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In a 3-year period (January, 1970, to January, 1973) three or more bypass grafts were placed in 397 patients who had severe triple coronary vessel disease. Ten patients (2.5%) died in the hospital postoperatively. Fifteen patients (4%) had postoperative myocardial infarctions. Late myocardial infarction occurred in 11 patients (2.8%), and in 6 of these the infarctions were fatal. Late deaths occurred in 11 patients; 7 of the deaths were of cardiac origin. Three patients were lost to follow-up. The remaining 373 patients were followed from 10 to 46 months. Three hundred sixty-one patients (96.7%) improved, 295 (79%) of these becoming asymptomatic. Two hundred twenty-one patients (672 grafts) were restudied from 6 weeks to 31 months after operation. The overall patency rate was 81.5%. There was a direct correlation between relief of angina and completeness of the revascularization. With one functioning graft, 9 patients (42.8%) became asymptomatic; with two functioning grafts, 52 patients (74.2%) became asymptomatic; and with three functioning grafts, 108 patients (87.8%) became asymptomatic. This experience suggests that three or more bypass grafts can be placed with a low operative risk in selected patients. Total or complete revascularization should be attempted in patients with severe triple-vessel disease.