1. A Preliminary Report on the Serology of Lucké and Burkitt Herpes-type Viruses: A Shared Antigen
- Author
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Lloyd J. Old, Gayla Geering, John M. Kirkwood, John H. Wallace, and Merle Mizell
- Subjects
biology ,medicine.diagnostic_test ,medicine.disease ,Immunofluorescence ,Virology ,Virus ,Lymphoma ,Serology ,Capsid ,Antigen ,Nasopharyngeal carcinoma ,immune system diseases ,hemic and lymphatic diseases ,Immunology ,medicine ,biology.protein ,Antibody - Abstract
Serological analysis of the Herpes-type virus (HTV) associated with cell lines derived from patients with Burkitt lymphoma has revealed two classes of antigens: a) soluble components detected by immunoprecipitation (12), and b) capsid antigens, most clearly demonstrated by coating reactions visualized by electron microscopy (4, 9). Immunoprecipitation, immunofluorescence, and complement-fixation tests indicate a high incidence of antibody to Burkitt HTV antigen in human populations (3, 5, 6, 7, 12). This antibody is found most frequently in patients with Burkitt lymphoma, lymphosarcoma, chronic lymphatic leukemia, and nasopharyngeal carcinoma (11). Naturally occurring antibodies to antigens related to this virus are not restricted to man, but are also found in the chimpanzee, and other subhuman primates (3, 11).
- Published
- 1969
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