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An isotopic assay of elastolytic activity is performed: the iodine-125 ions retained inside the elastin framework were removed by appropriate treatment. This acute substrate enables us to study the role of trypsin on elastase activity and facilitates the study of elastase role in atherosclerosis.

Bricaud Joanny. « L'Arménie qui agonise » . In: Échos d'Orient, tome 18, n°112-113, 1916. pp. 197-201.

To determinate the part of humoural and parietal factors in atherosclerotic injury genesis, metabolism alteration study is realised on aortic cell wall of rabbits which are submitted to a chronical lathyritic intoxication alone, or simultaneously or alternatively associated with a cholesterolemic diet. Catabolic activity increase of beta-glucuronidase occurs in hypercholesterolemic rabbits. Beta-aminoproprionitrile, lathyrogenic drug used, stimulates biosynthetic pathways: increase of soluble proteins, energetic enzyme activities (lacticodeshydrogenase, malicodeshydrogenase), conjonctival protein metabolism (procollagen lysyl hydroxylase); in the same time, cell wall disturbances and lipidic deposits are facilitate when rabbits are submitted to cholesterolemic diet.

The pharmacological study of dopamine was conducted on 14 patients: eleven normal patients and three with incipient myocardiopathies. The dosages used were 3, 6 and 12 mug/kg/min. The "pump" function, the peripheral resistances, the contractility and the ventricular compliance were studied. Dopamine is a positive inotropic agent without chronotropic action at doses of 6 and 12 mug/kg/min. It acts by increasing the contractility and the venous return and by decreasing the peripheral resistances; this effect disappears with strong dosages.

Cells obtained from the media and intima of ten days rat aorta, after enzymatic dissociation, were grown in subculture for up to three months. Electron microscopic observations demonstrate that these cells maintained the morphology of smooth muscle cells at all phases of their growth in subculture and kept their ability to synthesize and secrete intracellular proteins with better enzymatic features than the cells obtained by proliferation at the periphery of an explant.

An isotopic assay of elastolytic activity is performed; the iodine-125 ions retained inside the elastin framework were removed by appropriate treatment. This acute substrate enables us to study the role of trypsin on elastase activity and facilitates the study of elastase role in atherosclerosis.

The authors report the haemodynamic changes observed during isometric stress corresponding to 30% of the maximum isometric effort, sustained for 3 minutes, in 22 normal subjects and 12 patients with cardiomyopathy. Echocardiographic study of the left ventricular diameters of 10 cardiac patients completes the work. The heart rate in normal subjects during effort increases by 45 +/- 30%, and the flow by 30 +/- 24%. The blood pressure is raised by +/- 25 +/- 8 mmHg, without significant change in the left ventricular end-diastolic pressure (less than +4 mmHg), or in peripheral resistance. The external work of the left ventricle increases by 75 +/- 41%, demonstrating an increase in the inotropic state of the myocardium. Max. vec. and the various indices of contractility are increased on average by +8.29 +/- 4.55 28 c/s. Adaptation to the increased pressure brings into play only the contractile reserve of the myocardium.

One case of rapidly lethal endomyocardial fibrosis was observed in a man aged 47 who never left France and suffering from distomatosis. The relationship between this parasitic disease and this "autochtonus" endomyocardial fibrosis are discussed.

The existence of a parietal elastase and its physiological role in the pathology of the arterial wall remain unknown: it is probably difficult to demonstrate its specific activity because of existing tissular inhibitors, homologous to seric inhibitors. The change of seric inhibitor power when elastase is injected to animals with or without a cholesterol diet is discussed. Moreover, an aortic inhibiting power against elastase is shown. Our results emphasize some new aspects of elastase in its role in arterial wall pathology.

21 chronic anginal patients (AP), 23 patients with an overall number of 37 aorta-to-coronary artery by-passes (ACB) underwent a regular physical training (cycle, quick or uphill walking, gymnastics). The patients were compared to themselves in the course of a calibrated effort test, performed until angina occured or the maximal cardiac rate reached.