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Two patients with hemangiosarcoma of the heart are reported. Both patients presented with hemopericardium and congestive failure. They ran a prolonged febrile course with marked elevations of the serum lactic dehydrogenase but near normal levels of the serum glutamic-oxaloacetic transaminase. Embolization to the lungs produced dilatation and hypertrophy of the right ventricle. Metastases were found in the liver and spleen in one patient and in the adrenal glands and mesenteric lymph nodes in the second patient. Although the second patient had received antituberculosis therapy, necropsy findings also revealed miliary tuberculosis.