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Progenies from 68 self-pollinated panicles of 10 somatically unstable sorghum-sudangrass hybrid sectors were grown. Data are presented for 25 progenies from three representative unstable plants. Highly uniform progenies were obtained from most panicles. Results indicate chromosome assortment was not always at random. Major distinctions between panicle progenies suggested that: (a) sorghum-like and sudangrass-like genomes functioned as units; (b) gene transfer and association were non-random further indicating that somatic chromosome substitution or somatic translocations, or other gross changes, may have occurred; and (c) other deviating behaviors implied genetic segregation.

Durch Synthese und oxidative Kondensation des Tetrahydroxybenzophenons 2b wurde das Xanthon-Dienon 3b gewonnen. Dieses konnte durch stereoselektive Reduktion in 10-Methyl-10-desmethoxycarbonyl-hemisecalonsaure A (4) ubergefuhrt werden. 4 stimmt in der Konfiguration an seinen drei Chiralitatszentren mit einer Molekulhalfte des Ergochroms Secalon-saure A (1) uberein und unterscheidet sich davon nur durch den Austausch der CO2CH3-Gruppe gegen Methyl. Tm Rahmen dieser Totalsynthese wurden Bildung und Stereochemie von Umwandlungsprodukten der Xanthon-Dienone 3a und b, wie z. B. auch des mit dem Mutterkorn-Farbstoff Ergoxanthin (30) strukturverwandten seco-Xanthons 24, untersucht. Natural Products from Fungi, 23. Stereospecific Synthesis of 10-Methyl-10-desmethoxycarbonyl-hemisecalonic Acid A The xanthone dienone 3b was obtained by synthesis and oxidative condensation of the tetrahydroxybenzophenone 2b. 3b could be transformed into 10-methyl-10-desmethoxy-carbonyl-hemisecalonic acid A (4) by stereoselective reduction. 4 corresponds to one half of the ergochrome secalonic acid A (1) molecule with respect to its configuration at the three centers of chirality and differs from it only by exchange of the CO2CH3 group with methyl. In connection with this total synthesis an investigation was carried out on the formation and stereochemistry of transformation products of the xanthone dienones 3a and b, as for instance also the seco-xanthone 24, which is structurally related to the ergot pigment ergoxanthin (30).

The gross and microscopic pathologic findings in our 354 patients overwhelmingly favor the theory of acquired origin in most patients with pilonidal sinus. The facts appear to show that the reason there has been so much debate over whether pilonidal disease is congenital or acquired in origin is because there are two different types of the disease.