1. Ultrastructural changes in the nervous system after chronic exposure to halothane
- Author
-
Young K. Lee, Jordan Katz, Alden W. Dudley, and Louis W. Chang
- Subjects
Male ,Nervous system ,Pathology ,medicine.medical_specialty ,Necrosis ,Golgi Apparatus ,Biology ,Endoplasmic Reticulum ,Ultrastructural Pathology ,symbols.namesake ,Developmental Neuroscience ,Edema ,medicine ,Animals ,Cerebral Cortex ,Inclusion Bodies ,Neurons ,Brain Diseases ,Endoplasmic reticulum ,Rats, Inbred Strains ,Environmental Exposure ,Golgi apparatus ,Mitochondria ,Rats ,Microscopy, Electron ,medicine.anatomical_structure ,nervous system ,Neurology ,Chronic Disease ,symbols ,Female ,medicine.symptom ,Halothane ,Neuroglia ,Ribosomes ,Cytoplasmic Vacuolation ,medicine.drug - Abstract
The ultrastructural pathology of the rat nervous system after chronic exposure to low levels of halothane was investigated. After 8 wk of exposure to 10 ppm halothane, collapse of the neuronal rough endoplasmic reticulum was observed. Dilatation of the Golgi complex and focal cytoplasmic vacuolation were observed within many cortical neurons. After exposure to 500 ppm halothane, vacuolation of the Golgi complex became even more severe. Membraneous degeneration of the neuronal mitochondria, intracellular edema of the glial cells, and necrosis of the cortical neurons could also be found. The present study indicates that halothane is neurotoxic and may be considered as an occupational hazard.
- Published
- 1974