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Your search keyword '"Castel, V."' showing total 5 results
Start Over Author "Castel, V." Publication Year Range More than 50 years ago
5 results on '"Castel, V."'

4. Clinical tolerance and catabolism of plasmin-treated gamma-globulin for intravenous application.

Author

Barandun S, Castel V, Makula MF, Morell A, Plan R, and Skvaril F

Subjects
Adolescent, Adult, Aged, Antibodies, Bacterial analysis, Antibodies, Viral analysis, Bacterial Infections therapy, Child, Chromatography, Chromatography, Gel, Complement Inactivator Proteins, Dextrans, Humans, Immunization, Passive, Immunoglobulin Fab Fragments, Immunoglobulin Fc Fragments, Immunoglobulin G isolation & purification, Injections, Intravenous, Iodine Radioisotopes, Male, Middle Aged, Placenta immunology, Ultracentrifugation, Virus Diseases therapy, gamma-Globulins administration & dosage, gamma-Globulins metabolism, Fibrinolysin metabolism, Immunologic Deficiency Syndromes therapy, gamma-Globulins standards
Abstract

Plasmin-treated gamma-globulin of placental origin was tested in clinical and laboratory studies and found to be suitable for intravenous use both for prophylactic and therapeutic purposes. Plasmin treatment of gamma-globulin (IgG) results in proteolytic cleavage of 60-70% of the molecules into Fab and Fc fragments whereas 30-40% of the molecules are plasmin resistant. The antibody spectrum of plasmin-treated gamma-globulin is similar to that of standard gamma-globulin. Catabolic properties of the plasmin-resistant portion of this preparation and of standard gamma-globulin are identical. Plasmin-treated gamma-globulin has no anticomplementary activity and its intravenous administration is well tolerated even by highly sensitive immunodeficient patients.

Published
1975
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5. Interactions of anti-DNA antibodies with dinitrophenyl- and other hapten-protein-conjugates.

Author

Riesen W and Castel V

Subjects
Adenosine Monophosphate, Binding, Competitive, Cytidine, DNA, Single-Stranded, Guanosine, Humans, Immunoglobulin G, Iodine Isotopes, Lupus Erythematosus, Systemic immunology, Purines, Radioimmunoassay, Serum Albumin, Bovine, Uracil, Uracil Nucleotides, Antibodies, Antinuclear, Cross Reactions, DNA, Dinitrophenols, Haptens
Published
1973
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