1. TRANSPLANTATION AND CUTANEOUS GENETICS.
- Author
-
Billingham, R. E. and Silvers, Willys K.
- Subjects
- *
TRANSPLANTATION immunology , *TRANSPLANTATION of organs, tissues, etc. , *ISOANTIGENS , *HOMOGRAFTS , *HISTOCOMPATIBILITY , *CELL nuclei - Abstract
The exchange of tissues, most conveniently skin, between individuals has long afforded a means of evaluating their genetic identity or dissimilarity. The validity of the procedure depends upon the fact that in nearly all vertebrate species so far studied many different histocompatibility or H-loci, distributed on different chromosomes, determine isoantigenic specificities on the surfaces of virtually all nucleate cells of the body. The grafting of living tissue cells from a donor to a recipient of the same species results in rejection of the "homograft" unless the donor and recipient are members of the same highly inbred strain or they are identical twins.
- Published
- 1973
- Full Text
- View/download PDF