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A double-blind two-group comparison of fluphenazine/nortriptyline (F/N) with amitriptyline in 72 patients aged 65 or over suffering from mixed states of anxiety and depression, each treated for four weeks, showed F/N to be significantly superior to amitriptyline by Day 7 in terms of patients' self-ratings and clinicians' ratings. Patients' preference for F/N was even more pronounced by Day 28 (P less than 0.001), when the improvement in symptoms relating to depression was rated by the clinicians as significantly greater for the patients receiving F/N (P less than 0.025). The incidence of drowsiness was significantly greater (P less than 0.05) in the amitriptyline group than the F/N group. The implications of these results for the treatment of emotional disturbances in the elderly are discussed.

1. The cotton seed is composed of embryo, endosperm, perisperm, inner pigment layer, palisade (Malpighian) layer, colorless layer, outer pigment layer, and epidermis including lint hairs. 2. Traces of starch, in addition to oil and protein, occasionally occur in the cells of both young and mature embryos. 3. The substances commonly recognized as pentosans in the hulled seeds are located in the resin glands. These glands no doubt contain various other substances. 4. The cell walls of the embryo are composed chiefly of cellulose. 5. Starch, oil, and protein occur within the cells of the endosperm. The cell walls of this tissue are composed chiefly of cellulose. 6. Large quantities of starch are found in the two integuments of the developing ovule. It disappears, however, before maturity. 7. The pigmentation which occurs in the cells of the two pigment layers, and to a less extent in the palisade layer and epidermis, is associated with a hardening of the protoplast. 8. The palisade layer is a part of the inn...

A double-blind study involving sixty-two patients, aged 65 years or over, treated for twenty-eight days, showed that fluphenazine 0-5 mg/nortriptyline 10 mg three times daily was superior to promazine 50 mg three times daily in relieving symptoms of anxiety and was associated with a lower incidence of side-effects. The results are discussed in the light of the nature of anxiety/depression syndromes in the elderly and it is suggested that since symptoms of anxiety in these disorders are often manifestations of an underlying depressive illness, the antidepressant effect of the nortriptyline may have enhanced the 'anxiolytic' advantage of fluphenazine/nortriptyline.