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This article reports on findings of a cytogenic survey of 504 mentally retarded resident children of the South Carolina State Mental Retardation centres over a period of two and a half years during June 1971 to 1974. The survey, reportedly, was conducted with the goal of prevention of recurrence of mental retardation in the siblings of institutionalized children. The children were selected from a lower age group with the primary objective of the detection of parents who would still be within the reproductive age range and who could be carriers of chromosome aberrations. Six categories of chromosome aberration were found in institutionalized mentally retarded persons in South Carolina. Of the 504 studied, 112 had a chromosome aberration. Specific chromosome aberrations were clinically suspected in 98 persons; 89 of them had Down's Syndrome, 2 had Cri-du-chat Syndrome, 2 had Turner's Syndrome, 3 were hermaphrodites, and two had Pseudoklinefelter's Syndrome.

The article describes the clinical and biochemical findings in two further children with argininosuccinicaciduria and it illustrates the effects of a low protein diet on the children's progress during a six-month period. Studies carried out included fasting serum ammonia estimations and a further series of estimations after each child had been given a protein load of 30 g. Both children were kept on the low protein diet for six months and were assessed periodically. Their serum proteins, calcium and phosphorus levels and hemoglobin levels remained within normal limits. Both were said to be hungry at times on the diet but the calorific value was increased by substituting cream for part of the milk ration, giving extra sweets and jams, etc.

Grassland plots were dressed with different amounts of cow slurry in January or March and grazed by dairy heifers at intervals from late April to August. In the first experiment slurry was applied at levels up to 56 tonnes/ha (22.4 tons/ac) in March. Total herbage DM production was directly proportional to the amount of slurry applied. There was no effect of treatment on percentage herbage utilization. In the second experiment slurry was applied at levels up to 100 t/ha (40 tons/ac) in January or in March. There was no significant effect of time or level of slurry application on herbage production or on animal intake, but the behaviour of the heifers was modified during the first eight weeks after plots had been dressed with 75 or 100 t/ha (30 or 40 tons/ac). [ABSTRACT FROM AUTHOR]

This article presents abstracts and summaries of articles and papers that were presented at the Winter Meeting of the British Grassland Society, held in London, England, on December 5, 1973. Abstract of the paper "Intensification of Grassland: Future Trends and Implications," by W.F. Raymond, summarizes the study which suggests that better management, good levels of milk production and good daily gains by cattle can be achieved with little supplementary feeding. Abstract of the paper "Impact of Grazing Management on Sward Survival," by R. Hughes and D.K. Jackson, summarizes the study suggesting that sward survival depends on tiller replacement to maintain an effective density. It is strongly influenced by defoliation patterns, fouling, treading and conservation or topping practice, which interact with the sward type expressed by contrasting grass varieties. Abstract of the article "Current Research on Weed Problems Associated With Grassland Intensification," by R.J. Haggar, reports on the findings of various studies on weed problems.

Presents abstracts of several articles related to dermatology featured in medical journals. "Chemotherapy of Leprosy in Nigeria," by J. Lowe and M. Smith; "South African Leprosy Laws and Control Policy," by P. D. Winter; "Surgical Treatment of Primary Lesion of Leprosy," by R. Boenjamin.

Describes several cases of skin diseases and their treatment. Psoriasis; Acne; Dermatomyositis; Microsporon ringworm in children.

Presents abstracts of several research related to dermatology. "Nodular Vasculitis,' by Arthur R. Woodburne and O. S. Philpott in the journal "Arch. Derm. Syph."; "Is Bejel Syphilis?," by F. Akrawi in the journal "Brit. J. vener. Dis."; "Some Aspects of Congenital Syphilis," by David Nabarro in the journal "Brit. J. vener. Dis."

Presents abstracts of several research studies on dermatology and syphilis published in 1948 and 1949. "Decreasing Penicillin Effectivity-A Psychological Problem?," by J. Gunter; "The Symptology and Aetiology of Reiter's Disease," by K. A. Orlowski; "The Dangers of Cold Permanent Waves," by A. Hariri.

Presents abstracts of several studies about dermatology. "Cysts, Sinuses and Fistulas of Dermatologic Interest," by N. P. Anderson; "Sarcoidosis in Identical Twins," by J. F. Sheber and R. T. Kelley; "Penicillin in the Treatment of Human Anthrax," by Captain G. N. Mann.

Presents information on research regarding dermatology and syphilis published from 1947 to 1948. "The Treatment of Kaposi's Idiopathic Sarcoma," by A. M. Segers and Grantley Taylor; "The Use of Calcium Ointment in Dermatology," by N. Tobias; "Pruritus in Diabetes Mellitus," by H. Koenigstein; "Some Account of the History of the Treatment of Syphilis," by J. Johnston Abraham.

Presents abstracts of studies on skin disease. "Regional Adenitis in Oriental Boil," by Vito Grillo; "Histamine and Antihistaminic Agents: Their Experimental and Therapeutic Status," by Samuel M. Feinberg; "Experimental Study of the Absorption of Amyloid in Localized Amyloidosis by Skin Grafting," by F. Sagher.

Presents abstracts of several studies on dermatology. "Dermatoses From Glasswool," by J. Pellerat and J. Coudert; "Cutaneous Histamine," by M. J. Pellerat and M. Murat; "Immunization Therapy for Lichen Planus," by H. Biberstein and J. Wachtel.

Presents several case studies on dermatology published in various medical publications. "The Incidence of Leukaemia in Radiologists," by H. Ulrich; "Vitamin B Complex for Vitiligo," J. C. Hathaway; "Polycythaemia With an Unusual Eruption," by A. Strickler.

Presents several abstracts of dermatology-related articles featured in various medical journals. "Pellagra in South Africa," by M. M. Suzman; "Thiamine Hydrochloride: An Obligate Wheal-Producing Agent," by Frederick Katz; "The Morbidity and Mortality Status of Hospitalized Eczemas," by J. Schwartzman.

Presents abstracts of several studies on dermatology and syphilis. "Dermatitis Venenate Due to Nail Lacquer," by E. D. Osborne, J. W. Jordon and P. C. Campbell; "Dermatoses Seen in Wartime," by Eli Davis; "Electrophoretic Skin Studies. I. Reaction to Common Grasses," by H. H. Shilkret; "Acrokeratosis Verruciformis," by A. B. Loveman and P. V. Graham; "Congential Syphilis: A Statistical Study, with Special Regard to Sex Incidence," by U. J. Wile, L. K. Mundt and A. Arbor.

Provides information on several studies on dermatology and syphilis published from 1941 to 1942. "Respirator Dermatitis," by J. Petro; "The Need for Co-operative Thought on Industrial Dermatitis," by P. B. Mumford; "Epithelioma Attributable to Arsenic," by Hamilton Montgomery and Morris Waisman; "Acquired Syphilis in Childhood and Early Adolescence: Results of Contact Investigation," by R. Dyar and M. H. Goodwin.

Presents several abstracts of medical studies related to dermatology and syphilis. "The Personality Factor in Psychoneurogenous Reactions of the Skin," by J. H. Stokes; "Staphylococcic Impetigo Contagiosa," by S. Epstein; "Derris Root Dermatitis," by M. Dorne and T. B. Friedman.

Provides an overview of several articles on dermatology. Relation of vitamin c to the production of arsphenamine sensitiveness; Use of liver extract as antidote; Comparison of frostbite and trench foot.

Presents abstracts of articles on skin diseases. "Salicylates and Virus Nucleoprotein," by R. J. Best; "Metastases of the Scalp Simulating Turban Tumours," by F. Ronchese; Histaminase in the Treatment of Allergy," by H. Miller and G. Piness.

Presents several abstracts of medical studies related to dermatology and syphilis. "Study of Duhring-Brocq's Disease, Its Physicochemical Pattern," by R. Turpin and P. Chassagne; "The Biophotometric Study of Vitamin A in Dermatological Conditions," by H. L. Baer and H. R. Vogel; "Tobacco Skin Reactions and Their Clinical Significance," by Joseph Harkavy.

Presents abstracts of studies on skin diseases. "Diphtheritic Infection of the Umbilicus," by A. R. Thompson; "On the Skin Test in Lymphogranuloma Inguinale," by Wilhelm Frei; "Patterned Alopecia About the Calves and Its Apparent Lack of Significance," by F. Ronchese and R. R. Chace.

Presents several abstracts of dermatology-related articles featured in various medical journals. "Yaws in Cuba," by V. Pardo-Castello; "Lupus Erythematosus With a Generalized Follicular Papular Rash,"by s. Nicolau and S. Theodorescou; "The Flora of Streptococcal Dermatitis," by P. Negroni and C. Briz de Negroni.

The article presents a report of a cytogenetic survey of the special hospitals of Rampton and Moss Side which took place during 1967 and 1968. It includes cases originally detected in a sex chromatin survey of 1963 and in a chromosome survey of height selected patients of 1966, but independently reascertained during the course of the present survey. A comparison of the behaviour of patients with chromosome abnormality with randomly selected controls has been made on the basis of convictions recorded on hospital notes.

Presents abstracts of several studies on skin diseases. "Acrodermatitis Hiemalis," by M. B. Hartzell; "Recurrent Acrodermatosis of Warm Countries," by R. Rinz-Arnau; "Elephantiasis Nostras," by J. A. Elliot; "On a Rare Form of Scleroderma," by A. Ravogli; "A Case of Sporotrichosis," by David M. Greig.

Three pot experiments are described in which perennial ryegrass (S23) and Plantago lanceolata (ribgrass) were grown alone and in mixed stands at varying densities and cut at different frequencies. With frequent cutting the yield of ryegrass was reduced to a greater extent than that of ribgrass, but the mean plant weights of both species were independent of sowing density. The pattern of competition was not altered by a single cutting treatment, the balance being quickly restored by the rapid regrowth of the ryegrass. [ABSTRACT FROM AUTHOR]

The effects of various systems of winter-grazing management on pasture production in the following spring and summer were studied in four trials in the Pentland Hills, Scotland. Winter grazing reduced the yield of herbage in spring, but growth in May and June was primarily influenced by the level of nitrogen application in spring, irrespective of winter-grazing treatments. [ABSTRACT FROM AUTHOR]

Seven species or varieties of grass, and a mixture of 3 of them, were sown in pure swards, treated with 4 levels of nitro-chalk (0, 17-5, 35, and 70 lb N/ac/cut) and cut 4 or 5 times each year. Each species and the mixture were also sown with white clover, and the effect of fertilizer N on the yield of N in each grass was compared with the effect of clover on the yield of N harvested from the grass/clover swards. The regression line for response in yield of N with increasing levels of fertilizer N showed slight, but significant, upward curvature. The grasses differed in their uptake of N from the soil, S37 cocksfoot and S48 timothy showing relatively high uptakes, and the ability of each grass to take up fertilizer N was usually related to its uptake of N from the soil. Differences in the yield of dry matter between the species, at a similar level of N, are discussed, and it was concluded that perennial ryegrasses were most efficient and Agrostis tenuis was least efficient in using the N taken up in the production of DM. In general, there were no significant differences between the yields of N of the grass/clover mixtures; the N yields of the grass components were significantly different and tended to be inversely related to the N yields of clover. Grasses which gave high yields of N with fertilizer were also high yielding when grown in association with clover. Pure grass swards required more than 200 lb fertilizer N/ac/yr in order to yield the same amount of N as the grass/clover swards. The amount of N estimated to have been derived by grass from clover (indirect effect of clover) increased each year; it was highest with S37 cocksfoot and lowest with Irish perennial ryegrass, averaging 46 and 23 lb N/ac/yr, respectively. [ABSTRACT FROM AUTHOR]

On 6 dates during a period of 14 days, S48 timothy seed was combine harvested directly and then dried in layers 6 in. deep at air temperatures of 77, 95, 104 and 122 ° F and airflows of 20 and 35 ft/min. The effect of these drying conditions upon subsequent laboratory germination was measured. An experimental drier of 8 units developed for this work is described. Results showed that the depression of germination by increasing temperatures depended on the stage of ripeness when the initial moisture content was greater than 30% wet basis.® Below this moisture level, no significant depression was found at temperatures up to 122 ° F. Seed of acceptable commercial standard was obtained when harvested at 41-3% m.c.w.b., but only under the gentlest drying treatment, 77 ° F and 20 ft/min. [ABSTRACT FROM AUTHOR]

Preliminary studies have been undertaken to determine the degree to which diploid and tetraploid ryegrass varieties intercross under field conditions. The results obtained through the use of diploid and tetraploid non-red-base tester plants indicate that pollen from tetraploid ryegrasses constitutes little or no danger to the genetic purity of diploid seed crops, even if grown in close proximity. A small proportion of viable triploid hybrids can arise in the progenies of tetraploid plants heavily exposed to diploid pollen, but here again their frequency and incidence are not of practical consequence. [ABSTRACT FROM AUTHOR]

Further investigation into the value of gülle as a fertilizer for grassland indicates that weather affects responses. Dry weather permits good recovery of gülle N. On the other hand, on dry soil, losses of gülle N by volatilization may be increased if the quantity of sludge applied is insufficient to penetrate the soil. Cow-and-pig gülle may be more efficient than the pure-cow type as a fertilizer, the former being well balanced in N and K, whereas cow gülle requires N supplementation. [ABSTRACT FROM AUTHOR]

Physical data, from an experiment to determine the effect of drying on the quality of S48 timothy seed, are used to derive an equation relating the average drying rate of the seed to the temperature and flow of the drying air. The relationship, which can be of use in practical problems, demonstrates the importance of air temperature in determining the drying rate, particularly when compared with similar data for wheat. [ABSTRACT FROM AUTHOR]

Seven species or varieties of grass, and a mixture of 3 of them, were sown in pure swards and treated with 4 levels of nitrogenous fertilizer (0, 17.5, 35 and 70lb N per acre per cut). Each species, and the mixture, was also sown with white clover. The experiment was cut 4 or 5 times per year. The effect of fertilizer on the yield of each grass was compared with the effect of clover on the yield of the grass/clover swards. Mean annual yields showed an approximately linear response to N; there was a small but significant fall in response to the highest level of N. Response among the species ranged from 20 to 30 lb of dry matter per lb N applied for the intermediate level of fertilizer and from 14 to 23 Ib for the final increment of fertilizer. S37 cocksfoot, S48 timothy, S24 ryegrass, and a mixture of these grasses, were high yielding and responded well to fertilizer N; Irish ryegrass and Agrostis tenuis were less productive and gave poorer responses to N. S215 meadow fescue and S23 ryegrass were intermediate in yield and response. There were no significant differences between the annual yields of the 8 grass/clover mixtures; the yields of the grass and clover components of each mixture were inversely related. The effect of clover on the yield of the grass/clover mixtures was estimated to be equivalent to the effect of an annual application of 205 Ib N per acre to Agrostis tenuis and 120 lb N to S48 timothy. The fluctuations in annual yields were greater with grass/ clover mixtures than with grass swards receiving N. The yields of grasses when sown with clover were in similar order to their yields when sown pure; but whereas the latter tended to fall from year to year, the yields of the grass components of mixtures (except Irish ryegrass) did not. [ABSTRACT FROM AUTHOR]

Results from current trials indicate that soil type, time of application and weather influence responses to applications of gülle. Over 3 sites guile N had an efficiency of about 60% of that of fertilizer N. Best results were obtained from heavy clay soils or those containing much organic matter. Winter applications of dilute gülle to light soils under wet conditions may result in large losses of N through leaching. Generally, winter gülle applications may lead to severe losses of plants in short-term ryegrasses with associated heavy uptakes of K in spring. It is concluded that much of the guile produced should be broadcast in winter on to swards destined for mowing in early summer. Optimum utilization of gülle calls for supplementation with fertilizer N, when the full potential of the K derived from the sludge can be exploited. [ABSTRACT FROM AUTHOR]

Eight lots of seed of S23 perennial ryegrass which had been artificially dried to different moisture levels and stored for 20 years were tested for germinating capacity, and the effects of long-term storage on subsequent plant development were studied. The results of the germination tests indicated a continuation of the downward trend in viability previously reported. Observations on the derived mature plants revealed no difference between lots in general growth habit; a few seedlings showed symptoms of some retardation in growth but most plants manifested the high tillering and prostrate growth typical of S23 perennial ryegrass. Pollen fertility was markedly reduced in 38% of all the plants sampled. The seed-setting capacity was affected to an even greater extent, 44% of the plants giving seed-set values decidedly below those obtained for plants grown from new seed. Where pollen fertility had been much reduced, seed-setting also was usually low, but there were some instances of satisfactory pollen fertility associated with a low seed set. [ABSTRACT FROM AUTHOR]

A further report is made of work on the fertilizer value of gülle for grassland. Organic N had an efficiency in grass production about 84% of that of inorganic N. The gülle used in this trial was particularly rich in available N and K. The abundance of K in gülle may require balancing with supplementary N in order to achieve efficient utilization of plant nutrients. Potassium/magnesium relationships in the nutrition of the grass plant are discussed. [ABSTRACT FROM AUTHOR]

An estimate was made of the fertilizer value of gülle for grassland under conditions in the East of Scotland. Organic nitrogen from liquid manure had an efficiency in herbage production about half that of inorganic nitrogen. The liquid manure was a rich source of potassium. Generally, nitrogen response in this trial was low owing to the strong growth of clovers. [ABSTRACT FROM AUTHOR]

This is a preliminary report on an instrument being developed for the measurement of pasture yield in situ. In essence the instrument is an electrical capacitance measuring unit in which the introduction of herbage to a measuring head causes a change in the electrical capacitance of the system. This capacitance change is measured at a radio frequency and used as an indicator of the mass of herbage contained within the measuring head. The development and construction of the instrument is described and data are presented for 15 calibration series in which frequency change has been related to pasture yield. Within series the instrument accounts for approximately 90% of the variation in pasture sample yield measured either as wet, dry or organic matter. However, significant differences exist between series. These differences would give rise to bias if pasture yield were estimated from a prediction equation derived from the pooled data. Possible sources of the differences between series are discussed and avenues for further development indicated. [ABSTRACT FROM AUTHOR]

Data from 291 digestion trials have been used to derive regression equations relating the organic-matter digestibility of herbage to the nitrogen percentage of its dry matter and to the nitrogen percentage in the organic matter of the resulting faeces. The residual errors are very high and it is shown that the deviations from the lines are not randomly distributed but have a seasonal trend. The seasonal biases have been calculated, and the inclusion of month of cutting as a factor is found to improve the two regressions to some extent. Monthly regressions have also been calculated. Even with these, however, the errors are still too high for many practical purposes. [ABSTRACT FROM AUTHOR]

Under mowing conditions in the absence of the animal, ultra-simple swards based either on ryegrass or cocksfoot gave large increases in yield of dry matter and nitrogen from the inclusion of white clover in the seeds mixture. Raising the clover seed rate from 1 to 3 lb./acre gave a further response in yield. As the swards aged, the continuing effect of increased clover seed rate was dependent on applied nitrogen. The rate of transference of nitrogen from clover to the soil depended upon the species of the associated grass, the clover seed rate, the age of the sward and the degree of reduction of the clover in the sward. Suppression of clover led to an increase in soil nitrogen, particularly with high seed rates of clover. Dry matter response to applied nitrogen (69 lb./acre/annum) was greater in cocksfoot than in ryegrass. Fertilizer nitrogen had little effect on the yield of nitrogen from the sward except where the high seed rate of clover had been used. [ABSTRACT FROM AUTHOR]

The utilization of Scottish hill-land potential is severely limited by inadequate wintering facilities resulting from a low proportion of inbye land to hill-land. The machair lands of the Uists, in the Outer Hebrides, however, provide a more suitable ratio, which is not commonly found in the Highlands of Scotland. Investigations into the grassland problems of the Hebrides were intensified in 1955; and some of the data obtained from trials are given here, as are suggestions for improving the production and utilization of grass in these areas. The climate, soil, and agricultural system all interact to provide conditions which are rarely seen elsewhere. [ABSTRACT FROM AUTHOR]

A trial designed to show the effects of animal excreta on sward productivity is described. It was estimated that the grazing sheep returns in a season nutrients capable of immediate uptake by the plant equivalent to 5-6 cwt. nitro-chalk and 2-2 1/2 cwt. 60% muriate of potash per acre. A large part of sward yield depended on animal return. Clover depression from the effects of animal excreta and, under mowing treatment, from the effects of fertilizer nitrogen, did not result in marked loss of transferred clover nitrogen. There appeared to be a gain in clover soil-nitrogen from a reduction of the clover stand. A comparison is made between the results obtained from sheep excreta on the sward with those obtained from mowing treatment. The interaction between animal or fertilizer nitrogen and the clover plant is discussed. [ABSTRACT FROM AUTHOR]

Presents the results of several clinical and laboratory studies in a 20 year old male with the Smith-Lemli-Opitz syndrome. Case history of the patient; Factor which may account for the rarity of the syndrome among residents of schools for the mentally retarded; Clinical condition of the disease.

Ring formation in a chromosome of the C-group has been described for an X-chromosome in females with gonadal dysgenesis and its associated anomalies (Lindsten, 1963). Next in frequency are reports of patients with ring formation of a chromosome in the D or E groups. It is of interest that, to our knowledge, no ring formation has been reported in spontaneous abortions (Inhom, 1967). Three case reports have appeared describing the occurrence of a C-group ring chromosome in males (Turner, Jennings, den Dulk and Stapleton, 1962; Atkins, Pant, Hazard and Ouellette, 1966). A further case is known to us through a personal communication of Dr. H. Punnett. In this paper we report clinical, cytogenetic and other laboratory findings in a young boy with a C-group ring chromosome, and similar studies in his parents and sibs. [ABSTRACT FROM AUTHOR]

Focuses on a study which examined the methionine induction of experimental tyrosinaemia in guinea pigs. Clinical characteristics of tyrosinaemia; Physiological effect of L-tyrosine induction on newborn guinea pigs; Results and discussion.

The article presents a paper that describes a four-year follow-up study on the influence of serum bilirubin levels upon the ultimate development of low birthweight infants. First, zero order correlations were computed between all nine variables for each of the sexes and for the entire group. There were no striking correlations between the peak serum bilirubins and the examination at three and fours years of age. Second, the infants were divided into those with peak bilirubin levels above and below 18 mg per cent. There was no significant difference in the examinations carried out at 3 and 4 years between the two groups.

This article cites a study containing several experiments that investigated the effects of proximal and distal proactive interference on recall by mentally subnormals, or mongols. The main aim of the first experiment was to determine to what extent irrelevant auditory stimulation preceding a learning task affected recall in subnormals. Eight mongol, eight epileptic and eight undifferentiated subnormals took part in the first experiment. The aim of the second experiment, reportedly, was to determine the effects of varying the loudness of proximal proactive interference on recall. Eight mongol and eight epileptic subnormals took part in this experiment. Because there was no difference in the performance of the non-mongol subjects in the first experiment, the undifferentiated subnormals were excluded. Mongols and non-mongols matched on chronological age, mental age and digit span took part in four experiments in which a 1,000 cps tone immediately preceded the presentation of a digit message or was separated from it by a one and a half second silent delay.

This article cites a study assessing the impact of postnatal undernutrition on human brain development. Postnatal undernutrition is the most common cause of substandard health in the world's children. In the present study brain cell number, cell size, water and protein content, and lipid analyses are reported for infants who had the onset of malnutrition in the latter half of the first year of life, and who died between the ages of twelve and twenty-four months, as well as for control infants. Brain samples were obtained from six rural Guatemalan infants of Anglo-Indian descent. Bodies were kept refrigerated between death and the time of autopsy. Half brains were obtained at autopsy, performed between six and nineteen hours after death, and were immediately frozen in dry ice. DNA results were analyzed statistically using the Student t-test. It was noticed that total DNA, representing total cell number, was similar in the brains of the control and undernourished children.

The article presents the case study of a young girl suffering from Hallermann-Streiff syndrome. The Hallermann-Streiff syndrome is characterised by proportionate dwarfism, dyscephaly with bird-like facies, mandibular hypoplasia, microphthalmia, congenital cataract, cutaneous atrophy localised to the scalp and face, hypotrichosis, and dental anomalies. The girl, in this study, was seen initially when aged seven years with severe physical and mental retardation. At birth the infant had an odd facies. Subsequent development showed marked physical and mental retardation.

The article presents a study, in which banding technique was used to ascertain the exact nature of partial trisomy 15 and of 8/21 translocation in human beings. Two residents of a school for the mentally retarded were earlier described as having a low ridge count due to a high number of arches on the finger-tips associated with differing chromosomal abnormalities that could not be accurately defined. These patients have been restudied with the use of banding techniques; one has a partial trisomy 15 and the other has a translocation of the long arms of the No. 21 chromosome to the short arms of the No. 8 chromosome with loss of the short arms and centromere of the No. 21.

The article cites a study in which chromosomal analysis of an eleven-year-old mentally retarded girl showed karyotype. The clinical features of the Wolf-Hirschorn syndrome show an aggregation which is specific and which in only a few instances resembles the cri-du-chat syndrome. As with the majority of autosomal conditions associated with mental retardation there is the usual high incidence of short stature, microcephaly, micrognathia, low-set ears, epicanthi, strabismus, etc. Clinical features in the case suggest a diagnosis of Wolf-Hirschorn syndrome, and this is confirmed by cytogenetic studies.