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Start Over Author "Castaneda B" Publication Year Range More than 50 years ago
5 results on '"Castaneda B"'

1. Preliminary study of WR 33063 in the treatment of falciparum malaria in northeast Thailand.

Author

Segal HE, Chinvanthananond P, Laixuthai B, Phintuyothin P, Pearlman EJ, Na-Nakorn A, and Castaneda BF

Subjects
Adolescent, Adult, Antibodies analysis, Antimalarials adverse effects, Clinical Trials as Topic, Ethanolamines adverse effects, Ethanolamines therapeutic use, Fever etiology, Follow-Up Studies, Hematocrit, Humans, Kidney Function Tests, Leukocyte Count, Liver Function Tests, Malaria blood, Malaria complications, Malaria diagnosis, Malaria immunology, Male, Middle Aged, Parasite Egg Count, Phenanthrenes adverse effects, Quinine adverse effects, Quinine therapeutic use, Thailand, Antimalarials therapeutic use, Malaria drug therapy, Phenanthrenes therapeutic use, Plasmodium falciparum drug effects
Published
1974
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2. Chemosuppressive field trials in Thailand. II. The suppression of Plasmodium falciparum and Plasmodium vivax parasitemias by a diformyldapsone-pyrimethamine combination.

Author

Pearlman EJ, Thiemanun W, and Castaneda BF

Subjects
Adolescent, Adult, Aged, Child, Dapsone administration & dosage, Drug Administration Schedule, Drug Evaluation, Drug Therapy, Combination, Female, Humans, Malaria drug therapy, Male, Middle Aged, Plasmodium falciparum isolation & purification, Plasmodium vivax isolation & purification, Pyrimethamine administration & dosage, Thailand, Antimalarials therapeutic use, Dapsone analogs & derivatives, Dapsone therapeutic use, Malaria prevention & control, Pyrimethamine therapeutic use
Abstract

In an area of Thailand where chloroquine-resistant falciparum malaria is known to exist, a chemosuppressive field trial was undertaken to test the efficacy of the preparation diformyldapsone (DFD) combined with pyrimethamine (Py) in suppressing falciparum and vivax parasitemias. Six hundred and fifty-nine Thai villagers were randomly assigned to one of five treatment groups: DFD-Py; dapsone (DDS)-Py; DFD alone; Py alone; and placebo. Five hundred and ninety-three study subjects completed the 26-week trial. The combination DFD-Py given weekly was shown to be an effective chemosuppressive against both falciparum and vivax parasitmias, causing a more than fourfold reduction in falciparum and an approximately threefold reduction in vivax parasitemias; however, this combination was not more efficacious than DDS-Py for the chemosuppression of falciparum malaria. DFD alone was only moderately effective, while there was no difference in chemosuppression between Py alone and placebo.

Published
1975

3. Comparison of diaminodiphenylsulphonepyrimethamine and sulfadoxine-pyrimethamine combinations in the treatment of falciparum malaria in Thailand.

Author

Segal HE, Chinvanthananond P, Laixuthai B, Pearlman EJ, Hall AP, Phintuyothin P, Na-Nakorn A, and Castaneda BF

Subjects
Adolescent, Adult, Dapsone adverse effects, Dapsone analogs & derivatives, Drug Evaluation, Drug Synergism, Female, Humans, Male, Middle Aged, Plasmodium falciparum analysis, Pyrimethamine adverse effects, Sulfadoxine adverse effects, Sulfadoxine analogs & derivatives, Thailand, Dapsone therapeutic use, Malaria drug therapy, Plasmodium falciparum drug effects, Pyrimethamine therapeutic use, Sulfadoxine therapeutic use, Sulfanilamides therapeutic use
Published
1975
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4. The suppression of Plasmodium falciparum and Plasmodium vivax parasitaemias by a dapsone-pyrimethamine combination.

Author

Segal HE, Pearlman EJ, Thiemanun W, Castaneda BF, and Ames CW

Subjects
Adolescent, Adult, Child, Chloroquine therapeutic use, Dapsone therapeutic use, Drug Combinations, Female, Hematocrit, Humans, Malaria blood, Male, Pyrimethamine therapeutic use, Thailand, Dapsone administration & dosage, Malaria drug therapy, Plasmodium falciparum, Plasmodium vivax, Pyrimethamine administration & dosage
Published
1973

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