Search

Your search keyword '"Corinaldesi, R."' showing total 7 results
Start Over Author "Corinaldesi, R." Publication Year Range More than 50 years ago
7 results on '"Corinaldesi, R."'

1. The mechanism of action of gefarnate in the light of the latest data on digestive physiopathlogy

Author

M. Giorgi-conciato, L. Barbara, G. Busca, Luchetta L, and Corinaldesi R

Subjects
Adult, Male, medicine.medical_specialty, Gefarnate, Pathology, Adolescent, Biopsy, Peptic, Radioimmunoassay, Administration, Oral, Gastroenterology, Internal medicine, Gastrins, Gastric mucosa, Humans, Medicine, Stomach Ulcer, Aged, chemistry.chemical_classification, Gastric Juice, Histocytochemistry, Terpenes, business.industry, Anti-ulcer Agent, Stomach, Endoscopy, Hexosamines, General Medicine, Middle Aged, Pathophysiology, medicine.anatomical_structure, chemistry, Gastric Mucosa, Fatty Acids, Unsaturated, Female, Gastritis, medicine.symptom, business
Abstract

SummaryA study to investigate the mechanism of action of gefarnate (treatment: 600 mg. daily by mouth for 30 days) was carried out in 25 patients with gastric ulcer.The following parameters were evaluated before and after treatment: a) the macroscopic (endoscopy), microscopic (optic microscopy and histochemistry) and ultra-structural appearance (electron microscopy) of the gastric mucosa; b) mucous secretion (hexosamines); c) hydrochloric acid and peptic secretion; and d) serum levels ofgastrin (radioimmunoassay).Endoscopic examination after treatment showed that the ulcer was completely healed in 32% of cases with re-epithelising in the remaining patients: satellite gastritis was considerably improved in all patients. The normalisation of the histological, histochemical and ultrastructural picture of the mucoid cells was the main morphological change induced by the treatment. This was associated on a functional level with a statistically significant increased production of hexosamines. The hydrochloric a...

Published
1974

2. The mechanism of action of gefarnate in the light of the latest data on digestive physiopathlogy

Author

Barbara, L., Corinaldesi, R., Giorgi-conciato, M., Luchetta, L., and Busca, G.

Abstract

SummaryA study to investigate the mechanism of action of gefarnate (treatment: 600 mg. daily by mouth for 30 days) was carried out in 25 patients with gastric ulcer.The following parameters were evaluated before and after treatment: a) the macroscopic (endoscopy), microscopic (optic microscopy and histochemistry) and ultra-structural appearance (electron microscopy) of the gastric mucosa; b) mucous secretion (hexosamines); c) hydrochloric acid and peptic secretion; and d) serum levels ofgastrin (radioimmunoassay).Endoscopic examination after treatment showed that the ulcer was completely healed in 32% of cases with re-epithelising in the remaining patients: satellite gastritis was considerably improved in all patients. The normalisation of the histological, histochemical and ultrastructural picture of the mucoid cells was the main morphological change induced by the treatment. This was associated on a functional level with a statistically significant increased production of hexosamines. The hydrochloric acid and peptic secretion as well as the serum levels ofgastrin did not show any significant change.It would seem that the mechanism of action of gefarnate consists of the normalisation of the mucous secretion, followed by the restoration of the normal defensive mucous barrier.

Published
1974
Full Text
View/download PDF

3. [Gastroduodenal ulcer: pathogenetic and clinical aspects].

Author

Labò G, Barbara L, Miglioli M, Di Febo G, Cornia GL, Corinaldesi R, and Lami F

Subjects
Alcoholic Beverages adverse effects, Diet, Duodenal Ulcer etiology, Duodenal Ulcer physiopathology, Gastric Juice metabolism, Gastrins metabolism, Gastrointestinal Hormones metabolism, Histamine Release, Humans, Indomethacin adverse effects, Salicylates adverse effects, Secretin metabolism, Smoking complications, Stomach Ulcer etiology, Stomach Ulcer physiopathology, Stress, Psychological complications, Vagus Nerve physiopathology, Peptic Ulcer chemically induced, Peptic Ulcer etiology, Peptic Ulcer physiopathology, Peptic Ulcer therapy
Published
1974

4. [Plasma changes of some enzyme activities in myocardial infarct].

Author

Di Febo G, Corinaldesi R, Cornia GL, Maccolini E, Luchetta L, and Busca G

Subjects
Adult, Aged, Creatine Kinase blood, Female, Fructose-Bisphosphate Aldolase blood, Humans, Hydroxybutyrate Dehydrogenase blood, L-Lactate Dehydrogenase blood, Malate Dehydrogenase blood, Male, Middle Aged, Transaminases blood, Clinical Enzyme Tests, Myocardial Infarction diagnosis
Published
1974

7. [Clinico-therapeutic studies of the use of a new oral antibiotic in medical pathology].

Author

Corinaldesi R

Subjects
Administration, Oral, Adult, Aged, Cephalexin therapeutic use, Cephalosporins administration & dosage, Cephalosporins pharmacology, Clinical Trials as Topic, Drug Tolerance, Evaluation Studies as Topic, Female, Hematopoiesis drug effects, Humans, Kidney Function Tests, Liver Function Tests, Male, Middle Aged, Transaminases blood, Biliary Tract Diseases drug therapy, Cephalosporins therapeutic use, Respiratory Tract Infections drug therapy, Urinary Tract Infections drug therapy
Published
1973

Catalog

Books, media, physical & digital resources
See catalog results