstract
Tumors of the spinal cord and cauda equina show a wide spectrum of histology and require careful diagnosis and treatment. Primary intradural extramedullary Ewing sarcoma (IEES) is extremely rare, and initial imaging and clinical findings for this tumor mimic those of benign intradural spinal tumors. The present report describes a case of a 35-year-old woman who presented with IEES with meningeal seeding, and the literature on the management and clinical course of these tumors was reviewed. An examination revealed right-side leg dominant rapidly progressive hypoesthesia and motor deficits. MRI identified intradural tumors at the T12-L1 and L4-5 levels. Growth and an increase in the number of intradural tumors occurred over 3 weeks. Gadolinium-contrast T1-weighted MRI revealed diffusely enhanced signals for tumorous lesions with meningeal seeding in the cervical and thoracic spinal cord. Excision of a tumor at T12-L1 was performed to alleviate the symptoms and to make a histologic diagnosis. Microscopically, the tumor consisted of dense sheets of small round cells. Immunohistochemically, tumor cells showed intense and diffuse positive staining for CD99, ETS transcription factor ERG and Fli-1 proto-oncogene, ETS transcription factor (FLI1). The sequence analysis revealed the EWS RNA binding protein 1-FLI1 fusion transcript. The lesion was diagnosed as primary intradural ES. Adjuvant chemotherapy following radiotherapy for the whole spine was performed; however, multiple brain metastases were found at 10 months after diagnosis and the patient died of diffusely disseminated disease limited to the central nervous system without evidence of distant metastases at 16 months after the initial diagnosis. In a literature review of IEES cases, the 1- and 5-year overall survival rates were 79.8 and 26.6%, respectively, and the 1-, 2- and 5-year progression-free survival rates were 61.0, 52.3 and 10.9%, respectively. Therefore, primary IEES has a poor prognosis compared with ES of bone, and novel agents and treatment strategies are required.
- Published
- 2020
32. Induction of High Endothelial Venule–like Vessels in Oral and Cutaneous Lichen Planus: A Comparative Study
- Author
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Hisato Yoshida, Yoshiaki Imamura, Motohiro Kobayashi, and Hitoshi Yoshimura
- Subjects
CD4-Positive T-Lymphocytes ,0301 basic medicine ,Pathology ,medicine.medical_specialty ,Histology ,Biopsy ,Lymphocyte ,Mucocutaneous zone ,High endothelial venules ,CD34 ,Pathogenesis ,03 medical and health sciences ,0302 clinical medicine ,Venules ,stomatognathic system ,Addressin ,Humans ,Medicine ,Oral mucosa ,biology ,business.industry ,Endothelial Cells ,Membrane Proteins ,Articles ,stomatognathic diseases ,030104 developmental biology ,medicine.anatomical_structure ,Gene Expression Regulation ,030220 oncology & carcinogenesis ,Antigens, Surface ,biology.protein ,Anatomy ,business ,Peripheral lymph ,Lichen Planus, Oral - Abstract
Lichen planus (LP) is a chronic inflammatory mucocutaneous disease involving the oral mucosa and skin. Both oral LP (OLP) and cutaneous LP (CLP) are histopathologically characterized by dense subepithelial lymphocyte infiltrates; however, the mechanisms underlying lymphocyte recruitment to sites of LP lesions are not fully understood. Here, we assessed the induction of peripheral lymph node addressin (PNAd)-expressing high endothelial venule (HEV)-like vessels in 19 OLP and 17 CLP cases. To do so, we performed immunohistochemical staining for PNAd and CD34, followed by quantitative analysis. We also conducted triple immunohistochemistry for PNAd and either CD3 and CD20 or CD4 and CD8 to identify the lymphocyte subset preferentially recruited via HEV-like vessels. PNAd-expressing HEV-like vessels were induced in and around lymphocyte aggregates in all cases of OLP and in 10 of 17 CLP cases, and these vessels were more frequently observed in OLP relative to CLP. Although the number of T-cells attached per HEV-like vessel exceeded the number of B-cells in both OLP and CLP, the number of CD4+ T-cells attached was greater than the number of CD8+ T-cells only in OLP. These findings combined suggest that PNAd-expressing HEV-like vessels play a more important role in the pathogenesis of OLP compared with CLP.
- Published
- 2020
33. Effect of microscopic magnification on the establishment of an artificial intelligence for cervical cells using deep learning
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Kunihiro Inai, Yoshiaki Imamura, Masaki Mori, Shouhei Higuchi, Yasushi Hirano, Shoji Kido, and Taisuke Tsumori
- Subjects
business.industry ,Computer science ,Deep learning ,Magnification ,Computer vision ,Artificial intelligence ,Cervical cells ,business - Published
- 2020
34. The implicated clinical factors for outcomes in 304 patients with salivary duct carcinoma: Multi-institutional retrospective analysis in Japan
- Author
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Kimihide Kusafuka, Yoko Sato, Eiji Nakatani, Satoshi Baba, Matsuyoshi Maeda, Koji Yamanegi, Kaori Ueda, Hiroshi Inagaki, Yoshiro Otsuki, Naoto Kuroda, Kensuke Suzuki, Hiroshi Iwai, Yoshiaki Imamura, Junya Itakura, Shoji Yamanaka, Hideaki Takahashi, Ichiro Ito, Takumi Akashi, Tsutomu Daa, Mei Hamada, Masanori Yasuda, Ryo Kawata, Hidetaka Yamamoto, Yuri Tachibana, Junya Fukuoka, Aya Muramatsu, Kazumori Arai, and Makoto Suzuki
- Subjects
Carcinoma, Ductal ,Male ,Otorhinolaryngology ,Japan ,Adenoma, Pleomorphic ,Humans ,Salivary Ducts ,Female ,Neoplasm Recurrence, Local ,Salivary Gland Neoplasms ,Aged ,Retrospective Studies - Abstract
Salivary duct carcinoma (SDC) is a high-grade salivary malignancy that frequently occurs as the carcinomatous component of carcinoma ex pleomorphic adenoma. We herein examined the clinical factors affecting outcomes in a large cohort of SDC.We selected 304 SDC cases and investigated clinical characteristics and the factors affecting outcomes.The median age of the cases examined was 68 years, the most common primary site was the parotid gland (238 cases), and there was a male predominance (M/F = 5:1). Outcomes were significantly worse when the primary tumor site was the minor salivary glands (SG) than when it was the major SG. Outcomes were also significantly worse in pN(+) cases (161 cases) than in pN0 cases, particularly those with a metastatic lymph node number ≥11. The cumulative incidence of relapse and distant metastases was significantly higher in stage IV cases than in stage 0-III cases.The absolute number of lymph node metastases, higher stages, and the minor SG as the primary tumor site were identified as factors affecting the outcome of SDC.
- Published
- 2021
35. Successful early diagnosis of monomorphic epitheliotropic intestinal T-cell lymphoma manifesting as chronic diarrhea and hypokalemia using video capsule endoscopy and double-balloon enteroscopy
- Author
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Tatsushi Naito, Takuto Nosaka, Kazuto Takahashi, Kazuya Ofuji, Hidetaka Matsuda, Masahiro Ohtani, Katsushi Hiramatsu, Yoshiaki Imamura, Takahiro Yamauchi, and Yasunari Nakamoto
- Subjects
Diarrhea ,Double-Balloon Enteroscopy ,Male ,Early Diagnosis ,Enteropathy-Associated T-Cell Lymphoma ,Gastroenterology ,Humans ,Hypokalemia ,General Medicine ,Capsule Endoscopy ,Granzymes ,T-Cell Intracellular Antigen-1 - Abstract
Monomorphic epitheliotropic intestinal T-cell lymphoma (MEITL), formerly known as enteropathy-associated T-cell lymphoma (EATL) type II, is a rare disease with a poor prognosis that is often diagnosed when patients present with intestinal perforation or obstruction. Our patient, a man in his 60 s, had a 5-month history of persistent watery diarrhea. Upper and lower gastrointestinal endoscopy, abdominal computed tomography (CT), and stool culture results were unremarkable. He was admitted to our hospital 8 months later with a weight loss of 20 kg, general fatigue, and hypokalemia. Contrast-enhanced CT of the abdomen revealed mild thickening and contrast enhancement of the small intestinal wall. Video capsule endoscopy and double-balloon enteroscopy were performed to reveal a broad ulcer in the jejunum and multiple erosions throughout the small intestine. Examination of the biopsy specimens showed infiltration of atypical lymphocytes with pale cytoplasm in the glandular epithelium. The atypical lymphocytes were positive for CD3, CD8, CD56, granzyme B, and T-cell intracellular antigen-1 by immunostaining. Early diagnosis of MEITL was made, and the patient survived for 21 months with continuous chemotherapy. Aggressive examination of the small intestine is effective for the early diagnosis of serious diseases, such as MEITL, in patients with chronic diarrhea of unknown origin.
- Published
- 2021
36. Pathological diagnosis of general rules for the description of thyroid cancer by Japanese Society of Thyroid Pathology and Japan Association of Endocrine Surgery
- Author
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Tomohiro Chiba, Tetsuo Kondo, Mitsuyoshi Hirokawa, Hiroshi Kamma, Yoshiaki Imamura, Masahiro Nakashima, and Kaori Kameyama
- Subjects
medicine.medical_specialty ,medicine.diagnostic_test ,Thyroid pathology ,business.industry ,Endocrinology, Diabetes and Metabolism ,medicine.medical_treatment ,General surgery ,Bethesda system ,Endocrine Surgical Procedures ,medicine.disease ,World health ,Endocrine surgery ,Endocrinology ,Japan ,Adenocarcinoma, Follicular ,medicine ,Humans ,Cyst ,Thyroid Neoplasms ,business ,Thyroid tumors ,Pathological ,Thyroid cancer - Abstract
The Japanese Society of Thyroid Pathology and the Japan Association of Endocrine Surgeons developed the eighth edition of the General Rules for the Description of Thyroid Cancer (GRDTC) in December 2019. This article describes the pathological diagnosis of the GRDTC, which has been improved through repeated revisions based on the experience of Japanese pathologists and translated into English to introduce the Japanese diagnostic standard to foreign countries. In this edition of the GRDTC, the histopathological classification and descriptions differ in some respects from those of the fourth edition of the World Health Organization (WHO) classification as revised in 2017. For example, the GRDTC does not adopt the concept of borderline lesions (FT-UMP, WDT-UMP, and NIFTP) of the WHO, taking into consideration the popular histological criteria accepted by Japanese pathologists. The cytological reporting system of the GRDTC was partly modified from the Bethesda system in 2015. It has an additional cyst fluid category separated from the unsatisfactory category that has been demonstrated to be useful in Japan. This translated edition makes it easy to submit Japanese clinicopathological studies of thyroid tumors in an international journal. We also wish to contribute to the improvement, standardization, and globalization of the pathological diagnosis of thyroid tumors.
- Published
- 2021
37. 18F-Fluoroestradiol Tumor Uptake Is Influenced by Structural Components in Breast Cancer
- Author
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Takanori Goi, Sakon Noriki, Yasushi Kiyono, Tetsuya Mori, Yoshiaki Imamura, Hiroyuki Maeda, Hidehiko Okazawa, Mizuho Takahashi, Hiroko Kono, and Tetsuya Tsujikawa
- Subjects
Pathology ,medicine.medical_specialty ,Stromal cell ,medicine.diagnostic_test ,Estradiol ,business.industry ,Biopsy ,Estrogen receptor ,Breast Neoplasms ,General Medicine ,medicine.disease ,Primary tumor ,Immunohistochemistry ,Staining ,Breast cancer ,Receptors, Estrogen ,Positron-Emission Tomography ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Female ,Breast cancer cells ,business - Abstract
PURPOSE Estrogen receptor (ER) is expressed in the majority of invasive breast cancer and is an important prognostic indicator. The tumor stroma also plays an important role in disease progression. This study evaluated the effect of stromal components on 16α-[18F]-fluoro-17β-estradiol (18F-FES) uptake in breast cancer and proposed a partial-volume correction method for 18F-FES PET based on histopathological analyses. PATIENTS AND METHODS Fifteen patients with biopsy-confirmed breast cancer underwent preoperative 18F-FES PET. Estrogen receptor expression in biopsy specimens was assayed by immunohistochemistry, cellular components in surgical specimens were measured using hematoxylin-eosin staining, and nuclear components in surgical and biopsy specimens were measured using Azan-Mallory staining. The relationship between 18F-FES SUV of the primary tumor and histopathological findings including ER expression, the Allred score, ER-positive cellular component ratio, and ER-positive nuclear component ratio (NCR) was examined. The relationship between stroma-free 18F-FES SUV and ER expression was also examined. RESULTS 18F-FES uptake was not significantly positively correlated with ER expression (r = 0.44, P = 0.10). 18F-FES uptake was significantly correlated with the Allred score, ER-positive cellular component ratio, and ER-positive NCR in surgical specimens (ρ = 0.60, P = 0.02; r = 0.55, P = 0.03; and r = 0.65, P = 0.01, respectively). 18F-FES uptake was predominantly correlated with ER-positive NCR in biopsy specimens (r = 0.84, P < 0.001). Stroma-free 18F-FES SUV was significantly correlated with ER expression (r = 0.78, P < 0.01). CONCLUSIONS 18F-FES PET predominantly demonstrates the level of ER expression in breast cancer cell nucleus. Although tumor 18F-FES uptake is affected by the degree of stromal components, the partial volume effect on the uptake can be corrected by stroma-volume fraction in Azan-Mallory staining.
- Published
- 2021
38. Pembrolizumab-induced autoimmune side effects of colon and pancreas in a patient with lung cancer
- Author
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Tatsushi Naito, Takuto Nosaka, Katsushi Hiramatsu, Tamotsu Ishizuka, Yasunari Nakamoto, Kazuya Ofuji, Masahiro Ohtani, Yoshiaki Imamura, Hidetaka Matsuda, and Kazuto Takahashi
- Subjects
Aged, 80 and over ,Male ,medicine.medical_specialty ,Lung Neoplasms ,business.industry ,Colon ,Gastroenterology ,Rectum ,Sigmoid colon ,General Medicine ,Pembrolizumab ,medicine.disease ,Antibodies, Monoclonal, Humanized ,Ulcerative colitis ,medicine.anatomical_structure ,Internal medicine ,medicine ,Pancreatitis ,Humans ,Colitis ,business ,Lung cancer ,Pancreas ,Autoimmune pancreatitis - Abstract
Immune checkpoint inhibitors have been shown to be effective for treating many carcinomas. However, the activated immune response may lead to the development of multiple immune-related adverse events, including rare immune-mediated inflammation due to autoimmune mechanisms. An 82-year-old man was diagnosed with large cell lung cancer (T1aN3M1 stage IVB) and was treated with inhibitors of the programmed cell death receptor-1, pembrolizumab. Diarrhea and melena occurred after six doses of pembrolizumab, and colonoscopy revealed mucosal inflammation of the rectum and sigmoid colon in a continuous manner, resembling the typical endoscopic findings of ulcerative colitis. Subsequently, fever and hyperamylasemia appeared, and the patient was diagnosed with pancreatitis resembling type 2 autoimmune pancreatitis on imaging tests and cytological examination, which showed infiltration of inflammatory cells, mainly neutrophils. Steroid therapy was administered and both, colitis and pancreatitis markedly improved. Here, we present a patient who developed colitis and pancreatitis after ICI treatment for advanced lung cancer. Both are thought to be due to autoimmune side effects of pembrolizumab. Although pancreatitis is a rare irAE, clinicians should be aware of the development of pancreatitis, especially in the case of irAE colitis resembling ulcerative colitis.
- Published
- 2021
39. Simultaneous Presentation of Lymphomatoid Granulomatosis and Multiple myeloma in an Immunodeficient Patient with Rheumatoid Arthritis
- Author
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Shin Lee, Takahiro Yamauchi, Eiju Negoro, Hisashi Oki, and Yoshiaki Imamura
- Subjects
rheumatoid arthritis ,Pathology ,medicine.medical_specialty ,Lung Neoplasms ,Lymphomatoid granulomatosis ,Biopsy ,medicine.medical_treatment ,Case Report ,030204 cardiovascular system & hematology ,methotrexate ,Arthritis, Rheumatoid ,03 medical and health sciences ,Fatal Outcome ,0302 clinical medicine ,Internal Medicine ,Humans ,Medicine ,tacrolimus ,Multiple myeloma ,Aged ,Chemotherapy ,medicine.diagnostic_test ,Brain Neoplasms ,business.industry ,Brain biopsy ,Immunologic Deficiency Syndromes ,Lymphomatoid Granulomatosis ,General Medicine ,medicine.disease ,Magnetic Resonance Imaging ,Tacrolimus ,multiple myeloma ,medicine.anatomical_structure ,Rheumatoid arthritis ,Female ,030211 gastroenterology & hepatology ,Bone marrow ,Tomography, X-Ray Computed ,business - Abstract
A 75-year-old Japanese woman with a 20-year history of rheumatoid arthritis presented with symptomatic bilateral pleural effusion and lung and brain tumors. She had received methotrexate for five years and tacrolimus for one year. A brain biopsy specimen showed the pathological features of lymphoproliferative disease, but a bone marrow biopsy showed proliferation of plasma cells. She was finally diagnosed with coexistent lymphomatoid granulomatosis (LYG) of the brain and lung and multiple myeloma (MM) of the bone marrow and received chemotherapy for both. This report shows that immunodeficient patients are at risk of developing the unusual coexistence of LYG and MM.
- Published
- 2019
40. Successful treatment of hepatocellular carcinoma with bile duct tumor thrombus using surgical resection with pre- and postoperative transcatheter arterial chemoembolization: a case report
- Author
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Tomoyuki Nemoto, Yohei Midori, Yoshiaki Imamura, Takuto Nosaka, Yasushi Saito, Tomoko Tanaka, Yosuke Murata, Yumi Yoshida, Yasunari Nakamoto, Masahiro Ohtani, Kazuto Takahashi, Katsushi Hiramatsu, Kazuya Ofuji, Hidetaka Matsuda, and Tatsushi Naito
- Subjects
Surgical resection ,medicine.medical_specialty ,Hepatology ,business.industry ,Hepatocellular carcinoma ,Medicine ,Radiology ,Bile Duct Tumor ,Thrombus ,business ,medicine.disease ,Transcatheter arterial chemoembolization - Published
- 2019
41. Three-Dimensional Volumetric Analysis of Unicystic Ameloblastoma before and after Marsupialization Using OsiriX Software
- Author
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Takaaki Ueno, Hisato Yoshida, Kazuo Sano, Hitoshi Yoshimura, Shinpei Matsuda, and Yoshiaki Imamura
- Subjects
Orthodontics ,business.industry ,Unicystic Ameloblastoma ,medicine.medical_treatment ,Medicine (miscellaneous) ,Cell Biology ,Marsupialization ,Biochemistry ,Biomaterials ,Software ,Medicine ,Orthopedics and Sports Medicine ,business ,General Dentistry - Published
- 2019
42. Metastatic invasive lobular breast cancer presenting as linitis plastica of the colon: Tumour characterization using [
- Author
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Tetsuya, Tsujikawa, Mizuho, Takahashi, Hiroyuki, Maeda, Tetsuya, Mori, Akira, Makino, Yasushi, Kiyono, Yoshiaki, Imamura, Takanori, Goi, and Hidehiko, Okazawa
- Subjects
Linitis Plastica ,Carcinoma, Lobular ,Colon ,Stomach Neoplasms ,Positron-Emission Tomography ,Humans ,Breast Neoplasms ,Female ,Magnetic Resonance Imaging - Abstract
Metastatic invasive lobular breast cancer (ILC) to the colon is rare and usually ER-positive. We present an ER-negative case of metastatic ILC presenting as linitis plastica of the colon where [
- Published
- 2021
43. Heterotopic ossification in lymph node metastasis after rectal cancer resection: a case report and literature review
- Author
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Takanori Goi, Yasunori Sato, Takeshi Watanabe, Hideki Nagano, Yoshiaki Imamura, Toshihisa Kimura, Tamotsu Togawa, Sakon Noriki, Atsushi Iida, and Kenji Ohnishi
- Subjects
0301 basic medicine ,Heterotopic ossification ,Pathology ,medicine.medical_specialty ,Gli2 ,lcsh:Surgery ,Case Report ,lcsh:RC254-282 ,Lesion ,03 medical and health sciences ,0302 clinical medicine ,BMP-2 ,TGF-β1 ,Metaplasia ,medicine ,Rectal Adenocarcinoma ,Humans ,Rectal cancer ,Lymph node ,Aged, 80 and over ,Rectal Neoplasms ,Osteoblast-like cell ,Ossification ,business.industry ,Ossification, Heterotopic ,Rectum ,lcsh:RD1-811 ,lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,Prognosis ,Epithelial-mesenchymal transition ,medicine.disease ,Primary tumor ,030104 developmental biology ,medicine.anatomical_structure ,Oncology ,Lymphatic Metastasis ,030220 oncology & carcinogenesis ,Female ,Surgery ,medicine.symptom ,business ,Brain metastasis - Abstract
BackgroundHeterotopic ossification (HO) is the formation of osseous tissue outside the skeleton. HO in malignant tumors of the digestive tract is extremely rare, as is ossification in metastatic lesions from HO-negative digestive tract tumors. Regarding the pathogenesis of HO, two theories have been proposed. The first is that the osteoblastic metaplasia of tumor cells (driven by the epithelial-mesenchymal transition, EMT) results in HO, and the second is that factors secreted by cancer cells lead to the metaplasia of stromal pluripotent cells into osteoblasts. However, the osteogenic mechanisms remain unclear.Case presentationAn 83-year-old Japanese woman underwent low anterior rectal resection for rectal cancer before presentation at our institution, in June 2018. The final diagnosis was stage IIB rectal adenocarcinoma (T4aN0M0). Histological examination did not reveal HO in the primary tumor. Thirteen months after the operation, a solitary metastatic lesion in the brain 20 mm in size and a solitary metastatic lesion in a right axillary lymph node 20 mm in size were diagnosed. The patient was treated with gamma-knife therapy for the brain metastasis. One month later, she was referred to our institution. She underwent lymph node resection. Histological examination revealed that most portions of the affected lymph node were occupied by metastatic tumor cells and that central necrosis and four small ossified lesions without an osteoblast-like cell rim were present in the peripheral region. Immunohistochemical analysis showed tumor cells positive for BMP-2, osteonectin, osteocalcin, AE1/AE3, TGF-β1, Gli2, Smad2/3, and CDX2 and negative for nestin, CD56, and CK7.ConclusionThis is the first English case report of HO in a metachronous metastatic lymph node after the curative resection of HO-negative rectal cancer. Unlike HO lesions in past reports, the HO lesion did not show peripheral osteoblast-like cells, and the immunohistochemical findings indicated that the present case resulted from the EMT.
- Published
- 2021
44. Expression of functional E-selectin ligands on the plasma membrane of carcinoma cells correlates with poor prognosis in clear cell renal cell carcinoma
- Author
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Masataka Murahashi, Makoto Tanio, Yoshiaki Imamura, Akifumi Muramoto, Osamu Yokoyama, Hitomi Hoshino, and Motohiro Kobayashi
- Subjects
Male ,Urology ,030232 urology & nephrology ,Metastasis ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Immunochemistry ,E-selectin ,Carcinoma ,Medicine ,Humans ,Correlation of Data ,Carcinoma, Renal Cell ,Aged ,biology ,business.industry ,Cell Membrane ,Sialyl-Lewis A ,Middle Aged ,medicine.disease ,Prognosis ,Kidney Neoplasms ,Survival Rate ,Clear cell renal cell carcinoma ,Sialyl-Lewis X ,Oncology ,chemistry ,030220 oncology & carcinogenesis ,Cancer research ,biology.protein ,Immunohistochemistry ,Female ,business ,E-Selectin - Abstract
Objectives Given the relatively high frequency of metastatic recurrence of clear cell renal cell carcinoma (ccRCC), reliable prognostic markers of ccRCC, particularly those associated with metastasis, are needed. Here, in search of those factors, we assessed the contribution of sialyl Lewis x (sLex) and sialyl Lewis a (sLea), as well as functional E-selectin ligand carbohydrates expressed on carcinoma cells, to metastasis and consequent poor prognosis in ccRCC. Materials and methods Patients who underwent surgical resection (curative nephrectomy) for RCC, and whose post-operative pathological diagnosis was ccRCC (n = 117) were enrolled in this study. Expression of sLex/sLea carbohydrate antigens in ccRCC was evaluated by immunohistochemistry with an anti-sLex/sLea monoclonal antibody HECA-452. To evaluate membrane expression of sLex/sLea carbohydrate antigens quantitatively, we employed a histological scoring system used to evaluate membrane expression of human epidermal growth factor receptor 2 (HER2) in breast cancer. We also conducted an E-selectin•IgM chimera in situ binding assay to assess expression of functional E-selectin ligand carbohydrates in ccRCC. We then carried out statistical analysis to determine whether membrane expression of HECA-452-reactive sLex/sLea glycans as well as of E-selectin•IgM-binding functional E-selectin ligand carbohydrates correlates with progression-free, overall, or cancer-specific survival. Results Based on HECA-452 immunochemistry, 106 of 117 ccRCC specimens expressed detectable levels of sLex/sLea glycans, primarily on the plasma membrane, and of those, 31 that showed robust membrane expression were judged as HECA-452-positive. Membrane expression of HECA-452-positive sLex/sLea glycans correlated with shortened progression-free and overall survival. Moreover, in in situ analysis, these HECA-452-positive ccRCC tissues were decorated with E-selectin•IgM chimeric proteins, calcium-dependently. Comparable analysis in normal kidney showed both HECA-452 positivity and chimera binding almost exclusively in epithelial cells that constitute proximal tubules. Membrane expression of functional E-selectin ligand carbohydrates, as detected by the E-selectin•IgM chimera, correlated more significantly with poor prognosis of patients, namely, shortened progression-free, overall and cancer-specific survival, than did HECA-452 positivity. Conclusions Expression of E-selectin•IgM-binding functional E-selectin ligand carbohydrates can serve as a reliable and potentially superior prognostic biomarker of patients with ccRCC.
- Published
- 2020
45. [Conversion Therapy for HER2-Positive Metastatic Breast Cancer with Intrathoracic Lymph Node Metastasis]
- Author
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Hiroko, Kono, Hiroyuki, Maeda, Shoko, Yao, Mizuho, Takahashi, Shigehiro, Yokoi, Takanori, Goi, and Yoshiaki, Imamura
- Subjects
Adult ,Positron Emission Tomography Computed Tomography ,Humans ,Lymph Node Excision ,Breast Neoplasms ,Female ,Lymph Nodes ,Neoplasm Recurrence, Local ,Combined Modality Therapy ,Mastectomy - Abstract
A 42-year-old woman consulted our hospital with chief complaints of a right breast mass and pain. Based on needle biopsy of the breast tumor, the pathological diagnosis was invasive ductal carcinoma(scirrhous type), which tested positive for estrogen, progesterone, and HER2 receptor. PET-CT(FDG)showed intrathoracic lymph node metastasis. After several tests, she received a diagnosis of cT2N1M1(LYM), Stage Ⅳ breast cancer. She received pertuzumab, trastuzumab, and docetaxel treatments. After chemotherapy, the intrathoracic lymph node and breast tumors were not observed. She underwent mastectomy and axillary lymph node dissection. The pathological diagnosis showed a complete response after surgery. The patient's postoperative course was uneventful; she had received radiotherapy and anti-HER2 therapy. Twenty-three months after the surgery, no recurrence was observed. Herein, we report successful treatment of Stage Ⅳ breast cancer with conversion therapy.
- Published
- 2020
46. A typical case of resected pancreatic hamartoma: a case report and literature review on imaging and pathology
- Author
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Takanori Goi, Kenji Koneri, Makoto Murakami, Yasuo Hirono, Yoshiaki Imamura, Satomi Hatta, Hokahiro Katayama, and Kyohei Azuma
- Subjects
Pathology ,medicine.medical_specialty ,lcsh:Surgery ,CD34 ,Case Report ,Imaging ,Lesion ,03 medical and health sciences ,0302 clinical medicine ,Carcinoembryonic antigen ,Biopsy ,medicine ,Atypia ,Hamartoma ,biology ,medicine.diagnostic_test ,business.industry ,Magnetic resonance imaging ,lcsh:RD1-811 ,medicine.disease ,Pancreatic hamartoma ,Characteristics ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,biology.protein ,030211 gastroenterology & hepatology ,medicine.symptom ,Pancreas ,business - Abstract
Background Pancreatic hamartomas are rare entities and difficult to diagnose before resection. We report a case of resected pancreatic hamartoma and literature review of typical characteristics of the lesion. Case presentation A 78-year-old man presented with a mass in his pancreas, which was incidentally identified when he experienced pneumonia. No remarkable symptoms were observed, and laboratory tests showed no abnormalities, except a slight carcinoembryonic antigen elevation. Enhanced computed tomography and magnetic resonance imaging showed a well-demarcated solid mass with heterogeneous contrast that was 2 cm in size. A gradual enhancement pattern was also observed. The biopsy revealed no specific findings; therefore, surgical resection was necessitated to confirm the diagnosis. Histopathologically, ducts, acinar cells, and adipose cells without atypia were observed among abundant fibrous stroma, but islets of Langerhans and peripheral nerves were absent. An immunohistochemical examination demonstrated CD34 and c-kit positive staining in the stromal cells, S-100 positivity in the adipose cells, and a lack of elastic fibers in the duct walls. The lesion was diagnosed as a pancreatic hamartoma. Conclusion Asymptomatic pancreatic hamartomas can avoid resection. A careful consideration of imaging and appropriate immunohistochemistry of biopsy specimen may facilitate accurate diagnosis before resection. Therefore, sufficient recognition of the characteristics of pancreatic hamartomas is desirable.
- Published
- 2020
47. Duplication cyst of the ileum presenting with severe anemia detected by double-balloon endoscopy
- Author
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Takanori Goi, Tatsushi Naito, Katsushi Hiramatsu, Hidetaka Matsuda, Yoshihiko Ozaki, Masahiro Ohtani, Yosuke Murata, Yu Akazawa, Tomoyuki Nemoto, Yoshiaki Imamura, Kazuya Ofuji, Kazuto Takahashi, Yumi Takegawa, Yasushi Saito, Hiroyuki Suto, and Yasunari Nakamoto
- Subjects
Enteroscopy ,medicine.medical_specialty ,Abdominal pain ,medicine.diagnostic_test ,business.industry ,Colonoscopy ,Ileum ,medicine.disease ,03 medical and health sciences ,0302 clinical medicine ,medicine.anatomical_structure ,Iron-deficiency anemia ,Melena ,030220 oncology & carcinogenesis ,Intussusception (medical disorder) ,Case report ,Medicine ,lcsh:Diseases of the digestive system. Gastroenterology ,030211 gastroenterology & hepatology ,Pharmacology (medical) ,Cyst ,Radiology ,lcsh:RC799-869 ,medicine.symptom ,business - Abstract
Background and study aims Duplication cysts of the ileum are rare and present with non-specific clinical manifestations such as abdominal pain, vomiting, melena, and intussusception. Therefore, preoperative diagnosis is difficult. Here, we report a case of duplication cyst of the small intestine that was diagnosed preoperatively using double-balloon enteroscopy. A 19-year-old man presented with severe iron deficiency anemia, abdominal pain, and exertional dyspnea. Gastroscopy and colonoscopy revealed no remarkable findings. Abdominal computed tomography revealed a cystic structure in the ileum. Therefore, we performed double-balloon enteroscopy via the anal route. The intestinal tract was bifurcated, with one segment ending in a blind sac containing normal villi and an ulceration. Tc-99 m pertechnetate scintigraphy showed no accumulation in the lesion. Accordingly, we diagnosed a duplication cyst and suspected that this was the cause of severe anemia. Following small bowel resection with cyst excision and anastomosis, the anemia and presenting symptoms resolved. This report highlights the usefulness of double-balloon enteroscopy of the small intestine for preoperative diagnosis of the obscure gastrointestinal bleeding, including duplication cysts.
- Published
- 2018
48. Alveolar Macrophages Drive Hepatocellular Carcinoma Lung Metastasis by Generating Leukotriene B4
- Author
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Makoto Arita, Naofumi Mukaida, Hideaki Yurino, Tomohisa Baba, Soichiro Sasaki, Tatsunori Nishimura, Shin-ichi Hashimoto, Takuto Nosaka, Yamato Tanabe, Yasunari Nakamoto, and Yoshiaki Imamura
- Subjects
0301 basic medicine ,biology ,Cell growth ,Leukotriene B4 ,business.industry ,Immunology ,respiratory system ,CCL2 ,medicine.disease ,respiratory tract diseases ,03 medical and health sciences ,chemistry.chemical_compound ,030104 developmental biology ,chemistry ,Interstitial space ,Cell culture ,Hepatocellular carcinoma ,medicine ,Cancer research ,Carcinoma ,biology.protein ,Immunology and Allergy ,Cyclooxygenase ,business - Abstract
Macrophages in lungs can be classified into two subpopulations, alveolar macrophages (AMs) and interstitial macrophages (IMs), which reside in the alveolar and interstitial spaces, respectively. Accumulating evidence indicates the involvement of IMs in lung metastasis, but the roles of AMs in lung metastasis still remain elusive. An i.v. injection of a mouse hepatocellular carcinoma (HCC) cell line, BNL, caused lung metastasis foci with infiltration of AMs and IMs. Comprehensive determination of arachidonic acid metabolite levels revealed increases in leukotrienes and PGs in lungs in this metastasis model. A 5-lipoxygenase (LOX) inhibitor but not a cyclooxygenase inhibitor reduced the numbers of metastatic foci, particularly those of a larger size. A major 5-LOX metabolite, LTB4, augmented in vitro cell proliferation of human HCC cell lines as well as BNL cells. Moreover, in this lung metastasis course, AMs exhibited higher expression levels of the 5-LOX and LTB4 than IMs. Consistently, 5-LOX–expressing AMs increased in the lungs of human HCC patients with lung metastasis, compared with those without lung metastasis. Furthermore, intratracheal clodronate liposome injection selectively depleted AMs but not IMs, together with reduced LTB4 content and metastatic foci numbers in this lung metastasis process. Finally, IMs in mouse metastatic foci produced CCL2, thereby recruiting blood-borne, CCR2–expressing AMs into lungs. Thus, AMs can be recruited under the guidance of IM-derived CCL2 into metastatic lungs and can eventually contribute to the progression of lung metastasis by providing a potent arachidonic acid–derived tumor growth promoting mediator, LTB4.
- Published
- 2018
49. A Case of Epicardial Primary Synovial Sarcoma with Cardiac Tamponade Caused by Bleeding
- Author
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Yoshiaki Imamura, Kouichi Morioka, Narihisa Yamada, Takaaki Koshiji, Atsushi Takamori, Sawaka Tanabe, and Yuko Kawamura
- Subjects
medicine.medical_specialty ,Primary Synovial Sarcoma ,business.industry ,Cardiac tamponade ,General Engineering ,medicine ,General Earth and Planetary Sciences ,business ,medicine.disease ,General Environmental Science ,Surgery - Published
- 2018
50. Adenoid cystic carcinoma of the sublingual gland developing lung metastasis 20 years after primary treatment
- Author
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Keiichi Ohta, Shinpei Matsuda, Akitoshi Okada, Masato Sasaki, Yoshiaki Imamura, and Hitoshi Yoshimura
- Subjects
General Medicine - Published
- 2021
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