Search

Copyright of Revista Catalana de Dret Públic is the property of Revista Catalana de Dret Public and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

1. Improving resistance against disease is important in the animal and poultry industry. Besides drugs and vaccines, genetic selection for improved immune systems may be an effective approach.2. Traits related to the immune system were studied in a 938 pedigreed Japanese quail population infected by sheep red blood cells (SRBC). Besides body weight at 35 d of age (BW35), weight of the gizzard (G), liver (Li), lungs (Lu), bursa (Bu), spleen (S), heart (H), and digestive track (D) and length of ileum (I) and caecum (C) were recorded. Total antibody (TA), mercaptoethanol-resistant (IgG), mercaptoethanol-sensitive titres (IgM), the number of monocyte (M), basophil (B) and eosinophil (E) and the ratio of heterophil to lymphocyte (H/L) were measured. Co-variance components were estimated via Gibbs sampling using GIBBS3F90 software. Five univariate animal models, including simple forms, were used for genetic parameter estimations, and the best model was determined by the deviance information criterion (DIC). Genetic and environmental correlations were estimated using a bivariate animal model.3. Direct heritability estimates for internal organs ranged from 0.06 (Lu) to 0.57 (G) and for immune system traits from 0.05 (IgM) to 0.17 (IgG). Negative genetic correlations were found between BW35 and internal organs (−0.22 to −0.80).4. Including one of the internal organs, such as the spleen, in the selection index improved the immune response in heavier birds. Additionally, because of the moderate heritability of IgG (0.17) and its effect on lasting immunity, selecting for higher IgG concentration may improve the resistance of Japanese quail against pathogens. [ABSTRACT FROM AUTHOR]

CoVID-19 has been linked to long-term consequences on several human body organs, including lung ailments, kidney malfunctions, heart dysrhythmia, alterations in brain nutrient levels, psychological difficulties, abrupt changes in blood pressure, and more. Because of the considerable variety in the impacts on different body parts, researchers find it challenging to create models that can incorporate these effects for treatment recommendations and future disease prevention scenarios. Thus, this article examines some of the most recently proposed models for identifying the impacts of CoVID19 on various human organs. This review examines the underlying theories in terms of clinical nuances, functional advantages, contextual limits, and potential empirical applications. Based on this discussion, researchers will be able to find the best models for detecting particular diseases on specific body parts. It was discovered that hybrid bioinspired models, when paired with deep learning-based classification algorithms, can effectively detect these impacts. This text also parametrically analyses these models in terms of accuracy, precision, and recall, allowing readers to select the best models for their performance-specific use cases. To expand on this discussion, this book evaluates a unique CoVID19 Classification Rank Metric (CCRM) that integrates these factors for thorough model identification. Based on this criteria, researchers will be able to develop appropriate models for clinical scenarios that have high accuracy, low delay, and scalability while costing less. [ABSTRACT FROM AUTHOR]

Background: There is no specified diagnostic procedure that can help in determining the cause of death and the diagnosis of drowning because the pathohistological signs are almost identical and non-specified. Aim: Our study aims to recognize and prove diatom appearance in organs from a forensic aspect in Bosnia and Herzegovina, and to examine which is the more specific method in the diagnosis of drowning, the diatom test or the pathohistological finding. Methods: Rats of the recommended body weight were divided into four groups: G1 (n = 8; mechanism of death--asphyxia; cause of death--suffocation, submerged 1 hour after death); G2 (n = 8: mechanism of death-asphyxia; cause of death-suffocation, immersed 72 hours after death); G3 (n = 8: mechanism of death-asphyxia; cause of death-drowning, autopsy immediately after death), and G4 (n = 8: mechanism of death-asphyxia; cause of death-drowning, post mortem 24 hours after death). Results: During the diatom analysis, four species of diatoms, Diatoma vulgaris, Melosira varians, Epithemia adnata, and Cymbella sp, were successfully recovered from the stomach. Microscopic analysis did not detect diatoms in the kidneys and brains of rats, while the pathohistological changes were relatively uniform. Conclusion: Our results propose that the diatom test is a sustainable tool for supporting the diagnosis of drowning in the forensic pathology analysis of the cause of death. This experimental study is a starting point toward the optimization of tests and sampling in cases of unexplained etiology. [ABSTRACT FROM AUTHOR]

Després de deu anys de l’aprovació de la Llei catalana 19/2014, de 29 de desembre, de transparència, accés a la informació pública i bon govern, es presenta un balanç del que ha suposat aquesta regulació per a la institucionalització de la Comissió de Garantia del Dret d’Accés a la Informació Pública (GAIP) i de com ha impactat el seu disseny en el desenvolupament d’aquest òrgan que ha de garantir el dret d’accés a la informació i resoldre les reclamacions amb plena independència orgànica i funcional. És per això que es fa un recorregut inicial per la configuració de l’òrgan a partir de la seva regulació en l’àmbit europeu i la pluralitat de models per entrar a fons en la situació actual i constatar les necessitats de recursos tant personals com econòmics i fixar els punts febles que caldria revisar.

This study examines for the first time the relationships with music, family musical traditions, and their importance to all family members – but especially to the composer and painter Mikalojus Konstantinas Čiurlionis (1875–1911) – of the two generations of the Čiurlionis family who lived in Druskininkai since the 19th century. Also, for the first time, this study explores the histories of musical instruments belonging to the Čiurlionis. Near Druskininkai, at the church in the village of Kabeliai, an instrument was discovered on which Mikalojus Konstantinas Čiurlionis’ father Konstantinas had played, and archival work was carried out to find supporting evidence. The sources found confirmed the hypothesis held by the author of the article that the church organ in Kabeliai indeed was the instrument used by Konstantinas Čiurlionis, the organist and father of Čiurlionis. It is likely that the future artist and composer Mikalojus Konstantinas also had contact with this instrument. The history of Kabeliai and the discovery of the organ inspired the study of the histories of all musical instruments (both surviving and lost) belonging to the Čiurlionis family and special attention was paid to the exhibits of the M. K. Čiurlionis House-Museum. This article publishes for the first time the authentic memories collected by the author of this work, describing the acquisition histories of the mentioned house-museum exhibits. The result of the research is new facts about music-making in the Čiurlionis household, supplemented, refined, or reconstructed histories of musical instruments used by the Čiurlionis family. Twelve musical instruments were found and described during the study. It was revealed that the Čiurlionis family paid great attention to musical instruments and their quality. Pianos from famous companies in their not very wealthy homes testify that music here was not only educational but also had clear professional ambitions to play classical music and create original (their own) music. The Čiurlionis family was united by the method of learning to play by ear, and the conscious continuation of this family musical tradition is evident in our times at the “Summer of Piano Music in Druskininkai” festival.

Background: There is no specified diagnostic procedure that can help in determining the cause of death and the diagnosis of drowning because the pathohistological signs are almost identical and non-specified. Aim: Our study aims to recognize and prove diatoms appearance in organs from a forensic aspect in Bosnia and Herzegovina, and to examine which is the more specific method in the diagnosis of drowning, the diatom test or the pathohistological finding. Methods: Rats of the recommended body weight were divided into four groups: G1 (n=8; mechanism of death - asphyxia; cause of death - suffocation, submerged 1 hour after death); G2 (n=8: mechanism of death-asphyxia; cause of death-suffocation, immersed 72 hours after death); G3 (n=8: mechanism of death-asphyxia; cause of death-drowning, autopsy immediately after death) and G4 (n=8: mechanism of death-asphyxia; cause of death-drowning, post mortem 24 hours after death). Results: During the diatom analysis, four species of diatoms, Diatoma vulgaris, Melosira varians, Epithemia adnata, and Cymbella sp, were successfully recovered from the stomach. Microscopic analysis did not detect diatoms in the kidneys and brains of rats, while the pathohistological changes were relatively uniform. Conclusion: Our results propose that the diatom test is a sustainable tool for supporting the diagnosis of drowning in the forensic pathology analysis of the cause of death. This experimental study is a starting point towards the optimization of tests and sampling in cases of unexplained etiology. [Open Vet J 2024; 14(11.000): 3047-3054]

Recent years have witnessed significant advancements in the cryopreservation of various tissues and cells, yet several challenges persist. This review evaluates the current state of cryopreservation, focusing on contemporary methods, notable achievements, and ongoing difficulties. Techniques such as slow freezing and vitrification have enabled the successful preservation of diverse biological materials, including embryos and ovarian tissue, marking substantial progress in reproductive medicine and regenerative therapies. These achievements highlight improved post-thaw survival and functionality of cryopreserved samples. However, there are remaining challenges such as ice crystal formation, which can lead to cell damage, and the cryopreservation of larger, more complex tissues and organs. This review also explores the role of cryoprotectants and the importance of optimizing both cooling and warming rates to enhance preservation outcomes. Future research priorities include developing new cryoprotective agents, elucidating the mechanisms of cryoinjury, and refining protocols for preserving complex tissues and organs. This comprehensive overview underscores the transformative potential of cryopreservation in biomedicine, while emphasizing the necessity for ongoing innovation to address existing challenges. [ABSTRACT FROM AUTHOR]

Instances of multicellularity across the tree of life have fostered the evolution of complex organs composed of distinct cell types that cooperate, producing emergent biological functions. How organs originate is a fundamental evolutionary problem that has eluded deep mechanistic and conceptual understanding. Here I propose a cell- to organ-level transitions framework, whereby cooperative division of labor originates and becomes entrenched between cell types through a process of functional niche creation, cell-type subfunctionalization, and irreversible ratcheting of cell interdependencies. Comprehending this transition hinges on explaining how these processes unfold molecularly in evolving populations. Recent single-cell transcriptomic studies and analyses of terminal fate specification indicate that cellular functions are conferred by modular gene expression programs. These discrete components of functional variation may be deployed or combined within cells to introduce new properties into multicellular niches, or partitioned across cells to establish division of labor. Tracing gene expression program evolution at the level of single cells in populations may reveal transitions toward organ complexity. [ABSTRACT FROM AUTHOR]

This article argues that beneath the veneer of legitimacy in the organ, tissue, and body part transplantation systems exists a horrifying history of human commodification whose vestiges surprisingly linger in contemporary supply and allocation systems. This history, as the Article demonstrates, dates back to the colonial period in the United States, where "grave robbing" became an important feature in the advancement of medicine. This legacy lives on. [ABSTRACT FROM AUTHOR]

Introduction: The allocation of nitrogen (N) and phosphorus (P) among plant organs is an important strategy affecting growth and development as well as ecological processes in terrestrial ecosystems. However, due to lack of systematic investigation data, the allocation strategies of N and P in the three primary plant organs (e.g., leaves, stems and roots) are still unclear. Methods: A total of 912 individuals of 62 Artemisia species were examined across a broad environmental expanse in China, and the N and P concentrations of leaves, stems and roots were measured to explore the allocation strategies in different subgenera, ecosystem types, and local sites. Results and discussion: Across all 62 species, the N vs. P scaling exponents for leaves, stems and roots were 0.67, 0.59 and 0.67, respectively. However, these numerical values differed among subgenera, ecosystem types, and local sites. Overall, the numerical values of N vs. P scaling exponents comply with a 2/3- power function for each Artemisia organ-type reflecting a phylogenetically conserved allocation strategy that has nevertheless diversified with respect to local environmental conditions. These results inform our understanding of N and P stoichiometric patterns and responses to abiotic factors in an ecologically broadly distributed angiosperm genus. [ABSTRACT FROM AUTHOR]

• Exploring potential medicinal value from production waste of Chinese herbal medicine and realizing its resourceful utilization is an important way to enhance income and alleviate poverty. • Essential oils from the branches, leaves, flowers and fruits of finger citron were studied for composition and antioxidant activity. • Extraction rate and relative content of essential components of young leaf essential oil were high and antioxidant capacity was moderate. • Young leaves could be preferred in the late development of finger citron non-medicinal parts to develop by-products such as finger citron essential oil perfume and fragrance. The finger citron (Citrus medica L.var. sarcodactylis Swingle) is a both medicinal and edible species specified by the China Ministry of Health, It is also a regional medicinal plant grown in Chinaʼs Chongqing Municipality. We explored the utilization value of flower, leaf, and branch resources of non-medicinal sections of finger citron of Chongqing origin and identified variations in its yield, content, and antioxidant activity in essential oils in several organs. From several finger citron organs, essential oils were extracted using ultrasonic-assisted steam distillation, and their essential components were identified using gas chromatography-mass spectrometry (GC–MS). To assess antioxidant properties of various finger citron organs, DPPH free radical scavenging rate, ABTS free radical scavenging rate, and total reducing power of essential oils were determined. A total of 71 chemical components were discovered, and a cluster heat map revealed that d-limonene, Citral, (Z)-3,7-dimethylocta-2,6-dienal, γ-Terpinene, O Cymene, and Ocimene were the most significant components and that their composition and concentration in essential oils of different organs varied substantially, with the average total amount in the four major organs in descending order: branches (79.34 %), leaves (73.40 %), flowers (68.85 %), and dried fruits (55.69 %). Finger citron's non-medicinal sections and organs' essential oils exhibited some level of antioxidant activity. The maximal clearance rate of the final flower group was 19.26 % when the essential oil concentration of each group was 4.0 mg·mL−1 for the assessment of DPPH free radical scavenging activity. DPPH free radical clearance rates of the bud group, initial flower group, full flower group, final flower group, branch group, and young leaf group were significantly different from the medicinal parts dried fruits group (P < 0.05), whereas there was no significant difference in the old leaf group (P > 0.05). When the essential oil concentration of each group was 0.10 mg·mL−1 for the ABTS radical scavenging ability measurement, the bud group had the highest scavenging rate of 32.24 %, and significant differences in the ABTS radical scavenging rates of the bud group, primary flower group, full flower group, final flower group, and branch group were observed when compared to the dried fruits group (P < 0.05). Between the young leaf and old leaf groups, there was no significant difference (P > 0.05). When the essential oil concentration was 3.0 mg·mL−1 for the measurement of overall reduction capacity, the old leaf group's highest absorbance value was 0.310. and the total reduction capacity of the bud group, first flower group, complete flower group, last flower group, branch group, young leaf group, and old leaf group substantially differed from the dried fruits (P < 0.05). This study provides a reference for the formation of "green" concurrent consumption and development of medicinal and non-medicinal elements of Chinese medicinal materials as well as theoretical support for the diverse utilization of finger citron resources. [ABSTRACT FROM AUTHOR]

Rodents represent over 40% of known mammal species and are found in various terrestrial habitats. They are significant reservoirs for zoonotic viruses, including harmful pathogens such as arenaviruses and hantaviruses, yet knowledge of their hosts and distributions is limited. Therefore, characterizing the virome profile in these animals is invaluable for outbreak preparedness, especially in potential hotspots of mammal diversity. This study included 681 organs from 124 rodents and one Chinese tree shrew collected from Yunnan Province, China, during 2020-2021. Metagenomic analysis revealed unique features of mammalian viruses in rodent organs across habitats with varying human disturbances. R. tanezumi in locations with high anthropogenic disturbance exhibited the highest mammal viral diversity, with spleen and lung samples showing the highest diversities for these viruses at the organ level. Mammal viral diversity for both commensal and non-commensal rats was identified to positively correlate with landscape disturbance. Some virus families were associated with particular organs or host species, suggesting tropism for these pathogens. Notably, known and novel viral species that are likely to infect humans were identified. R. tanezumi was identified as a reservoir and carrier for various zoonotic viruses, including porcine bocavirus, hantavirus, cardiovirus, and lyssavirus. These findings highlight the influence of rodent community composition and anthropogenic activities on diverse virome profiles, with R. tanezumi as an important reservoir for zoonotic viruses.

Despite their claimed low intraspecific variability, plant reproductive traits are less frequently used in functional ecology. Here we focused on underrepresented plant organs, i.e. flowers and fruits, by comparing their traits with well‐established leaf traits. We evaluated 16 functional traits (six floral, six fruit, and four leaf traits) in a randomly selected group of woody species under comparable environmental conditions. We aimed to assess interspecific and intraspecimen variability and explore the potential of the proposed flower and fruit traits for ecological research. Traits related to the dry mass of flowers and fruits exhibited the highest interspecific variability, while carbon content traits in flowers and leaves had the lowest. At a specimen level, specific leaf area revealed the highest variation. Carbon content traits for all organs demonstrated the least intraspecimen variability, with flower carbon content being the least variable. Our study revealed connections between the newly proposed traits and widely recognized functional traits, uncovering intriguing links between the established traits and the floral and fruit traits upon which we focused. This complements the already well‐recognized variability in plant form and function with additional insights into reproductive processes. [ABSTRACT FROM AUTHOR]

Phosphotriesterases (PTE) are a new and promising approach for the treatment of organophosphate poisoning, since the current therapy of such intoxications shows some limitations. A previous rat in vivo study confirmed the therapeutic effect of PTE, which were specifically designed for VX breakdown, and demonstrated rapid degradation of VX in whole blood samples. The present study now focuses on the degradation of VX and its distribution in organ tissues of the animals used in the aforementioned study. In order to gain a broader overview, we have extended the investigations to the VX metabolites EA-2192 and EMPA by using methods developed for an LC-ESI-MS/MS system. Applying these methods, we were able to verify the effectiveness of the PTE treatment and gained an overview of VX tissue distribution in poisoned but untreated rats. • Rat tissue samples after VX and phosphotriesterase administration were studied. • The distribution of VX, EMPA, EA-2192 in various rat tissues was studied. • Modified LC-ESI-MS/MS methods were applied. • PTE administration results in markedly lower or even absent VX tissue levels. • An overview of tissue distribution of EMPA and EA-2192 was gained. [ABSTRACT FROM AUTHOR]

Microplastics environmental pollution and their impact on organisms' health are currently widely debated. This study aimed to determine the effects of polystyrene microplastics (PS--MPs) on lipid peroxidation (LPO) and glutathione (GSH) levels in the brain, liver, ovaries/ testes, kidneys, and lungs of mice. Sexually mature male and female albino mice were divided into control groups and groups exposed to 1 μm PS--MPs at a dose of 0.1 mg/24h, administered orally for 14 days. The results showed that in female mice PS--MPs administration led to significant increase of LPO in the kidneys and lungs. In contrast, in male mice, LPO was significantly decreased in the brain, liver, and kidneys. PS--MPs administration also led to significantly increased GSH concentrations in the liver in both male and female mice, and a decrease in the brain and testes in males. In conclusion, PS--MPs induced varying degrees of oxidative stress in male and female mice. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Babylon Center for Humanities Studies is the property of Republic of Iraq Ministry of Higher Education & Scientific Research (MOHESR) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

International organizations have fascinated international lawyers for decades. Part of this attraction may be the difficulty of defining them. This contribution argues that identifying typical characteristics could be the most appropriate way of getting a better understanding of what international organizations are. [ABSTRACT FROM AUTHOR]

Early life stress (ELS) is a risk factor for the development of chronic diseases resulting from functional alterations of organs in the cardiorespiratory and renal systems. This work studied the changes in oxidative stress enzyme activities (EAs) of SOD, CAT, GPX, GR, GST, NOS, MDA, and FRAP in different organs (heart, liver, kidney, adrenal glands (AGs), and pancreas) of male and female Sprague–Dawley rat pups on postnatal day (PN) 15, immediately after basal and acute or chronic stress conditions were accomplished, as follows: basal control (BC; undisturbed maternal pups care), stress control (SC; 3 h maternal separation on PN15), basal maternal separation (BMS; daily 3 h maternal separation on PN 1-14), and stress maternal separation (SMS; daily 3 h maternal separation on PN 1-14 and 3 h maternal separation on PN15). Acute or long-term stress resulted in overall oxidative stress, increase in EA, and reduced antioxidant capacity in these organs. Some different response patterns, due to precedent SMS, were observed in specific organs, especially in the AGs. Acute stress exposure increases the EA, but chronic stress generates a response in the antioxidant system in some of the organs studied and is damped in response to a further challenge. [ABSTRACT FROM AUTHOR]

Hemerocallis citrina is an edible and medicinal homologous plant, which is rich in many nutrients and bioactive components. Terpenoids are a kind of important bioactive component in H. citrina. To understand the dominant terpenoid metabolites in H. citrina roots, stems, leaves, and flowers, respectively, this study analyzed the terpenoid metabolites in these 4 organs based on the ultra performance liquid chromatography-tandem mass spectrometry technology of widely targeted metabolomics. A total of 43 terpenoids were identified, including 7 kinds of monoterpenoids (16.2%), 18 kinds of ditepenoids (41.9%), 16 kinds of triterpene (37.2% ), and 2 kinds of triterpene saponin (4.7%). Principal component analysis and clustering analysis indicated that the mass spectrometry data were reliable, and the accumulation of terpenoids in different organs was significantly different. The dominant terpenoid metabolites in roots included isopimaradieneone, pimaradienone, abietic acid, scutebarbolide C, and isopimaric acid. The dominant terpenoid metabolites in stems included 3, 9-dihydroxy-13(14)-labden-16,15-olide and 9,19-cyclolanost-24-en-3-ol (cycloartenol). The dominant terpenoid metabolites in leaves included viteagnusin A and ent-3β-acetoxyisopimar-15-8β-ol. The dominant terpenoid metabolites in flowers included vitexilactone and 7-Ocoumaroyl- loganic acid. This study listed the relative contents of all terpenoids in roots, stems, leaves, and flowers of H. citrina in detail, which provided the foundation for further investigation of the different usages of various plant organs of H. citrina, and the information is important for the food industry and medical treatment. [ABSTRACT FROM AUTHOR]

One-hundred-and-twenty-day-old mixed-sex marshall breed of broiler chicks was randomly assigned to four (4) treatment groups (30 birds/experimental oral dosage levels). The treatment groups comprised T1 (control), T2, T3, and T4 containing 5ml, 10ml, and 20ml of Phyllanthus nuriri extract (PNE) stock solution per litre of water which was provided to the birds as drinking water regularly for the six weeks of the experiment. The haematological, serum metabolites, serum proteins, and gross pathology of some internal organs of the birds were examined. No significant effect (P>0.05) was observed in the packed cell volume, red blood cells, haemoglobin concentration, mean cell haemoglobin concentration, lymphocyte, heterophil, monocyte, basophil, and eosinophil, except for mean cell volume and mean cell haemoglobin. Likewise, the serum proteins were not influenced (P>0.05) by PNE but alanine aminotransferase and aspartate aminotransferase were significantly reduced when compared to the control group. No significant differences (P>0.05) were recorded on the gross pathology of the liver, heart, spleen, caecum, crop, proventriculus, and kidney of the broiler chickens provided with the different dosage levels of PNE. Conclusively, PNE up to 20 mL support normal haemopoietic activity and confers hepato-protective effects on broiler chickens. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Agricultural, Environmental & Veterinary Sciences is the property of Arab Journal of Sciences & Research Publishing (AJSRP) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Preserved feed from meadows contaminated with ragwort (Jacobaea vulgaris, Gaertn.) may expose livestock to pyrrolizidine alkaloids (PA). Dairy cows are considered to be very susceptible animals and a PA ingestion can lead to liver and further organ damages and even death. Due to the lack of data, the present study aimed to evaluate critical PA doses based on organ effects, with a special focus on liver lesions and on indicators of energy metabolism. Therefore, 16 dairy cows (n = 4 per group) were exposed to increasing PA doses (group: CONMolasses: <0.001 mg PA/kg body weight (BW)/day (d); PA1: 0.47 mg PA/kg BW/d; PA2: 0.95 mg PA/kg BW/d; PA3: 1.91 mg PA/kg BW/d) for 28 days. Constant dosing was ensured by a defined PA extract administered orally once daily. Histological examinations of the livers showed infiltration by immune cells, higher proportions of apoptotic cells and enlargement of hepatocyte nuclei in the highest exposed group. In addition, bile volume increased with PA dose, which may indicate a cholestasis. Despite the signs of incipient liver damage, liver lipid content and clinical chemical parameters related to energy metabolism, such as glucose, non-esterified fatty acids and βhydroxybutyrate, remained unaffected. Fat depot masses were also not significantly altered over time, suggesting that PA exposure did not induce a wasting syndrome. The liver showed slight microscopic changes already at a dosage of 0.95 mg PA/kg BW/d. However, the short-term metabolic indicators of energy status, lipolysis and ketogenesis, glucose, NEFA and BHB, as well as changes in fat depot, which serves as a longer-term indicator of lipolysis, remained unaffected in all treatment groups in the chosen scenario. These findings suggest that despite histopathological and clinical-chemical evidence of PA-associated hepatocellular lesions, liver function was not compromised. [ABSTRACT FROM AUTHOR]

Copyright of Church in the World / Crkva u Svijetu is the property of University of Split, Catholic Faculty of Theology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

The excessive dose use can have a deleterious effect on human beings. Clinical pharmacokinetics is the application of drug therapy which gives the ideal dosage regimen of a particular drug for safe and effective treatment. The maximum effectiveness and minimize the toxic effects can be studied between drug dosage regimen and drug concentration-time profile. The drug dose for infants and children has different dosing requirements than adults. The pharmacokinetic and pharmacodynamics of most drugs are still not well-known children under 12 years of age this may be due to body composition and maturity of organs. Thus, different dose requirements are needed in pediatrics. In case dosage guidelines are not available for a drug, empirical dose adjustment methods are often used, based on body surface area or body weight. There are various methods reported to calculate the dosage for children and infants all of which calculate the children as a fraction of the adult dose. The geriatric population is defined as patients who are older than 65 years. The performance capacity and the loss of homeostatic reserve decrease with advanced age. Aging-related changes in physiologic and cognitive functioning can impact medication compliance as well as the therapeutic safety and effectiveness of a prescription. Since, they often have various illnesses, older people also frequently take multiple medications. Age-related changes in various critical physiological activities have been documented by markers: respiratory capacity, cardiac output, glomerular filtration, renal plasma flow and cardiac output all decline from 10% to 30% in older people relative to those in their 30s. One possible explanation for this increased apparent medication sensitivity in the elderly is alterations in pharmacodynamic and pharmacokinetic factors. [ABSTRACT FROM AUTHOR]

Copyright of Acta Prataculturae Sinica is the property of Acta Prataculturae Sinica Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

The ongoing anthropogenic pollution of the biosphere with As, Cd, Hg and Pb will inevitably result in an increased influx of their corresponding toxic metal(loid) species into the bloodstream of human populations, including children and pregnant women. To delineate whether the measurable concentrations of these inorganic pollutants in the bloodstream are tolerable or implicated in the onset of environmental diseases urgently requires new insight into their dynamic bioinorganic chemistry in the bloodstream–organ system. Owing to the human exposure to multiple toxic metal(loid) species, the mechanism of chronic toxicity of each of these needs to be integrated into a framework to better define the underlying exposure–disease relationship. Accordingly, this review highlights some recent advances into the bioinorganic chemistry of the Cd2+, Hg2+ and CH3Hg+ in blood plasma, red blood cells and target organs and provides a first glimpse of their emerging mechanisms of chronic toxicity. Although many important knowledge gaps remain, it is essential to design experiments with the intent of refining these mechanisms to eventually establish a framework that may allow us to causally link the cumulative exposure of human populations to multiple toxic metal(loid) species with environmental diseases of unknown etiology that do not appear to have a genetic origin. Thus, researchers from a variety of scientific disciplines need to contribute to this interdisciplinary effort to rationally address this public health threat which may require the implementation of stronger regulatory requirements to improve planetary and human health, which are fundamentally intertwined. [ABSTRACT FROM AUTHOR]

Basella alba is a frequently consumed leafy vegetable. However, research on its nutritional components is limited. This study aimed to explore the variation in the nutritional components and antioxidant capacity of different cultivars and organs of Basella alba. Here, we primarily chose classical spectrophotometry and high-performance liquid chromatography (HPLC) to characterize the variation in nutritional components and antioxidant capacity among different organs (inflorescences, green fruits, black fruits, leaves, and stems) of eight typical cultivars of Basella alba. The determination indices (and methods) included the total soluble sugar (anthrone colorimetry), total soluble protein (the Bradford method), total chlorophyll (the ethanol-extracting method), total carotenoids (the ethanol-extracting method), total ascorbic acid (the HPLC method), total proanthocyanidins (the p-dimethylaminocinnamaldehyde method), total flavonoids (AlCl3 colorimetry), total phenolics (the Folin method), and antioxidant capacity (the FRAP and ABTS methods). The results indicated that M5 and M6 exhibited advantages in their nutrient contents and antioxidant capacities. Additionally, the inflorescences demonstrated the highest total ascorbic acid and total phenolic contents, while the green and black fruits exhibited relatively high levels of total proanthocyanidins and antioxidant capacity. In a comparison between the green and black fruits, the green fruits showed higher levels of total chlorophyll (0.77–1.85 mg g−1 DW), total proanthocyanidins (0.62–2.34 mg g−1 DW), total phenolics (15.28–27.35 mg g−1 DW), and ABTS (43.39–59.16%), while the black fruits exhibited higher levels of total soluble protein (65.45–89.48 mg g−1 DW) and total soluble sugar (56.40–207.62 mg g−1 DW) in most cultivars. Chlorophyll, carotenoids, and flavonoids were predominantly found in the leaves of most cultivars, whereas the total soluble sugar contents were highest in the stems of most cultivars. Overall, our findings underscore the significant influence of the cultivars on the nutritional composition of Basella alba. Moreover, we observed notable variations in the nutrient contents among the different organs of the eight cultivars, and proanthocyanidins may contribute significantly to the antioxidant activity of the fruits. On the whole, this study provides a theoretical basis for the genetic breeding of Basella alba and dietary nutrition and serves as a reference for the comprehensive utilization of this vegetable. [ABSTRACT FROM AUTHOR]

Zanthoxylum armatum (Z. armatum) is an economic crop widely planted for both spice and medicinal purposes in Southwest China. Soil is a key environmental condition that affects seedling growth and development, and screening suitable soil types is of great significance for the large-scale cultivation of crops. This study designed growth experiments of Z. armatum seedlings in red soil (RS), yellow soil (YS), acidic purple soil (ACPS), alkaline purple soil (ALPS), and alluvial soil (AS) to screen for more suitable soil types. The growth traits of Z. armatum seedlings and the carbon (C), nitrogen (N), phosphorus (P), C:N:P stoichiometry, and non-structural carbohydrate (NSC) content of different organs were comparatively analyzed. The results showed that the morphological indexes of Z. armatum seedlings cultured in AS were better than those in the other four soils.AS and RS may be beneficial for the culture of Z. armatum seedlings due to higher nutrient levels in three organs. Two-factor ANOVA and PCA analysis showed that C, N, and P and their proportions would affect the uptake and distribution of NSC in various organs of Z. armatum seedlings. These results showed that soil types and plant organs significantly affected the accumulation and distribution of N, P, and NSC in Z. armatum seedlings. These results are conducive to screening soil types suitable for the growth and development of Z. armatum and provide data support for further large-scale cultivation of Z. armatum in suitable areas. [ABSTRACT FROM AUTHOR]

We explored the resource acquisition and growth strategies of plants adapting to different environments, focusing on the typical forest types of Sygera Mountain: Pinus armandii, Picea likiangensis var. Linzhiensis, Abies georgei var. Smithii, and Juniperus saltuaria. Then, we analyzed the nutrient content and stoichiometric ratios of C, N, P, and K in different plant organs (leaves, branches, trunks, and roots) to examine the stoichiometric characteristics and nutrient balance mechanisms in these forests. Results show that within the same forest type, different plant organs exhibit high C and low N, P, and K levels. N content in all organs followed the order leaves > branches > roots > trunks. During the growth phase, the concentrations of P and K in PLL and AGS follow the order branches > leaves > roots > trunks. In the dormant phase, the distribution in different organs had the order leaves > branches > roots > trunks. C content remained relatively stable over time. In the same organ across different forest types, increase in nitrogen content in plant leaves is an active adaptation of JS plants, indicating that JS has a conservative growth strategy and can adapt to environmental stress. Owing to the influence of seasons, the evolution process of N and P content fluctuates, allocating nutrients to supporting and transporting organs for resource optimization and allocation. The N and P content were lower in the growth phase than in the dormant phase. Seasonal variations in the C/N, C/P, and C/K ratios in different forests were inversely correlated with changes in N, P, and K content in plant organs, supporting the "growth rate hypothesis." Stoichiometric analysis suggests that different limiting elements exist in organs across various forest types. Principal component analysis indicates that the seasonal patterns of stoichiometric ratios in the organs of different forest types show species-specific characteristics, reflecting the evolutionary nutrient utilization strategies of plant genera. In summary, plant growth in different Sygera Mountain forest types is limited by N and P, with a high tendency toward nitrogen limitation. The nutrient utilization and distribution differences among various organs during different growth stages are primarily influenced by the limited availability of environmental nutrients and inherent physiological characteristics of the plants. [ABSTRACT FROM AUTHOR]

[Objective]To understand the main nutrients content and distribution characteristics in each organ of Paris polyphylla Smith var. chinensis during flowering period in order to provide scientific basis for understory cultivation and nutrient management. [Method]With Paris polyphylla Smith var. chinensis of under-forest the Cunninghamia lanceolata as the research object,samples were collected at flowering stage, and the content and distribution characteristics and their correlation of main nutrients in each organ were analyzed. [Result]N content in each organ was ranked from high to low as leaf, flower, fibrous root, tuber, stem from high to low, and the highest N content in leaf was 29. 61 g / kg. P content was ranked from high to low as flower, leaf, fibrous root, tuber, stem, and the highest P content in flower was 4. 75 g / kg. K content was ranked from high to low as leaf, flower, stem, fibrous root, tuber, and the highest K content in leaf was 25. 23 g / kg. Ca content was ranked from high to low as tuber, fibrous root, stem, leaf, flower and the highest Ca content in tuber was 4. 75 g / kg. Mg content was ranked from high to low as leaf, flower, fibrous root, tuber, stem and the highest Mg content in leaf was 3. 11 g / kg. The average nutrient content of each organ of Paris polyphylla Smith var. chinensis was ranked from high to low as N, K, Ca, Mg, P. Except N and Mg contents in tuber showed significant negative correlation (P<0. 05), the rest of the correlation was not significant. [Conclusion]The nutrients in each organ of Paris polyphylla Smith var. chinensis during flowering period were mainly concentrated in the leaves and flowers. N and P may be the main nutrient elements limiting the growth of Paris polyphylla Smith var. chinensis. [ABSTRACT FROM AUTHOR]

Abstract Despite their claimed low intraspecific variability, plant reproductive traits are less frequently used in functional ecology. Here we focused on underrepresented plant organs, i.e. flowers and fruits, by comparing their traits with well‐established leaf traits. We evaluated 16 functional traits (six floral, six fruit, and four leaf traits) in a randomly selected group of woody species under comparable environmental conditions. We aimed to assess interspecific and intraspecimen variability and explore the potential of the proposed flower and fruit traits for ecological research. Traits related to the dry mass of flowers and fruits exhibited the highest interspecific variability, while carbon content traits in flowers and leaves had the lowest. At a specimen level, specific leaf area revealed the highest variation. Carbon content traits for all organs demonstrated the least intraspecimen variability, with flower carbon content being the least variable. Our study revealed connections between the newly proposed traits and widely recognized functional traits, uncovering intriguing links between the established traits and the floral and fruit traits upon which we focused. This complements the already well‐recognized variability in plant form and function with additional insights into reproductive processes.

Exposure to several stressors and other lifestyle factors converge to affect the chemistry, structure, and function of body tissues over time. Chronic unpredictable stress (CUS) protocol has been widely used to study the impact of stress exposure in several animal models. Moringa oleifera leaf extract (MOLE) is known to have hepatoprotective and antioxidant properties. The study aimed to determine the effect of the administration of MOLE during conditions of chronic stress on the histology of reproductive organs, heart and liver. Twenty mature inbred healthy virgin female Wistar rats were randomly placed into four groups of five rats per group as follows: Group One (water and normal rat chow ad libitum), Group Two (CUS protocol only), Group Three (CUS protocol + 200 mg/kg MOLE), Group Four (CUS protocol + 300 mg/kg of MOLE). CUS protocol was applied unpredictably for two weeks. The chromatogram of the GC–MS analysis indicated the presence of 41 compounds. Photomicrograph examination of the uterus, ovaries, and liver showed severe alterations in the histology of the tissues. Consumption of MOLE during chronic stress has shown deleterious effects and is not advised for consumption during stress conditions.

Abstract The elemental status of cattle is one of the important factors, which determine its growth, fertility, fetal development, meat and dairy production, etc. Therefore, the study of content of different elements in cattle organs and tissues and its correlation with cattle characteristics and diet is urgent task. It is also important to develop intravital and low-invasive methods to analyze element content in cattle to regulate its diet during lifetime. In the present work, we have studied the content and distribution of manganese in Hereford cattle from an ecologically clean zone of Western Siberia (Russia). 252 samples were taken from 31 bulls aged 15-18 months. They were collected from various livestock farms in the region and analyzed using atomic absorption spectrophotometry (organs and muscle tissue) and inductively coupled plasma atomic emission spectrometry (hair). The median values of manganese concentration obtained in natural moisture for hair, heart, kidneys, liver, lungs, muscles, spleen, testes, and brain were 25, 0.37, 1.0, 2.6, 0.4, 0.2, 0.4, 0.5, and 0.5 ppm. Accordingly, the concentration of manganese differs significantly in the organs and tissues of animals (H = 188.6, df = 8, p

Cystic echinococcosis (CE) remains a significant challenge in Uganda with precise status largely undocumented in most communities. To determine CE prevalence, post-mortem examination was done on 14 937 livestock (5873 goats, 1377 sheep, 3726 zebu cattle and 3054 Ankole cattle) slaughtered in abattoirs in the districts of Moroto in Karamoja region, Kumi in Teso region and Nakasongola and Luwero in Buganda region. The overall CE prevalence was 21.9% in sheep, 15.2% in zebu cattle, 5.5% in goats and 2.1% in Ankole cattle. Moroto district had a higher prevalence of CE than other districts with 31.3% in zebu cattle, sheep 28%, goats 29.1% and (0%) in Ankole cattle. On organ locations, the lungs were the most affected in all livestock in all the study areas. Considering cyst fertility, 33.9, 1.7 and 6.4% of Ankole cattle, sheep and zebu cattle respectively had fertile cysts in the liver while 4.5% of goats and 4% Ankole cattle had fertile cysts in the lungs. In conclusion, CE is widespread and occurs among cattle, sheep and goats in pastoral and agro-pastoral areas in Uganda. Therefore, there is an urgent need to create awareness among the communities on role of livestock in CE epidemiology and transmission.

Evolutionary processes acting on populations of organized molecules preceded the origin of living organisms. These prebiotic entities were independently and repeatedly produced [i.e. (re)-produced] by the assembly of their components, following an iterative process giving rise to nearly but not fully identical replicas, allowing for a prebiotic form of Darwinian evolution. Natural selection favored the more persistent assemblies, some possibly modifying their own internal structure, or even their environment, thereby acquiring function. We refer to these assemblies as proto-organs. In association with other assemblies (e.g. in a coacervate or encapsulated within a vesicle), such proto-organs could evolve and acquire a role within the collective when their coexistence favored the selection of the ensemble. Along millions of years, an extraordinarily small number of successful combinations of those proto-organs co-occurring in spatially individualizing compartments might have co-evolved forming a proto-metabolic and proto-genetic informative network, eventually leading to the selfreplication of a very few. Thus, interactions between encapsulated proto-organs would have had a much higher probability of evolving into proto-organisms than interactions among simpler molecules. Multimolecular forms evolve functions; thus, functional organs would have preceded organisms. [ABSTRACT FROM AUTHOR]

• Fine particles (FPs) and ultrafine particles (UFPs) have diverse properties. • FPs and UFPs can enter the organism through multiple ways and reach organs. • FPs and UFPs can cause oxidative stress, inflammatory response, and apoptosis. • FPs and UFPs can produce great adverse effects on different organs. Particulate pollution is a global risk factor that seriously threatens human health. Fine particles (FPs) and ultrafine particles (UFPs) have small particle diameters and large specific surface areas, which can easily adsorb metals, microorganisms and other pollutants. FPs and UFPs can enter the human body in multiple ways and can be easily and quickly absorbed by the cells, tissues and organs. In the body, the particles can induce oxidative stress, inflammatory response and apoptosis, furthermore causing great adverse effects. Epidemiological studies mainly take the population as the research object to study the distribution of diseases and health conditions in a specific population and to focus on the identification of influencing factors. However, the mechanism by which a substance harms the health of organisms is mainly demonstrated through toxicological studies. Combining epidemiological studies with toxicological studies will provide a more systematic and comprehensive understanding of the impact of PM on the health of organisms. In this review, the sources, compositions, and morphologies of FPs and UFPs are briefly introduced in the first part. The effects and action mechanisms of exposure to FPs and UFPs on the heart, lungs, brain, liver, spleen, kidneys, pancreas, gastrointestinal tract, joints and reproductive system are systematically summarized. In addition, challenges are further pointed out at the end of the paper. This work provides useful theoretical guidance and a strong experimental foundation for investigating and preventing the adverse effects of FPs and UFPs on human health. [Display omitted] [ABSTRACT FROM AUTHOR]

This study aimed to assess the sonographic features of abdominal organs in healthy captive Neotropical otters (Lontra longicaudis). The sonograph showed that the urinary bladder was located in the caudal abdomen and its content was uniformly anechoic. The bladder wall had three layers: outer hyperechoic serosa, hypoechoic muscular layer and hyperechoic mucosa. The mean total wall thickness was 0.10 cm. The splenic parenchyma had a homogeneous echotexture with greater echogenicity than that of the left renal cortex and liver. The borders were regular and tapered. Rugal folds were observed in the stomach when undistended. The mean gastric wall thickness was 0.28 cm and five distinct layers were visible. The liver had smooth contours, and division of the hepatic lobes was not precisely visualized. The hepatic parenchyma had a homogeneous echotexture with greater echogenicity as compared to the right kidney and lesser echogenicity than that of the spleen. The gallbladder appeared as an oval or rounded structure in the transverse plane, filled with homogeneous anechogenic content; the wall was thin, regular and hyperechoic, with a mean thickness of 0.09 cm. The kidneys had a lobulated appearance with renicular subunits. The mean total length of the kidneys in longitudinal plane was 6.18 cm for the left and 6.27 cm for the right. Each reniculus was covered by an echogenic capsule, and the medullary region was more hypoechogenic than the cortical region. In conclusion, sonographic features in most of the abdominal organs in Neotropical otters are similar to the ultrasound patterns observed in healthy dogs and cats, except for kidneys with reniculi. [ABSTRACT FROM AUTHOR]

Simple Summary: Symbiotic bacteria play an essential role in the digestion, detoxification, and nutrient supply of bark and ambrosia beetles. They may even promote the invasiveness and adaptability of invasive beetles. However, as a newly invasive pest in China, the diversity and community structure of bacteria associated with Hylurgus ligniperda is still unclear. This hinders our ability to comprehend their invasion mechanism and ecological adaptability. Therefore, this study revealed the differences in the diversity and community composition of associated bacteria in the beetle's elytra, prothorax, and gut. Our findings revealed that the microbial population of the elytra was distinct from that of the prothorax and gut. Additionally, gender disparities existed throughout the bacterial population of elytra. The distribution of associated bacteria in different organs of males and females may indicate that they undertake different ecological functions. This study will help to understand the bacterial communities that may play important roles in Hylurgus ligniperda. Hylurgus ligniperda (Fabricius) (Curculionidae: Scolytinae) is a new invasive pest beetle in China, which colonized the Shandong province, causing devastating damage. Originating in Europe, it has spread to Oceania, Asia, North and South America. Bacterial associates have been frequently reported to play a vital role in strengthening the ecological adaptations of bark and ambrosia beetles. The environmental adaptability of H. ligniperda may be supported by their associated bacteria. Bacterial communities colonizing different body parts of insects may have different functions. However, little is known about the bacteria associated with H. ligniperda and their potential involvement in facilitating the adaptation and invasion of the beetles into new environments. In this study, we employed high-throughput sequencing technology to analyze the bacterial communities associated with male and female adults of H. ligniperda by comparing those colonizing the elytra, prothorax, and gut. Results showed that the bacterial communities of male and female adults were similar, and the elytra samples had the highest bacterial diversity and richness, followed by the gut, while the prothorax had the lowest. The dominant phyla were Proteobacteria, Firmicutes, and Actinobacteriota, while the dominant genera were Serratia, Lactococcus, Rhodococcus, unclassified Enterobacteriaceae, and Gordonia. Among these, Rhodococcus and Gordonia were the specific genera of endobacteria and ectobacteria, respectively. Differences in the distribution of associated bacteria may suggest that they have different ecological functions for H. ligniperda. The results of functional prediction showed that bacteria were enriched in terpenoid backbone biosynthesis, degradation of aromatic compounds, limonene and pinene degradation, neomycin, kanamycin and gentamicin biosynthesis, indicating that they may assist their beetles in synthesizing pheromones, degrading toxic secondary metabolites of host trees, and antagonizing pathogenic fungi. These results help us understand the interaction between H. ligniperda and bacteria and highlight possible contributions to the invasion process. [ABSTRACT FROM AUTHOR]

Cystic echinococcosis (CE) remains a significant challenge in Uganda with precise status largely undocumented in most communities. To determine CE prevalence, post-mortem examination was done on 14 937 livestock (5873 goats, 1377 sheep, 3726 zebu cattle and 3054 Ankole cattle) slaughtered in abattoirs in the districts of Moroto in Karamoja region, Kumi in Teso region and Nakasongola and Luwero in Buganda region. The overall CE prevalence was 21.9% in sheep, 15.2% in zebu cattle, 5.5% in goats and 2.1% in Ankole cattle. Moroto district had a higher prevalence of CE than other districts with 31.3% in zebu cattle, sheep 28%, goats 29.1% and (0%) in Ankole cattle. On organ locations, the lungs were the most affected in all livestock in all the study areas. Considering cyst fertility, 33.9, 1.7 and 6.4% of Ankole cattle, sheep and zebu cattle respectively had fertile cysts in the liver while 4.5% of goats and 4% Ankole cattle had fertile cysts in the lungs. In conclusion, CE is widespread and occurs among cattle, sheep and goats in pastoral and agro-pastoral areas in Uganda. Therefore, there is an urgent need to create awareness among the communities on role of livestock in CE epidemiology and transmission. [ABSTRACT FROM AUTHOR]

Copyright of Agroindustria, Sociedad y Ambiente is the property of Revista Cientifica Agroindustria, Sociedad y Ambiente, ASA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)