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125 results on '"Zhou, Fu-You"'

1. Survival influence of gender on 42,345 patients with gastric cardia adenocarcinoma

Author

Xu, Rui Hua, Zhao, Xue Ke, Song, Xin, Lei, Ling Ling, Zhong, Kan, Han, Wen Li, Wang, Ran, De Bao, Qi, Hu, Jing Feng, Wei, Meng Xia, Ji, Jia Jia, Li, Liu Yu, Fan, Zong Min, Han, Xue Na, Li, Bei, Yang, Yuan Ze, Sun, Lin, Li, Jia, Yang, Miao Miao, Li, Xing Song, You, Duo, Bai, He Lin, Qiao, Jia Xin, Xie, Ye Zhen, Zhou, Fu You, Li, Xue Min, Li, Ai Li, and Wang, Li Dong

Published
2023
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3. Transthoracic, thoracoabdominal, and transabdominal surgical approaches for gastric cardia adenocarcinomas: a survival evaluation based on a cohort of 7103 patients

Author

Chen, Yao, Zhao, Xue Ke, Xu, Rui Hua, Song, Xin, Yang, Miao Miao, Zhou, Fu You, Lei, Ling Ling, Fan, Zong Min, Han, Xue Na, Gao, She Gan, Wang, Xian Zeng, Liu, Zhi Cai, Li Li, Ai, Gao, Wen Jun, Hu, Jing Feng, Zhang, Li Guo, Wei, Jin Chang, Jiao, Fu Lin, Zhong, Kan, Wang, Wei Peng, Li, Liu Yu, Ji, Jia Jia, Li, Xue Min, and Wang, Li Dong

Published
2022
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4. HER2 Prognostic Significance and Therapeutic Implications in Gastric Cardia Adenocarcinoma: Insights from Multi-Omics Profiling

Author

Wang, Li-Dong, primary, Xing, Pengwei, additional, Zhao, Xue-Ke, additional, Song, Xin, additional, Wei, Meng-Xia, additional, Lei, Ling-Ling, additional, Xu, Rui-Hua, additional, Wang, Ran, additional, Ma, Lei, additional, You, Duo, additional, Chen, Pei-Nan, additional, Xie, Minglu, additional, Zhao, Miao, additional, Zhang, He, additional, Lv, Hui-Fang, additional, Li, Ai-Li, additional, Wang, Xian-Zeng, additional, Zhou, Fu-You, additional, Gao, She-Gan, additional, and Chen, Xingqi, additional

Published
2024
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5. Novel metabolic biomarker for early detection and diagnosis to the patients with gastric cardia adenocarcinoma

Author

Wei, Meng Xia, primary, Yang, Zheng, additional, Wang, Pan Pan, additional, Zhao, Xue Ke, additional, Song, Xin, additional, Xu, Rui Hua, additional, Hu, Jing Feng, additional, Zhong, Kan, additional, Lei, Ling Ling, additional, Han, Wen Li, additional, Yang, Miao Miao, additional, Zhou, Fu You, additional, Han, Xue Na, additional, Fan, Zong Min, additional, Li, Jia, additional, Wang, Ran, additional, Li, Bei, additional, and Wang, Li Dong, additional

Published
2024
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7. Clinicopathological characteristics and postoperative prognosis of patients with nuclear pedigree of esophageal squamous cell carcinoma

Author

Wei, Meng Xia, primary, Song, Xin, additional, Zhao, Xue Ke, additional, Han, Wen Li, additional, Bao, Qi De, additional, Han, Xue Nan, additional, Xu, Rui Hua, additional, Li, Xin Min, additional, Fan, Zong Min, additional, Wang, Ran, additional, Li, Xing Song, additional, Hu, Jing Feng, additional, Li, Jia, additional, Li, Bei, additional, Tan, Hui Fang, additional, Gao, She Gan, additional, Zhou, Fu You, additional, and Wang, Li Dong, additional

Published
2023
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8. Long-term effect of hospital volume on the postoperative prognosis of 158,618 patients with esophageal squamous cell carcinoma in China

Author

Lei, Ling-Ling, primary, Song, Xin, additional, Zhao, Xue-Ke, additional, Xu, Rui-Hua, additional, Wei, Meng-Xia, additional, Sun, Lin, additional, Wang, Pan-Pan, additional, Yang, Miao-Miao, additional, Hu, Jing-Feng, additional, Zhong, Kan, additional, Han, Wen-Li, additional, Han, Xue-Na, additional, Fan, Zong-Min, additional, Wang, Ran, additional, Li, Bei, additional, Zhou, Fu-You, additional, Wang, Xian-Zeng, additional, Zhang, Li-Guo, additional, Bao, Qi-De, additional, Qin, Yan-Ru, additional, Chang, Zhi-Wei, additional, Ku, Jian-Wei, additional, Yang, Hai-Jun, additional, Yuan, Ling, additional, Ren, Jing-Li, additional, Li, Xue-Min, additional, and Wang, Li-Dong, additional

Published
2023
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9. Increases prognostic value of clinical-pathological nomogram in patients with esophageal squamous cell carcinoma

Author

Hu, Jing Feng, primary, Song, Xin, additional, Zhong, Kan, additional, Zhao, Xue Ke, additional, Zhou, Fu You, additional, Xu, Rui Hua, additional, Li, Ji Lin, additional, Wang, Xian Zeng, additional, Li, Xue Min, additional, Wang, Pan Pan, additional, Lei, Ling Ling, additional, Wei, Meng Xia, additional, Wang, Ran, additional, Fan, Zong Min, additional, Han, Xue Na, additional, Chen, Yao, additional, Li, Liu Yu, additional, Ji, Jia Jia, additional, Yang, Yuan Ze, additional, Li, Bei, additional, Yang, Miao Miao, additional, Yang, Hai Jun, additional, Chang, Fu Bao, additional, Ren, Jing Li, additional, Zhou, Sheng Li, additional, and Wang, Li Dong, additional

Published
2023
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11. Survival influence of gender on 42,345 patients with gastric cardia adenocarcinoma

Author

Xu, Rui Hua, primary, Zhao, Xue Ke, additional, Song, Xin, additional, Lei, Ling Ling, additional, Zhong, Kan, additional, Han, Wen Li, additional, Wang, Ran, additional, De Bao, Qi, additional, Hu, Jing Feng, additional, Wei, Meng Xia, additional, Ji, Jia Jia, additional, Li, Liu Yu, additional, Fan, Zong Min, additional, Han, Xue Na, additional, Li, Bei, additional, Yang, Yuan Ze, additional, Sun, Lin, additional, Li, Jia, additional, Yang, Miao Miao, additional, Li, Xing Song, additional, You, Duo, additional, Bai, He Lin, additional, Qiao, Jia Xin, additional, Xie, Ye Zhen, additional, Zhou, Fu You, additional, Li, Xue Min, additional, Li, Ai Li, additional, and Wang, Li Dong, additional

Published
2022
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12. The prognostic value of keratin pearls in patients with esophageal squamous cell carcinoma

Author

Zhong, Kan, Song, Xin, Zhao, Xue Ke, Hu, Jing Feng, Zhou, Fu You, Li, Ji Lin, Ren, Jing Li, Li, Xue Min, Wang, Xian Zeng, Huang, Gai Rong, Ku, Jian Wei, Zhang, Dong Yun, Wang, Pan Pan, Lei, Lin Lin, Wei, Meng Xia, Fan, Zong Min, Han, Xue Na, Wang, Ran, Ji, Jia Jia, Chen, Yao, Li, Liu Yu, Yang, Yuan Ze, Yang, Miao Miao, Li, Bei, and Wang, Li Dong

Subjects
Original Article
Abstract

Keratin pearls (KP) is an important indicator of the degree of tumor cell differentiation of esophageal squamous cell carcinomas (ESCC). However, the independent prognostic value of KP in ESCC patients remains unclear. The hematoxylin-eosin (H&E) stained tissue microarrays (TMAs) or whole slides of the patients were prepared to identify the existence of KP. Kaplan-Meier (KM) survival analysis as well as univariate and multivariate Cox regression analyses were used to evaluate the prognostic value of KP. A nomogram based on KP and other clinicopathologic characteristics was constructed. The C-index, calibration curve, Receiver Operating Characteristic (ROC) curve, and Decision Curve Analysis (DCA) were used to evaluate the nomogram. The results indicated KP is a protective factor against lymph node metastasis and is closely associated with the differentiation degree in ESCC patients. KM survival analysis showed that the overall survival (OS) of patients with KP was significantly better than for patients without KP. In addition, multivariate Cox regression analysis revealed that KP was an independent predictor of OS. Furthermore, ROC curve demonstrated that KP combined with differentiation degree could more accurately predict the 5-year survival rate than differentiation degree alone. Importantly, the nomogram showed good discrimination and calibration abilities in both training and validation groups, which could more accurately predict the 3-, 5-, and 10-year survival rates of ESCC patients and adds to the predictive value of TNM stage alone. In conclusion, KP is an independent predictor of prognosis in patients with ESCC and provides incremental prognostic value to degree of differentiation.

Published
2022

14. Serum Metabolomic Profiling Reveals Biomarkers for Early Detection and Prognosis of Esophageal Squamous Cell Carcinoma

Author

Wang, Pan Pan, primary, Song, Xin, additional, Zhao, Xue Ke, additional, Wei, Meng Xia, additional, Gao, She Gan, additional, Zhou, Fu You, additional, Han, Xue Na, additional, Xu, Rui Hua, additional, Wang, Ran, additional, Fan, Zong Min, additional, Ren, Jing Li, additional, Li, Xue Min, additional, Wang, Xian Zeng, additional, Yang, Miao Miao, additional, Hu, Jing Feng, additional, Zhong, Kan, additional, Lei, Ling Ling, additional, Li, Liu Yu, additional, Chen, Yao, additional, Chen, Ya Jie, additional, Ji, Jia Jia, additional, Yang, Yuan Ze, additional, Li, Jia, additional, and Wang, Li Dong, additional

Published
2022
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15. Characterization of E-cadherin expression in normal mucosa, dysplasia and adenocarcinoma of gastric cardia and its influence on prognosis

Author

Wang, Hai-Ling, primary, Zhao, Xue-Ke, additional, Zhou, Fu-You, additional, Song, Xin, additional, Li, Liu-Yu, additional, Huang, Gai-Rong, additional, Bao, Qi-De, additional, Lei, Ling-Ling, additional, Yang, Hai-Jun, additional, Li, Li, additional, Xu, Rui-Hua, additional, Li, Ai-Li, additional, Wang, Xian-Zeng, additional, Han, Wen-Li, additional, Ren, Jing-Li, additional, and Wang, Li-Dong, additional

Published
2022
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16. Joint analysis of three genome-wide association studies of esophageal squamous cell carcinoma in Chinese populations

Author

Wu, Chen, Wang, Zhaoming, Song, Xin, Feng, Xiao-Shan, Abnet, Christian C, He, Jie, Hu, Nan, Zuo, Xian-Bo, Tan, Wen, Zhan, Qimin, Hu, Zhibin, He, Zhonghu, Jia, Weihua, Zhou, Yifeng, Yu, Kai, Shu, Xiao-Ou, Yuan, Jian-Min, Zheng, Wei, Zhao, Xue-Ke, Gao, She-Gan, Yuan, Zhi-Qing, Zhou, Fu-You, Fan, Zong-Min, Cui, Ji-Li, Lin, Hong-Li, Han, Xue-Na, Li, Bei, Chen, Xi, Dawsey, Sanford M, Liao, Linda, Lee, Maxwell P, Ding, Ti, Qiao, You-Lin, Liu, Zhihua, Liu, Yu, Yu, Dianke, Chang, Jiang, Wei, Lixuan, Gao, Yu-Tang, Koh, Woon-Puay, Xiang, Yong-Bing, Tang, Ze-Zhong, Fan, Jin-Hu, Han, Jing-Jing, Zhou, Sheng-Li, Zhang, Peng, Zhang, Dong-Yun, Yuan, Yuan, Huang, Ying, Liu, Chunling, Zhai, Kan, Qiao, Yan, Jin, Guangfu, Guo, Chuanhai, Fu, Jianhua, Miao, Xiaoping, Lu, Changdong, Yang, Haijun, Wang, Chaoyu, Wheeler, William A, Gail, Mitchell, Yeager, Meredith, Yuenger, Jeff, Guo, Er-Tao, Li, Ai-Li, Zhang, Wei, Li, Xue-Min, Sun, Liang-Dan, Ma, Bao-Gen, Li, Yan, Tang, Sa, Peng, Xiu-Qing, Liu, Jing, Hutchinson, Amy, Jacobs, Kevin, Giffen, Carol, Burdette, Laurie, Fraumeni, Jr, Joseph F, Shen, Hongbing, Ke, Yang, Zeng, Yixin, Wu, Tangchun, Kraft, Peter, Chung, Charles C, Tucker, Margaret A, Hou, Zhi-Chao, Liu, Ya-Li, Hu, Yan-Long, Liu, Yu, Wang, Li, Yuan, Guo, Chen, Li-Sha, Liu, Xiao, Ma, Teng, Meng, Hui, Sun, Li, Li, Xin-Min, Li, Xiu-Min, Ku, Jian-Wei, Zhou, Ying-Fa, Yang, Liu-Qin, Wang, Zhou, Li, Yin, Qige, Qirenwang, Yang, Wen-Jun, Lei, Guang-Yan, Chen, Long-Qi, Li, En-Min, Yuan, Ling, Yue, Wen-Bin, Wang, Ran, Wang, Lu-Wen, Fan, Xue-Ping, Zhu, Fang-Heng, Zhao, Wei-Xing, Mao, Yi-Min, Zhang, Mei, Xing, Guo-Lan, Li, Ji-Lin, Han, Min, Ren, Jing-Li, Liu, Bin, Ren, Shu-Wei, Kong, Qing-Peng, Li, Feng, Sheyhidin, Ilyar, Wei, Wu, Zhang, Yan-Rui, Feng, Chang-Wei, Wang, Jin, Yang, Yu-Hua, Hao, Hong-Zhang, Bao, Qi-De, Liu, Bao-Chi, Wu, Ai-Qun, Xie, Dong, Yang, Wan-Cai, Wang, Liang, Zhao, Xiao-Hang, Chen, Shu-Qing, Hong, Jun-Yan, Zhang, Xue-Jun, Freedman, Neal D, Goldstein, Alisa M, Lin, Dongxin, Taylor, Philip R, Wang, Li-Dong, and Chanock, Stephen J

Published
2014
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17. Prevalence of human papillomavirus infection in esophageal and cervical cancers in the high incidence area for the two diseases from 2007 to 2009 in Linzhou of Henan Province, Northern China

Author

Liu, Hong Yan, Zhou, Sheng Li, Ku, Jian Wei, Zhang, Dong Yun, Li, Bei, Han, Xue Na, Fan, Zong Min, Cui, Ji Li, Lin, Hong Li, Guo, Er Tao, Chen, Xi, Yuan, Yuan, Han, Jing Jing, Zhang, Wei, Zhang, Lian Qun, Zhou, Fu You, Liao, Shi Xiu, Hong, Jun Yan, and Wang, Li Dong

Published
2014
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22. Extrachromosomal DNA is associated with chromothripsis events and diverse prognoses in gastric cardia adenocarcinoma

Author

Zhao, Xue-Ke, primary, Xing, Pengwei, additional, Song, Xin, additional, Zhao, Miao, additional, Zhao, Linxuan, additional, Dang, Yonglong, additional, Lei, Ling-Ling, additional, Xu, Rui-Hua, additional, Han, Wen-Li, additional, Wang, Pan-Pan, additional, Yang, Miao-Miao, additional, Hu, Jing-Feng, additional, Zhong, Kan, additional, Zhou, Fu-You, additional, Han, Xue-Na, additional, Meng, Chao-Long, additional, Ji, Jia-Jia, additional, Chen, Xingqi, additional, and Wang, Li-Dong, additional

Published
2021
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23. Genome-wide association study of esophageal squamous cell carcinoma in Chinese subjects identifies a susceptibility locus at PLCE1

Author

Wang, Li-Dong, Zhou, Fu-You, Li, Xue-Min, Sun, Liang-Dan, Song, Xin, Jin, Yan, Li, Jiang-Man, Kong, Guo-Qiang, Qi, Hong, Cui, Juan, Zhang, Lian-Qun, Yang, Jie-Zhi, Li, Ji-Lin, Li, Xing-Chuan, Ren, Jing-Li, Liu, Zhi-Cai, Gao, Wen-Jun, Yuan, Ling, Wei, Wu, Zhang, Yan-Rui, Wang, Wei-Peng, Sheyhidin, Ilyar, Li, Feng, Chen, Bao-Ping, Ren, Shu-Wei, Liu, Bin, Li, Dan, Ku, Jian-Wei, Fan, Zong-Min, Zhou, Sheng-Li, Guo, Zhi-Gang, Zhao, Xue-Ke, Liu, Na, Ai, Yong-Hong, Shen, Fang-Fang, Cui, Wen-Yan, Song, Shuang, Guo, Tao, Huang, Jing, Yuan, Chao, Huang, Jia, Wu, Yue, Yue, Wen-Bin, Feng, Chang-Wei, Li, Hong-Lei, Wang, Yan, Tian, Jin-Ya, Lu, Yue, Yuan, Yi, Zhu, Wen-Liang, Liu, Min, Fu, Wen-Jing, Yang, Xia, Wang, Han-Jing, Han, Suo-Li, Chen, Jie, Han, Min, Wang, Hai-Yan, Zhang, Peng, Li, Xiu-Min, Dong, Jin-Cheng, Xing, Guo-Lan, Wang, Ran, Guo, Ming, Chang, Zhi-Wei, Liu, Hai-Lin, Guo, Li, Yuan, Zhi-Qing, Liu, Hai, Lu, Qin, Yang, Liu-Qin, Zhu, Fu-Guo, Yang, Xiu-Feng, Feng, Xiao-Shan, Wang, Zhou, Li, Yin, Gao, She-Gan, Qige, Qirenwang, Bai, Long-Tang, Yang, Wen-Jun, Lei, Guang-Yan, Shen, Zhong-Ying, Chen, Long-Qi, Li, En-Min, Xu, Li-Yan, Wu, Zhi-Yong, Cao, Wei-Ke, Wang, Jian-Po, Bao, Zhi-Qin, Chen, Ji-Li, Ding, Guang-Cheng, Zhuang, Xiang, Zhou, Ying-Fa, Zheng, Hou-Feng, Zhang, Zheng, Zuo, Xian-Bo, Dong, Zi-Ming, Fan, Dong-Mei, He, Xin, Wang, Jin, Zhou, Qi, Zhang, Qin-Xian, Jiao, Xin-Ying, Lian, Shi-Yong, Ji, Ai-Fang, Lu, Xiao-Mei, Wang, Jin-Sheng, Chang, Fu-Bao, Lu, Chang-Dong, Chen, Zhi-Guo, Miao, Jian-Jun, Fan, Zeng-Lin, Lin, Ruo-Bai, Liu, Tai-Jiang, Wei, Jin-Chang, Kong, Qing-Peng, Lan, Yu, Fan, Yu-Jing, Gao, Fu-Sheng, Wang, Tian-Yun, Xie, Dong, Chen, Shu-Qing, Yang, Wan-Cai, Hong, Jun-Yan, Wang, Liang, Qiu, Song-Liang, Cai, Zhi-Ming, and Zhang, Xue-Jun

Published
2010
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26. Genotypic variants at 2q33 and risk of esophageal squamous cell carcinoma in China: a meta-analysis of genome-wide association studies

Author

Abnet, Christian C., Wang, Zhaoming, Song, Xin, Hu, Nan, Zhou, Fu-You, Freedman, Neal D., Li, Xue-Min, Yu, Kai, Shu, Xiao-Ou, Yuan, Jian-Min, Zheng, Wei, Dawsey, Sanford M., Liao, Linda M., Lee, Maxwell P., Ding, Ti, Qiao, You-Lin, Gao, Yu-Tang, Koh, Woon-Puay, Xiang, Yong-Bing, Tang, Ze-Zhong, Fan, Jin-Hu, Chung, Charles C., Wang, Chaoyu, Wheeler, William, Yeager, Meredith, Yuenger, Jeff, Hutchinson, Amy, Jacobs, Kevin B., Giffen, Carol A., Burdett, Laurie, Fraumeni, Joseph F., Jr, Tucker, Margaret A., Chow, Wong-Ho, Zhao, Xue-Ke, Li, Jiang-Man, Li, Ai-Li, Sun, Liang-Dan, Wei, Wu, Li, Ji-Lin, Zhang, Peng, Li, Hong-Lei, Cui, Wen-Yan, Wang, Wei-Peng, Liu, Zhi-Cai, Yang, Xia, Fu, Wen-Jing, Cui, Ji-Li, Lin, Hong-Li, Zhu, Wen-Liang, Liu, Min, Chen, Xi, Chen, Jie, Guo, Li, Han, Jing-Jing, Zhou, Sheng-Li, Huang, Jia, Wu, Yue, Yuan, Chao, Huang, Jing, Ji, Ai-Fang, Kul, Jian-Wei, Fan, Zhong-Min, Wang, Jian-Po, Zhang, Dong-Yun, Zhang, Lian-Qun, Zhang, Wei, Chen, Yuan-Fang, Ren, Jing-Li, Li, Xiu-Min, Dong, Jin-Cheng, Xing, Guo-Lan, Guo, Zhi-Gang, Yang, Jian-Xue, Mao, Yi-Ming, Yuan, Yuan, Guo, Er-Tao, Zhang, Wei, Hou, Zhi-Chao, Liu, Jing, Li, Yan, Tang, Sa, Chang, Jia, Peng, Xiu-Qin, Han, Min, Yin, Wan-Li, Liu, Ya-Li, Hu, Yan-Long, Liu, Yu, Yang, Liu-Qin, Zhu, Fu-Guo, Yang, Xiu-Feng, Feng, Xiao-Shan, Wang, Zhou, Li, Yin, Gao, She-Gan, Liu, Hai-Lin, Yuan, Ling, Jin, Yan, Zhang, Yan-Rui, Sheyhidin, Ilyar, Li, Feng, Chen, Bao-Ping, Ren, Shu-Wei, Liu, Bin, Li, Dan, Zhang, Gao-Fu, Yue, Wen-Bin, Feng, Chang-Wei, Qige, Qirenwang, Zhao, Jian-Ting, Yang, Wen-Jun, Lei, Guang-Yan, Chen, Long-Qi, Li, En-Min, Xu, Li-Yan, Wu, Zhi-Yong, Bao, Zhi-Qin, Chen, Ji-Li, Li, Xian-Chang, Zhuang, Xiang, Zhou, Ying-Fa, Zuo, Xian-Bo, Dong, Zi-Ming, Wang, Lu-Wen, Fan, Xue-Pin, Wang, Jin, Zhou, Qi, Ma, Guo-Shun, Zhang, Qin-Xian, Liu, Hai, Jian, Xin-Ying, Lian, Sin-Yong, Wang, Jin-Sheng, Chang, Fu-Bao, Lu, Chang-Dong, Miao, Jian-Jun, Chen, Zhi-Guo, Wang, Ran, Guo, Ming, Fan, Zeng-Lin, Tao, Ping, Liu, Tai-Jing, Wei, Jin-Chang, Kong, Qing-Peng, Fan, Lei, Wang, Xian-Zeng, Gao, Fu-Sheng, Wang, Tian-Yun, Xie, Dong, Wang, Li, Chen, Shu-Qing, Yang, Wan-Cai, Hong, Jun-Yan, Wang, Liang, Qiu, Song-Liang, Goldstein, Alisa M., Yuan, Zhi-Qing, Chanock, Stephen J., Zhang, Xue-Jun, Taylor, Philip R., and Wang, Li-Dong

Published
2012
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28. Porphyromonas gingivalis promotes progression of esophageal squamous cell cancer via TGFβ-dependent Smad/YAP/TAZ signaling

Author

Qi, Yi-Jun, primary, Jiao, Ye-Lin, additional, Chen, Pan, additional, Kong, Jin-Yu, additional, Gu, Bian-Li, additional, Liu, Ke, additional, Feng, Dan-Dan, additional, Zhu, Ya-Fei, additional, Ruan, Hao-Jie, additional, Lan, Zi-Jun, additional, Liu, Qi-Wei, additional, Mi, You-Jia, additional, Guo, Xiang-Qian, additional, Wang, Ming, additional, Liang, Gao-Feng, additional, Lamont, Richard J., additional, Wang, Huizhi, additional, Zhou, Fu-You, additional, Feng, Xiao-Shan, additional, and Gao, She-Gan, additional

Published
2020
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29. piR-823 demonstrates tumor oncogenic activity in esophageal squamous cell carcinoma through DNA methylation induction via DNA methyltransferase 3B

Author

Su, Jing-Fen, primary, Zhao, Fang, additional, Gao, Zhao-Wei, additional, Hou, Yong-Jie, additional, Li, Yuan-Yuan, additional, Duan, Li-Juan, additional, Lun, Shu-Min, additional, Yang, Hai-Jun, additional, Li, Jun-Kuo, additional, Dai, Ning-Tao, additional, Shen, Fang-Fang, additional, and Zhou, Fu-You, additional

Published
2020
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30. Association of genotypes of rs671 within ALDH2 with risk for gastric cardia adenocarcinoma in the Chinese Han population in high- and low-incidence areas

Author

Zhang Lian-Qun, Song Xin, Zhao Xue-Ke, Huang Jia, Zhang Peng, Wang Lu-Wen, Meng Hui, Ku Jian-Wei, Kong Guo-Qiang, Jiang Tao, Li Xin-Min, Lv Xiao-Long, Ma Teng, Yuan Guo, Wu Min-Jie, Hu Shou-Jia, Lv Shuang, Zhang Tang-Juan, Ji Ling-Fen, Fan Zong-Min, Wang Neng-Chao, Zhang Yao-Wen, Zhou Fu-You, and Wang Li-Dong

Subjects
0301 basic medicine, Cancer Research, Multivariate statistics, medicine.medical_specialty, Gastric cardia adenocarcinoma, Biology, Gastroenterology, lcsh:RC254-282, 03 medical and health sciences, 0302 clinical medicine, immune system diseases, Polymorphism (computer science), Internal medicine, Genotype, medicine, cardiovascular diseases, Allele, skin and connective tissue diseases, ALDH2, Traditional medicine, Incidence (epidemiology), Odds ratio, Gastric Cardia Adenocarcinoma, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, rs671, 030104 developmental biology, Oncology, 030220 oncology & carcinogenesis, cardiovascular system
Abstract

Objective : This study aimed to determine if gastric cardia adenocarcinoma (GCA) risk was associated with the lys (A or *2) allele at the rs671 (glu504lys) polymorphism within the aldehyde dehydrogenase 2 (ALDH2) gene in a Chinese Han population. We also aimed to investigate ALDH2 genotypic distributions between subjects from high- and low-incidence areas for both GCA and esophageal squamous cell carcinoma (ESCC).Methods : We designed a case-control study including 2,686 patients with GCA and 3,675 control subjects from high- and low-incidence areas for both GCA and ESCC in China. TaqMan allele discrimination assay was used to genotype the rs671 polymorphism. χ2 test and binary logistic regression analysis were used to estimate the odds ratios for the development of GCA, and multivariate ordinal logistic regression was used to analyze ALDH2 genotypic distributions among different groups.Results : Compared with ALDH2*1/*1 homozygotes, ALDH2*1/*2 and ALDH2*2/*2 carriers did not increase the risk for GCA in the Chinese Han population (P>0.05). Interestingly, the ratio of homozygous or heterozygous ALDH2 *2 carriers in high-incidence areas for both GCA and ESCC was lower than that in low-incidence areas (PConclusions : Genotypes of rs671 at ALDH2 may not increase GCA susceptibility in Chinese Han populations. In addition, the ALDH2 genotypic distribution differs between Chinese Han populations from high- and low-incidence areas for both GCA and ESCC. Our findings may shed light on the possible genetic mechanism for the dramatic geographic differences of GCA occurrence in China.

Published
2017

31. Truth telling for patients with esophageal squamous cell carcinoma in Henan, China

Author

Zhang Lian-Qun, Chen Pei-Nan, Wang Hai-Ling, Sun Li, Zhao Xue-Ke, Song Xin, Wu Min-Jie, Zhang Tang-Juan, Ji Ling-Fen, Han Wei-Li, Fan Zong-Min, Yuan Yuan, Yang Hai-Jun, Wang Jian-Po, Zhou Fu-You, Qi Yi-Jun, and Wang Li-Dong

Subjects
Cancer Research, medicine.medical_specialty, Multivariate analysis, diagnosis, Esophageal squamous cell carcinoma, lcsh:RC254-282, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, 030212 general & internal medicine, Family history, China, business.industry, Advanced stage, Cancer, Truth telling, medicine.disease, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Independent factor, Surgery, esophageal squamous cell carcinoma, Oncology, 030220 oncology & carcinogenesis, Original Article, business
Abstract

Objective : This study aims to investigate the truth-telling status and the relevant factors of esophageal squamous cell carcinoma (ESCC) patients in Henan, China.Methods : A cross-sectional study from April to June 2015 using questionnaires was given to 301 family members of hospitalized ESCC patients based in three affiliated hospitals of Zhengzhou University (i.e., The First Hospital, The Second Hospital, and Tumor Hospital) and Anyang Tumor Hospital.Results : Among the 41.9% (126/301) hospitalized ESCC patients who knew of their true diagnoses, only 4.0% patients were informed by their corresponding responsible doctors, 39.7% by their family members, and 56.3% by themselves. Univariate analyses showed that disclosure of confirmed ESCC diagnosis to patients was correlated with gender, family history of cancer (FHC), education level, vocation, hospital administrative level, and attitudes of family members (P < 0.05). Furthermore, multivariate analysis indicated that attitude of family members was the most important and an independent factor for diagnosis disclosure. Those patients with a negative FHC, under-education, manual occupation, advanced stages, and hospitalized in municipal hospitals exhibited a low rate of truth telling.Conclusions : Truth telling for ESCC patients in Henan is not prevalent and may be improved through consultation with family members, particularly for patients with a negative FHC, poor education, manual occupation, and advanced stages.

Published
2017

32. Decreased expression of SPINT1-AS1 and SPINT1 mRNA might be independent unfavorable prognostic indicators in esophageal squamous cell carcinoma

Author

Shen,Fang-Fang, Pan,Ying, Yang,Hai-Jun, Li,Jun-Kuo, Zhao,Fang, Su,Jing-Fen, Li,Yan-Yan, Tian,Lin-Qiang, Yu,Pan-Ting, Cao,Yan-Tian, Zhang,Yao-Wen, Zhou,Fu-You, Shen,Fang-Fang, Pan,Ying, Yang,Hai-Jun, Li,Jun-Kuo, Zhao,Fang, Su,Jing-Fen, Li,Yan-Yan, Tian,Lin-Qiang, Yu,Pan-Ting, Cao,Yan-Tian, Zhang,Yao-Wen, and Zhou,Fu-You

Abstract

Fang-Fang Shen,1,* Ying Pan,1,* Hai-Jun Yang,2 Jun-Kuo Li,2 Fang Zhao,2 Jing-Fen Su,2 Yan-Yan Li,1 Lin-Qiang Tian,1 Pan-Ting Yu,1 Yan-Tian Cao,1 Yao-Wen Zhang,2 Fu-You Zhou1,21The Key Laboratory for Tumor Translational Medicine, The Third Affiliated Hospital of Xinxiang Medical University, Xinxiang, Henan, People’s Republic of China; 2Anyang Key Laboratory for Esophageal Cancer Research, Anyang Tumor Hospital, Anyang, Henan, People’s Republic of China*These authors contributed equally to this workPurpose: The serine peptidase inhibitor, Kunitz type 1 antisense RNA1 (SPINT1-AS1), a long non-coding RNA , has been linked to cancer progression. In this study, we aimed to explore the SPINT1-AS1 expression in matched esophageal squamous cell carcinoma (ESCC) and normal tissues, and analyze the potential correlations of SPINT1-AS1 expression with clinicopathological characteristics, in order to evaluate its prognosis and therapeutic value.Methods: SPINT1-AS1 expression was detected in 99 cases of matched ESCC and normal tissues samples using the quantitative real-time polymerase chain reaction method.Results: The expression level (â–³Ct) of SPINT1-AS1 and SPINT1 mRNA was significantly downregulated in ESCC tissues compared with matched normal tissues (P=0.0005; P=0.0002, respectively), and there was an obvious positive correlation between SPINT1-AS1 and SPINT1 mRNA expression. Clinicopathological characteristics indicated that SPINT1-AS1 expression was correlated with age and tumor size, while SPINT1 mRNA expression was correlated with age and gender. The receiver operating characteristic (ROC) curve analysis of the expression level of SPINT1-AS1 and SPINT1 mRNA yielded an area under the ROC curve value of 0.638 and 0.625, respectively. The overall survival is shorter in patients with low SPINT1-AS1 expressed than those with high levels of SPINT1-AS1 (P=0.044), and SPINT1 mRNA expression level is associated with the OS (P=0.001). Univariate and multivar

Published
2019

33. Association between polymorphisms in the CYP1A1, CYP2E1 and GSTM1 genes, and smoking, alcohol and upper digestive tract carcinomas in a high‑incidence area of northern China

Author

Zhao, Fang, primary, Su, Jing‑Fen, additional, Lun, Shu‑Min, additional, Hou, Yong‑Jie, additional, Duan, Li‑Juan, additional, Wang, Neng‑Chao, additional, Shen, Fang‑Fang, additional, Zhang, Yao‑Wen, additional, Gao, Zhao‑Wei, additional, Li, Jing, additional, Du, Xian‑Juan, additional, and Zhou, Fu‑You, additional

Published
2019
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34. Decreased expression of SPINT1-AS1 and SPINT1 mRNA might be independent unfavorable prognostic indicators in esophageal squamous cell carcinoma

Author

Shen, Fang-Fang, primary, Pan, Ying, additional, Yang, Hai-Jun, additional, Li, Jun-Kuo, additional, Zhao, Fang, additional, Su, Jing-Fen, additional, Li, Yan-Yan, additional, Tian, Lin-Qiang, additional, Yu, Pan-Ting, additional, Cao, Yan-Tian, additional, Zhang, Yao-Wen, additional, and Zhou, Fu-You, additional

Published
2019
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35. Corrigendum: Genome-wide association study of esophageal squamous cell carcinoma in Chinese subjects identifies susceptibility loci at PLCE1 and C20orf54

Author

Wang, Li-Dong, Zhou, Fu-You, Li, Xue-Min, Sun, Liang-Dan, Song, Xin, Jin, Yan, Li, Jiang-Man, Kong, Guo-Qiang, Qi, Hong, Cui, Juan, Zhang, Lian-Qun, Yang, Jie-Zhi, Li, Ji-Lin, Li, Xing-Chuan, Ren, Jing-Li, Liu, Zhi-Cai, Gao, Wen-Jun, Yuan, Ling, Wei, Wu, Zhang, Yan-Rui, Wang, Wei-Peng, Sheyhidin, Ilyar, Li, Feng, Chen, Bao-Ping, Ren, Shu-Wei, Liu, Bin, Li, Dan, Ku, Jian-Wei, Fan, Zong-Min, Zhou, Sheng-Li, Guo, Zhi-Gang, Zhao, Xue-Ke, Liu, Na, Ai, Yong-Hong, Shen, Fang-Fang, Cui, Wen-Yan, Song, Shuang, Guo, Tao, Huang, Jing, Yuan, Chao, Huang, Jia, Wu, Yue, Yue, Wen-Bin, Feng, Chang-Wei, Li, Hong-Lei, Wang, Yan, Tian, Jin-Ya, Lu, Yue, Yuan, Yi, Zhu, Wen-Liang, Liu, Min, Fu, Wen-Jing, Yang, Xia, Wang, Han-Jing, Han, Suo-Li, Chen, Jie, Han, Min, Wang, Hai-Yan, Zhang, Peng, Li, Xiu-Min, Dong, Jin-Cheng, Xing, Guo-Lan, Wang, Ran, Guo, Ming, Chang, Zhi-Wei, Liu, Hai-Lin, Guo, Li, Yuan, Zhi-Qing, Liu, Hai, Lu, Qin, Yang, Liu-Qin, Zhu, Fu-Guo, Yang, Xiu-Feng, Feng, Xiao-Shan, Wang, Zhou, Li, Yin, Gao, She-Gan, Qige, Qirenwang, Bai, Long-Tang, Yang, Wen-Jun, Lei, Guang-Yan, Shen, Zhong-Ying, Chen, Long-Qi, Li, En-Min, Xu, Li-Yan, Wu, Zhi-Yong, Cao, Wei-Ke, Wang, Jian-Po, Bao, Zhi-Qin, Chen, Ji-Li, Ding, Guang-Cheng, Zhuang, Xiang, Zhou, Ying-Fa, Zheng, Hou-Feng, Zhang, Zheng, Zuo, Xian-Bo, Dong, Zi-Ming, Fan, Dong-Mei, He, Xin, Wang, Jin, Zhou, Qi, Zhang, Qin-Xian, Jiao, Xin-Ying, Lian, Shi-Yong, Ji, Ai-Fang, Lu, Xiao-Mei, Wang, Jin-Sheng, Chang, Fu-Bao, Lu, Chang-Dong, Chen, Zhi-Guo, Miao, Jian-Jun, Fan, Zeng-Lin, Lin, Ruo-Bai, Liu, Tai-Jiang, Wei, Jin-Chang, Kong, Qing-Peng, Lan, Yu, Fan, Yu-Jing, Gao, Fu-Sheng, Wang, Tian-Yun, Xie, Dong, Chen, Shu-Qing, Yang, Wan-Cai, Hong, Jun-Yan, Wang, Liang, Qiu, Song-Liang, Cai, Zhi-Ming, and Zhang, Xue-Jun

Published
2014
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37. GWAS follow-up study of esophageal squamous cell carcinoma identifies potential genetic loci associated with family history of upper gastrointestinal cancer

Author

Song, Xin, primary, Li, Wen-Qing, additional, Hu, Nan, additional, Zhao, Xue Ke, additional, Wang, Zhaoming, additional, Hyland, Paula L., additional, Jiang, Tao, additional, Kong, Guo Qiang, additional, Su, Hua, additional, Wang, Chaoyu, additional, Wang, Lemin, additional, Sun, Li, additional, Fan, Zong Min, additional, Meng, Hui, additional, Zhang, Tang Juan, additional, Ji, Ling Fen, additional, Hu, Shou Jia, additional, Han, Wei Li, additional, Wu, Min Jie, additional, Zheng, Peng Yuan, additional, Lv, Shuang, additional, Li, Xue Min, additional, Zhou, Fu You, additional, Burdett, Laurie, additional, Ding, Ti, additional, Qiao, You-Lin, additional, Fan, Jin-Hu, additional, Han, Xiao-You, additional, Giffen, Carol, additional, Tucker, Margaret A., additional, Dawsey, Sanford M., additional, Freedman, Neal D., additional, Chanock, Stephen J., additional, Abnet, Christian C., additional, Taylor, Philip R., additional, Wang, Li-Dong, additional, and Goldstein, Alisa M., additional

Published
2017
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38. Abstract 3293: Impact of the invasive depth on lymph node metastasis and survival in Chinese patients with esophageal squamous cell carcinoma

Author

Song, Xin, primary, Zhou, Fu You, additional, Yang, Hai Jun, additional, Han, Xue Na, additional, Zhang, Tang Juan, additional, Zhang, Lian Qun, additional, Liu, Ning, additional, Ren, Jing Li, additional, Chang, Zhi Wei, additional, Tian, Xin, additional, Wang, Hai Ling, additional, Tan, Hui Fang, additional, and Wang, Li Dong, additional

Published
2017
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41. Abstract 264: Time trending for the ratio of rural and urban patients with esophageal squamous cell carcinoma in a single institute in northern China over the past 30 years

Author

Hu, Shou Jia, primary, Yang, Hai Jun, additional, Wang, Neng Chao, additional, Li, Xiu Min, additional, Lv, Shuang, additional, Bao, Qi De, additional, Yue, Wen Bin, additional, Meng, Hui, additional, Du, Dan Feng, additional, Li, Xue Min, additional, Zhou, Fu You, additional, Li, Jian, additional, and Wang, Li Dong, additional

Published
2017
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43. Abstract 764: Survival analysis for the elderly esophageal cancer patients (≥80 years) with surgery and non-surgery treatments

Author

Du, Dan Feng, primary, Du, Dan Feng, additional, Zhou, Fu You, additional, Zhang, Lian Qun, additional, Han, Xue Na, additional, Yuan, Yuan, additional, Fan, Zong Min, additional, Wang, Jian Po, additional, Zhang, Yao Wen, additional, Liu, Tai Jiang, additional, Liu, Guo Hua, additional, Qi, Yi Jun, additional, Zhang, Yan Rui, additional, and Wang, Li Dong, additional

Published
2017
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44. Abstract 3275: The impact of tumor locations on survival of the patients with esophageal squamous cell carcinoma

Author

Jin, Yan, primary, Jin, Yan, additional, Zhou, Fu You, additional, Wang, Ran, additional, Li, Zhi Qiang, additional, Liu, Zhi Cai, additional, Wang, Dao Cun, additional, Li, Yin, additional, Lu, Ping, additional, Zheng, Peng Yuan, additional, Feng, Chang Wei, additional, Kong, Guo Qiang, additional, Han, Shao Hua, additional, and Wang, Li Dong, additional

Published
2017
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45. Variations in the MHC Region Confer Risk to Esophageal Squamous Cell Carcinoma on the Subjects from High-Incidence Area in Northern China

Author

Shen, Fang-Fang, primary, Yue, Wen-Bin, additional, Zhou, Fu-You, additional, Pan, Ying, additional, Zhao, Xue-Ke, additional, Jin, Yan, additional, Song, Xin, additional, Li, Bei, additional, Han, Xue-Na, additional, Tang, Sa, additional, Li, Yan, additional, Yuan, Guo, additional, Chen, Li-Sha, additional, Liu, Ya-Li, additional, Hu, Yan-Long, additional, Li, Xiu-Min, additional, Ren, Jing-Li, additional, and Wang, Li-Dong, additional

Published
2014
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46. Abstract 5525: Influence of total dissected lymph node number on metastatic detection rate and survival in 10,382 esophageal cancer patients from the high incidence area for esophageal cancer in northern China

Author

Wang, Li Dong, primary, Dong, Jin Cheng, additional, Zhang, Peng, additional, Zhou, Fu You, additional, Li, Xue Min, additional, Li, Ai Li, additional, Ji, Ai Fang, additional, Liu, Zhi Cai, additional, Song, Xin, additional, Zhao, Xue Ke, additional, and Wang, Xian Zeng, additional

Published
2012
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48. Clinicopathological features and hereditary susceptibility of patients with esophageal cancer in a high incidence area in China: an analysis of 1259 cases

Author

Li, Xiu-Min, primary, Zhao, Zhi-Min, additional, Chang, Ting-Min, additional, Zhang, Yuan-Zhi, additional, Zhou, Fu-You, additional, Wang, Jian-Po, additional, Wang, Li-Dong, additional, Chang, Fu-Bao, additional, Guo, Tao, additional, Kong, Guo-Qiang, additional, Zhang, Lian-Qun, additional, and Hou, Xiao-Hua, additional

Published
2009
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50. The prognostic value of keratin pearls in patients with esophageal squamous cell carcinoma.

Author

Zhong K, Song X, Zhao XK, Hu JF, Zhou FY, Li JL, Ren JL, Li XM, Wang XZ, Huang GR, Ku JW, Zhang DY, Wang PP, Lei LL, Wei MX, Fan ZM, Han XN, Wang R, Ji JJ, Chen Y, Li LY, Yang YZ, Yang MM, Li B, and Wang LD

Abstract

Keratin pearls (KP) is an important indicator of the degree of tumor cell differentiation of esophageal squamous cell carcinomas (ESCC). However, the independent prognostic value of KP in ESCC patients remains unclear. The hematoxylin-eosin (H&E) stained tissue microarrays (TMAs) or whole slides of the patients were prepared to identify the existence of KP. Kaplan-Meier (KM) survival analysis as well as univariate and multivariate Cox regression analyses were used to evaluate the prognostic value of KP. A nomogram based on KP and other clinicopathologic characteristics was constructed. The C-index, calibration curve, Receiver Operating Characteristic (ROC) curve, and Decision Curve Analysis (DCA) were used to evaluate the nomogram. The results indicated KP is a protective factor against lymph node metastasis and is closely associated with the differentiation degree in ESCC patients. KM survival analysis showed that the overall survival (OS) of patients with KP was significantly better than for patients without KP. In addition, multivariate Cox regression analysis revealed that KP was an independent predictor of OS. Furthermore, ROC curve demonstrated that KP combined with differentiation degree could more accurately predict the 5-year survival rate than differentiation degree alone. Importantly, the nomogram showed good discrimination and calibration abilities in both training and validation groups, which could more accurately predict the 3-, 5-, and 10-year survival rates of ESCC patients and adds to the predictive value of TNM stage alone. In conclusion, KP is an independent predictor of prognosis in patients with ESCC and provides incremental prognostic value to degree of differentiation., Competing Interests: None., (AJTR Copyright © 2022.)

Published
2022

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