1. Low dosage anti-D immunoglobulin in the prevention of rhesus isoimmunization
- Author
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Giorgio Mello, P. Curiel, Erminia Carapella, and G. B. Massi
- Subjects
Time Factors ,Low dosage ,Pregnancy Complications, Cardiovascular ,Physiology ,Immunoglobulins ,Injections, Intramuscular ,Erythroblastosis, Fetal ,Isoantibodies ,Pregnancy ,Transplacental haemorrhage ,Medicine ,Humans ,Rhesus positive ,Fetus ,Rh-Hr Blood-Group System ,biology ,business.industry ,Rhesus Isoimmunization ,Obstetrics and Gynecology ,medicine.disease ,Delivery, Obstetric ,Rhesus negative ,Immunology ,biology.protein ,Female ,Antibody ,business - Abstract
Summary Immediately after delivery of a rhesus positive child, a dose of 100 to 125 μg. of anti-D immunoglobulin was given to 838 rhesus negative mothers in whom a Kleihauer test showed either no fetal cells or suggested a transplacental haemorrhage (TPH) of less than 0.25 ml. Out of 523 patients tested at six months after delivery only one (0.19 per cent) was found to have anti-D antibodies. Sixty women had a further pregnancy and delivered a rhesus positive child. None developed anti-D antibodies and all children were unaffected by rhesus isoimmunization. A dose of 100 to 125 μg. of anti-D immunoglobulin proved effective in reducing rhesus isoimmunization in rhesus negative women with minimal TPH but since a large TPH is rare, such a dose is probably sufficient in 98 per cent of cases.
- Published
- 1974