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A total of 61 lumbar sympathetic blockades were performed on 5 patients with gangrene on one or several toes and on 6 patients with intermittent claudication only. Subcutaneons blood flow on the dorsum of the foot was measured by the Xenon clearance technique before and after the blockades. In the gangrene group successful lumbar blockades resulted in a significant decrease in the blood flow from 7.4 ml/100 g/min to 5.5 mI/100 g/min while in the patients only suffering from intermittent claudication a significant increase in the blood flow from 3.4 ml, 100 g/min to 4.7 ml/100 g/min was found. Additional observations suggested that measurement of skin temperature and the sympathogalvanic reflex are not adequate criteria for selecting those patients in which lumbar sympathetic blockades produces an increased peripheral blood flow. The indications for sympathetic denervation in patients with arterial obstructions are discussed. [ABSTRACT FROM AUTHOR]

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