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Highly purified T 5-receptor substance was irradiated with X-rays, and a one-hit dose response was obtained. By comparing quantitatively the results of two independent tests, both of which measure “survival“ of receptor after irradiation, it was possible to conclude that the receptor-active site of one receptor particle must be larger than the cross-section of a T 5-phage tail. However, since receptor particles were never definitely observed to have combined with more than one T 5-particle, secondary processes must be involved in the binding reaction, leading to a rapid inactivation of any surplus receptor-active areas on the receptor particle undergoing the reaction.