1. INDUCTION OF DELAYED HYPERSENSITIVITY IN GUINEA PIGS BY AFLATOXINS, OTHER COUMARINS AND FURAZOLIUM.
- Author
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Chung, Choong W., Giles, Albert L., and Carson, Theophilus R.
- Subjects
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ALLERGIES , *GUINEA pigs , *AFLATOXINS , *COUMARINS , *MYCOTOXINS , *PERFUMES - Abstract
Aflatoxins B1, B2, G1 and G2, highly toxic mycological metabolic products occurring as food contaminants, were capable in minute quantities of causing delayed hypersensitivity in guinea pigs. Structurally related compounds, sterigmatocystin (a mycotoxin), coumarin, 8-methoxypsoralen and furazolium chloride were also equally or more active in causing delayed hypersensitivity in guinea pigs. Animals which were strongly sensitized to aflatoxin B1 showed cross-reactivity to other aflatoxins (B2, G1 and G2), sterigmatocystin, coumarins, 8-methoxypsoralen, furans and commerical perfumes. Less strongly immunized animals, on the other hand, showed differential cross-reactivity in that other aflatoxins produced frank erythema whereas closely related compounds were more moderate in action. None of these immunized animals showed any circulating antibodies. [ABSTRACT FROM AUTHOR]
- Published
- 1970
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