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Reaction of streptokinase with 1 mole of 2-hydroxy-5-nitrobenzyl bromide results in a 50% loss of potency in the standard clot lysis assay. Reaction with a second mole of reagent results in only a slight additional loss in potency. However, the modification of the 2 residues of streptokinase does not inhibit the formation of the stoichiometric complex with plasminogen or the formation of the active enzymatic site in the complex as measured by the hydrolysis of α-N-toluene sulfonyl-l-arginine methyl ester.

TO THE EDITOR:— A positive Galeazzi's sign may indicate a femoropelvic pathology. Frequently, however, it is only an indication of a benign asymmetry of the femur which requires no treatment.Galeazzi in 19301 described shortening of the thigh as indicative of a femoropelvic pathology (Fig 1). He suggested that this sign might result from a defective acetabulum with subluxation, congenital dislocation of the hip, coxa vara, rudimentary development of the head, shaft, or neck of the femur, absence of a portion of the shaft of the femur, etc. A positive Galeazzi's sign, however, may simply indicate that one thigh is somewhat shorter than the other. This latter condition—benign asymmetry of the femur—will correct itself.In the seven-year period from 1956 through 1963, we have seen 52 infants with a positive Galeazzi's sign. Forty of these patients had significant pathology of congenital dysplasia, dislocation, subluxation, etc, and 12 had