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The rejection of an organ or tissue transplant is immunological in nature and is the direct consequence of antigenic disparity between the transplant dotter and recipient. Cellular antigens, which differentiate individuals and cause the rejection of transplants, are defined as histocompatibility antigens. The immunologic properties of histocompatibiuty antigens are regulated by histocompatibility genes. The most comprehensive studies on the genetics of tissue transplantation were undertaken with the aid of highly inbred strains of laboratory mice. There evolved from a multitude of experiments performed in numerous laboratories a generally adopted rationale to account for the success or failure of tissue transplants.

Analyzes the biochemistry of antigens that influence histocompatibility. Properties of major histocompatibility loci; Application of an assay system to purify the substance; Location of the histocompatibility antigens according to tissue distribution, subcellular distribution and stabilization techniques.