1,611 results on '"Zimmermann, Frank"'
Search Results
2. Criminal Liability for Political Decision-Making
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Zimmermann, Frank, primary and Zerbst, Ronja, additional
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- 2024
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3. Using the LHeC ERL to generate high-energy photons
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Mirian, Najmeh Sadat, Salehi, Elham, and Zimmermann, Frank
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Physics - Accelerator Physics - Abstract
The Large Hadron electron Collider (LHeC) is a proposed future particle physics project colliding 60 GeV electrons from a six-pass recirculating energy-recovery linac (ERL) with 7 TeV protons stored in the LHC. The ERL technology allows for much higher beam current and, therefore, higher luminosity than a traditional linac. The high-current, high-energy electron beam can also be used to drive a free electron laser (FEL). In this contribution, we examine how the LHeC ERL can serve as a source of high-energy photons for studies in nuclear physics, high-energy physics, Axion detection, dark energy, and protein crystallography. In the first section, we discuss the performance of the LHeC-based FEL, operated in the SASE mode for generating photon pulses at wavelengths ranging from 200 keV to 600 keV. In the second section, we investigate photon production via Laser Compton scattering (LCS)., Comment: 4
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- 2023
4. FCC-ee Status and Overview
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Zimmermann, Frank
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Physics - Accelerator Physics ,High Energy Physics - Experiment - Abstract
We report on the Future Circular Collider (FCC) Feasibility Study, the mid-term review in autumn 2023, and the longer term timeline., Comment: Invited contribution to ICFA Newsletter no. 85
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- 2023
5. Optics design and correction challenges for the high energy booster of FCC-ee
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Chance, Antoine, Dalena, Barbara, Da Silva, Tatiana, Mashal, Ahmad, Migliorati, Mauro, Ghribi, Adnan, Rajabi, Ali, and Zimmermann, Frank
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Physics - Accelerator Physics - Abstract
One of the major upcoming challenges in particle physics is achieving precise measurements of the Z, W, and H bosons, as well as the top quark. To meet these targets, the next e\textsuperscript{+}e\textsuperscript{-} collider complex, FCC-ee, will need to achieve unprecedented luminosities. The FCC-IS European Study is investigating the feasibility of these challenges, with a cornerstone of the study being the design and optimization of the high-energy booster (HEB). This paper provides an update on the status of the HEB of FCC-ee in light of recent developments in the injector and collider survey, as well as an overview of ongoing work on longitudinal stability and design robustness in relation to field, alignment, and diagnostics errors. Constraints and effects related to the design frequency of the accelerating cavities, as well as collective effects, are also highlighted. Lastly, the paper presents an investigation into an alternative arcs cell design., Comment: pre-print of ICFA Newsletter 2023
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- 2023
6. Report of the Topical Group on Physics Beyond the Standard Model at Energy Frontier for Snowmass 2021
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Bose, Tulika, Boveia, Antonio, Doglioni, Caterina, Griso, Simone Pagan, Hirschauer, James, Lipeles, Elliot, Liu, Zhen, Shah, Nausheen R., Wang, Lian-Tao, Agashe, Kaustubh, Alimena, Juliette, Baum, Sebastian, Berkat, Mohamed, Black, Kevin, Gardner, Gwen, Gherghetta, Tony, Greaves, Josh, Haehn, Maxx, Harris, Phil C., Harris, Robert, Hogan, Julie, Jayawardana, Suneth, Kahn, Abraham, Kalinowski, Jan, Knapen, Simon, Lewis, Ian M., Narain, Meenakshi, Pachal, Katherine, Reece, Matthew, Reina, Laura, Robens, Tania, Tricoli, Alessandro, Wagner, Carlos E. M., Xu, Riley, Yu, Felix, Zarnecki, Filip, Aboubrahim, Amin, Albert, Andreas, Albrow, Michael, Altmannshofer, Wolfgang, Andonian, Gerard, Apresyan, Artur, Assamagan, Kétévi Adikle, Azzi, Patrizia, Baer, Howard, Baker, Michael J., Banerjee, Avik, Barger, Vernon, Batell, Brian, Bauer, Martin, Beauchesne, Hugues, Bein, Samuel, Belyaev, Alexander, Beniwal, Ankit, Berggren, Mikael, Bhattiprolu, Prudhvi N., Blinov, Nikita, Blondel, Alain, Brandt, Oleg, Cacciapaglia, Giacomo, Capdevilla, Rodolfo, Carena, Marcela, Cazzaniga, Cesare, Celiberto, Francesco Giovanni, Cesarotti, Cari, Chekanov, Sergei V., Cheng, Hsin-Chia, Chen, Thomas Y., Chen, Yuze, Chivukula, R. Sekhar, Citron, Matthew, Cline, James, Cohen, Tim, Collins, Jack H., Corrigan, Eric, Craig, Nathaniel, Craik, Daniel, Crivellin, Andreas, Curtin, David, Darmora, Smita, Das, Arindam, Dasu, Sridhara, de Cosa, Annapaola, Deandrea, Aldo, Delgado, Antonio, Demiragli, Zeynep, d'Enterria, David, Deppisch, Frank F., Dermisek, Radovan, Desai, Nishita, Deshpande, Abhay, de Vries, Jordy, Dickinson, Jennet, Dienes, Keith R., Di Petrillo, Karri Folan, Dolan, Matthew J., Dong, Peter, Draper, Patrick, Drewes, Marco, Dreyer, Etienne, Du, Peizhi, Eble, Florian, Ekhterachian, Majid, Endo, Motoi, Essig, Rouven, Farr, Jesse N., Fassi, Farida, Feng, Jonathan L., Ferretti, Gabriele, Filipetto, Daniele, Flacke, Thomas, Franceschini, Roberto, Franzosi, Diogo Buarque, Fujii, Keisuke, Fuks, Benjamin, Gadam, Sri Aditya, Gao, Boyu, Garcia-Bellido, Aran, Garcia, Isabel Garcia, Garzelli, Maria Vittoria, Gedney, Stephen, Genest, Marie-Hélène, Ghosh, Tathagata, Golkowski, Mark, di Cortona, Giovanni Grilli, Guler, Emine Gurpinar, Guler, Yalcin, Guo, C., Graf, Nate, Haisch, Ulrich, Hajer, Jan, Hamaguchi, Koichi, Han, Tao, Harris, Philip, Heinemeyer, Sven, Hill, Christopher S., Hiltbrand, Joshua, Holmes, Tova Ray, Homiller, Samuel, Hong, Sungwoo, Hopkins, Walter, Hsu, Shih-Chieh, Ilten, Phil, Islam, Wasikul, Iwamoto, Sho, Jeans, Daniel, Jeanty, Laura, Jia, Haoyi, Jindariani, Sergo, Johnson, Daniel, Kahlhoefer, Felix, Kahn, Yonatan, Karchin, Paul, Katsouleas, Thomas, Kawada, Shin-ichi, Kawamura, Junichiro, Kelso, Chris, Khoda, Elham E, Khoze, Valery, Kim, Doojin, Kitahara, Teppei, Klaric, Juraj, Klasen, Michael, Kong, Kyoungchul, Kotlarski, Wojciech, Kotwal, Ashutosh V., Kozaczuk, Jonathan, Kriske, Richard, Kulkarni, Suchita, Kumar, Jason, Kunkel, Manuel, Landsberg, Greg, Lane, Kenneth, Lange, Clemens, Lee, Lawrence, Liao, Jiajun, Lillard, Benjamin, Li, Lingfeng, Li, Shuailong, Li, Shu, List, Jenny, Li, Tong, Liu, Hongkai, Liu, Jia, Long, Jonathan D, Lunghi, Enrico, Lyu, Kun-Feng, Marfatia, Danny, Martinez, Dakotah, Martin, Stephen P., McGinnis, Navin, McGinty, Karrick, Mękała, Krzysztof, Meloni, Federico, Mikulenko, Oleksii, Huang, Ming, Mishra, Rashmish K., Mitra, Manimala, Mitsou, Vasiliki A., Moon, Chang-Seong, Moreno, Alexander, Moroi, Takeo, Mourou, Gerard, Mrowietz, Malte, Muggli, Patric, Nakajima, Jurina, Nath, Pran, Nelson, J., Neubert, Matthias, Nosler, Laura, de Vera, Maria Teresa Núñez Pardo, Okada, Nobuchika, Okada, Satomi, Okorokov, Vitalii A., Onel, Yasar, Ou, Tong, Ovchynnikov, Maksym, Padhan, Rojalin, Pani, Priscilla, Panizzi, Luca, Papaefstathiou, Andreas, Pedro, Kevin, Peña, Cristián, Piazza, Federica, Pinfold, James, Pinna, Deborah, Porod, Werner, Potter, Chris, Prim, Markus Tobias, Profumo, Stefano, Proudfoot, James, Rai, Mudit, Rajec, Filip, Ramos, Reese, Ramsey-Musolf, Michael J., Resta-Lopez, Javier, Reuter, Jürgen, Ringwald, Andreas, Rizzi, Chiara, Rizzo, Thomas G., Rossi, Giancarlo, Ruiz, Richard, Rygaard, L., Sahai, Aakash A., Salam, Shadman, Sandick, Pearl, Sathyan, Deepak, Scherb, Christiane, Schwaller, Pedro, Schwarze, Leonard, Scott, Pat, Sekmen, Sezen, Sengupta, Dibyashree, Sen, S., Sfyrla, Anna, Shackelford, Eric, Sharma, T., Sharma, Varun, Shelton, Jessie, Shepherd, William, Shin, Seodong, Simmons, Elizabeth H., Sloneker, Zoie, Sierra, Carlos Vázquez, Sjöstrand, Torbjörn, Snyder, Scott, Song, Huayang, Stark, Giordon, Stengel, Patrick, Stohr, Joachim, Stolarski, Daniel, Strassler, Matt, Strobbe, Nadja, Gonski, Julia, Suarez, Rebeca Gonzalez, Suehara, Taikan, Su, Shufang, Su, Wei, Syed, Raza M., Tait, Tim M. P., Tajima, Toshiki, Tang, Andy, Tata, Xerxes, Tchalokov, Teodor, Thamm, Andrea, Thomas, Brooks, Toro, Natalia, Tran, Nhan V., Truong, Loan, Tsai, Yu-Dai, Tuecke, Eva, Venkatasubramanian, Nikhilesh, Verhaaren, Chris B., Vuosalo, Carl, Wang, Xiao-Ping, Wang, Xing, Wang, Yikun, Wang, Zhen, Weber, Christian, White, Glen, White, Martin, Williams, Anthony G., Williams, Brady, Williams, Mike, Willocq, Stephane, Woodcock, Alex, Wu, Yongcheng, Xie, Ke-Pan, Xie, Keping, Xie, Si, Yeh, C. -H., Yonamine, Ryo, Yu, David, Yu, S. -S., Zaazoua, Mohamed, Żarnecki, Aleksander Filip, Zembaczynski, Kamil, Zhang, Danyi, Zhang, Jinlong, Zimmermann, Frank, and Zurita, Jose
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High Energy Physics - Phenomenology ,High Energy Physics - Experiment - Abstract
This is the Snowmass2021 Energy Frontier (EF) Beyond the Standard Model (BSM) report. It combines the EF topical group reports of EF08 (Model-specific explorations), EF09 (More general explorations), and EF10 (Dark Matter at Colliders). The report includes a general introduction to BSM motivations and the comparative prospects for proposed future experiments for a broad range of potential BSM models and signatures, including compositeness, SUSY, leptoquarks, more general new bosons and fermions, long-lived particles, dark matter, charged-lepton flavor violation, and anomaly detection., Comment: 108 pages + 38 pages references and appendix, 37 figures, Report of the Topical Group on Beyond the Standard Model Physics at Energy Frontier for Snowmass 2021. The first nine authors are the Conveners, with Contributions from the other authors
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- 2022
7. Impact of Imaging-Guided Localization on Performance of Tailored Axillary Surgery in Patients with Clinically Node-Positive Breast Cancer: Prospective Cohort Study Within TAXIS (OPBC-03, SAKK 23/16, IBCSG 57-18, ABCSG-53, GBG 101)
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Weber, Walter P., Heidinger, Martin, Hayoz, Stefanie, Matrai, Zoltan, Tausch, Christoph, Henke, Guido, Zwahlen, Daniel R., Gruber, Günther, Zimmermann, Frank, Montagna, Giacomo, Andreozzi, Mariacarla, Goldschmidt, Maite, Schulz, Alexandra, Mueller, Andreas, Ackerknecht, Markus, Tampaki, Ekaterini Christina, Bjelic-Radisic, Vesna, Kurzeder, Christian, Sávolt, Ákos, Smanykó, Viktor, Hagen, Daniela, Müller, Dieter J., Gnant, Michael, Loibl, Sibylle, Fitzal, Florian, Markellou, Pagona, Bekes, Inga, Egle, Daniel, Heil, Jörg, and Knauer, Michael
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- 2024
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8. The efficacy of the “Talk-to-Me” suicide prevention and mental health education program for tertiary students: a crossover randomised control trial
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Afsharnejad, Bahareh, Milbourn, Ben, Hayden-Evans, Maya, Baker-Young, Ellie, Black, Melissa H., Thompson, Craig, McGarry, Sarah, Grobler, Melissa, Clifford, Rhonda, Zimmermann, Frank, Kacic, Viktor, Hasking, Penelope, Bölte, Sven, Romanos, Marcel, Machingura, Tawanda, and Girdler, Sonya
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- 2023
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9. The Development of Energy-Recovery Linacs
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Adolphsen, Chris, Andre, Kevin, Angal-Kalinin, Deepa, Arnold, Michaela, Aulenbacher, Kurt, Benson, Steve, Bernauer, Jan, Bogacz, Alex, Boonekamp, Maarten, Brinkmann, Reinhard, Bruker, Max, Brüning, Oliver, Curatolo, Camilla, Duthill, Patxi, Fischer, Oliver, Hoffstaetter, Georg, Holzer, Bernhard, Hounsell, Ben, Hutton, Andrew, Jensen, Erk, Kaabi, Walid, Kayran, Dmitry, Klein, Max, Knobloch, Jens, Krafft, Geoff, Kühn, Julius, Kuske, Bettina, Litvinenko, Vladimir, Marhauser, Frank, Militsyn, Boris, Nagaitsev, Sergei, Neil, George, Neumann, Axel, Pietralla, Norbert, Rimmer, Bob, Serafini, Luca, Shevchenko, Oleg A., Shipman, Nick, Spiesberger, Hubert, Tanaka, Olga, Telnov, Valery, Tennant, Chris, Vaccarezza, Cristina, Verney, David, Vinokurov, Nikolay, Williams, Peter, Yamamoto, Akira, Yokoya, Kaoru, and Zimmermann, Frank
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Physics - Accelerator Physics - Abstract
Energy-recovery linacs (ERLs) have been emphasised by the recent (2020) update of the European Strategy for Particle Physics as one of the most promising technologies for the accelerator base of future high-energy physics. The current paper has been written as a base document to support and specify details of the recently published European roadmap for the development of energy-recovery linacs. The paper summarises the previous achievements on ERLs and the status of the field and its basic technology items. The main possible future contributions and applications of ERLs to particle and nuclear physics as well as industrial developments are presented. The paper includes a vision for the further future, beyond 2030, as well as a comparative data base for the main existing and forthcoming ERL facilities. A series of continuous innovations, such as on intense electron sources or high-quality superconducting cavity technology, will massively contribute to the development of accelerator physics at large. Industrial applications are potentially revolutionary and may carry the development of ERLs much further, establishing another shining example of the impact of particle physics on society and its technical foundation with a special view on sustaining nature.
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- 2022
10. 'Colliders or Bust'
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Zimmermann, Frank
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Physics - Accelerator Physics ,High Energy Physics - Experiment - Abstract
Charged-particle colliders have proven key instruments of discovery in high-energy physics. Pushing the frontiers of our knowledge ever further has relied on, and still keeps calling for, ever better performance and novel techniques. During more than four decades, Swapan Chattopadhyay has made numerous essential contributions to this endeavour. Often far ahead of his time, he helped advance many areas of collider development, notably in the domains of stochastic cooling, the development of asymmetric B factories, the design of next- and next-next-generation of high-energy colliders, and the harnessing of energy-recovery for particle colliders., Comment: Invited Contribution to Swapan Chattopadhyay Retirement Symposium, 30 April 2021. To be published in a special volume of IJMPA
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- 2022
11. PetaVolts per meter Plasmonics: Snowmass21 White Paper
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Sahai, Aakash A., Golkowski, Mark, Gedney, Stephen, Katsouleas, Thomas, Andonian, Gerard, White, Glen, Stohr, Joachim, Muggli, Patric, Filipetto, Daniele, Zimmermann, Frank, Tajima, Toshiki, Mourou, Gerard, and Resta-Lopez, Javier
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Physics - Accelerator Physics ,Condensed Matter - Mesoscale and Nanoscale Physics ,Condensed Matter - Materials Science ,High Energy Physics - Experiment ,Physics - Plasma Physics - Abstract
Plasmonic modes offer the potential to achieve PetaVolts per meter fields, that would transform the current paradigm in collider development in addition to non-collider searches in fundamental physics. PetaVolts per meter plasmonics relies on collective oscillations of the free electron Fermi gas inherent in the conduction band of materials that have a suitable combination of constituent atoms and ionic lattice structure. As the conduction band free electron density, at equilibrium, can be as high as $\rm 10^{24}cm^{-3}$, electromagnetic fields of the order of $\rm 0.1 \sqrt{\rm n_0(10^{24}cm^{-3})} ~ PVm^{-1}$ can be sustained by plasmonic modes. Engineered materials not only allow highly tunable material properties but quite critically make it possible to overcome disruptive instabilities that dominate the interactions in bulk media. Due to rapid shielding by the free electron Fermi gas, dielectric effects are strongly suppressed. Because the ionic lattice, the corresponding electronic energy bands and the free electron gas are governed by quantum mechanical effects, comparisons with plasmas are merely notional. Based on this framework, it is critical to address various challenges that underlie PetaVolts per meter plasmonics including stable excitation of plasmonic modes while accounting for their effects on the ionic lattice and the electronic energy band structure over femtosecond timescales. We summarize the ongoing theoretical and experimental efforts as well as map out strategies for the future. Extreme plasmonic fields can shape the future by not only bringing tens of TeV to multi-PeV center-of-mass-energies within reach but also by opening novel pathways in non-collider HEP. In view of this promise, we invite the scientific community to help realize the immense potential of PV/m plasmonics and call for significant expansion of the US and international R\&D program., Comment: contribution to Snowmass 2021
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- 2022
12. Mitigation of Electron Cloud Effects in the FCC-ee Collider
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Yaman, Fatih, Iadarola, Giovanni, Kersevan, Roberto, Ogur, Salim, Ohmi, Kazuhito, Zimmermann, Frank, and Zobov, Mikhail
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Physics - Accelerator Physics - Abstract
Electron clouds forming inside the beam vacuum chamber due to photoemission and secondary emission may limit the accelerator performance. Specifically, the electron clouds can blow up the vertical emittance of a positron beam, through a head-tail-type single-bunch instability, if the central electron density exceeds a certain threshold value, that can be estimated analytically. Using the codes PyECLOUD and VSim, we carried out detailed simulations of the electron-cloud build up for the main arcs and the damping ring of the FCC-ee collider, in order to identify the effective photoemission rate and secondary emission yield required for achieving and maintaining the design emittance. To this end, we present the simulated electron density at the centre of the beam pipe for various bunch spacings, secondary emission yields, and photoemission parameters, in the damping ring and in the arcs of the collider positron ring. To gain further insight into the underlying dynamics, the obtained spatial and energy distributions of the cloud electrons are illustrated as a function of time. In addition, we compare results obtained for two different secondary emission models ("Furman-Pivi" and "ECLOUD"), thereby indicating the uncertainty inherent in this type of study, without any prototype vacuum chambers yet available. We also point out a few situations where the two secondary-emission models yield similar density values. Finally, based on our simulation results for two different design variants, we conclude that the new parameter baseline of the FCC-ee will facilitate electron-cloud mitigation.
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- 2022
13. Trends in use of neoadjuvant systemic therapy in patients with clinically node-positive breast cancer in Europe: prospective TAXIS study (OPBC-03, SAKK 23/16, IBCSG 57-18, ABCSG-53, GBG 101)
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Tausch, Christoph, Däster, Kavitha, Hayoz, Stefanie, Matrai, Zoltan, Fitzal, Florian, Henke, Guido, Zwahlen, Daniel R., Gruber, Günther, Zimmermann, Frank, Andreozzi, Mariacarla, Goldschmidt, Maite, Schulz, Alexandra, Maggi, Nadia, Saccilotto, Ramon, Heidinger, Martin, Mueller, Andreas, Tampaki, Ekaterini Christina, Bjelic-Radisic, Vesna, Sávolt, Ákos, Smanykó, Viktor, Hagen, Daniela, Müller, Dieter J., Gnant, Michael, Loibl, Sibylle, Markellou, Pagona, Bekes, Inga, Egle, Daniel, Ruhstaller, Thomas, Muenst, Simone, Kuemmel, Sherko, Vrieling, Conny, Satler, Rok, Becciolini, Charles, Bucher, Susanne, Kurzeder, Christian, Simonson, Colin, Fehr, Peter M., Gabriel, Natalie, Maráz, Robert, Sarlos, Dimitri, Dedes, Konstantin J., Leo, Cornelia, Berclaz, Gilles, Fansa, Hisham, Hager, Christopher, Reisenberger, Klaus, Singer, Christian F., Montagna, Giacomo, Reitsamer, Roland, Winkler, Jelena, Lam, Giang Thanh, Fehr, Mathias K., Naydina, Tatiana, Kohlik, Magdalena, Clerc, Karine, Ostapenko, Valerijus, Lelièvre, Loïc, Heil, Jörg, Knauer, Michael, and Weber, Walter Paul
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- 2023
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14. ASO Visual Abstract: Impact of Imaging-Guided Localization on Performance of Tailored Axillary Surgery in Patients with Clinically Node-Positive Breast Cancer: Prospective Cohort Study Within TAXIS (OPBC-03, SAKK 23/16, IBCSG 57-18, ABCSG-53, GBG 101)
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Weber, Walter P., Heidinger, Martin, Hayoz, Stefanie, Matrai, Zoltan, Tausch, Christoph, Henke, Guido, Zwahlen, Daniel R., Gruber, Günther, Zimmermann, Frank, Montagna, Giacomo, Andreozzi, Mariacarla, Goldschmidt, Maite, Schulz, Alexandra, Mueller, Andreas, Ackerknecht, Markus, Tampaki, Ekaterini Christina, Bjelic-Radisic, Vesna, Kurzeder, Christian, Sávolt, Ákos, Smanykó, Viktor, Hagen, Daniela, Müller, Dieter J., Gnant, Michael, Loibl, Sibylle, Fitzal, Florian, Markellou, Pagona, Bekes, Inga, Egle, Daniel, Heil, Jörg, and Knauer, Michael
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- 2024
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15. Alignment & stability challenges for FCC-ee
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Charles, Tessa K., Holzer, Bernhard, Tomas, Rogelio, Oide, Katsunobu, van Riesen-Haupt, Léon, and Zimmermann, Frank
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- 2023
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16. High Energy LHC Machine Options in the LHC Tunnel
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Bottura, Luca, primary and Zimmermann, Frank, additional
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- 2023
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17. A very high energy hadron collider on the Moon
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Beacham, James and Zimmermann, Frank
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High Energy Physics - Experiment ,High Energy Physics - Phenomenology ,Physics - Accelerator Physics - Abstract
The long-term prospect of building a hadron collider around the circumference of a great circle of the Moon is sketched. A Circular Collider on the Moon (CCM) of $\sim$11000 km in circumference could reach a proton-proton center-of-mass collision energy of 14 PeV -- a thousand times higher than the Large Hadron Collider at CERN -- optimistically assuming a dipole magnetic field of 20 T. Several aspects of such a project are presented, including siting, construction, availability of necessary materials on the Moon, and powering, as well as a discussion of future studies and further information needed to determine the more concrete feasibility of each. Machine parameters and vacuum requirements are explored, and an injection scheme is delineated. Other unknowns are set down. Due to the strong interest from multiple organizations in establishing a permanent Moon presence, a CCM could be the (next-to-) next-to-next-generation discovery machine for high-energy particle physics and a natural successor to next-generation machines, such as the proposed Future Circular Collider at CERN or a Super Proton-Proton Collider in China, and other future machines, such as a Collider in the Sea, in the Gulf of Mexico. A CCM would serve as an important stepping stone towards a Planck-scale collider sited in our Solar System., Comment: 37 pages, 5 figures, 2 tables; new section on "Classification of Unknowns" added; accepted for publication in the New Journal of Physics
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- 2021
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18. Challenges for the interaction region design of the Future Circular Collider FCC-ee
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Boscolo, Manuela, Bacchetta, Nicola, Benedikt, Michael, Brunetti, Laurent, Burkhardt, Helmut, Ciarma, Andrea, Dam, Mogens, Fransesini, Francesco, Jones, Mark, Kersevan, Roberto, Koratzinos, Mike, Lueckhof, Marian, Migliorati, Mauro, Montbarbon, Eva, Novokhatski, Alexander, Oide, Katsunobu, Pellegrino, Luigi, Poirier, Freddy, Serluca, Maurizio, Sullivan, Michael K., Watrelot, Leonard, and Zimmermann, Frank
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Physics - Accelerator Physics - Abstract
The FCC-ee is a proposed future high-energy, high-intensity and high-precision lepton collider. Here, we present the latest development for the FCC-ee interaction regions, which shall ensure optimum conditions for the particle physics experiments. We discuss measures of background reduction and a revised interaction region layout including a low impedance compact beam chamber design. We also discuss the possible impact of the radiation generated in the interaction region including beamstrahlung., Comment: 3 pp, 5 figs, presented at IPAC21, May 24-28th, 2021
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- 2021
19. Preventing suicide in post-secondary students: a scoping review of suicide prevention programs
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Black, Melissa H., Scott, Melissa, Baker-Young, Elliot, Thompson, Craig, McGarry, Sarah, Hayden-Evans, Maya, Snyman, Zelma, Zimmermann, Frank, Kacic, Viktor, Falkmer, Torbjorn, Romanos, Marcel, Bölte, Sven, Girdler, Sonya, and Milbourn, Benjamin
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- 2023
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20. Esophageal Cancer
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Brunner, Thomas B., Zimmermann, Frank, Grosu, Anca-Ligia, editor, Nieder, Carsten, editor, and Nicolay, Nils Henrik, editor
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- 2023
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21. Anästhesie in der Augenheilkunde
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Stein, Alexandra, Zimmermann, Frank, Wilhelm, Frank, and Wilhelm, Frank, editor
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- 2023
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22. FCC-hh Experimental Insertion Region Design
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Abelleira, Jose L., Appleby, Robert B., Arsenyev, Sergey, Barranco, Javier, Benedikt, Michael, Besana, Maria Ilaria, Garcia, Oscar Blanco, Boscolo, Manuela, Boutin, David, Buffat, Xavier, Burkhardt, Helmut, Cerutti, Francesco, Chance, Antoine, Collamati, Francesco, Cruz-Alaniz, Emilia, Dalena, Barbara, Hofer, Michael, Humann, Barbara L., Infantino, Angelo, Keintzel, Jacqueline, Langner, Andy, Luckhof, Marian, Martin, Roman, Pieloni, Tatiana, Rafique, Haroon, Riegler, Werner, Van Riesen-Haupt, Leon, Schulte, Daniel, Seryi, Andrei, Tambasco, Claudia, Tomas, Rogelio, and Zimmermann, Frank
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Physics - Accelerator Physics ,High Energy Physics - Experiment - Abstract
The Future Circular Collider study is exploring possible designs of circular colliders for the post-LHC era, as recommended by the European Strategy Group for High Energy Physics. One such option is FCC-hh, a proton-proton collider with a centre-of-mass energy of 100 TeV. The experimental insertion regions are key areas defining the performance of the collider. This paper presents the first insertion region designs with a complete assessment of the main challenges, as collision debris with two orders of magnitude larger power than current colliders, beam-beam interactions in long insertions, dynamic aperture for optics with peak $\beta$ functions one order of magnitude above current colliders, photon background from synchrotron radiation and cross talk between the insertion regions. An alternative design avoiding the use of crab cavities with a small impact on performance is also presented., Comment: 74 pages
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- 2020
23. Modern and Future Colliders
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Shiltsev, Vladimir and Zimmermann, Frank
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Physics - Accelerator Physics ,High Energy Physics - Experiment ,Nuclear Experiment - Abstract
Since the initial development of charged particle colliders in the middle of the 20th century, these advanced scientific instruments have been at the forefront of scientific discoveries in high energy physics. Collider accelerator technology and beam physics have progressed immensely and modern facilities now operate at energies and luminosities many orders of magnitude greater than the pioneering colliders of the early 1960s. In addition, the field of colliders remains extremely dynamic and continues to develop many innovative approaches. Indeed, several novel concepts are currently being considered for designing and constructing even more powerful future colliders. In this paper, we first review the colliding beam method and the history of colliders, and then present the major achievements of operational machines and the key features of near-term collider projects that are currently under development. We conclude with an analysis of numerous proposals and studies for far-future colliders. The evaluation of their respective potentials reveals tantalizing prospects for further significant breakthroughs in the collider field., Comment: 65pages including references, 42 figures
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- 2020
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24. Beam Blow Up due to Beamstrahlung in Circular $e^+e^-$ Colliders
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García, Marco Alan Valdivia and Zimmermann, Frank
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Physics - Accelerator Physics ,High Energy Physics - Experiment - Abstract
After the discovery of the Higgs boson at the Large Hadron Collider in 2012, several possible future circular colliders -- Higgs factories are proposed, such as FCC-ee and CEPC. At these highest-energy $e^+e^-$ colliders, beamstrahlung, namely the synchrotron radiation emitted in the field of the opposing beam, can greatly affect the equilibrium bunch length and energy spread. If the dispersion function at the collision point is not zero, beamstrahlung will also increase the transverse emittances. In this letter, we first show that, for circular Higgs factories, a classical description of the beamstrahlung is adequate. We then derive analytical formulae describing the equilibrium beam parameters, taking into account the variation of the electromagnetic field during the collision. We illustrate the importance of beamstrahlung, including the increase of bunch length and the implied tolerance on the spurious dispersion function at the collision point, by considering a few examples.
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- 2019
25. Polarization and Centre-of-mass Energy Calibration at FCC-ee
- Author
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Blondel, Alain, Janot, Patrick, Wenninger, Jörg, Aßmann, Ralf, Aumon, Sandra, Azzurri, Paolo, Barber, Desmond P., Benedikt, Michael, Bogomyagkov, Anton V., Gianfelice-Wendt, Eliana, Kerchen, Dima El, Koop, Ivan A., Koratzinos, Mike, Levitchev, Evgeni, Lefevre, Thibaut, Milanese, Attilio, Muchnoi, Nickolai, Nikitin, Sergey A., Oide, Katsunobu, Perez, Emmanuel, Rossmanith, Robert, Sagan, David C., Tenchini, Roberto, Tydecks, Tobias, Shatilov, Dmitry, Voutsinas, Georgios, Wilkinson, Guy, and Zimmermann, Frank
- Subjects
Physics - Accelerator Physics ,High Energy Physics - Experiment - Abstract
The first stage of the FCC (Future Circular Collider) is a high-luminosity electron-positron collider (FCC-ee) with centre-of-mass energy ranging from 88 to 365 GeV, to study with high precision the Z, W, Higgs and top particles, with samples of $5 \times 10^{12}$ Z bosons, $10^8$ W pairs, $10^6$ Higgs bosons and $10^6$ top quark pairs. A cornerstone of the physics program lays in the precise (ppm) measurements of the W and Z masses and widths, as well as forward-backward asymmetries. To this effect the centre-of-mass energy distribution should be determined with the high precision. This document describes the capacity offered by FCC-ee, starting with transverse polarization of the beams around the Z pole and the W pair threshold. A running scheme based on regular measurements of the beam energy by resonant depolarization of pilot bunches, during physics data taking, is proposed. The design for polarization wigglers, polarimeter and depolarizer is outlined. The $e^\pm$ beam energies will be monitored with a relative precision of $10^{-6}$. The centre-of-mass energy is derived subject to further corrections, related to the beam acceleration, synchrotron radiation and beamstrahlung; these effects are identified and evaluated. Dimuon events $e^+e^- \to \mu^+ \mu^-$, recorded in the detectors, provide with great precision the beam crossing angle, the centre-of-mass energy spread, and the $e^+$ and $e^-$ energy difference. Monitoring methods to minimize absolute error and relative uncertainties are discussed. The impact on the physics measurements is given. A programme of further simulations, design, monitoring and R&D is outlined., Comment: 107 pages, 15 tables, 58 figures
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- 2019
26. FCC-ee: Your Questions Answered
- Author
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Blondel, Alain, Janot, Patrick, Tehrani, Niloufar Alipour, Azzi, Patrizia, Azzurri, Paolo, Bacchetta, Nicola, Benedikt, Michael, Blekman, Freya, Boscolo, Manuela, Dam, Mogens, De Curtis, Stefania, d'Enterria, David, Ellis, John, Ganis, Gerardo, Gluza, Janusz, Helsens, Clément, Jadach, Staszek, Koratzinos, Mike, Klute, Markus, Leonidopoulos, Christos, Locci, Elizabeth, Mangano, Michelangelo, Monteil, Stéphane, Oide, Katsunobu, Okorokov, Vitaly, Perez, Emmanuel, Riemann, Tord, Tenchini, Roberto, Selvaggi, Michele, Voutsinas, Georgios, Wenninger, Jörg, and Zimmermann, Frank
- Subjects
High Energy Physics - Phenomenology ,High Energy Physics - Experiment ,Physics - Accelerator Physics - Abstract
This document answers in simple terms many FAQs about FCC-ee, including comparisons with other colliders. It complements the FCC-ee CDR and the FCC Physics CDR by addressing many questions from non-experts and clarifying issues raised during the European Strategy symposium in Granada, with a view to informing discussions in the period between now and the final endorsement by the CERN Council in 2020 of the European Strategy Group recommendations. This document will be regularly updated as more questions appear or new information becomes available., Comment: Contribution to the European Particle Physics Strategy Update 2018-2020. Forty-five pages, six figures
- Published
- 2019
27. Machine detector interface for the $e^+e^-$ future circular collider
- Author
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Boscolo, Manuela, Blanco-Garcia, Oscar, Bacchetta, Nicola, Belli, Eleonora, Benedikt, Michael, Burkhardt, Helmut, Costa, Miguel Gil, Elsener, Konrad, Leogrande, Emilia, Janot, Patrick, Kate, Herman Ten, Khechen, Dima El, Kolano, Anna, Kersevan, Roberto, Lueckof, Marian, Oide, Katsunobu, Perez, Emmanuel, Teherani, Nilou, Viazlo, O., Voutsinas, Yorgos, Zimmermann, Frank, Dam, Mogens, Blondel, Alain, Koratzinos, M., Novokhatski, Alexander, Sullivan, Michael, Bogomyagkov, Anton, Levichev, Evgeny, Sinyatkin, Sergey, and Collamati, Francesco
- Subjects
Physics - Accelerator Physics ,High Energy Physics - Experiment - Abstract
The international Future Circular Collider (FCC) study aims at a design of $pp$, $e^+e^-$, $ep$ colliders to be built in a new 100 km tunnel in the Geneva region. The $e^+e^-$ collider (FCC-ee) has a centre of mass energy range between 90 (Z-pole) and 375 GeV (tt_bar). To reach such unprecedented energies and luminosities, the design of the interaction region is crucial. The crab-waist collision scheme has been chosen for the design and it will be compatible with all beam energies. In this paper we will describe the machine detector interface layout including the solenoid compensation scheme. We will describe how this layout fulfills all the requirements set by the parameters table and by the physical constraints. We will summarize the studies of the impact of the synchrotron radiation, the analysis of trapped modes and of the backgrounds induced by single beam and luminosity effects giving an estimate of the losses in the interaction region and in the detector., Comment: 6 pages, 7 figures, 62th ICFA ABDW on High Luminosity Circular $e^+e^-$ Colliders, eeFACT2018, Hong Kong, China
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- 2019
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28. Beam-beam Blowup in the presence of x-y coupling sources at FCC-ee
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Khechen, Dima El, Oide, Katsunobu, and Zimmermann, Frank
- Subjects
Physics - Accelerator Physics - Abstract
FCC-ee, the lepton version of the Future Circular Collider (FCC), is a 100 Km future machine under study to be built at CERN. It acquires two experiments with a highest beam energy of 182.5 GeV. FCC-ee aims to operate at four different energies, with different luminosities to fulfil physics requirements. Beam-beam effects at such a high energy/luminosity machine are very challenging and require a deep understanding, especially in the presence of x-y coupling sources. Beam-beam effects include the beamstrahlung process, which limits the beam lifetime at high energies, as well as dynamic effects at the Interaction point (IP) which include changes in the beta functions and emittances. In this report, we will define the beam-beam effects and their behaviours in the FCC-ee highest energy lattice after introducing x-y coupling in the ring.
- Published
- 2019
29. Scenarios for LHC/FCC Based Gamma-Proton Colliders
- Author
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Nergiz, Zafer, Sultansoy, Saleh, Aksakal, Husnu, and Zimmermann, Frank
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Physics - Accelerator Physics ,High Energy Physics - Experiment - Abstract
The advantage of the linac-ring type electron proton collider is that it allows for the straightforward construction of $\gamma$p collider. In a $\gamma$p collider high energy photons can be generated from Compton backscattering of laser photons off electrons from a linear accelerator. In this study main parameters of photon-proton colliders based on some future electron linear accelerator projects and protons supplied form LHC or FCC are evaluated., Comment: 11 pages, 13 figures
- Published
- 2019
30. Maligne Hodentumoren in der Cisplatin-Ära: Todesursachen und Letalität in einer Kohortenstudie
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Papachristofilou, Alexandros and Zimmermann, Frank
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- 2022
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31. Ergänzung der Bestechungsdelikte durch einen Tatbestand des Amtsmissbrauchs?
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Zimmermann, Frank, primary
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- 2023
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32. Die Zuständigkeit der EUStA im Ermittlungsverfahren und der Grundsatz „ne bis in idem“
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Zimmermann, Frank, primary
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- 2023
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33. Tailored axillary surgery with or without axillary lymph node dissection followed by radiotherapy in patients with clinically node-positive breast cancer (OPBC-03/SAKK 23/16/IBCSG 57-18/ABCSG-53/GBG-101-TAXIS).
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Weber, Walter Paul, primary, Matrai, Zoltan, additional, Hayoz, Stefanie, additional, Tausch, Christoph, additional, Henke, Guido, additional, Zimmermann, Frank, additional, Montagna, Giacomo, additional, Fitzal, Florian, additional, Gnant, Michael, additional, Ruhstaller, Thomas, additional, Muenst, Simone, additional, Mueller, Andreas, additional, Lelièvre, Loïc, additional, Heil, Jörg, additional, Kurzeder, Christian, additional, Egle, Daniel, additional, Sávolt, Ákos, additional, Heidinger, Martin, additional, and Knauer, Michael, additional
- Published
- 2024
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34. Radiotherapie beim Prostatakarzinom – kurativ und palliativ
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Papachristofilou, Alexandros and Zimmermann, Frank
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- 2022
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35. Machine Parameters and Projected Luminosity Performance of Proposed Future Colliders at CERN
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Bordry, Frederick, Benedikt, Michael, Bruning, Oliver, Jowett, John, Rossi, Lucio, Schulte, Daniel, Stapnes, Steinar, and Zimmermann, Frank
- Subjects
Physics - Accelerator Physics ,High Energy Physics - Experiment - Abstract
In response to a request from the CERN Scientific Policy Committee (SPC), the machine parameters and expected luminosity performance for several proposed post-LHC collider projects at CERN are compiled: three types of hadron colliders (HL-LHC upgrade, FCC-hh and HE-LHC), a circular lepton collider (FCC-ee), a linear lepton collider (CLIC), and three options for lepton-hadron colliders (LHeC, HE-LHeC, and FCC-eh). Particular emphasis is put on availability, physics run time, and efficiency. The information contained in this document was presented at the SPC Meeting of September 2018. It will serve as one of the inputs to the 2019/20 Update of the European Strategy for Particle Physics.
- Published
- 2018
36. Proton Colliders at the Energy Frontier
- Author
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Benedikt, Michael and Zimmermann, Frank
- Subjects
Physics - Accelerator Physics ,High Energy Physics - Experiment - Abstract
Since the CERN ISR, hadron colliders have defined the energy frontier. Noteworthy are the conversion of the Super Proton Synchrotron (SPS) into a proton-antiproton collider, the Tevatron collider, as well as the abandoned SSC in the United States. Hadron colliders are likely to determine the pace of particle-physics progress also during the next hundred years. Discoveries at past hadron colliders were essential for establishing the so-called Standard Model of particle physics. The world's present flagship collider, the LHC, including its high-luminosity upgrade HL-LHC, is set to operate through the second half of the 2030's. Further increases of the energy reach during the 21st century require another, still more powerful hadron collider. Three options for a next hadron collider are presently under investigation. The Future Circular Collider (FCC) study, hosted by CERN, is designing a 100 TeV collider, to be installed inside a new 100 km tunnel in the Lake Geneva basin. A similar 100 km collider, called SppC, is being pursued by CAS-IHEP in China. In either machine, for the first time in hadron storage rings, synchrotron radiation damping will be significant. In parallel, the synchrotron-radiation power emitted inside the cold magnets becomes an important design constraint. One important difference between FCC and SppC is the magnet technology. FCC uses 16 Tesla magnets based on Nb3Sn superconductor, while SppC magnets shall be realized with cables made from iron-based high-temperature superconductor. Initially the SppC magnets are assumed to provide a more moderate dipole field of 12 T, but they can later be pushed to a final ultimate field of 24 T. A third collider presently under study is the High-Energy LHC (HE-LHC), which is a higher energy collider in the existing LHC tunnel, exploiting the FCC magnet technology in order to double the LHC energy at significantly higher luminosity., Comment: Submitted to Nucl. Instr. Methods A "Siegbahn 2017" issue
- Published
- 2018
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37. Future Colliders for Particle Physics - 'Big and Small'
- Author
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Zimmermann, Frank
- Subjects
Physics - Accelerator Physics - Abstract
Discoveries at high-energy particle colliders have established the standard model of particle physics. Technological innovation has helped to increase the collider energy at a much faster pace than the corresponding costs. New concepts will allow reaching ever higher luminosities and energies throughout the coming century. Cost-effective strategies for the collider implementation include staging. For example, a future circular collider could first provide electron-positron collisions, then hadron collisions (proton-proton and heavy-ion), and finally the collision of muons. Cooling-free muon colliders, realizable in a number of ways, promise an attractive and energy-efficient path towards lepton collisions at tens of TeV. While plasma accelerators and dielectric accelerators offer unprecedented gradients, the construction of a high-energy collider based on these new technologies still calls for significant improvements in cost and performance. Pushing the accelerating gradients or bending fields ever further, the breakdown of the QED vacuum may set an ultimate limit to electromagnetic acceleration. Finally, some ideas are sketched for reaching, or exceeding, the Planck energy., Comment: Submitted to the proceedings of the Third European Advanced Accelerator Concepts Workshop "EAAC2017", La Biodola, 24-30 September 2017; to be published in NIMA Proceedings
- Published
- 2018
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38. Dose‐intensified stereotactic body radiotherapy for painful vertebral metastases: A randomized phase 3 trial.
- Author
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Guckenberger, Matthias, Billiet, Charlotte, Schnell, Daniel, Franzese, Ciro, Spałek, Mateusz, Rogers, Susanne, Stelmes, Jean‐Jacques, Aebersold, Daniel M., Hemmatazad, Hossein, Zimmermann, Frank, Zimmer, Jörg, Zilli, Thomas, Bruni, Alessio, Baumert, Brigitta G., Nägler, Franziska, Gut, Philipp, Förster, Robert, and Madani, Indira
- Subjects
CLINICAL trials ,STEREOTACTIC radiotherapy ,EXTERNAL beam radiotherapy ,VERTEBRAL fractures ,METASTASIS - Abstract
Background: The purpose of this randomised study was to determine whether dose‐intensified stereotactic body radiotherapy (SBRT) for painful vertebral metastases results in increased rates of pain improvement compared with conventional external beam radiotherapy (cEBRT) (control) 6 months after treatment. Methods: This randomized, controlled phase 3 trial was conducted between November 2016 and January 2023, when it was stopped early. Patients were eligible if they were aged 18 years or older; had one or two painful, stable, or potentially unstable vertebral metastases; and had a life expectancy of 1 year or longer according to the investigator's estimates. Patients received 48.5 grays (Gy) in 10 fractions (with epidural involvement) or 40 Gy in five fractions (without epidural involvement) in the SBRT group and 30 Gy in 10 fractions or 20 Gy in five fractions in the cEBRT group, respectively. The primary end point was an improvement in the pain score at the treated site by at least 2 points (on a visual analog scale from 0 to 10 points) at 6‐month follow‐up. Data were analyzed on an intention‐to‐treat and per‐protocol basis. Results: Of 214 patients who were screened for eligibility, 63 were randomized 1:1 between SBRT (33 patients with 36 metastases) and cEBRT (30 patients with 31 metastases). The median age of all patients was 66 years, and 40 patients were men (63.5%). In the intention‐to‐treat analysis, the 6‐month proportion of patients who had metastases with pain reduction by 2 or more points was significantly higher in the SBRT group versus the control group (69.4% vs. 41.9%, respectively; two‐sided p =.02). Changes in opioid medication intake relative to baseline were nonsignificant between the groups. No differences were observed in vertebral compression fracture or adverse event rates between the groups. Conclusions: Dose‐intensified SBRT improved pain score more effectively than cEBRT at 6 months. In this randomized clinical trial that included 63 patients with 67 painful vertebral metastases, the proportion of those who had metastases with pain improvement at 6‐month follow‐up was 69% in the stereotactic body radiotherapy group versus 42% in the conventional external beam radiotherapy group: a significant difference. Changes in opioid medication intake relative to baseline between the groups were not significant, and dose‐intensified stereotactic body radiotherapy was not associated with increased risks of adverse events. [ABSTRACT FROM AUTHOR]
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- 2024
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39. A Novel SCA3 Knock-in Mouse Model Mimics the Human SCA3 Disease Phenotype Including Neuropathological, Behavioral, and Transcriptional Abnormalities Especially in Oligodendrocytes
- Author
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Haas, Eva, Incebacak, Rana D., Hentrich, Thomas, Huridou, Chrisovalantou, Schmidt, Thorsten, Casadei, Nicolas, Maringer, Yacine, Bahl, Carola, Zimmermann, Frank, Mills, James D., Aronica, Eleonora, Riess, Olaf, Schulze-Hentrich, Julia M., and Hübener-Schmid, Jeannette
- Published
- 2022
- Full Text
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40. Low-Dose Radiation Therapy for Severe COVID-19 Pneumonia: A Randomized Double-Blind Study
- Author
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Papachristofilou, Alexandros, Finazzi, Tobias, Blum, Andrea, Zehnder, Tatjana, Zellweger, Núria, Lustenberger, Jens, Bauer, Tristan, Dott, Christian, Avcu, Yasar, Kohler, Götz, Zimmermann, Frank, Pargger, Hans, and Siegemund, Martin
- Published
- 2021
- Full Text
- View/download PDF
41. 1981–2020 winter ozone trends, Erzgebirge, Central Europe
- Author
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Gebhardt, Hannah, Zimmermann, Frank, and Matschullat, Jörg
- Published
- 2021
- Full Text
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42. Dose-intensified stereotactic body radiotherapy for painful vertebral metastases: A randomized phase 3 trial
- Author
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Guckenberger, Matthias; https://orcid.org/0000-0002-7146-9071, Billiet, Charlotte; https://orcid.org/0000-0002-8483-850X, Schnell, Daniel, Franzese, Ciro; https://orcid.org/0000-0001-6893-6284, Spałek, Mateusz; https://orcid.org/0000-0002-3960-7673, Rogers, Susanne, Stelmes, Jean-Jacques; https://orcid.org/0000-0003-4887-6039, Aebersold, Daniel M; https://orcid.org/0000-0002-9493-3834, Hemmatazad, Hossein, Zimmermann, Frank, Zimmer, Jörg, Zilli, Thomas; https://orcid.org/0000-0002-4784-9883, Bruni, Alessio; https://orcid.org/0000-0003-1068-5958, Baumert, Brigitta G; https://orcid.org/0000-0001-8871-4654, Nägler, Franziska, Gut, Philipp, Förster, Robert, Madani, Indira, Guckenberger, Matthias; https://orcid.org/0000-0002-7146-9071, Billiet, Charlotte; https://orcid.org/0000-0002-8483-850X, Schnell, Daniel, Franzese, Ciro; https://orcid.org/0000-0001-6893-6284, Spałek, Mateusz; https://orcid.org/0000-0002-3960-7673, Rogers, Susanne, Stelmes, Jean-Jacques; https://orcid.org/0000-0003-4887-6039, Aebersold, Daniel M; https://orcid.org/0000-0002-9493-3834, Hemmatazad, Hossein, Zimmermann, Frank, Zimmer, Jörg, Zilli, Thomas; https://orcid.org/0000-0002-4784-9883, Bruni, Alessio; https://orcid.org/0000-0003-1068-5958, Baumert, Brigitta G; https://orcid.org/0000-0001-8871-4654, Nägler, Franziska, Gut, Philipp, Förster, Robert, and Madani, Indira
- Abstract
BACKGROUND The purpose of this randomised study was to determine whether dose-intensified stereotactic body radiotherapy (SBRT) for painful vertebral metastases results in increased rates of pain improvement compared with conventional external beam radiotherapy (cEBRT) (control) 6 months after treatment. METHODS This randomized, controlled phase 3 trial was conducted between November 2016 and January 2023, when it was stopped early. Patients were eligible if they were aged 18 years or older; had one or two painful, stable, or potentially unstable vertebral metastases; and had a life expectancy of 1 year or longer according to the investigator's estimates. Patients received 48.5 grays (Gy) in 10 fractions (with epidural involvement) or 40 Gy in five fractions (without epidural involvement) in the SBRT group and 30 Gy in 10 fractions or 20 Gy in five fractions in the cEBRT group, respectively. The primary end point was an improvement in the pain score at the treated site by at least 2 points (on a visual analog scale from 0 to 10 points) at 6-month follow-up. Data were analyzed on an intention-to-treat and per-protocol basis. RESULTS Of 214 patients who were screened for eligibility, 63 were randomized 1:1 between SBRT (33 patients with 36 metastases) and cEBRT (30 patients with 31 metastases). The median age of all patients was 66 years, and 40 patients were men (63.5%). In the intention-to-treat analysis, the 6-month proportion of patients who had metastases with pain reduction by 2 or more points was significantly higher in the SBRT group versus the control group (69.4% vs. 41.9%, respectively; two-sided p = .02). Changes in opioid medication intake relative to baseline were nonsignificant between the groups. No differences were observed in vertebral compression fracture or adverse event rates between the groups. CONCLUSIONS Dose-intensified SBRT improved pain score more effectively than cEBRT at 6 months.
- Published
- 2024
43. Status and Challenges for FCC-ee
- Author
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Benedikt, Michael, Oide, Katsunobu, Zimmermann, Frank, Bogomyagkov, Anton, Levichev, Eugene, Migliorati, Mauro, and Wienands, Uli
- Subjects
Physics - Accelerator Physics - Abstract
We report the design status and beam dynamics challenges for the electron-positron branch of the Future Circular Collider (FCC) study, as of August 2015. After recalling motivation and physics requirements for the FCC-ee, we briefly discuss configurations and parameters, collider layout, the superconducting RF system, possible staging scenarios, final-focus optics, interaction-region (IR) issues, machine detector interface and IR synchrotron radiation, dynamic aperture, beam-beam effects, top-up injection, mono-chromatization option, impedances, instabilities, energy calibration and polarization, and SuperKEKB as a key demonstrator, before presenting conclusions and outlook., Comment: Combination of two articles invited for the ICFA Beam Dynamics Newsletter, September 2015 issue
- Published
- 2015
44. Measurement and Control of Charged Particle Beams
- Author
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Minty, Michiko G. and Zimmermann, Frank
- Subjects
Particle Acceleration and Detection, Beam Physics ,Measurement Science and Instrumentation ,Accelerator Physics ,CERN ,DESY ,Particle accelerator ,Storage ring ,control ,measurement ,Open Access ,Particle & high-energy physics ,Scientific standards, measurement etc ,bic Book Industry Communication::P Mathematics & science::PH Physics::PHP Particle & high-energy physics ,bic Book Industry Communication::P Mathematics & science::PD Science: general issues::PDD Scientific standards::PDDM Mensuration & systems of measurement - Abstract
From the reviews: "This book is a very welcome and valuable addition to the accelerator literature. As noted by the authors, there is relatively little material in the book specifically for low-energy machines, but industrial users may still find it useful to read." Cern Courier ; The intent of this book is to bridge the link between experimental obser vations and theoretical principles in accelerator physics. The methods and concepts, taken primarily from high energy accelerators, have for the most part already been presented in internal reports and proceedings of accelera tor conferences, a portion of which has appeared in refereed journals. In this book we have tried to coherently organize this material so as to be useful to designers and operators in the commissioning and operation of particle accelerators. A point of emphasis has been to provide, wherever possible, experimental data to illustrate the particular concept under discussion. Of the data pre sented, most are collected from presently existing or past accelerators and we regret the problem of providing original data some of which appear in less accessible publications - for possible omissions we apologize. Regarding the uniformity of the text, particularly with respect to symbol definitions, we have taken the liberty to edit certain representations of the data while trying to maintain the essence of the presented observations. Throughout the text we have attempted to provide references which are readily available for the reader.; This reference and advanced textbook is the first comprehensive and systematic review of all methods used for the measurement, correction, and control of the beam dynamics of modern particle accelerators. Based on material presented in several lectures at the US Particle Accelerator School, the text is intended for graduate students starting research or work in the field of beam physics. Relativistic beams in linear accelerators and storage rings provide the focus. After a review of linear optics, the text addresses basic and advanced techniques for beam control, plus a variety of methods for the manipulation of particle-beam properties. In each case, specific procedures are illustrated by examples from operational accelerators. The book also treats special topics such as injection and extraction methods, beam cooling, spin transport, and polarization. Problems and solutions enhance the books usefulness in graduate courses.
- Published
- 2003
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45. Knowledge gaps in oncoplastic breast surgery
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González, Eduardo, Elzayat, Mona, Koller, Rupert, Gnant, Michael, Brenelli, Fabricio, Paulinelli, Regis Resende, Zobel, Vappu, Joukainen, Sarianna, Karhunen-Enckell, Ulla, Kauhanen, Susanna, Piat, Jean-Marc, Bjelic-Radisic, Vesna, Faridi, Andree, Heitmann, Christoph, Hoffmann, Juergen, Kneser, Ulrich, Kümmel, Sherko, Kühn, Thorsten, Kontos, Michalis, Tampaki, Ekaterini Christina, Barry, Mitchel, Allweis, Tanir M, Carmon, Moshe, Hadar, Tal, Catanuto, Giuseppe, Garcia-Etienne, Carlos A, Gentilini, Oreste D, Knox, Susan, Klein, Barbara, Koppert, Linetta, Gouveia, Pedro F, Svensjö, Tor, Bucher, Heiner C, Ess, Silvia, Ganz-Blättler, Ursula, Günthert, Andreas, Hauser, Nik, Hynes, Nancy, Knauer, Michael, Pfeiffer, Marlen, Rochlitz, Christoph, Tausch, Christoph, Harder, Yves, Zimmermann, Frank, Schwab, Fabienne D, D'Amico, Veronica, Soysal, Savas D, Castrezana Lopez, Liliana, Fulco, Ilario, Hemkens, Lars G, Lohsiriwat, Visnu, Gulluoglu, Bahadir M, Karadeniz, Guldeniz, Karanlik, Hasan, Sezer, Atakan, Gulcelik, Mehmet Ali, Emiroglu, Mustafa, Kovacs, Tibor, Rattay, Tim, Romics, Laszlo, Vidya, Raghavan, Wyld, Lynda, El-Tamer, Mahmoud, Sacchini, Virgilio, Weber, Walter P, Morrow, Monica, Boniface, Jana de, Pusic, Andrea, Montagna, Giacomo, Kappos, Elisabeth A, Ritter, Mathilde, Haug, Martin, Kurzeder, Christian, Saccilotto, Ramon, Schulz, Alexandra, Benson, John, Fitzal, Florian, Matrai, Zoltan, Shaw, Jane, Peeters, Marie-Jeanne Vrancken, Potter, Shelley, and Heil, Joerg
- Published
- 2020
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46. Saraf-dependent activation of mTORC1 regulates cardiac growth
- Author
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Sanlialp, Ayse, Schumacher, Dagmar, Kiper, Leon, Varma, Eshita, Riechert, Eva, Ho, Thanh Cao, Hofmann, Christoph, Kmietczyk, Vivien, Zimmermann, Frank, Dlugosz, Sascha, Wirth, Angela, Gorska, Agnieszka A., Burghaus, Jana, Camacho Londoño, Juan E., Katus, Hugo A., Doroudgar, Shirin, Freichel, Marc, and Völkers, Mirko
- Published
- 2020
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47. ASO Visual Abstract: Impact of Imaging-Guided Localization on Performance of Tailored Axillary Surgery in Patients with Clinically Node-Positive Breast Cancer: Prospective Cohort Study Within TAXIS (OPBC-03, SAKK 23/16, IBCSG 57-18, ABCSG-53, GBG 101)
- Author
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Weber, Walter P., primary, Heidinger, Martin, additional, Hayoz, Stefanie, additional, Matrai, Zoltan, additional, Tausch, Christoph, additional, Henke, Guido, additional, Zwahlen, Daniel R., additional, Gruber, Günther, additional, Zimmermann, Frank, additional, Montagna, Giacomo, additional, Andreozzi, Mariacarla, additional, Goldschmidt, Maite, additional, Schulz, Alexandra, additional, Mueller, Andreas, additional, Ackerknecht, Markus, additional, Tampaki, Ekaterini Christina, additional, Bjelic-Radisic, Vesna, additional, Kurzeder, Christian, additional, Sávolt, Ákos, additional, Smanykó, Viktor, additional, Hagen, Daniela, additional, Müller, Dieter J., additional, Gnant, Michael, additional, Loibl, Sibylle, additional, Fitzal, Florian, additional, Markellou, Pagona, additional, Bekes, Inga, additional, Egle, Daniel, additional, Heil, Jörg, additional, and Knauer, Michael, additional
- Published
- 2023
- Full Text
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48. Experimental and Theoretical Progress of Linear Collider Final Focus Design and ATF2 Facility
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Seryi, Andrei, Tomas, Rogelio, Zimmermann, Frank, Kubo, Kiyoshi, Kuroda, Shigeru, Okugi, Toshiyuki, Tauchi, Toshiaki, Terunuma, Nobuhiro, Urakawa, Junji, White, Glen, Woodley, Mark, and Angal-Kalinin, Deepa
- Subjects
Physics - Accelerator Physics - Abstract
In this brief overview we will reflect on the process of the design of the linear collider (LC) final focus (FF) optics, and will also describe the theoretical and experimental efforts on design and practical realisation of a prototype of the LC FF optics implemented in the ATF2 facility at KEK, Japan, presently being commissioned and operated.
- Published
- 2014
- Full Text
- View/download PDF
49. Proceedings of ECLOUD'12: Joint INFN-CERN-EuCARD-AccNet Workshop on Electron-Cloud Effects, La Biodola, Isola d'Elba, Italy, 5 - 9 Jun 2012
- Author
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Cimino, Roberto, Rumolo, Giovanni, and Zimmermann, Frank
- Subjects
Physics - Accelerator Physics - Abstract
This report contains the Proceedings of the Joint INFN-Frascati, INFN-Pisa, CERN-LER and EuCARD-AccNet Mini-Workshop on Electron-Cloud Effects, "ECLOUD12", held at La Biodola, Isola d'Elba, from 5 to 9 June 2012. The ECLOUD12 workshop reviewed many recent electron-cloud (EC) observations at existing storage rings, EC predictions for future accelerators, electron-cloud studies at DAFNE, EC mitigation by clearing electrodes and graphite/carbon coatings, modeling of incoherent EC effects, self-consistent simulations, synergies with other communities like the Valencia Space Consortium and the European Space Agency. ECLOUD12 discussed new EC observations at existing machines including LHC, CesrTA, PETRA-3, J-PARC, and FNAL MI; latest experimental efforts to characterize the EC - including EC diagnostics, experimental techniques, mitigation techniques such as coating and conditioning, advanced chemical and physical analyses of various vacuum-chamber surfaces, beam instabilities and emittance growth -; the status of EC physics models and (new, more versatile and additional) simulation codes and their comparison with recently acquired experimental data; and the mitigation requirements and potential performance limitations imposed by the EC on upgraded and future machines, including HL-LHC, FAIR, ILC, Project-X, SuperB and SuperKEKB. A dedicated session addressed problems related to RF breakdown and multipacting for space applications. A number of open questions and future R&D needs were identified., Comment: 39 lectures, 286 pages, published as CERN Yellow Report https://cds.cern.ch/record/1529710?ln=en
- Published
- 2014
- Full Text
- View/download PDF
50. The challenge of monochromatization: The Challenge of Monochromatization Direct s-Channel Higgs Production: e+e- -> H
- Author
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Faus-Golfe, Angeles, Valdivia Garcia, Marco Alan, and Zimmermann, Frank
- Published
- 2022
- Full Text
- View/download PDF
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