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1. 10-year stroke prevention after successful carotid endarterectomy for asymptomatic stenosis (ACST-1): a multicentre randomised trial

Author

Halliday, A, Harrison, M, Hayter, E, Kong, X, Mansfield, A, Marro, J, Pan, H, Peto, R, Potter, J, Rahimi, K, Rau, A, Robertson, S, Streifler, J, Thomas, D, Fraedrich G, Asymptomatic Carotid Surgery Trial Collaborative G. r. o. u. p., Schmidauer, C, Hölzenbein, Th, Huk, I, Haumer, M, Kretschmer, G, Metz, V, Polterauer, P, Teufelsbauer, H, Cras, P, Hendriks, J, Lauwers, P, Van Schil, P, de Souza EB, Dourado, Me, Gurgel, G, Rocha, Gm, Petrov, V, Slabakov, G, Cooper, Me, Gubitz, G, Holness, R, Howes, W, Langille, R, Legg, K, Nearing, S, Mackean, G, Mackay, M, Phillips, Sj, Sullivan, J, Wood, J, Erdelez, L, Sosa, T, Angelides, Ns, Christopoulos, G, Malikidou, A, Pesta, A, Ambler, Z, Mracek, J, Polivka, J, Rohan, V, Sevcik, P, Simaná, J, Benes, V, Kramár, F, Kaste, M, Lepäntalo, M, Soinne, L, Cardon, Jm, Legalou, A, Gengenbach, B, Pfadenhauer, K, Wölfl, Kd, Flessenkämper, I, Klumpp, Bf, Marsch, J, Kolvenbach, R, Pfeiff, T, Sandmann, W, Beyersdorf, F, Hetzel, A, Sarai, K, Schöllhorn, J, Spillner, G, Lutz, Hj, Böckler, D, Maeder, N, Busse, O, Grönniger, J, Haukamp, F, Balzer, K, Knoob, Hg, Roedig, G, Virreira, L, Franke, S, Moll, R, Schneider, J, Dayantas, J, Sechas, Mn, Tsiaza, S, Kiskinis, D, Apor, A, Dzinich, C, Entz, L, Hüttl, K, Jàrànyi, Z, Mogan, I, Nagy, Z, Szabo, A, Varga, D, Juhász, G, Mátyás, L, Hutchinson, M, Mehigan, D, Aladjem, Z, Harah, E, Elmakias, S, Gurvich, D, Yoffe, B, Ben Meir, H, Dagan, L, Karmeli, R, Keren, G, Shimony, A, Weller, B, Avrahami, R, Koren, R, Streifler, Jy, Tabachnik, S, Zelikovski, A, Angiletta, D, Federico, F, Impedovo, G, Marotta, V, Pascazio, L, Regina, G, Andreoli, A, Pozzati, E, Bonardelli, S, Giulini, Sm, Guarneri, B, Caiazzo, P, Mascoli, F, Becchi, G, Masini, R, Santoro, E, Simoni, G, Ventura, M, Scarpelli, P, Spartera, C, Arena, O, Collice, M, Puttini, M, Romani, F, Santilli, I, Segramora, V, Sterzi, R, Deriu, G, Verlato, F, Cao, Pg, Cieri, Enrico, De Rango, P, Moggi, L, Ricci, S, Antico, A, Spigonardo, F, Malferrari, G, Tusini, N, Vecchiati, E, Cavallaro, A, Kasemi, H, Marino, M, Sbarigia, E, Speziale, F, Zinicola, N, Alò, Fp, Bartolini, M, Carbonari, L, Caporelli, S, Grili Cicilioni, C, Lagalla, G, Ioannidis, G, Pagliariccio, G, Silvestrini, M, Palombo, D, Peinetti, F, Adovasio, R, Chiodo Grandi, F, Mase, G, Zamolo, F, Fregonese, V, Gonano, N, Mozzon, L, Blair, R, Chuen, J, Ferrar, D, Garbowski, M, Hamilton, Mj, Holdaway, C, Muthu, S, Shakibaie, F, Vasudevan, Tm, Kroese, A, Slagsvold, Ce, Dahl, T, Johnsen, Hj, Lange, C, Myhre, Ho, Gniadek, J, Andziak, P, Elwertowski, M, Leszczynski, J, Malek, Ak, Mieszkowski, J, Noszczyk, W, Szostek, M, Toutounchi, S, Correia, C, Pereira, Mc, Akchurin, Rs, Flis, V, Miksic, K, Stirn, B, Tetickovic, E, Cairols, M, Capdevila, Jm, Iborra Ortega, E, Obach, V, Riambau, V, Vidal Barraquer, F, Vila Coll, R, Diaz Vidal, E, Iglesias Negreia JI, Tovar Pardo, A, Iglesias, Rj, Alfageme, Af, Barba Velez, A, Estallo Laliena, L, Garcia Monco JC, Gonzalez, Lr, Corominas, C, Julia, J, Lozano, P, Marti Masso JF, Porta, Rm, Carrera, Ar, Gomez, J, Blomstrand, C, Gelin, J, Holm, J, Karlström, L, Mattsson, E, Bornhov, S, Dahlstrom, J, De Pedis, G, Jensen, Sm, Pärsson, H, Plate, G, Qvarfordt, P, Arvidsson, B, Brattström, L, Forssell, C, Potemkowski, A, Skiöldebrand, C, Stoor, P, Blomqvist, M, Calander, M, Lundgren, F, Almqvist, H, Norgren, L, Norrving, B, Ribbe, E, Thörne, J, Gottsäter, A, Mätzsch, T, Nilsson, Me, Lonsson, M, Stahre, B, Stenberg, B, Konrad, P, Jarl, L, Lundqvist, L, Olofsson, P, Rosfors, S, Swedenborg, J, Takolander, R, Bergqvist, D, Ljungman, C, Kniemeyer, Hw, Widmer, Mk, Kuster, R, Kaiser, R, Nagel, W, Sege, D, Weder, B, De Nie, J, Doelman, J, Yilmaz, N, Buth, J, Stultiens, G, Boiten, J, Boon, A, van der Linden, F, Busman, Dc, Sinnige, Ha, Yo, Ti, de Borst GJ, Eikelboom, Bc, Kappelle, Lj, Moll, F, Dortland, Rw, Westra, Te, Jaber, H, Manaa, J, Meftah, Rb, Nabil, Br, Sraieb, T, Bateman, D, Budd, J, Horrocks, M, Kivela, M, Shaw, L, Walker, R, D'Sa, Aa, Fullerton, K, Hannon, R, Hood, Jm, Lee, B, Mcguigan, K, Morrow, J, Reid, J, Soong, Cv, Simms, M, Baird, R, Campbell, M, Cole, S, Ferguson, It, Lamont, P, Mitchell, D, Sassano, A, Smith, Fc, Blake, K, Kirkpatrick, Pj, Martin, P, Turner, C, Clegg, Jf, Crosley, M, Hall, J, De Cossart, L, Edwards, P, Fletcher, D, Rosser, S, Mccollum, Pt, Davidson, D, Levison, R, Bradbury, Aw, Chalmers, Rt, Dennis, M, Murie, J, Ruckley, Cv, Sandercock, P, Campbell, Wb, Frankel, T, Gardner Thorpe, C, Gutowski, N, Hardie, R, Honan, W, Niblett, P, Peters, A, Ridler, B, Thompson, Jf, Bone, I, Welch, G, Grocott, Ec, Overstall, P, Aldoori, Mi, Dafalla, Be, Bryce, J, Clarke, C, Ming, A, Wilkinson, Ar, Bamford, J, Berridge, D, Scott, J, Abbott, Rj, Naylor, R, Harris, P, Humphrey, P, Adiseshiah, M, Aukett, M, Baker, D, Bishop, Cc, Boutin, A, Brown, M, Burke, P, Burnand, Kg, Colchester, A, Coward, L, Davies, Ah, Espasandin, M, Giddings, Ae, Hamilton, G, Judge, C, Kakkos, S, Mcguiness, C, Morris Vincent, P, Nicolaides, A, Padayachee, Ts, Riordan, H, Sullivan, E, Taylor, P, Thompson, M, Wolfe, Jh, Mccollum, Cn, O'Neill, Pa, Welsh, S, Barnes, J, Cleland, P, Davis, M, Gholkar, A, Jones, R, Jaykishnam, V, Mendelow, Ad, O'Connell, Je, Siddique, Ms, Stansby, G, Vivar, R, Ashley, S, Cosgrove, C, Gibson, J, Wilkins, Dc, Chant, Ad, Frankel, J, Shearman, Cp, Williams, J, Hall, G, Holdsworth, R, Davies, Jn, Mclean, B, Woodburn, Kr, Brown, G, Curley, P, Loizou, L, Chaturvedi, S, Diaz, F, Radak, D, Todorovic, Pr, Kamugasha, D, Baxter, A, Berry, C, Burrett, J, Collins, R, Crowther, J, Davies, C, Farrell, B, Godwin, J, Gray, R, Harwood, C, Hirt, L, Hope, C, Knight, S, Lay, M, Munday, A, Murawska, A, Peto, Cg, Radley, A, Richards, S., Cras, Patrick, van Schil, Paul, et al., Asymptomatic Carotid Surgery Trial (ACST) Collaborative Group, Halliday, A, Harrison, M, Hayter, E, Kong, X, Mansfield, A, Marro, J, Pan, H, Peto, R, Potter, J, Rahimi, K, Rau, A, Robertson, S, Streifler, J, Thomas, D, Adovasio, Roberto, and Asymptomatic Carotid Surgery Trial Collaborative, Group

Subjects
Male, Time Factors, medicine.medical_treatment, Kaplan-Meier Estimate, Carotid endarterectomy, Aged, 80 and over, Carotid Stenosis, Endarterectomy, Carotid, Female, Humans, Incidence, Middle Aged, Primary Prevention, Stroke, Treatment Outcome, Stroke/epidemiology, law.invention, Randomized controlled trial, law, Aged, 80 and over, Endarterectomy, Carotid, endarterectomy, Carotid Stenosis/mortality, Incidence (epidemiology), Carotid*/mortality, General Medicine, Carotid Stenosis | Internal Carotid Artery | Endarterectomy, medicine.symptom, medicine.medical_specialty, Asymptomatic, Internal medicine, asymptomatic carotid artery stenosi, medicine, asymptomatic carotid artery stenosis, business.industry, Carotid Stenosis/complications, Stroke/prevention & control, Perioperative, medicine.disease, Surgery, Stenosis, Human medicine, business
Abstract

SummaryBackgroundIf carotid artery narrowing remains asymptomatic (ie, has caused no recent stroke or other neurological symptoms), successful carotid endarterectomy (CEA) reduces stroke incidence for some years. We assessed the long-term effects of successful CEA.MethodsBetween 1993 and 2003, 3120 asymptomatic patients from 126 centres in 30 countries were allocated equally, by blinded minimised randomisation, to immediate CEA (median delay 1 month, IQR 0·3–2·5) or to indefinite deferral of any carotid procedure, and were followed up until death or for a median among survivors of 9 years (IQR 6–11). The primary outcomes were perioperative mortality and morbidity (death or stroke within 30 days) and non-perioperative stroke. Kaplan-Meier percentages and logrank p values are from intention-to-treat analyses. This study is registered, number ISRCTN26156392.Findings1560 patients were allocated immediate CEA versus 1560 allocated deferral of any carotid procedure. The proportions operated on while still asymptomatic were 89·7% versus 4·8% at 1 year (and 92·1% vs 16·5% at 5 years). Perioperative risk of stroke or death within 30 days was 3·0% (95% CI 2·4–3·9; 26 non-disabling strokes plus 34 disabling or fatal perioperative events in 1979 CEAs). Excluding perioperative events and non-stroke mortality, stroke risks (immediate vs deferred CEA) were 4·1% versus 10·0% at 5 years (gain 5·9%, 95% CI 4·0–7·8) and 10·8% versus 16·9% at 10 years (gain 6·1%, 2·7–9·4); ratio of stroke incidence rates 0·54, 95% CI 0·43–0·68, p

Published
2010
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2. Long-term mortality and its predictors in patients with critical leg ischemia

Author

Belgrano, Ea, Nardella, L, Ponzio, E, Nessi, E, Guala, A, Mazzucchetti, S, Graziano, L, Urban, I, Palombo, D, Brustia, P, Calzoni, D, Bellone, M, Altieri, M, Agus, Gb, De Angelis, R, Marrocu, R, Grossi, A, Frigerio, D, Biasi, Gm, Piglionica, Mr, Agrifoglio, G, Costantini, A, Della Vedova, Mr, Miglierina, L, Lavorato, E, Emanuelli, G, Rossi, R, Flandoli, C, Ponti, Gb, Berra, S, Losapio, Gm, Ambrosi, R, Inzoli, Mr, Lombardi, G, Tarantola, P, Zocca, N, Sforza, M, Russo, R, Tenchini, P, Bruni, T, Fontanili, M, Guidetti, D, Odero, A, Salvini, M, Pedeferri, G, Bordoni, Mc, Visconti, W, Vedovato, E, Bittolo Bon, G, Maffei, L, Marcon, G, Dell'Olivo, I, Gracco, L, Petralia, G, Cordiano, C, Dorucci, V, Pagnan, A, Visona', A, Tonietto, G, Agresta, E, Burigo, E, Giansante, C, Fiotti, N, Pamich, G, Santirocco, C, Mozzon, L, Gonano, N, Petrilli, Gl, Puzzo, A, Baldino, G, Podestà, A, Guastini, A, Traversaro, A, Zinicola, N, Baglietto, F, Borgatti, E, Filippini, M, Ferrari, E, Tuscano, G, Lonardi, R, Botta, Gc, Banchini, E, Pavarini, E, Delmonte, E, Bucherini, E, Moratti, A, Ieran, M, Bertini, D, Pratesi, C, Corsi, C, Pollastri, M, Marrapodi, E, Vanni, D, Ralli, L, Cecchi, M, Bigalli, A, Del Carratore, G, Mosca, E, Vatteroni, F, Setacci, C, Cao, Piergiorgio, Verzini, Fabio, Mannarino, Elmo, Pasqualini, L, Fedeli, E, Alò, E, Ioannidis, G, Spartera, C, Marino, G, Medori, M, Pola, P, Dal Lago, Aa, Di Giovanani, V, Colli, R, Maniscalco, G, Bartolo, M, Todini, Ar, Benedetti Valentini, E, Irace, L, Fiorani, P, Taurino, M, Marcialis, A, Valitutti, P, Vigliotti, G, Regina, G, Fullone, M, Rizzo, S, Rolli, E, Pascali, M, Lucentini, L, Grilli, M, Correra, H, Florena, M, Cassina, I, Notarbartolo, A, Belvedere, M, Andreozzi, Gm, Di Pino, L, Martini, R, Signorelli, S, Romeo, S, Cormaci, Of, Costanzo, C, Grasso, A, Avanzini, F, Bedoni, P, Bertele', V, Colombo, F, Fellin, G, Pangrazzi, J, Roncaglioni, Mc, Samori, G, Tognoni, G, De Gaetano, G, Garattini, S, and Tognoni, G.

Subjects
Critical leg ischaemia, Peripheral vascular disease, Mortality, Predictive variables
Published
1997

3. A prospective epidemiological survey of the natural history of chronic leg ischaemia. Evidence of the severity of prognosis and need for large-scale clinical trials

Author

Belgrano, Ea, Nardella, L, Ponzio, E, Nessi, E, Guala, A, Mazzucchetti, S, Graziano, L, Urban, I, Palombo, D, Brustia, P, Calzoni, D, Bellone, M, Altieri, M, Agus, Gb, De Angelis, R, Marrocu, R, Grossi, A, Frigerio, D, Biasi, Gm, Piglionica, Mr, Agrifoglio, G, Costantini, A, Della Vedova MR, Miglierina, L, Lavorato, E, Emanuelli, G, Rossi, R, Flandoli, C, Ponti, Gb, Berra, S, Losapio, Gm, Ambrosi, R, Inzoli, Mr, Lombardi, G, Tarantola, P, Zocca, N, Sforza, M, Russo, R, Tenchini, P, Bruni, T, Fontanili, M, Guidetti, D, Odero, A, Salvini, M, Pedeferri, G, Bordoni, Mc, Visconti, W, Vedovato, E, Bittolo Bon, G, Maffei, L, Marcon, G, Dell'Olivo, I, Gracco, L, Petralia, G, Cordiano, C, Dorucci, V, Pagnan, A, Visona', A, Tonietto, G, E Favretti E, Agresta, Burigo, E, Giansante, C, Fiotti, N, Pamich, G, Santirocco, C, Mozzon, L, Gonano, N, Petrilli, Gl, Puzzo, A, Baldino, G, Podestà, A, Guastini, A, Traversaro, A, Zinicola, N, Baglietto, F, Borgatti, E, Filippini, M, E Ridolfi Coppi G, Ferrari, Tuscano, G, Lonardi, R, Botta, Gc, Banchini, E, Pavarini, E, Delmonte, E, Bucherini, E, Moratti, A, Ieran, M, Bertini, D, Pratesi, C, Corsi, C, Pollastri, M, Marrapodi, E, Vanni, D, Ralli, L, Cecchi, M, Bigalli, A, Del Carratore, G, Mosca, E, Vatteroni, F, Setacci, C, Cao, P, Verzini, F, Mannarino, E, Pasqualini, L, Fedeli, E, Alò, E, Ioannidis, G, Spartera, C, Marino, G, Medori, M, Pola, P, Dal Lago AA, Di Giovanani, V, Colli, R, Maniscalco, G, Bartolo, M, Todini, Ar, Benedetti-Valentini, E, Irace, L, Fiorani, P, Taurino, M, Marcialis, A, Valitutti, P, Vigliotti, G, Regina, G, Fullone, M, Rizzo, S, Rolli, E, Pascali, M, Lucentini, L, Grilli, M, Correra, H, Florena, M, Cassina, I, Notarbartolo, A, Belvedere, M, Andreozzi, Gm, Di Pino, L, Martini, R, Signorelli, S, Romeo, S, Cormaci, Of, Costanzo, C, Grasso, A, Avanzini, F, Bedoni, P, Bertele', V, Colombo, F, Fellin, G, Pangrazzi, J, Roncaglioni, Mc, Samori, G, Tognoni, G, De Gaetano, G, and Garattini, S

Subjects
Epidemiology, Critical leg ischaemia, Peripheral vascular disease
Published
1996

4. [Iliac PTA: long-term results and current prospects].

Author

Bonelli U, Cerruti R, Baglietto F, Arnuzzo L, and Zinicola N

Subjects
Aged, Female, Follow-Up Studies, Humans, Male, Middle Aged, Time Factors, Angioplasty, Balloon, Arterial Occlusive Diseases therapy, Iliac Artery
Abstract

The authors outline their experience with reference to the treatment of segmentary lesions at the level of the iliac artery. They analyse a series of 93 patients undergoing PTA. In 85 cases it was possible to conclude the procedure: 4 patients presented a small occlusion and 81 stenosis which was associated with femoro-popliteal occlusion in 35 cases. The authors analyse the results using life tables and show that treatment is optimal for the common iliac artery whereas the percentage of restenosis increases parallel to progress in a distal direction. In conclusion, the authors affirm that the procedure is safe and in order to improve results, above all at the level of the external iliac artery, il will probably be necessary in the future to use additional endovascular techniques such asm for example, the systematic use of stent.

Published
1995

5. [Incidence and treatment of vascular prosthesis infection in the groin. Personal experience].

Author

Bonelli U, Cerruti R, Baglietto F, Cantello C, and Zinicola N

Subjects
Aged, Aged, 80 and over, Anti-Bacterial Agents therapeutic use, Bacterial Infections drug therapy, Bacterial Infections etiology, Bacterial Infections microbiology, Candidiasis etiology, Emergencies, Female, Humans, Infections drug therapy, Infections microbiology, Male, Middle Aged, Polyethylene Terephthalates, Polytetrafluoroethylene, Reoperation, Blood Vessel Prosthesis adverse effects, Groin, Infections etiology
Abstract

The incidence of prosthesis infection in the groin ranges between 1 and 3%, with high morbidity and mortality rates. Contamination, irrespective of whether it is endogenous or exogenous, may occur during surgery of afterwards due to a secondary bacterial load which is often associated with a traumatic surgical technique for tissues, often in emergency surgery or re-operations. MATERIALS AND METHODS. Over the past 5 years a total of 410 prosthetic alloplastic grafts have been made by our Division of Vascular Surgery with at least one anastomosis at an inguinal level. The materials used for prosthesis were dacron and PTFE. Thirty-one infections were observed in the groin of which 11 involved the prosthesis and 20 were apparently restricted to the superficial and deep layer of the dermis. A cell culture test and antibiogram was always performed. Surgical or medical therapy (loco-regional + general) was used according to individual cases. RESULTS. With regard to the 11 patients with manifest infections of the prosthesis, only trans-obturator bypass surgery gave positive long-term results, whereas other operations (femoro-femoral bypass, axillo-popliteal bypass) were not satisfactory. Of the other 20 patients treated using loco-regional and general medical therapy, 9 developed pseudo aneurysm over time for which it was then necessary to resort to surgery. DISCUSSION AND CONCLUSION. Currently there is no universally accepted treatment protocol for the management of prosthesis infection. However, it is generally considered useful to isolate any pathological agent (using routine biopsies of arterial wall or thrombo-endoluminal fragments during the primary operation) before infection can develop so as to be able to commence specific antibiotic therapy. In this context the authors underline the more devastating action of some bacteria (pseudomonas, Staphylococcus aureus) in comparison to others (Staphylococcus epidermidis). Turning to therapeutic measures, when there are anatomical grounds and with the greatest possible respect for periarterial tissues, it is considered that trans-obturator bypass is preferable in the presence of manifest infection of the prosthesis, whereas medical therapy can be used (loco-regional + general) if infection is limited to the surface layers of the inguinal area. Possible complications over time may be corrected using surgery and in situ reconstruction if infection is no longer present.

Published
1994

6. [Controversies regarding an algorithm and the type of surgical treatment in popliteal aneurysms].

Author

Patrone P, Cantello C, Cerruti R, Bonelli U, and Zinicola N

Subjects
Acute Disease, Aneurysm complications, Aneurysm surgery, Aneurysm, Ruptured complications, Aneurysm, Ruptured diagnosis, Aneurysm, Ruptured surgery, Chronic Disease, Humans, Ischemia diagnosis, Ischemia etiology, Ischemia surgery, Leg blood supply, Radiography, Algorithms, Aneurysm diagnosis, Popliteal Artery diagnostic imaging, Popliteal Artery surgery
Abstract

Having outlined their 20-year experience in the treatment of popliteal aneurysms (PA), the authors discuss the type of therapeutic approach used. From the authors' point of view an overly aggressive approach to PA is unnecessary, and the decision to adopt a given therapy must instead be weighed up on the basis of the careful clinical evaluation of each individual case, taking into account the patient's clinical conditions at the time, the pathological anatomy of the lesion and its consequences. The authors divide primary PA into symptomatic and asymptomatic cases; in the latter surgery is definitely indicated and the possible contraindications represented by anesthesiological risk or small aneurysm diameter need not be evaluated. In the case of symptomatic PA, treatment varies depending on whether they are manifested by rupture, acute ischemia or chronic ischemia. While there are no grounds for uncertainty regarding the need for immediate surgery in the first case, in the second and third cases the authors attribute decisive importance to the evaluation and possible improvement of run-off before surgical correction. In the event of acute arterial insufficiency of the limb, the careful assessment of clinical conditions (degree of loss of sensitivity, motility and cutaneous vascularization) and anamnestic data (possible presence of signs and symptoms of previous chronic arterial insufficiency) allow the surgeon to decide whether or not to resort to immediate surgery or to obtain an improved run-off by using loco-regional fibrinolytic therapy and therefore postpone surgical treatment.(ABSTRACT TRUNCATED AT 250 WORDS)

Published
1993

7. Ureteroarterial fistula: a case report.

Author

Puppo P, Perachino M, Ricciotti G, Zinicola N, and Patrone PE

Subjects
Aged, Aged, 80 and over, Humans, Male, Arteriovenous Fistula surgery, Iliac Artery surgery, Ureteral Diseases surgery, Urinary Fistula surgery
Abstract

Ureteroarterial fistulas are rare, with less than 20 well documented cases reported. We report a case of a fistula between the left external iliac artery and the left ureter in a patient who underwent a previous operation for bladder cancer. The diagnostic and therapeutic approaches in these rare but high risk patients are discussed.

Published
1992
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8. Indobufen vs acetylsalicylic acid plus dipyridamole in long-term patency after femoropopliteal bypass.

Author

D'Addato M, Curti T, Bertini D, Donini I, Ferrero R, Fiorani P, Pellegrino F, Vecchioni R, Visconti W, and Zinicola N

Subjects
Aged, Arterial Occlusive Diseases diagnostic imaging, Arterial Occlusive Diseases mortality, Double-Blind Method, Drug Therapy, Combination, Female, Femoral Artery diagnostic imaging, Humans, Isoindoles, Male, Patient Compliance, Popliteal Vein diagnostic imaging, Radiography, Survival Rate, Arterial Occlusive Diseases surgery, Arteriovenous Shunt, Surgical adverse effects, Aspirin therapeutic use, Dipyridamole therapeutic use, Femoral Artery surgery, Phenylbutyrates therapeutic use, Platelet Aggregation Inhibitors therapeutic use, Popliteal Vein surgery, Vascular Patency drug effects
Abstract

To compare the effects of indobufen (INB) with those of ASA+dipyridamole (DP) on graft patency, 113 patients undergoing femoropopliteal bypass surgery were randomly and blindly assigned to treatment with INB 400 mg daily or with ASA 900 mg daily plus DP 225 mg daily. Treatment started 2 days before surgery and lasted for 12 months. All patients underwent two angiographic examinations: the first early after surgery (mean 6 days) and the second at the end of the study (mean 368 days). The 1 year cumulative patency rate for INB was 60% higher but not statistically different from the ASA-DP group (53.2%). The relative risk (INB/ASA+DP) calculated by the Mantel-Haenszel test was 0.86 (confidence limits 0.54-1.35). Only the site of operation (above-knee or below-knee) has a significant prognostic value on the fate of the graft.

Published
1992

9. [Traumatic lesion of the popliteal artery. Synthesis of our experience].

Author

Zinicola N, Patrone P, Bonelli U, and Cerruti R

Subjects
Exostoses complications, Female, Humans, Male, Popliteal Artery surgery, Spasm diagnosis, Spasm etiology, Popliteal Artery injuries
Abstract

The Authors reported experiences from 26 traumas of popliteal artery; 2 are related to continuous microtrauma from exotosis; 2 vasospasms implied vascular intervention. Tibial artery bypasses with vein grafts have been advocated to obviate any exploration of popliteal hematoma. A multidisciplinary approach consisting of orthopedist, plastic and vascular surgeons should be employed.

Published
1991

10. [The current value of the whipstitch suture following carotid TEA].

Author

Bonelli U, Cerruti R, and Zinicola N

Subjects
Adult, Aged, Carotid Artery Thrombosis diagnostic imaging, Carotid Artery Thrombosis epidemiology, Female, Follow-Up Studies, Humans, Lasers, Male, Middle Aged, Recurrence, Saphenous Vein transplantation, Sex Factors, Ultrasonography, Carotid Artery Thrombosis surgery, Endarterectomy methods, Suture Techniques
Abstract

There is no consensus of opinion regarding the type of suture to be used followed carotid TEA. The paper reports a study carried out in 123 operated patients who were followed for a variable period ranging from 6 months to 4 years with six-monthly controls using B-mode echotomography, supplemented by digital angiography via a venous route if necessary. A direct suture was used in 92 of the patients, while a venous patch was applied in the remaining 31. Subsequent controls revealed a relative frequency of restenosis of a fundamentally benign nature at a point which was proximal or distal to TEA. In addition, the study showed that continuous suture may be valid in male patients but doubts continue to exist regarding its use in female patients. In the latter, it is therefore preferable to encourage a more widespread use of the venous patch.

Published
1990

11. [Improved survival in the treatment of ruptured abdominal aortic aneurysm].

Author

Patrone P, Barabino G, Geddo E, Brunori C, Dagnino A, and Zinicola N

Subjects
Aorta, Abdominal surgery, Aortic Rupture mortality, Critical Care, Humans, Survival Analysis, Aortic Rupture surgery
Abstract

Personal experience in the management of 70 ruptured abdominal aortic aneurysm over the past 5 years is reported dividing patients into 2 groups, before and after establishment of intensive care unit: survival was 30.76% on the first, 66.66% in the second. Factors that allowed that result are discussed.

Published
1990

12. [Carotid lesion associated with contralateral occlusion: diagnostic and therapeutic approach].

Author

Bonelli U, Cerruti R, Patrone P, and Zinicola N

Subjects
Aged, Arterial Occlusive Diseases diagnosis, Arterial Occlusive Diseases surgery, Carotid Artery Diseases diagnosis, Carotid Artery Diseases surgery, Constriction, Pathologic diagnosis, Constriction, Pathologic surgery, Constriction, Pathologic therapy, Female, Follow-Up Studies, Humans, Male, Middle Aged, Arterial Occlusive Diseases therapy, Carotid Artery Diseases therapy
Abstract

The treatment of atheromatous carotid lesions combined with occlusion of the contralateral carotid artery remains a problem and one that is much debated. With this in mind the present paper reports personal experience of 25 cases, 16 treated surgically and 9 medically. The criteria for the selection of either type of treatment on the basis of the clinical situations, angiographic findings and Doppler ultrasound studies of the carotid plaque, are analysed. The surgical technique and the methods used in monitoring and protecting the brain during the operation are reported as are the short and long-term results. Finally, it is claimed that an "aggressive" approach is appropriate in such cases, thought there are situations in which careful monitoring of the lesion may be the first logical reaction to the treatment of these patients.

Published
1989

13. [Recent vascular injuries of the extremities. Personal experience in several cases].

Author

Zinicola N, Zanelli G, Patrone P, Cerruti R, Bonelli U, and Baglietto F

Subjects
Adolescent, Adult, Angiography, Contusions etiology, Hematoma etiology, Hematoma surgery, Humans, Male, Popliteal Artery injuries, Saphenous Vein transplantation, Wounds, Penetrating surgery, Arm Injuries complications, Blood Vessels injuries, Femoral Artery injuries, Femoral Fractures complications, Leg Injuries complications, Tibial Fractures complications
Published
1982

14. [Traumatic arterial spasm. Reflections on several personal cases].

Author

Zinicola N, Zanelli G, and Cerruti R

Subjects
Adolescent, Arm blood supply, Brachial Artery injuries, Child, Female, Humans, Leg blood supply, Male, Vascular Diseases etiology, Arteries injuries, Humeral Fractures complications, Spasm etiology, Tibial Fractures complications
Abstract

Four personal cases and the treatment adopted are described. The incidence of this event is discussed. Attention is drawn to what is felt to be the most suitable treatment of traumatic ischaemia with a possibility of underlying spasm at in the light of the existing knowledge.

Published
1978

15. [Factors determining prognosis in the treatment of abdominal aortic aneurysm in the rupture stage].

Author

Bonelli U, Cerruti R, Patrone P, and Zinicola N

Subjects
Aorta, Abdominal, Aortic Rupture mortality, Female, Humans, Male, Prognosis, Aortic Rupture surgery
Abstract

Personal experience in the treatment of 70 ruptures of the subrenal abdominal aorta over the past 15 years is reported. The various factors determining prognosis are analysed with particular reference to the time between onset of symptoms and admission to hospital, clinical condition (state of shock, kidney function) and rupture location (anterior or posterior). Preoperative investigations and types of surgical treatment are described together with results. Despite the high mortality rate it is concluded that time and rupture location are the decisive factors in the prognosis for these patients, since all other factors are more easy to monitor and modify using modern techniques of intensive postoperative care.

Published
1989

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