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6. CASE FINDING IN PHENYLKETONURIA. II. THE GUTHRIE TEST.

Author

PARTINGTON MW and SINNOTT B

Subjects
Canada, Humans, Infant, Infant, Newborn, Bacteriological Techniques, Biological Assay, Clinical Laboratory Techniques, Filtration, Hematologic Tests, Hospitalization, Hospitals, Hospitals, Psychiatric, Infant, Newborn, Diseases, Laboratories, Mass Screening, Paper, Phenylalanine, Phenylketonurias, Prisons, Urine
Abstract

Experience with over 6000 Guthrie tests is presented. This test is a screening procedure for phenylketonuria using small amounts of blood spotted on a filter paper which are tested by a bacterial "inhibition assay". Certain technical aspects of the test (e.g. relation between the concentration of phenylalanine in the blood and extent of the bacterial growth zones produced, type of filter paper, size of the blood spot on the paper) were investigated. It was shown that the Guthrie test clearly distinguishes between subjects with normal plasma phenylalanine levels and patients with untreated phenylketonuria.Applications of the Guthrie test in screening a mental hospital population, admissions to a penitentiary and newborn babies are described.

Published
1964

9. [On the standardization of surface disinfection-tests (author's transl)]

Author

G, Reybrouck

Subjects
Paper, Analysis of Variance, Bacteriological Techniques, Time Factors, Cell Survival, Staphylococcus, Sterilization, Cell Count, Sodium Chloride, Wood, Hospitals, Evaluation Studies as Topic, Pseudomonas aeruginosa, Methods, Glass, Equipment and Supplies, Hospital, Disinfectants
Published
1974

14. CASE FINDING IN PHENYLKETONURIA. II. THE GUTHRIE TEST

Author

M W, PARTINGTON and B, SINNOTT

Subjects
Hospitals, Psychiatric, Paper, Bacteriological Techniques, Canada, Hematologic Tests, Clinical Laboratory Techniques, Phenylalanine, Infant, Newborn, Infant, Original Articles, Urine, Hospitals, Infant, Newborn, Diseases, Hospitalization, Phenylketonurias, Prisons, Humans, Mass Screening, Biological Assay, Laboratories, Filtration
Abstract

Experience with over 6000 Guthrie tests is presented. This test is a screening procedure for phenylketonuria using small amounts of blood spotted on a filter paper which are tested by a bacterial "inhibition assay". Certain technical aspects of the test (e.g. relation between the concentration of phenylalanine in the blood and extent of the bacterial growth zones produced, type of filter paper, size of the blood spot on the paper) were investigated. It was shown that the Guthrie test clearly distinguishes between subjects with normal plasma phenylalanine levels and patients with untreated phenylketonuria.Applications of the Guthrie test in screening a mental hospital population, admissions to a penitentiary and newborn babies are described.

Published
1964