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ABSTRACT Background Aims Methods Conclusion The demand for aesthetic procedures aimed at restoring and preserving a youthful appearance is growing. While numerous non‐surgical facial rejuvenation techniques are available, there is a need for a comprehensive review of clinic‐based procedures targeting non‐facial body parts.This review aims to describe and evaluate clinic‐based techniques for rejuvenating the neck, chest, and hands, focusing on various types of fillers and other non‐invasive procedures.In this first part of this review, we conducted an extensive literature review on PubMed, reporting the effectiveness of different fillers, detailing their preparation, required volume per area, injection methods, durability, and any associated side effects. We also discuss the use of mesotherapy, microneedling, chemical peeling, and Profhilo in these specific body areas.The review synthesizes the latest data on the effectiveness and safety of these procedures, highlighting the advancements in filler technology and the growing popularity of non‐invasive techniques for body rejuvenation. This article serves as a valuable resource for practitioners and patients interested in non‐surgical body rejuvenation, providing insights into the best practices. [ABSTRACT FROM AUTHOR]

The widespread availability of banana peels makes them an excellent resource for bio-fillers in developing environmentally conscious and biodegradable composites, serving as substitutes for plastic and synthetic waste. This study focuses on using banana peel waste as a bio-filler to produce lighter and cheaper materials. The extracted banana peels were subjected to alkali treatment to improve interfacial interaction, and their crystalline performance, functional categories, and morphological studies were examined using XRD, FTIR, and SEM techniques. Composite samples were fabricated with varying bio-filler ratios (0.0, 2.5, 5.0, 7.5, and 10%) to examine their thermo-mechanical and tribological attributes. The inclusion of banana peel in the epoxy matrix at up to 5% significantly enhanced mechanical performance, while 7.5% composites demonstrated higher thermal endurance with a degradation temperature of 395 °C and reduced water retention. Frictional wear of the specimens was assessed by varying sliding speeds under different loads, with the highest coefficient of friction and temperature observed under a 30 N force for BPC-10.0 specimens. This research innovatively uses banana peel powder (approx. 65 µm) to create polymeric composites, addressing the need for sustainable materials with higher specific modulus and strength compared to conventional substances. The study uniquely evaluates the physical, mechanical, structural, and tribological efficiency of raw and processed banana peel particles, with chemical modifications improving crystallinity and interfacial bonding. This comprehensive approach provides vital insights for developing sustainable alternatives to reduce plastic usage. [ABSTRACT FROM AUTHOR]

Background Chloasma is a common skin hyperpigmentation condition, with treatment options ranging from topical agents to advanced interventions such as chemical peels and laser therapy. Salicylic acid, including its supramolecular form (SSA), has shown promise in managing chloasma. However, to date, no multicentre randomized controlled trial of SSA for chloasma is available. Objectives The purpose of this study was to assess the efficacy and safety of 30% SSA combined with 10% niacinamide in treating -chloasma. Methods This multicentre (n = 15), randomized, double-blind, parallel placebo-controlled trial (Clinical trial registration number: ChiCTR2200065346) enrolled and randomized 300 participants (1 : 1) to either 30% SSA treatment or placebo, with 150 allocated to treatment and 150 to placebo in the full analysis set, and 144 to treatment and 147 to placebo in the per-protocol set. A Visia® Skin Analysis System was used at each visit to assess the degree of improvement in chloasma lesions. The primary endpoint was the effective rate after 16 weeks, assessed using the modified Melasma Area and Severity Index (mMASI) score [(pretreatment score − post-treatment score)/pretreatment score × 100%]. Results The total mMASI score, overall score on the Griffiths 10-point scale, and Griffiths 10 score for the left and the right sides of the face were significantly lower in the 30% SSA group than in the placebo group (all P < 0.001). One study of drug-related adverse events (AEs) and one study of drug-unrelated AEs were reported in the 30% SSA group. No AE was reported in the placebo group. Conclusions Among our patients, 30% SSA combined with 10% niacinamide was shown to be effective and safe for treating chloasma. [ABSTRACT FROM AUTHOR]

Background: The hands are one of the areas where skin aging is most noticeable, alongside the face, but limited studies used dermoscopic evaluation on hand aging. The Dermoscopy Photoaging Scale (DPAS) is frequently used to assess face aging but is never used for hand aging. Treating skin aging using chemical peeling is a commonly used method to rejuvenate the skin on the hands, as it is relatively affordable. Using multiple chemical peels may yield more significant results. Aims: To determine the effectiveness of a chemical peeling combination in retarding hand aging and to assess the utility of DPAS in this process. Methods: This study involved 69 Fitzpatrick skin types III–IV volunteers aged 20–69. One hand of each participant was treated with 20% glycolic acid (GA), while the other received a combination of peels consisting of 20% GA and 15% trichloroacetic acid (TCA). The hands were clinically examined before and after the treatments, and dermoscopic examinations were performed using a modified DPAS. Results: Four treatments improved clinical and dermoscopic characteristics in both hands. The combined peeling considerably improved pigmentation intensity on the dorsal hand compared to the GA peel (p < 0.001). Post‐chemical peeling patient satisfaction increased significantly. Conclusions: The modified DPAS is a valuable instrument to assess the signs of hand aging. The combination of GA and TCA effectively improves skin aging of the hands and offers an accessible and economical option for addressing skin aging. [ABSTRACT FROM AUTHOR]

One of the most severe peel physiological disorders of orange fruits is Stem End Rind Breakdown (SERB), a severe postharvest physiological disorder. We expected foliar Ca and K application to reduce orange SERB by modifying several peel biochemical and physical characteristics. Therefore, one experiment (2018–2020) was designed in complete randomized blocks in four treatments with three replicates. Experimental treatments included foliar spray of (1) K nitrate; (2) Ca nitrate; (3) Ca, and K nitrate separately, with a time interval (Ca + K; combination of treatments 1 and 2); (4) control. The effects of treatments were evaluated on several parameters underlying fruit peel quality at harvest and intensity of SERB damage after 12 wk of fruit storage at 5 ◦C and 85% RH. The results showed that K-treated fruits had higher TSS and TSS/TA than other fruits. Also, the Ca treatments (including Ca and Ca + K treatments) increased Ca content in fruit peels and significantly decreased SERB damage and weight loss by 70% and 30%, respectively. In addition, Thomson orange peel obtained from Ca-treated trees (including Ca and Ca + K treatments) displayed elevated levels of pectin than other fruits. In contrast, the peels of fruits picked from trees sprayed with Ca, especially those treated with Ca + K, exhibited lower levels of total phenolic, antioxidant, and electrolyte leakage than other fruits. This study suggests that foliar application of Ca(NO3)2 and KNO3 during the fruit growth cycle while improving the internal quality of the fruit is an effective agronomical strategy that prolongs Thomson orange shelf life. [ABSTRACT FROM AUTHOR]

Highlights Functionalized thin films with excellent flexibility and conductivity can meet the current requirements for electromagnetic(EM) shielding materials. In this paper, 2D transitions metal carbide and nitride nanomaterials Ti3C2Tx MXene were prepared by chemical exfoliation, and PVDF/MWCNTs/3 wt%/RGO@Fe3O4@ AgNWs‐10 based on PVDF/MWCNTs‐3 wt%/RGO@Fe3O4@AgNWs‐10, The samples were prepared through a simple solution mixing process followed by vacuum‐assisted filtration (VAF), and PVDF/MWCNTs/MXene/RGO@Fe3O4@AgNWs three‐layer PVDF‐based composite films, which were analyzed for electrical conductivity and EM shielding properties, which increased and then decreased with the rise in the Ti3C2Tx MXene content, in which the highest electrical conductivity of the three‐layer composite films of M3/MX‐10/R@F@Ag was obtained when the Ti3C2Tx MXene addition amount reached 10 mL as 3.9 × 103 S/m, the EMI SET is 54.9 dB, the EMI SEA is 44.8 dB, the absorption loss is 81.6%, and the SSEt of the M3/MX‐10/R@F@Ag three‐layer composite film is the highest 1672.5 dB/(cm−2·g). And the SEA/SER ratios of the M3/MX‐X/R@F@Ag three‐layer composite films are all greater than 1. The result shows that the EM attenuation mechanism of the M3/MX‐X/R@F@Ag three‐layer composite films is primarily driven by absorption loss and that the incorporation of Ti3C2Tx Mxene improves the EM shielding performance of the composite films. The relatively novel exploration of the performance study and structural design of the M3/MX‐X/R@F@Ag three‐layer EM shielding composite film provides structural design and research ideas for the application of the new MXenes material in EM shielding composites. The addition of Ti3C2Tx MXene will generate more conductive network nodules A complete 3D conductive network is constructed in the membrane This paper discusses the influence of Ti3C2Tx MXene on EM shielding Multiple internal reflections of EMW between Ti3C2Tx MXene 2D nanosheets The EM shielding mechanism of the film is discussed from the angle of 3D [ABSTRACT FROM AUTHOR]

Background: The aim of this study was to compare functional and anatomical changes in patients with small full thickness macular holes (FTMHs) who underwent pars plana vitrectomy (PPV) with or without Internal limiting membrane (ILM) peeling. Methods: 42 eyes of 42 patients diagnosed for FTMHs (< 250 micron) were included in our prospective interventional study. Main outcome measures were: Best Corrected Visual Acuity (BCVA), Macular hole closure rate, Ellipsoid Zone (EZ) and External Limiting Membrane (ELM) recover, Vessel Density in both Superficial (VDSCP) and deep (VDDCP) capillary plexus, Macular pigment Optical density (MPOD) and mean Central Macular Sensitivity (CMS).Patients were randomly divided into "peeling group" (21 patients), in which the ILM peeling maneuver was performed and "no-peeling group" (21 patients) in which the ILM was not peeled off. Examinations were repeated one month (T1), three months (T2) and six months (T3) after surgery. Results: Although significant improvements in terms of MPOD, CMS, VDSCP and VDDCP over time (p < 0.001) no significant differences were found between the peeling and no peeling group. Conversely, FTMHs closure was achieved in all cases (100%) in the peeling group, whereas 10% of cases in the no peeling group experienced the hole re-opening at T3, with reported different rates of ELM/EZ recover between the two groups. Nevertheless, BCVA improved significantly (p < 0.001) but without significant differences between the two groups. Conclusions: No significant differences were found in terms of anatomical and functional outcomes between the peeling or not the ILM in small FTMHs at 6 months follow-up. [ABSTRACT FROM AUTHOR]

Melasma is a chronic, relapsing hyperpigmentation disorder that primarily affects photoexposed areas, occurring most frequently in adult women with darker skin phototypes. The primary factors contributing to its development include sun exposure, sex hormones (e.g., pregnancy), and genetic predisposition. Melasma is highly prevalent in Latin America, where many countries lie in intertropical zones and exhibit significant ethnic diversity because of centuries of intermixing among Native Americans, Europeans, and Sub‐Saharan Africans. Nine Latin American experts formulated a DELPHI‐based consensus to develop a valuable approach for treating melasma in this diverse population. After establishing an accurate diagnosis, assessing the impact on quality of life, and determining disease severity, the consensus recommends mitigating known triggers and promoting rigorous photoprotection. Active therapy should be tailored based on individual characteristics (e.g., pregnancy status, previous treatments, skin sensitivity). Treatment options include topical depigmenting agents, systemic therapies, and procedural interventions such as laser therapy, microneedling, and chemical peels. Periodic reassessment of the treatment is essential, with strategies adjusted if targeted outcomes are not achieved. Once clinical remission is attained, patients should continue using topical depigmenting agents and maintain strict photoprotection measures to prevent recurrence. [ABSTRACT FROM AUTHOR]

ABSTRACT Background Methods Results Conclusions Melasma is a chronic condition characterized by dark patches on the facial skin. It has a known female gender dominancy, and women usually think of melasma as being a serious cosmetic problem. Treatment of melasma can be seriously challenging, thus, dermatologists may employ different approaches for melasma. This study aimed to investigate how dermatologists diagnose and treat patients with melasma and to present the general characteristics of patients with melasma.A survey was conducted using Google Forms targeting dermatologists in Turkiye. A total of 199 dermatologists (142 females/57 males) participated in the study.Most of the participants (52.3%) were residents. Majority gender of the patients was female and most common age range of patients with melasma was 30–40 years. Mixed melasma was the most common type (57.4%). Malar region was the most frequent location (58.6%). Wood's lamp examination was used by 25.6% of the participants. Topical treatment was the first‐line choice for melasma therapy (95%), with Kligman's formula being the most used topical agent (69.8%). Oral therapy was not used by 70.8% of the participants. Tranexamic acid was the first choice for oral treatment (23.4%). Only 24.9% of the dermatologists used laser/light therapy, and Q‐switched Nd‐YAG laser was the most preferred device (58%). The most common recurrence rate was 41%–60% (45.9%).The findings of the current study investigating the melasma management in Turkiye revealed a female predominance and peak prevalence in the 30–40 years age group. Kligman's formula is the preferred topical treatment, whereas oral tranexamic acid remains underutilized. Recurrence rates are high, highlighting the need for preventative strategies. This study emphasizes the importance of personalized approaches and ongoing research for effective melasma management. [ABSTRACT FROM AUTHOR]

Hydrogen (H₂) has great potential in the treatment of osteoarthritis, but its rapid diffusion and short retention time make it difficult to exert stable therapeutic effects. This study developed a short-fiber injectable material that can continuously generate hydrogen in situ to eliminate reactive oxygen species (ROS), alleviate oxidative stress and inflammation, and promote tissue repair. We prepared H–Si nanosheets with high hydrogen generation efficiency using a wet chemical exfoliation method and combined them with GelMA short fibers via electrospinning technology, achieving the in situ delivery of H–Si nanosheets and regulated hydrogen generation rate through the encapsulation and degradation of GelMA, ultimately achieving continuous and controlled hydrogen supply and stable therapeutic effects for osteoarthritis. In vitro and in vivo experiments confirmed the safety and efficacy of this material. The results showed that the material could continuously and efficiently generate hydrogen in simulated physiological environments (100 mg of material could generate 8.6 % hydrogen), effectively eliminate cellular reactive oxygen species (ROS positive rate reduced by 85.89 %), reduce cellular senescence and apoptosis (cell death rate decreased by 52 %, SA-βgal expression decreased by 78.3 %), promote normal chondrocyte function (Col II expression increased by 67.4 %, Ki67 expression increased by 87.5 %), and improve osteoarthritis in rats (OARSI score increased by 216 %). The in situ hydrogen generation and control system designed in this study provides a new method for the hydrogen's local and stable treatment of osteoarthritis. Hydrogen (H₂) has great potential in the treatment of osteoarthritis by alleviating oxidative stress, but its rapid diffusion and short retention time make it difficult to exert stable therapeutic effects. This study introduces an innovative injectable material combining H–Si nanosheets and GelMA short fibers to address this issue. By enabling continuous in situ hydrogen generation, this material effectively eliminates reactive oxygen species, reduces oxidative stress and inflammation, and promotes tissue repair. In vitro and in vivo experiments demonstrate its high hydrogen generation efficiency, safety, and therapeutic efficacy, offering a promising new approach for osteoarthritis management. [Display omitted] [ABSTRACT FROM AUTHOR]

Thailand is a prominent global producer of mangoes, providing a wide range of mango cultivars and dealing with the challenge of managing biomass. Thus, biorefining mango peel to extract valuable components has the potential to reduce organic waste and create a new revenue source for the mango processing sector. This study aims to examine the physiology, physiochemical, and chemical characteristics in peel of nine Thai mango cultivars, along with the relationship between their characteristics. The Thai mango cultivars Mahachanok, Chok anan, and Rad exhibited a yellow appearance, while the other six cultivars appeared yellow-green. However, the firmness of the fruit was directly correlated with the firmness of the pulp. A proximate composition study revealed that the predominant constituent of mango peel was carbohydrates, comprising up to 75% of its composition. This was followed by fibre, which accounted for up to 13%. The Nga mango had the highest levels of total phenolic content (220 mgGAE/g) and total flavonoid content (5.5 mgCE/g). The primary phenolic acids identified in Thai mango peel were epicatechin, caffeic acid, catechin, and gallic acid. The Mahachanok cultivar exhibited the highest antioxidant activity, as determined by the ABTS and DPPH assays, with values of 85.67% and 85.78%, respectively. This study demonstrated the connections between the physiochemical characteristics of mangoes and their chemical compositions in different cultivars, indicating the possibility of choosing particular cultivars for extracting targeted bioactive compounds. The multivariate analyses revealed that there was no correlation between the physiochemical and chemical profiles of mangoes. This study highlights the significance of mango peel as a valuable by-product that has significant environmental and economic ramifications for the mango processing industry. [ABSTRACT FROM AUTHOR]

With increasing age and edentulism, numerous esthetic changes occur to the perioral region. The upper lips lose definition, flatten, and lengthen, the cupid's bow is lost, and the oral commissures descend. The nasolabial folds deepen, marionette lines become prominent, vertical rhytids around the lips form, and chin rhytids form. Chronic exposure to UVA radiation from the sun can lead to photodamage, characterized by wrinkles, lentigines, actinic keratoses, and other pigment changes. In addition, edentulism leads tojaw atrophy, which often compromises soft tissue support. Removable dentures, the conventional treatment to restore missing teeth, not only replace teeth, but also provide support to the lips via the labial flange. Implant-supported Axed prostheses are a very popular option to restore completely edentulous arches; these prostheses are flangeless, providing no bulk to the lips. Addressing changes in the perioral region due to aging and edentulism requires a combination of treatments, with each addressing different issues. Onabotulinum toxin A can be used to treat dynamic perioral and chin rhytids, and upturn the corners of the mouth. Hyaluronic acid filler can be used to treat deep nasolabial folds, marionette lines, and re-volumize the lips. Chemical peels can treat photodamaged skin, static rhytids, and other dermatologic pathologies. The subnasal lip lift, developed by Cardoso and Sperli in 1971, has become an increasingly common technique used to rejuvenate the upper lip in elderly and edentulous patients. This case report describes an elderly patient who was treated with a combination of subnasal lip lift, hyaluronic acid filler, onabotulinum toxin A, and chemical peel to achieve superior perioral esthetics. This case highlights the synergy of each procedure when done in combination to achieve highly effective results. [ABSTRACT FROM AUTHOR]

It is established that 2D magnetic materials are the ideal platform for building up modern-day electronic and spintronic devices. The popular ways to achieve 2D magnetic materials are mechanical exfoliation and chemical vapor deposition. However, the direct chemical synthesis route of such magnetic 2D materials on a large scale is relatively unexplored. This article reports an easy and cost-effective facile chemical synthesis with a proper capping agent and magnetic study of free-standing 2D Cr2S3 nanosheets and Cr2S3 nanoparticles within the temperature range of 2–300 K under the magnetic field of up to 5 T. Although few magnetic results on 2D Cr2S3 are available in the literature, there is enough scope to work for an in-depth understanding of the magnetic aspects of this 2D material. Here, ferrimagnetic ordering with a sufficiently high coercivity of up to 0.139 T at 2 K along with a tendency to the saturation in magnetization down to a certain temperature limit is observed. Contrary to the strong antiferromagnetic coupling with a Néel temperature, as observed by previous researchers, is also observed for this chemically synthesized 2D Cr2S3 nanosheets. A transition temperature of 117 K is observed for the Cr2S3 nanosheets, whereas for Cr2S3 nanoparticles, a transition temperature of 101.7 K is observed with negligible coercivity. This facile synthesis technique may be applied to achieve other non-van der Waals type 2D magnetic materials. These kinds of non-van der Waals type 2D magnets will be useful to modern-day spintronic devices. [ABSTRACT FROM AUTHOR]

Hyperpigmentation is a skin disorder characterized by excessive production of melanin in the skin and includes dyschromias such as post-inflammatory hyperchromias, lentigens, melasma and chloasma. Topical products containing depigmenting agents offer a less aggressive treatment option for hyperpigmentation compared to methods like chemical peels and laser sessions. However, some of these agents can cause side effects such as redness and skin irritation. Encapsulating these actives in nanosystems shows promise in mitigating these effects and improving product safety and efficacy. In addition, nanocarriers have the ability to penetrate the skin, potentially allowing for targeted delivery of actives to the affected areas. The most commonly investigated nanosystems are nanoemulsions, vesicular nanosystems and nanoparticles, in which different materials can be used to generate different compositions in order to improve the properties of these nanocarriers. Nanocarriers have already been widely explored, but it is necessary to understand the evolution of these technologies when applied to the treatment of skin hyperchromias. Therefore, this literature review aims to present the state of the art over the last 15 years on the use of nanosystems as a potential strategy for encapsulating depigmenting actives for potential application in cosmetic products for skin hyperchromia. By providing a comprehensive overview of the latest research findings and technological advances, this article can contribute to improving the care and quality of life of people affected by this skin condition. [ABSTRACT FROM AUTHOR]

Peeling is an essential unit operation before further processing of cassava. This study presents functional and proximate composition of gari and HQCF as affected by peeling methods and cassava cultivars. An abrasive peeling machine with dual function of mechanical and mild chemical peeling of cassava roots by recycling of fruit water was developed. The peeling machine utilizes abrasive peeling surface inscribed with indented 0.12 cm stainless steel of 77 cm height with 245 cm diameter, a stainless steel based cavity, fruit water recovery tank, water pump and the transmission system. The fruit water was used to soak the cassava tubers before peeling with the machine for 60 minutes. Peeling of cassava by hands were used as control for this study. Improved cassava varieties: TMS 30572 and TME 419 were used. High quality cassava flour (HQCF) and gari produced from the varieties with three different peeling methods: manual, mechanical and mechanical/chemical (hybrid), were analyzed. The moisture content (MC), crude fat (CFT), crude protein (CP), ash, carbohydrate, cyanide content (CC), pH, packed bulk density (PBD), oil absorption capacity (OAC), least gelation concentration (LGC), water absorption capacity (WAC), swelling power (SP) and solubility from proximate composition and functional properties of HQCF for TME 419 were 11.00%, 0.00%, 0.35%, 0.0%, 0.20%, 88.45%, 1.98 mg kg-1, 5.50, 0.64 g ml-1, 144%, 6.67%, 147.5%, 887.05%, and 6.28%, respectively while values for TMS 30572 were 10.8%, 0.0%, 0.24%, 0.0%, 0.10%, 88.86%, 2.04 mg kg-1, 5.96, 0.61 g mL -1, 125%, 4.00%, 152.5%, 854.38%, and 6.00%. The MC, CP, CFT, CF, ash, carbohydrate, CC, pH, PBD, WAC, SP and solubility from proximate composition and functional properties of the gari produced for TME 419 were 6.51%, 1.42%, 0.31%, 2.21%, 0.80%, 88.75%, 2.92 mg kg-1, 4.82, 0.56 g ml-1, 320.21%, 830.55% and 6.25%, respectively, while that of TMS 30572 were 7.00%, 1.52%, 0.42%, 2.33%, 0.71%, 88.02%, 3.14 mg kg-1, 4.35, 0.675 g mL -1, 430.39%, 860.38% and 6.50% across the peeling methods. HQCF and gari had proximate and functional properties that compared favourably with those of manual peeling of cassava for the products. The functional properties were well improved by the hybrid and mechanical peeling methods. [ABSTRACT FROM AUTHOR]

The study aimed to demonstrate the nutritional value of banana peels. The analysis of the chemical composition of banana peels showed that the percentage of moisture, fat, protein, ash, and carbohydrates reached 3.97, 2.90, 7.23, 9.07, and 76.83%, respectively. The total phenols in the ethanolic and methanolic extracts were 240.58 and 212.4 mg GAE/100 g, respectively, with an IC50 value of 2.39 μg/ml for banana peels. HPLC analysis revealed gallic acid, Rutin, Ferulic acid, Apigenin, Catechine, and Qurcetine in banana peels. They also contain vitamins (C, A, E, B6) and minerals (Na, P, Ca, Cu, Mg, K). Replacing cookies with different proportions of banana peels showed a change in the chemical estimates of its components. The percentages of moisture, fat, protein, ash, and carbohydrates ranged between (5.42 - 8.21) %, (23.62 - 23.87) %, (9.35 - 15.99) %, (4.39 - 5.90) %, and (50.33 -52.92) %, respectively. The substitution's effect on the cookie product's physical properties was (diameter 4.26-4.33 cm, thickness 1.45-1.62 cm, diffusion ratio 2.65-2.67). The antioxidant properties also increased significantly, as the total phenolic content ranged between 16.14−21.65 mg GAE/100 g, and the antioxidant activity ranged between 53.80−73.71% in the cookie product to which different concentrations of banana peel powder were added. Sensory evaluation of cookies with 5 and 7.5% banana peel powder revealed positive qualities. [ABSTRACT FROM AUTHOR]

Background: There is controversy on the efficacy and safety of chemical peels used to treat Hispanic women with melasma. Studies evaluating superficial peels for melasma are limited due to lack of controls, blinding or objective assessment tools, poor inclusion of darker phototypes, and small sample number. Objectives: We sought to evaluate the safety and efficacy of trichloroacetic acid (TCA) peels when added to hydroquinone and tretinoin in the treatment of melasma in Hispanic women. Methods: A single blinded, prospective, split-face trial of superficial TCA peels was performed on Hispanic women with melasma. Topical hydroquinone and tretinoin were used on both sides. A total of four monthly peels were performed on one side. The relative reduction of melasma severity was evaluated using narrowband reflectance spectrophotometry (NRS), Modified Melasma Area and Severity Index (mMASI), and Global Melasma Severity Assessment (GMSA). Adverse events were monitored. Results: Thirty-three patients completed the study. Pigment intensity was reduced on both sides based on all measures. A greater improvement of mMASI and GMSA was achieved on the peeled side. Limitations: Limitations include the single-center study design with one blinded investigator. Conclusion: Based on our results, TCA peels appear to be safe and effective in augmenting treatment response on melasma patients with phototypes III and IV treated with hydroquinone and tretinoin. [ABSTRACT FROM AUTHOR]

Acne scarring results from a common inflammatory condition present in many people. These scars can have an impact on quality of life by influencing self-esteem and social acceptance. Current acne scarring treatments, such as chemical peels and laser treatments, often have limited success due to their time-consuming nature and the variability of acne scar types. The subcision technique has shown promise for the treatment of rolling acne scars. There are few studies to date that examine the effects of multiple subcision treatments on rolling acne scars. We evaluated whether the use of multiple subcision treatments improved the appearance of rolling acne scars compared to no treatment. Five patients with rolling acne scars on both sides of their face who met inclusion and exclusion criteria were enrolled in the study. One side of the face was randomized to receive treatment, while the contralateral side of the face received no treatment. Subjects underwent five sequential subcision treatments, spaced 4 weeks apart, with two follow-up visits at weeks 20 and 36 from the 1st treatment. Photographs were taken before and after the initial treatment visit and at each subsequent visit. Acne scar appearance was evaluated by the subject, a blinded live rater, and two double-blinded dermatologist raters. Evaluations of treatment outcomes involved overall acne scar appearance on a 5-point scale, acne scar improvement on a percentage scale, a modified quantitative global scarring grading system, and potential treatment side effects. There was a greater decrease in global scarring scores in the multiple subcision side compared to the control side. There was a greater difference in the average acne scar appearance scores between the Week 36 follow-up visit and baseline for the multiple subcision side compared to that of the control side. 50% of patients reported being more satisfied with the treatment side compared to the control side in regard to overall improvement. The study results suggest that multiple subcision treatments may improve the appearance of rolling acne scars compared to no treatment. [ABSTRACT FROM AUTHOR]

Background: Chemical exfoliation of the skin is a frequently utilized treatment in dermatology to improve the appearance and health of photoaged skin. Photodamaged skin is especially prone to dryness and irritation. Over‐exfoliation with at‐home products are partially to blame for the "epidemic" of sensitive skin affecting over half the population. Combining AHA, BHA, and PHA together creates a complementary blend that has the potential to target numerous age‐related changes in the skin including the appearance of pores and smoothing skin texture, while firming skin and increasing its collagen and moisture content. Objectives: The following study tested the clinical efficacy of a triple acid blend designed specifically for sensitive skin and measured improvements in signs of photodamage and hydration levels in the skin over time. Methods: Thirty females aged 35–60 with mild to moderate facial lines, wrinkles, sun damage, uneven skin tone/texture, dark spots, or pores were enrolled. Subjects were instructed to use the test article, DWB‐EN, on a clean face at night 3 times weekly with 48 h between applications for 4 weeks. Results: Statistically significant improvements were noted in all parameters of photoaging clinical assessments (wrinkles, pores, overall appearance, luminosity, visible texture, skin tone evenness, hyperpigmentation) at the end of the 4‐week study period. There were no instances of skin irritation throughout the duration of this study despite half of the women having sensitive skin. Conclusions: Overall, this study demonstrated the clinical efficacy and tolerability of DWB‐EN for treating photoaging in subjects with all skin types. [ABSTRACT FROM AUTHOR]

The traditional alkaline peeling method generates high‐salinity wastewater, posing significant environmental risks. To avoid water waste and chemical use, a dry method using high‐temperature thermal radiation was explored for removing walnut skins. The mechanism of the high‐temperature thermal radiation dry method for removing walnut skins was revealed by studying the physical properties of walnut kernels. Research on the performance of the peeling device identified the optimal parameters: an infrared emitter surface temperature of 600°C, a radiation time of 20.7 seconds, and a distance of 129.46 mm between emitters, achieving a 95.18% skin removal rate with only 0.8% moisture loss and a quality score of 96.82. Raman spectroscopy showed that this method increased the unsaturated fatty acid content of walnut kernels by 27.26%, greatly enhancing their quality. SEM analysis revealed different microstructural changes between skins removed by infrared and alkaline methods, revealing the differences in their peeling mechanisms. These findings provide a scientific foundation for developing thermal radiation dry peeling technology and devices. Practical applications: The removal of walnut skins is an essential process for enhancing the added value of products. However, current industrial peeling methods such as hot alkaline peeling and steam peeling are water and energy‐intensive industries, generating large amounts of wastewater that negatively impact the environment. There is an urgent need to develop an efficient, green, and environmentally friendly dry peeling technology for walnut kernels in the food industry to replace traditional chemical peeling methods. The high‐temperature thermal radiation dry peeling technology provides a new approach that avoids the use of water and chemical reagents while maintaining high product quality after peeling. Research focuses on the theoretical study and several key points of dry peeling technology for achieving walnut kernel peeling. The research results provide scientific basis for the replacement of traditional alkaline peeling with high‐temperature thermal radiation dry peeling technology and offer theoretical support and reference for the development and optimization of related equipment. [ABSTRACT FROM AUTHOR]

Light penetration depth, as a characteristic parameter reflecting light attenuation and transmission in biological tissues, has been applied in nondestructive detection of fruits and vegetables. Recently, with emergence of new optical detection technologies, researchers have begun to explore methods evaluating optical properties of double-layer or even multilayer fruit and vegetable tissues due to the differences between peel and pulp in the chemical composition and physical properties, which has gradually promoted studies on light penetration depth. A series of demonstrated research on light penetration depth could ensure the accuracy of the optical information obtained from each layer of tissue, which is beneficial to enhance detection accuracy for quality assessment of fruits and vegetables. Therefore, the aim of this review is to give detailed outlines about the theory and principle of light penetration depth based on several emerging optical detection technologies and to focus primarily on its applications in the field of quality evaluation of fruits and vegetables, its future applicability in fruits and vegetables and the challenges it may face in the future. [ABSTRACT FROM AUTHOR]

Objective evidence for the effectiveness of sole carboxytherapy and carboxytherapy combined with acids in the reduction of dark circles, in particular vascular circles in the tear trough. Lactobionic acid, ferulic acid, and ascorbic acid can be used as safe supplements to enhance carboxytherapy. [ABSTRACT FROM AUTHOR]

Manganese oxide (MnOx) on the surface of the filter material can be used to effectively remove ammonium (NH4+) and manganese ions (Mn2+) from water, but overgrow oxide film gradually shortens backwashing interval after several years of long-term filtration system operation. Different influent pollutant loading result in different durations for chemical peeling film. A growth kinetics model for MnOx was established by adjusting the different initial concentrations of Mn2+ in the influent, which provided a theoretical basis for determining a specific time point for film peeling and recovered the shortened backwashing intervals in the filter columns. The variation in film thickness demonstrated a linear dependence on time, confirming the high accuracy of the kinetics model for film growth. The pseudo-first-order kinetic model better fits among adsorption and oxidation kinetic models of Mn2+. Hydrogen peroxide (H2O2) was identified as an effective agent in the chemical peeling film process. Hydroxyl radicals, generated by H2O2, destroy coordination bonds, producing extremely low solubility (≡MnO2), which was then removed during the backwashing process. [ABSTRACT FROM AUTHOR]

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Background and aim: The use of cosmetics among Iranian teenagers and youths has increased more than ever before. This study investigated the predisposing factors of cosmetic use in female students of Ardabil University of Medical Sciences by using the prototype willingness model (PWM). Methods: This cross-sectional study was conducted with 384 students, selected based on multistage sampling. Data were collected using a two-part questionnaire that included demographic variables and PWM questions. Then multiple regression analysis was used in SPSS (version 20). Results: There was a significant difference in the frequency of daily cosmetic use based on the education levels (F = 3.845, p-value = 0.034). The average daily use of cosmetics was higher in students whose use of cosmetics was high in their family (p = 0.024) and friends (p-value = 0.023). Prototypes were the strongest predictor of using cosmetics (OR = 1.317, p-value <0.001), followed by attitude (OR = 1.241, p-value <0.001). Conclusion: Prototypes (social imagination) and attitudes were the main predictors of using cosmetics among female students. To be effective in targeting cosmetic use, interventions must target both social and individual paths. [ABSTRACT FROM AUTHOR]

Effective transmission of stress between fillers and the host matrix is instrumental in enhancing the properties of nanocomposites and optimizing filler reinforcement. This study delves into understanding stress transfer in materials, exploring the impact of synthesis methods and matrix materials through a comprehensive examination of a bilayer graphene (BLG)‐polydimethylsiloxane (PDMS) nanocomposite. BLG was synthesized via chemical exfoliation and subjected to various strain conditions within a PDMS matrix. A precisely controlled strain, ranging from 0% to 0.19%, was applied using a meticulous 4‐point bending method, monitored with a standard strain gauge. The study unveiled significant shifts in the Raman spectra's 2D band, indicating a direct linear relationship with applied strain. Utilizing contour mapping techniques on well‐defined Raman spectra and stress‐induced band shifts, we mapped strain distribution within the BLG layer. The results revealed a gradual increase in strain from the lower to the upper end of the BLG structure, resembling strain behaviors observed in differently shaped fibers. These compelling findings advance our understanding of strain dynamics within BLG‐PDMS nanocomposites, highlighting the crucial role of strain mapping methodologies in scrutinizing the material's structural response to deformation. Highlights: The study reports successful synthesis of high‐quality bilayer graphene (BLG) using a chemical exfoliation method, as evidenced by the sharp 2D and G Raman peaks.Significant shifts in 2D band exhibited linear correlation between applied strain; observed within precise strain levels of 0% to 0.19%.Contour maps revealed a gradual increase in strain from the lower to the upper end of the BLG structure, akin to strain behaviors observed in differently shaped fibers. [ABSTRACT FROM AUTHOR]

Integrated skincare combines clinically proven skincare products with professional medical aesthetics to provide a comprehensive solution for beauty pursuers. Studies have demonstrated that a combination of medical aesthetic procedures and maintenance therapies is more effective than either treatment alone. This review outlines the current applications of integrated skincare, including different regimens of energy‐based aesthetic devices and active ingredients in cosmeceuticals or chemical peels. Additionally, the benefits and limitations of integrated skincare are discussed. Lastly, this review highlights the potential for improved satisfaction and long‐term maintenance of the desired outcomes through appropriate integrated skincare procedures. [ABSTRACT FROM AUTHOR]

Anti‐aging trends in Australia have changed considerably since the country emerged from the lockdowns associated with the SARS‐Cov2 pandemic. People now rely on social media influencers for skin care advice and skin care products, including professional skin care treatments that can be purchased on Internet platforms. The quest for the perfect 'zoom face' led to a 300% rise in cosmetic procedures across Australia in the year to April 2021. People now want to use less products on their skin, while looking healthy and natural (termed 'skin minimalism'). The popularity of retinoid derivatives for preventing wrinkles has been superseded by non‐irritating actives like hyaluronic acid (HA) and niacinamide that provide skin barrier protection, skin hydration, plumping and anti‐inflammatory effects. Botulinum toxin injections remain the most popular non‐surgical cosmetic procedure, followed by HA fillers, and biostimulators that promote the synthesis of collagen and give longer lasting but more gradual results than HA fillers. Laser resurfacing is widely used for epidermal resurfacing and skin tightening, as well as non‐ablative lasers, intense pulsed light and radiofrequency or ultrasound skin tightening devices. Superficial chemical peels are still popular because they are relatively gentle, inexpensive, and require no downtime, whereas medium‐to‐deep chemical peels have largely been superseded by laser technology. However, the most efficient approach to prevent skin aging is adopting a healthy lifestyle and taking action against all factors of the skin aging exposome. [ABSTRACT FROM AUTHOR]

This document provides information on the use of chemical peels for rejuvenating the eyelids and face. It discusses the benefits of deep peels with phenol and croton oil, including the elimination of skin issues such as dyschromias, sun damage, and pigmentation. The document emphasizes the importance of proper training and expertise in administering these peels and provides guidelines for selecting ideal candidates and proper pre and post-care. It also discusses different methods of chemical peels, including the dry method and the use of retinoic acid peels, and mentions anesthesia choices and potential complications. [Extracted from the article]

Purpose: To evaluate the outcomes of macular hole (MH) surgery as a historical perspective after its inception in 1991. Patients and Methods: Retrospective review of 1032 eyes of 949 patients with an idiopathic MH who were followed for at least one year after the initial surgery. All surgeries were performed from 1990 to 2016 by one surgeon (NO) and included phacovitrectomy for patients of ≥ 40-years-of-age, a removal of the posterior hyaloid and epiretinal membrane, and SF6 gas tamponade with a 1-week face-down. After 1998, internal limiting membrane (ILM) peeling became the conventional procedure. All surgeries were classified into four periods based on the year of the initial surgery. The first period was 1990~1995 (n = 222), the second period was 1996~1999 (n=327), the third period was 2000~2004 (n = 234), and the last period was 2005~2016 (n=249). Results: The mean follow-up period was 81.3, 79.8, 88.4, and 77.3 months; hole size was 0.33, 0.28, 0.25, and 0.24 disk diameter; hole duration was 15.1, 10.6, 8.2, and 6.1 months; the decimal visual acuity (VA) was 0.13, 0.15, 0.17, and 0.19. The initial closure rate was 61.3, 78.0, 96.6, and 96.4%. The final decimal visual acuity was 0.33, 0.50, 0.66, and 0.79. The rate of a final decimal VA of 0.5 or better was 48.2, 66.4, 82.1, and 88.8%. The rate of a final decimal visual acuity of 1.0 or more was 17.6, 29.3, 43.6, and 58.2%. Multiple regression analyses showed that hole duration and ILM peeling were significantly associated with both the anatomic and functional outcomes. Conclusion: The favorable outcomes of MH surgery was primarily achieved by earlier surgery and conventional ILM peeling. Favorable results might be obtained using only conventional ILM peeling. [ABSTRACT FROM AUTHOR]

Supplemental Digital Content is Available in the Text. BACKGROUND: Melasma is a common chronic, relapsing pigmentary disorder that causes psychological impact. Chemical peels are a well-known therapeutic modality used for accelerating the treatment of melasma. OBJECTIVE: To review the published evidence on the efficacy and safety of chemical peels in the treatment of melasma. METHODS: A systematic review was done. A meta-analysis could not be done due to the heterogeneity of data. RESULT: The authors conducted a PubMed search and included prospective case series of more than 10 cases and randomized controlled trials (RCTs) that have studied the safety and/or efficacy of chemical peel in melasma. Out of 24 studies, 9 were clinical/comparative trials and 15 were RCTs. The total sample size was 1,075. The duration of the study varied from 8 to 36 weeks. Only 8 studies were split face. All studies used self-assessment, physician global assessment, and Melasma Area and Severity Index (MASI) for quantifying the results. Glycolic acid was found to be the most safe and effective in melasma. CONCLUSION: Chemical peels were found to be safe and effective in the management of melasma. [ABSTRACT FROM AUTHOR]

Background: Tetrahexydecyl ascorbate (THDA) is a lipophilic precursor to ascorbic acid that may be stabilized by acetyl zingerone (AZ). Studies have shown that the topical application of THDA may have photoprotective effects. Similarly, AZ has been shown to mitigate oxidative and inflammatory stress, thereby improving the appearance of photoaging. Aims: To examine the effects of THDA and AZ (THDA‐AZ) on skin photoaging compared to THDA alone. Patients/Methods: In this double‐blind, randomized controlled trial, healthy individuals aged 30 to 65 were included and 44 participants were randomized to receive either THDA‐AZ (THDA 5% + AZ 1%) or THDA only (THDA 5%) for 8 weeks. Facial photographs were taken at 0, 4, and 8 weeks to analyze wrinkle severity, pigment intensity, and redness intensity. A skin colorimeter was used to assess infraorbital pigmentation and erythema. Self‐perception of skin and tolerability were assessed through questionnaires. Results: Average wrinkle severity was significantly decreased in the THDA‐AZ group at Weeks 4 and 8 by 0.75% (p = 0.023) and 3.72% (p = 0.048), respectively, compared to the THDA group where wrinkle severity at Weeks 4 and 8 was increased by 7.88% and 4.48%, respectively. Facial pigment intensity was significantly decreased in the THDA‐AZ group by 4.10% (p = 0.0002) at Week 8 compared to a 0.69% decrease in the THDA group. Facial redness intensity was decreased in the THDA‐AZ group at Weeks 4 and 8 by 3.73% (p = 0.0162) and 14.25% (p = 0.045), respectively, compared to the THDA group where at Weeks 4 and 8 erythema increased by 27.5% and 8.34%, respectively. There were no significant differences in either group for infraorbital pigmentation or erythema. Conclusions: Daily use of combined THDA and AZ may improve facial wrinkle severity, pigment intensity, and erythema to a greater extent than THDA. While THDA alone increases facial wrinkle severity and erythema, the addition of AZ reduces both. [ABSTRACT FROM AUTHOR]

The article discusses a new approach to treating static nose "bunny lines" using a super-localized phenol-croton peel. Bunny lines are wrinkles on the nose caused by muscle contractions. While botulinum toxin has been commonly used to target these muscles, it may not effectively treat deep, static lines. Phenol-croton peels, which have been considered a gold standard treatment for skin rejuvenation, can be used to treat these wrinkles. The article describes the procedure and presents a case report showing successful outcomes. However, further studies are needed to evaluate the safety and complication rates of this technique. [Extracted from the article]

Two-dimensional (2D) materials have recently drawn interest in various applications due to their superior electronic properties, high specific surface area, and surface activity. However, studies on the catalytic properties of the 2D counterpart of V2O5 are scarce. In the present study, the catalytic properties of 2D V2O5 vis-à-vis bulk V2O5 for the degradation of methylene blue dye are discussed for the first time. The 2D V2O5 catalyst was synthesized using a modified chemical exfoliation technique. A massive increase in the electrochemically active surface area of 2D V2O5 by one order of magnitude greater than that of bulk V2O5 was observed in this study. Simultaneously, ~ 7 times increase in the optical absorption coefficient of 2D V2O5 significantly increases the number of photogenerated electrons involved in the catalytic performance. In addition, the surface activity of the 2D V2O5 catalyst is enhanced by generating surface oxygen vacancy defects. In the current study, we have achieved ~ 99% degradation of 16 ppm dye using the 2D V2O5 nanosheet catalysts under UV light exposure with a remarkable degradation rate constant of 2.31 min−1, which is an increase of the order of 102 from previous studies using V2O5 nanostructures and nanocomposites as catalysts. Since the enhanced photocatalytic activity emerged from the surface and optical properties of the catalyst, the current study shows great promise for the future application of 2D V2O5 in photo- and electrocatalysis. [ABSTRACT FROM AUTHOR]

The adjustable structures and remarkable physicochemical properties of 2D monoelemental materials, such as silicene and germanene, have attracted significant attention in recent years. They can be transformed into silicane (SiH) and germanane (GeH) through covalent functionalization via hydrogen atom termination. However, synthesizing these materials with a scalable and low‐cost fabrication process to achieve high‐quality 2D SiH and GeH poses challenges. Herein, groundbreaking 2D SiH and GeH materials with varying compositions, specifically Si0.25Ge0.75H, Si0.50Ge0.50H, and Si0.75Ge0.25H, are prepared through a simple and efficient chemical exfoliation of their Zintl phases. These 2D materials offer significant advantages, including their large surface area, high mechanical flexibility, rapid electron mobility, and defect‐rich loose‐layered structures. Among these compositions, the Si0.50Ge0.50H electrode demonstrates the highest discharge capacity, reaching up to 1059 mAh g−1 after 60 cycles at a current density of 75 mA g−1. A comprehensive ex‐situ electrochemical analysis is conducted to investigate the reaction mechanisms of lithiation/delithiation in Si0.50Ge0.50H. Subsequently, an initial assessment of the c‐Li15(SixGe1‐x)4 phase after lithiation and the a‐Si0.50Ge0.50 phase after delithiation is presented. Hence, this study contributes crucial insights into the (de)lithiation reaction mechanisms within germanane‐silicane alloys. Such understanding is pivotal for mastering promising materials that amalgamate the finest properties of silicon and germanium. [ABSTRACT FROM AUTHOR]

Key point Background Methods Results Conclusion The 1064‐nm picosecond laser with holographic optics demonstrated significant efficacy in treating atrophic acne scars.Picosecond lasers with fractionated optics have enabled the development of a breakthrough skin rejuvenation method. The authors compared the fractionated, non‐ablative neodymium‐doped yttrium aluminum garnet 1064‐nm picosecond laser with holographic optics and the fractional CO2 laser in treating atrophic acne scars.One side of each patient's face was randomly allocated and treated with three sessions of the 1064‐nm picosecond laser with holographic optics at 2‐month intervals. In contrast, the other side was treated with the fractional CO2 laser. Participants were followed up 3 months after the final session. The primary outcome included the physicians' evaluation using the ECCA grading scale and a four‐point scale to assess improvement. The patients' assessment of progress, their overall satisfaction and preferences, and the side effects were also evaluated.No significant difference was observed between the two lasers in terms of the mean ECCA scores after treatments (P = 0.209). The physicians' improvement assessment was more significant for the fractional CO2 laser (P = 0.001). The patients' evaluation of improvement and subjective satisfaction were consistent with physicians' four‐point scale results. The picosecond laser side had fewer adverse effects (P < 0.001).The fractionated, non‐ablative Nd: YAG 1064‐nm picosecond laser with holographic optics and the fractional CO2 laser were effective and safe in treating atrophic acne scars. Significantly better clinical outcomes were observed with the fractional CO2 laser, whereas fewer adverse effects were noted with the 1064‐nm picosecond laser with holographic optics. [ABSTRACT FROM AUTHOR]

Macular holes (MHs), including atraumatic idiopathic and refractory MHs, affect central vision acuity due to full-thickness defects in the retinal tissue. The existing controversy regarding the pathophysiology and management of MHs has significantly improved with the implementation of internal limiting membrane (ILM) surgical techniques and improved MH closure rates. Thus, to determine the effect of ILM techniques on large idiopathic and refractory MH management, the present study systematically reviewed 5910 original research articles extracted from online literature databases, including PubMed, Cochrane, Google Scholar, and Embase, following the PRISMA guidelines. The primary outcome measures were MH closure rate and postoperative visual acuity. A total of 23 randomized controlled trials (RCTs) with adequate patient information and information on the effect of ILM peeling, inverted ILM flaps, autologous retinal transplantation (ART), and ILM insertion techniques on large idiopathic and refractory MH patients were retrieved and analyzed using RevMan software (version 5.3) provided by the Cochrane Collaboration. Statistical risk of bias analysis was also conducted on the selected sources using RoB2, which showed a low risk of bias in the included studies. A meta-analysis indicated that the inverted ILM flap technique had a significantly greater MH closure rate for primary MH than the other treatment methods (OR = 3. 22, 95% CI 1.34–7.43; p = 0.01). Furthermore, the findings showed that the inverted ILM flap group had significantly better postoperative visual acuity than did the other treatment options for patients with idiopathic MH (WMD = − 0.13; 95% CI = 0.22–0.09; p = 0.0002). The ILM peeling technique had the second highest statistical significance for MH closure rates in patients with idiopathic MH (OR = 2. 72, 95% CI: 1.26–6.32; p = 0.016). In refractory MHs, autologous retinal transplant (ART) and multilayer ILM plug (MIP) techniques improve the closure rate and visual function; human amniotic membrane grafting (hAMG) provides a high degree of anatomical outcomes but disappointing visual results. This study demonstrated the reliability and effectiveness of ILM techniques in improving the functional and anatomical outcomes of large idiopathic and refractory MH surgery. These findings will help clinicians choose the appropriate treatment technique for patients with idiopathic and refractory MH. [ABSTRACT FROM AUTHOR]