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Your search keyword '"Ciaranello RD"' showing total 20 results
Start Over Author "Ciaranello RD" Publication Year Range More than 50 years ago
20 results on '"Ciaranello RD"'

3. Genetic regulation of the catecholamine biosynthetic enzymes. II. Inheritance of tyrosine hydroxylase, dopamine-beta-hydroxylase, and phenylethanolamine N-methyltransferase.

Author

Ciaranello RD, Hoffman HJ, Shire JG, and Axelrod J

Subjects
Animals, Carbon Radioisotopes, Chromosome Mapping, Crosses, Genetic, Female, Genes, Genetic Code, Genotype, Hybridization, Genetic, Male, Mathematics, Mice, Mice, Inbred BALB C, Models, Biological, Mutation, Phenotype, Species Specificity, Statistics as Topic, Adrenal Glands enzymology, Catecholamines biosynthesis, Dopamine beta-Hydroxylase metabolism, Phenylethanolamine N-Methyltransferase metabolism, Tyrosine 3-Monooxygenase metabolism
Published
1974

4. Genetic aspects of monoamine mechanisms.

Author

Barchas JD, Ciaranello RD, Dominic JA, Deguchi T, Orenberg E, Renson J, and Kessler S

Subjects
Adrenal Glands enzymology, Adrenocorticotropic Hormone pharmacology, Animals, Brain drug effects, Brain enzymology, Brain Stem metabolism, Cerebral Cortex metabolism, Cold Temperature, Crosses, Genetic, Female, Glucocorticoids pharmacology, Hydroxyindoleacetic Acid metabolism, Male, Mice, Mice, Inbred Strains, Neurons physiology, Organ Specificity, Serotonin metabolism, Species Specificity, Time Factors, Tryptophan metabolism, Dopamine beta-Hydroxylase metabolism, Genetic Variation, Phenylethanolamine N-Methyltransferase metabolism, Tyrosine 3-Monooxygenase metabolism
Published
1974

5. Genetic differences in mechanisms involving neuroregulators.

Author

Barchas JD, Ciaranello RD, Dominic JA, Deguchi T, Orenberg EK, Renson J, and Kessler S

Subjects
Animals, Cyclic AMP metabolism, Dihydroxyphenylalanine metabolism, Dopamine metabolism, Dopamine beta-Hydroxylase metabolism, Epinephrine metabolism, Humans, Methyltransferases metabolism, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Mice, Inbred CBA, Mice, Inbred Strains, Molecular Biology, Norepinephrine metabolism, Phenethylamines metabolism, Schizophrenia metabolism, Serotonin metabolism, Species Specificity, Stress, Psychological, Tyrosine metabolism, Tyrosine 3-Monooxygenase metabolism, Adrenal Medulla metabolism, Brain metabolism, Catecholamines biosynthesis, Genotype
Published
1974
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6. Association between fighting behavior and catecholamine biosynthetic enzyme activity in two inbred mouse sublines.

Author

Ciaranello RD, Lipsky A, and Axelrod J

Subjects
Adrenal Glands enzymology, Animals, Dopamine beta-Hydroxylase metabolism, Genes, Recessive, Genetics, Behavioral, Humans, Male, Mice, Motor Activity, Phenylethanolamine N-Methyltransferase metabolism, Reaction Time, Species Specificity, Tyrosine 3-Monooxygenase metabolism, Aggression, Catecholamines biosynthesis, Genotype, Hybridization, Genetic, Mice, Inbred BALB C metabolism
Abstract

Levels of three adrenal catecholamine synthesizing enzymes and isolation-induced fighting behavior were studied in two related sublines of the Balb/c inbred mouse strain. Enzyme levels were twice as high in the adrenals of Balb/cJ mice as in those of the Balb/cN mice; heterozygous progeny were intermediate between their parents in the levels of the three enzymes. These sublines also showed marked differences in their fighting behavior after a 2-week isolation period. Balb/cJ mice fought immediately after presentation of an intruder mouse, while Balb/cN mice did not fight at any time during the test. Heterozygous progeny behaved more like the Balb/cN (non-fighters). Analysis of F(2) mice suggested that the differences in fighting behavior were determined by a single gene, with fighting being recessive.

Published
1974
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7. Effect of dexamethasone on phenylethanolamine N-methyltransferase in chromaffin tissue of the neonatal rat.

Author

Ciaranello RD, Jacobowitz D, and Axelrod J

Subjects
Acetyltransferases metabolism, Adrenal Cortex Hormones pharmacology, Animals, Animals, Newborn, Choline, Chromaffin System drug effects, Female, Ganglia, Autonomic cytology, Glucocorticoids pharmacology, Histocytochemistry, Microscopy, Fluorescence, Nerve Degeneration drug effects, Phenylethanolamine N-Methyltransferase metabolism, Pregnancy, Rats, Time Factors, Chromaffin System enzymology, Dexamethasone pharmacology, Methyltransferases metabolism
Published
1973
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9. Catecholamines: strain differences in biosynthetic enzyme activity in mice.

Author

Ciaranello RD, Barchas R, Kessler S, and Barchas JD

Subjects
Adrenal Glands enzymology, Animals, Brain enzymology, Carbon Isotopes, Dihydroxyphenylalanine biosynthesis, Epinephrine biosynthesis, Male, Methylation, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Mice, Inbred CBA, Mice, Inbred DBA, Norepinephrine biosynthesis, Phenylethanolamine N-Methyltransferase metabolism, S-Adenosylmethionine metabolism, Adrenal Glands metabolism, Brain metabolism, Catecholamines metabolism, Methyltransferases metabolism, Tyrosine 3-Monooxygenase metabolism
Published
1972
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10. Regulation of adrenal phenylethanolamine N-methyltransferase activity in three inbred mouse strains.

Author

Ciaranello RD, Dornbusch JN, and Barchas JD

Subjects
Adrenal Glands drug effects, Adrenocorticotropic Hormone antagonists & inhibitors, Adrenocorticotropic Hormone pharmacology, Aminoglutethimide pharmacology, Animals, Carbon Isotopes, Cold Temperature, Cycloheximide pharmacology, Dexamethasone pharmacology, Enzyme Induction, Genes, Regulator, Half-Life, Hypophysectomy, Mice, Mice, Inbred C57BL, Mice, Inbred CBA, Mice, Inbred DBA, Monoamine Oxidase metabolism, Pentolinium Tartrate pharmacology, Phenoxybenzamine pharmacology, Phenylethanolamine N-Methyltransferase biosynthesis, Phenylethanolamine N-Methyltransferase metabolism, Pituitary Gland physiology, Species Specificity, Tyrosine 3-Monooxygenase metabolism, Adrenal Glands enzymology, Methyltransferases biosynthesis
Published
1972

11. Genetically controlled alterations in the rate of degradation of phenylethanolamine N-methyltransferase.

Author

Ciaranello RD and Axelrod J

Subjects
Adrenal Medulla enzymology, Animals, Carbon Isotopes, Cattle, Drug Stability, Female, Genes, Genetics, Hybridization, Genetic, Kinetics, Male, Mice, Mice, Inbred BALB C, Mutation, Phenylethanolamine N-Methyltransferase biosynthesis, Phenylethanolamine N-Methyltransferase isolation & purification, Phenylethanolamine N-Methyltransferase metabolism, Precipitin Tests, Pregnancy, Rabbits immunology, Species Specificity, Structure-Activity Relationship, Tritium, Adrenal Glands enzymology, Methyltransferases metabolism
Published
1973

15. Rapid increase of phenylethanolamine N-methyltransferase by environmental stress in an inbred mouse strains.

Author

Ciaranello RD, Dornbusch JN, and Barchas JD

Subjects
Animals, Cycloheximide pharmacology, Environmental Exposure, Male, Mice, Mice, Inbred Strains, Phenethylamines, Time Factors, Adrenal Glands enzymology, Cold Temperature, Methyltransferases analysis, Stress, Physiological enzymology
Abstract

The activity of-phenylethanolamine N-methyltransferase in mice of the C57Bl/Ka strain was determined after a 4 degrees C stress. The enzyme activity increased 1.2-fold at the end of 3 hours and by 1.4-fold by the end of 6 hours of the stress. The results are in contrast to those from other species with intact animals in which the enzyme changes only after several days of chronic stress. Cycloheximide prevents the rise in enzyme activity, suggesting the increase may be due to protein synthesis. The increase may provide a model system for studying regulation of catecholamine biosynthetic enzymes.

Published
1972
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16. The enzymatic formation of methanol from S-adenosylmethionine by various tissues of the rat.

Author

Ciaranello RD, Dankers HJ, and Barchas JD

Subjects
Adrenal Glands enzymology, Animals, Benzoates, Brain enzymology, Carbon Isotopes, Chromatography, Paper, In Vitro Techniques, Kidney enzymology, Liver enzymology, Lung enzymology, Methyltransferases metabolism, Myocardium enzymology, Pancreas enzymology, Rats, S-Adenosylmethionine biosynthesis, S-Adenosylmethionine metabolism, Spleen enzymology, Sulfur Isotopes, Tritium, Adenosine metabolism, Methanol biosynthesis, Methionine metabolism
Published
1972

17. Epinephrine formation and metabolism in mammalian brain.

Author

Barchas JD, Ciaranello RD, and Steinman AM

Subjects
Animals, Brain enzymology, Brain Stem enzymology, Epinephrine administration & dosage, Epinephrine biosynthesis, Injections, Intravenous, Pineal Gland metabolism, Pituitary Gland metabolism, Rats, Transferases antagonists & inhibitors, Transferases metabolism, Tritium, Brain metabolism, Epinephrine metabolism
Published
1969

19. Genetic variation in activity of enzymes involved in synthesis of catecholamines.

Author

Kessler S, Ciaranello RD, Shire JG, and Barchas JD

Subjects
Amino Alcohols, Analysis of Variance, Animals, Carbon Isotopes, Genes, Dominant, Male, Mice, Mice, Inbred Strains, Phenethylamines, S-Adenosylmethionine, Adrenal Glands enzymology, Brain enzymology, Genes, Genetic Variation, Methyltransferases, Mixed Function Oxygenases, Tyrosine 3-Monooxygenase
Abstract

A genetic analysis of differences in adrenal phenylethanolamine N-methyltransferase (EC 2.1.1.X) and tyrosine hydroxylase (EC 1.99.1.X.) and brain tyrosine hydroxylase was performed in three inbred mouse strains. In adrenal glands, the pattern of inheritance of both enzymes was similar; genes carried by the CBA/J strain appeared to be dominant to those of the other strains. The pattern of inheritance of tyrosine hydroxylase activity in adrenals differed from that in the brain. In both tissues, dominant genes appeared to determine intermediate, rather than extreme, levels of enzyme activities.

Published
1972
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