1. Interaction of alcohol intake and cofactors on the risk of cirrhosis
- Author
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Stroffolini, T, Cotticelli, G, Medda, E, Niosi, M, Del Vecchio-Blanco, C, Addolorato, G, Petrelli, E, Salerno, Mt, Picardi, A, Bernardi, M, Almasio, P, Bellentani, S, Surace, La, Loguercio, C, AISF-SIA National Group, Vonghia, L, Volpe, M, Lomazzo, D, D’Avola, D, Caputo, F, Cottone, C, Scaglioni, F, Pontoriero, L, Stroffolini, T, Cotticelli, G, Medda, E, Niosi, M, Del Vecchio-Blanco, C, Addolorato, G, Petrelli, E, Salerno, MT, Picardi, A, Bernardi, M, Almasio, PL, Bellentani, S, Surace, LA, Loguercio, C, Del Vecchio Blanco, C, Salerno, Mt, Almasio, P, Surace, La, Loguercio, Carmelina, Stroffolini T, Cotticelli G, Medda E, Niosi M, Del Vecchio-Blanco C, Addolorato G, Petrelli E, Salerno MT, Picardi A, Bernardi M, Almasio P, Bellentani S, Surace LA, and Loguercio C.
- Subjects
Adult ,Liver Cirrhosis ,Male ,Hepatitis B virus ,Alcohol Drinking ,alcohol, cirrhosis coffee ,Hepacivirus ,Coffee ,Risk Assessment ,cirrhosis coffee ,Body Mass Index ,NO ,Risk Factors ,Odds Ratio ,Humans ,CIRRHOSIS ,Aged ,Hepatitis B Surface Antigens ,alcohol ,Hepatitis C Antibodies ,Middle Aged ,Hepatitis B ,Hepatitis C ,Italy ,Case-Control Studies ,Disease Progression ,RNA, Viral ,Female - Abstract
OBJECTIVE: Evaluation of the interaction between alcohol intake and cofactors [hepatitis B virus (HBV), hepatitis C virus (HCV), body mass index] and coffee consumption on the risk of cirrhosis. DESIGN: Seven hundred and forty-nine consecutive patients with chronic liver disease referring to units for liver or alcohol diseases in Italy during a 6-months period. Teetotalers were excluded. The odds ratios (OR) for cirrhosis were evaluated using chronic hepatitis cases as the control group. RESULTS: An alcohol intake of more than 3 units/day resulted associated with the likelihood of cirrhosis both in males (OR 4.3; 95% CI=2.5-7.3) and in females (OR 5.7; 95% CI=2.3-14.5). A multiplicative interaction on the risk of cirrhosis between risky alcohol intake and HBsAg or HCV-Ab/HCV-RNA positivity was observed. A reduction of cirrhosis risk was observed in subjects consuming more than 3 alcohol units/day with increasing coffee intake. The OR for the association with cirrhosis decreased from 2.3 (95% CI=1.2-4.4) in subjects drinking 0-2 cups of coffee/day to 1.4 (95% CI=0.6-3.6) in those drinking more than 2 cups/day. CONCLUSIONS: In subjects with an alcohol intake >3 units/day the coexistence of HBV or HCV multiplies the risk of cirrhosis. Coffee represents a modulator of alcoholic cirrhosis risk.
- Published
- 2010