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Your search keyword '"Zheng, Lianfang"' showing total 46 results
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46 results on '"Zheng, Lianfang"'

3. Human Equilibrative Nucleoside Transporter 1: Novel Biomarker and Prognostic Indicator for Patients with Gemcitabine-Treated Pancreatic Cancer.

Author

Xiao, Jianchun, Zhao, Fangyu, Luo, Wenhao, Yang, Gang, Wang, Yicheng, Qiu, Jiangdong, Liu, Yueze, You, Lei, Zheng, Lianfang, and Zhang, Taiping

Subjects
NUCLEOSIDE transport proteins, PANCREATIC cancer, BIOMARKERS, PANCREATIC surgery, SURVIVAL rate, DRUG resistance
Abstract

Aim: This article aimed to find appropriate pancreatic cancer (PC) patients to treat with Gemcitabine with better survival outcomes by detecting hENT1 levels. Methods: We collected surgical pathological tissues from PC patients who received radical surgery in our hospital from September 2004 to December 2014. A total of 375 PC tissues and paired adjacent nontumor tissues were employed for the construction of 4 tissue microarrays (TMAs). The quality of the 4 TMAs was examined by HE staining. We performed immunohistochemistry analysis to evaluate hENT1 expression in the TMAs. Moreover, we detected hENT1 expression level and proved the role of hENT1 in cell proliferation, drug resistance, migration and invasion in vivo and vitro. Results: The results indicated that low hENT1 expression indicated a significantly poor outcome in PC patients, including shortened DFS (21.6± 2.8 months versus 36.9± 4.0 months, p< 0.001) and OS (33.6± 3.9 versus 39.6± 3.9, p=0.004). Meanwhile, patients in stage I/II of TNM stage had a longer OS (40.2± 3.4 versus 15.4± 1.7, p=0.002) and DFS (31.0± 3.1 versus 12.4± 1.9, p=0.016) than patients in stage III/IV. Patients in M0 stage had a longer OS (39.7± 3.4 versus 16.2± 1.9, p=0.026) and DFS(30.7± 3.0 versus 11.8± 2.2, p=0.031) than patients in M1 stage, and patients with tumors not invading the capsule had a better DFS than those with tumor invasion into the capsule (30.8± 3.0 versus 12.6± 2.3, p=0.053). Patients with preoperative CA19-9 values ≤ 467 U/mL have longer DFS than that of patients who had preoperative CA19-9 values > 467 U/mL (37.9± 4.1 versus 22.9± 4.0, p=0.04). In the subgroup analysis, a high hENT1 expression level was related to a longer OS(39.4± 4.0 versus 31.5± 3.9, p=0.001) and DFS(35.7± 4.0 versus 20.6± 2.7; p< 0.0001) in the Gemcitabine subgroup. Conclusion: PC patients with high hENT1 expression have a better survival outcomes when receiving Gemcitabine. hENT1 expression can be a great prognostic indicator for PC patients to receive Gemcitabine treatment. [ABSTRACT FROM AUTHOR]

Published
2024
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19. Using a microRNA panel of circulating exosomes for diagnosis of pancreatic cancer: multicentre case–control study

Author

Yang, Gang, primary, Qiu, Jiangdong, additional, Xu, Jianwei, additional, Xiong, Guangbing, additional, Zhao, Fangyu, additional, Cao, Zhe, additional, Chen, Guangyu, additional, Liu, Yueze, additional, Tao, Jinxin, additional, Zheng, Lianfang, additional, Wang, Lei, additional, Qin, Renyi, additional, and Zhang, Taiping, additional

Published
2022
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21. The Role of Mitochondria in the Chemoresistance of Pancreatic Cancer Cells

Author

Fu, Y, Ricciardiello, F, Yang, G, Qiu, J, Huang, H, Xiao, J, Cao, Z, Zhao, F, Liu, Y, Luo, W, Chen, G, You, L, Chiaradonna, F, Zheng, L, Zhang, T, Fu, Yibo, Ricciardiello, Francesca, Yang, Gang, Qiu, Jiangdong, Huang, Hua, Xiao, Jianchun, Cao, Zhe, Zhao, Fangyu, Liu, Yueze, Luo, Wenhao, Chen, Guangyu, You, Lei, Chiaradonna, Ferdinando, Zheng, Lianfang, Zhang, Taiping, Fu, Y, Ricciardiello, F, Yang, G, Qiu, J, Huang, H, Xiao, J, Cao, Z, Zhao, F, Liu, Y, Luo, W, Chen, G, You, L, Chiaradonna, F, Zheng, L, Zhang, T, Fu, Yibo, Ricciardiello, Francesca, Yang, Gang, Qiu, Jiangdong, Huang, Hua, Xiao, Jianchun, Cao, Zhe, Zhao, Fangyu, Liu, Yueze, Luo, Wenhao, Chen, Guangyu, You, Lei, Chiaradonna, Ferdinando, Zheng, Lianfang, and Zhang, Taiping

Abstract

The first-line chemotherapies for patients with unresectable pancreatic cancer (PC) are 5-fluorouracil (5-FU) and gemcitabine therapy. However, due to chemoresistance the prognosis of patients with PC has not been significantly improved. Mitochondria are essential organelles in eukaryotes that evolved from aerobic bacteria. In recent years, many studies have shown that mitochondria play important roles in tumorigenesis and may act as chemotherapeutic targets in PC. In addition, according to recent studies, mitochondria may play important roles in the chemoresistance of PC by affecting apoptosis, metabolism, mtDNA metabolism, and mitochondrial dynamics. Interfering with some of these factors in mitochondria may improve the sensitivity of PC cells to chemotherapeutic agents, such as gemcitabine, making mitochondria promising targets for overcoming chemoresistance in PC.

Published
2021

22. The Role of Mitochondria in the Chemoresistance of Pancreatic Cancer Cells

Author

Fu, Yibo, primary, Ricciardiello, Francesca, additional, Yang, Gang, additional, Qiu, Jiangdong, additional, Huang, Hua, additional, Xiao, Jianchun, additional, Cao, Zhe, additional, Zhao, Fangyu, additional, Liu, Yueze, additional, Luo, Wenhao, additional, Chen, Guangyu, additional, You, Lei, additional, Chiaradonna, Ferdinando, additional, Zheng, Lianfang, additional, and Zhang, Taiping, additional

Published
2021
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36. Novel discoveries targeting gemcitabine‐based chemoresistance and new therapies in pancreatic cancer: How far are we from the destination?

Author

Luo, Wenhao, primary, Yang, Gang, additional, Qiu, Jiangdong, additional, Luan, Jingyang, additional, Zhang, Ying, additional, You, Lei, additional, Feng, Mengyu, additional, Zhao, Fangyu, additional, Liu, Yueze, additional, Cao, Zhe, additional, Zheng, Lianfang, additional, Zhang, Taiping, additional, and Zhao, Yupei, additional

Published
2019
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37. NF-κB in pancreatic cancer: Its key role in chemoresistance

Author

Li, Quanxiao, primary, Yang, Gang, additional, Feng, Mengyu, additional, Zheng, Suli, additional, Cao, Zhe, additional, Qiu, Jiangdong, additional, You, Lei, additional, Zheng, Lianfang, additional, Hu, Ya, additional, Zhang, Taiping, additional, and Zhao, Yupei, additional

Published
2018
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44. Novel therapies targeting hypoxia mechanism to treat pancreatic cancer.

Author

Luo W, Qiu J, Zheng L, and Zhang T

Abstract

Pancreatic cancer (PC) is one of the deadliest malignancies. The high mortality rate of PC largely results from delayed diagnosis and early metastasis. Therefore, identifying novel treatment targets for patients with PC is urgently required to improve survival rates. A major barrier to successful treatment of PC is the presence of a hypoxic tumor microenvironment, which is associated with poor prognosis, treatment resistance, increased invasion and metastasis. Recent studies have identified a number of novel molecules and pathways in PC cells that promote cancer cells progression under hypoxic conditions, which may provide new therapy strategies to inhibit the development and metastasis of PC. This review summarizes the latest research of hypoxia in PC and provides an overview of how the current therapies have the capacity to overcome hypoxia and improve PC patient treatment. These findings will eventually provide guidance for future PC management and clinical trials and hopefully improve the survival of patients with PC., Competing Interests: Conflicts of Interest: The authors have no conflicts of interest to declare., (Copyright ©2021Chinese Journal of Cancer Research. All rights reserved.)

Published
2021
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45. Current epidemiology of pancreatic cancer: Challenges and opportunities.

Author

Luo W, Tao J, Zheng L, and Zhang T

Abstract

Pancreatic cancer (PC) is an increasingly common disease worldwide. Having a better understanding of worldwide and regional epidemiologic features and risk factors of PC is essential to identify new approaches for prevention, early diagnosis, surveillance, and treatment. In this article, we review the epidemiologic features and risk factors for PC and discuss opportunities and challenges of PC future treatment., (Copyright © 2020 Chinese Journal of Cancer Research. All rights reserved.)

Published
2020
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46. Comparative [ 18 F]FDG and [ 18 F]DPA714 PET imaging and time-dependent changes of brown adipose tissue in tumour-bearing mice.

Author

Niu N, Xing H, Wang X, Ding J, Hao Z, Ren C, Ba J, Zheng L, Fu C, Zhao H, and Huo L

Subjects
Animals, Biomarkers, Cell Line, Tumor, Disease Models, Animal, Energy Metabolism, Heterografts, Humans, Mice, Molecular Imaging methods, Neoplasms diagnostic imaging, Neoplasms metabolism, Neoplasms pathology, Adipose Tissue, Brown diagnostic imaging, Adipose Tissue, Brown metabolism, Fluorodeoxyglucose F18, Positron-Emission Tomography methods, Pyrazoles, Pyrimidines
Abstract

Brown adipose tissue (BAT) is important in monitoring energy homeostasis and cancer cachexia. Different from white adipose tissue, BAT is characterized by the presence of a large number of mitochondria in adipocytes. Translocator protein 18 kDa (TSPO), a critical transporter, is expressed in the outer membrane of mitochondria. We speculated that [ 18 F]DPA714, a specific TSPO tracer, may monitor BAT activity in tumor-bearing mice in vivo. We first analyzed the radioactive uptake of positron emission tomography (PET) tracers in BAT of CT26 xenograft mice with 18F-fluorodeoxyglucose ([ 18 F]FDG) and [ 18 F]DPA714. We also studied the BAT uptake of [ 18 F]DPA714 in CT26, A549 and LLC tumor models. The dynamic distribution of [ 18 F]FDG is quite variable among animals, even in mice of the same tumor model (%ID/g-mean: mean ± SDM, 8.61 ± 8.90, n = 16). Contrarily, [ 18 F]DPA714 produced high-quality and stable BAT imaging in different tumor models and different animals of the same model. Interestingly, %ID/g-mean of [ 18 F]DPA714 in BAT was significantly higher on day 26 than that on day 7 in CT26 xenograft model. Taken together, these results strongly indicate the potential feasibility of [ 18 F]DPA714 PET imaging in investigating BAT and energy metabolism during tumor progression in preclinical and clinical study.

Published
2020
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