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During the period February 1963 to September 1964, the incidence of strains of tubercle bacilli excreted by newly diagnosed, previously untreated patients with tuberculosis in Canada that were resistant to the major antituberculosis drugs, viz. streptomycin, para-aminosalicylic acid and isoniazid, was 4.8%. Resistance to a single drug (3.8%) was observed more commonly than was resistance to two drugs (0.9%) or to all three drugs (0.3%), and the drug most frequently involved in this regard was streptomycin (1.8%). Data for the province of Ontario were almost the same as those for Canada. These data are compared with results of surveys in other countries and it is concluded that while drug-resistant tubercle bacilli do not constitute a major problem in Canada at present, awareness of this potential hazard should be maintained.