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Peritoneal exudate cells from old NZB/Bl mice were found to be more active in taking up I125 labelled bovine serum albumin than similar cells from age matched BALB/c, C57B1 and CBA mice. The cells from both young and old NZB/Bl mice were markedly less able to degrade the ingested antigen than cells from the other strains. These observations are discussed in relation to the development of autoimmune phenomena in the NZB/Bl strain, [ABSTRACT FROM AUTHOR]

The sera of NZB/BL mice have been found to be active in the complement fixation test against isogeneic liver antigens to a higher titre than the sera of CBA, C57BL and DBA/2 mice. Six sera from NZB mice were fractionated by zone ultracentrifugation in sucrose density gradients and the anti-liver activity was found to sediment with the high molecular weight immunoglobulin. No correlation was found between complement-fixing activity against liver antigens and the presence of globulin on red cells (positive direct Coombs test). [ABSTRACT FROM AUTHOR]