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Your search keyword '"Zou, Lina"' showing total 445 results
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445 results on '"Zou, Lina"'

38. Histological and functional assessment of a Takotsubo cardiomyopathy model established by immobilization stress.

Author

Pei, Quanwei, Yang, Jiemei, Li, Bin, Lin, Pengqi, Zou, Lina, Zhang, Junpei, Yin, Hongpeng, Sun, Jingmei, Wang, Xin, Vera A, Nevzorova, Dong, Zengxiang, and Yin, Dechun

Subjects
BIOLOGICAL models, RESEARCH funding, FUNCTIONAL assessment, ENZYME-linked immunosorbent assay, POLYMERASE chain reaction, VENTRICULAR remodeling, TAKOTSUBO cardiomyopathy, BEHAVIOR, HEART, RATS, FIBROSIS, VENTRICULAR tachycardia, PSYCHOLOGICAL stress, ANIMAL experimentation, WESTERN immunoblotting, THERAPEUTIC immobilization, INFLAMMATION, ECHOCARDIOGRAPHY, HISTOLOGY, ELECTROPHYSIOLOGY
Abstract

Introduction: Takotsubo cardiomyopathy (TTC), also known as stress‐induced cardiomyopathy, resembles acute heart failure syndrome but lacks disease‐specific diagnosis and treatment strategies. TTC accounts for approximately 5–6% of all suspected cases of acute coronary syndrome in women. At present, animal models of TTC are often created by large amounts of exogenous catecholamines such as isoproterenol. However, isoproterenol injection cannot fully simulate the onset of stress‐induced cardiomyopathy in humans since stress is not an instantaneous event. Methods: Rats were immobilized for 6 h per day for 1–14 days. To examine whether the TTC model was successful, echocardiography was employed; Elisa detected serum sympathetic activation markers; and the Open‐Field test (OFT) was used to analyze behavioral changes in rats after stress. Western blot and histology were used to assess sympathetic remodeling, inflammation levels, and fibrosis; qRT‐PCR was used to explore the levels of fibrosis and myocardial hypertrophy. The electrical stability of ventricular was determined by electrophysiological testing. Results: The rats showed severe stress behavior and local sympathetic remodeling of the heart after only 1 day of stress. After 3 days of stress, the induction of ventricular tachyarrhythmia increased prominently. The highest incidence of TTC in rats was at 5 days of immobilization stress. The pathological left ventricular remodeling caused by immobilization (IMO) stress includes inflammatory infiltration, fibrosis, and myocardial hypertrophy. Conclusions: Our study confirms the hypothesis that IMO stress can mimic Takotsubo cardiomyopathy, and the various effects on the heart depending on the duration of IMO stress. We observed the highest incidence of TTC occurred after 5 days of stress. Furthermore, there is a gradual occurrence of electrical and structural remodeling as the stress duration prolongs. [ABSTRACT FROM AUTHOR]

Published
2024
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47. Influence of Nitrogen Supply on Growth, Antioxidant Capacity and Cadmium Absorption of Kenaf (Hibiscus cannabinus L.) Seedlings.

Author

Li, Wenlue, Chen, Changli, Deng, Yong, Luo, Xiahong, Liu, Tingting, An, Xia, Zou, Lina, Luan, Mingbao, and Li, Defang

Subjects
KENAF, OXIDANT status, NITROGEN fertilizers, CADMIUM, CROP yields, N-type semiconductors
Abstract

Kenaf (Hibiscus cannabinus L.) is considered suitable for the remediation of cadmium (Cd)-contaminated farmlands, because of its large biomass and resistance to Cd stress. The addition of nitrogen (N) fertilizer is an important measure used to increase crop yields, and it may also affect Cd accumulation in plants. To clarify the effects of different forms and concentrations of N on plant growth and Cd absorption in kenaf, a hydroponic experiment was conducted using three N forms (NH4+–N, NO3−–N and urea–N) at four concentrations (0, 2, 4 and 8 mM, 0 mM as control) under Cd stress (30 μM). The plant growth, the antioxidant enzyme activity and the Cd contents of various parts of the kenaf seedlings were measured. The results showed that the N form had the greatest impact on the growth of the kenaf and the absorption and transport of the Cd, followed by the interaction effect between the N type and the concentration. Compared to the control, the addition of N fertilizer promoted the growth of kenaf to varying degrees. Among all the treatments, the use of 2 mM of NO3−–N enhanced the biomass and Cd accumulation to the greatest extent compared to CK from 2.02 g to 4.35 g and 341.30 μg to 809.22 μg per plant, respectively. The NH4+–N significantly reduced the Cd contents of different parts but enhanced the translocation factors of Cd stem to root (TF S/R) and leaf to stem (TF L/S) by 34.29~78.57% and 45.10~72.55%, respectively. The peroxidase (POD), superoxide dismutase (SOD) and catalase (CAT) enzyme activities of the kenaf increased with the N treatments, especially with NH4+–N. Overall, applying low concentrations of NO3−–N can better promote the extraction of Cd by kenaf. [ABSTRACT FROM AUTHOR]

Published
2023
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50. Bioinformatics Analysis of WRKY Family Genes in Flax (Linum usitatissimum)

Author

An, Xia, primary, Liu, Qin, additional, Jiang, Hui, additional, Dong, Guoyun, additional, Tian, Danqing, additional, Luo, Xiahong, additional, Chen, Changli, additional, Li, Wenlue, additional, Liu, Tingting, additional, Zou, Lina, additional, Ying, Jinyao, additional, Zhou, Huaping, additional, Zhu, Xuan, additional, and Chen, Xiaoyan, additional

Published
2023
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