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Your search keyword '"Zhu, Luyi"' showing total 362 results
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362 results on '"Zhu, Luyi"'

22. Exploring genetic association of systemic iron status and risk with incidence of diabetic neuropathy.

Author

Yu, Xinyue, Jin, Tianyu, Zhu, Luyi, Guo, Shunyuan, Deng, Binbin, and Cheng, Yifan

Abstract

Background: Diabetic neuropathy (DN), a frequent complication in individuals with diabetes mellitus (DM), is hypothesized to have a correlation with systemic iron status, though the nature of this relationship remains unclear. This study employs two-sample Mendelian randomization (MR) analysis to explore this potential genetic association. Methods: We used genetic instruments significant associated with iron status including serum iron, ferritin, transferrin, and transferrin saturation, derived from an extensive Genome-Wide Association Study (GWAS) undertaken by the Genetics of Iron Status Consortium, involving a cohort of 48,972 European ancestry individuals. Summary statistics for DN were collected from a public GWAS, including 1,415 patients and 162,201 controls of European descent. Our MR analysis used the inverse-variance-weighted (IVW) method, supplemented by MR-Egger, weighted-median (WM) methods, Cochran’s Q test, MR-Egger intercept analysis, MR-Pleiotropy Residual Sum and Outlier (MR-PRESSO) method, and leave-one-out analysis to ensure robustness and consistency of the findings. Results: No genetic causal relationship was found between iron status markers and DN (all IVW p value > 0.05). Interestingly, a causative effect of DN on ferritin (IVW: OR = 0.943, 95% CI = 0.892–0.996, p = 0.035) and transferrin saturation (IVW: OR = 0.941, 95% CI = 0.888–0.998, p = 0.044) emerged. Sensitivity analyses confirmed the absence of significant heterogeneity and horizontal pleiotropy. Conclusion: While systemic iron status was not found to be causally related to DN, our findings suggest that DN may increase the risk of iron deficiency. These results provide further evidence supporting iron supplementation in patients with DN. [ABSTRACT FROM AUTHOR]

Published
2024
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23. Single-Phase, Large Plastic Deformation, and Highly Flexible Yb2O3 Nanofibrous Membranes for Thermal Insulation.

Author

Ma, Dehua, Wang, Yifan, Wang, Lin, Peng, Ying, Yin, Yunguang, Hou, Shanyue, Zhu, Luyi, Wang, Xinqiang, Liu, Benxue, Zhang, Guanghui, Xie, Yongshuai, and Xu, Dong

Abstract

Ultralow-density (35–60 mg·cm–3) Yb2O3 nanofibrous membranes (YbFMs) with a multilayer structure were successfully prepared for the first time using Yb-acetylacetone coordination polymer as a precursor. Thanks to the high ceramic yield (62.1%) and excellent spinnability of the precursor, the YbFMs exhibited outstanding flexibility, which does not cause damage even when bent or knotted. The tensile strength of the YbFMs was 1.69 MPa, and the maximum elongation could reach 33%. Notably, the YbFMs exhibited robust fatigue resistance, retaining 87.2% of the initial stress even after 500 buckling cycles and preserving 84.75% of the initial stress in compression resilience. Moreover, the YbFMs exhibited flexibility and compressive performance in the temperature range of −196–1350 °C. The thermal conductivity of the YbFMs was 28.9–34.6 mW·m–1·K–1. At a hot surface temperature of 1350 °C, the 6 mm thick YbFMs could reduce the back temperature by about 1070 °C. Thus, YbFMs are expected to be a flexible insulation material at extremely high temperatures. [ABSTRACT FROM AUTHOR]

Published
2024
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