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The rupture of the metal-ligand bonds associated with β-decay of 171 Er and 177 Yb have been studied in the Er- and Yb-CyDTA (CyDTA = 1·2 cyclohexanediamine N,N,N′,N′ tetraacetic acid) chelate compounds. The observed percentage bond ruptures were 70 per cent in 177 Yb- and 100 per cent in 171 Er-compounds at pH 6·5. In the ytterbium system, the percentage bond rupture shows an increase with increase of hydrogen ion concentration. On the contrary, the addition of sodium thiosulfate in the both systems results in a decrease in the percentage bond rupture. These results are interpreted in terms of intramolecular electron transfer, multiple ionization and recoil due to the β-decay processes and by the reaction mechanisms such as geminate recombination and proton attack.

Terrestrial Al26 produced by cosmic-ray muons has been sought in silicate rock. Aluminum was isolated and purified from tens of kilograms of chert obtained from an area with a low erosion rate. Al26 was counted with a low-level gamma-gamma coincidence spectrometer. The specific activity for the present surface rock has been measured to be (0.02 ± 0.12) dpm/10 kg SiO2, and the specific activity for the rock at a depth of 24 meters of water equivalent, to be (0.00 ± 0.08) dpm/10 kg SiO2. The Al26 activity in terrestrial rocks has been limited to 0.01 dpm/kg SiO2.

この研究に報告されている実験は，坂元昂「学習過程における手がかりの機能」東京大学修士論文１９５７年（未公刊）の一部を構成するものである。また，この研究は，部分的に，文部省科学研究費，１９６５年度及び１９６６年度の各個研究費からの援助を受けている。

Cross sections of reactions induced by alpha particles on Ag/sup 107/ are measured up to 40 Mev by means of the radiochemical method with stacked foil targets. Observed excitation functions are for the ( alpha ,n), ( alpha ,2n), ( alpha ,3n), ( alpha ,pn), ( alpha , alpha n), and ( alpha , alpha 2n) reactions. For the ( alpha , alpha n) reaction the cross sections for one of the isomeric pair are determined. Excitation functions are calculated in terms of the statistical theory, using capture cross sections based on the diffusesurface optical model and the level density W(E) = C exp STA2{a(E - delta )} /sup 1/2/!. Adopting a = 3 Mev/sup -1/and pairing-energy values for delta , the experimental results are explained by the theory. Isomeric cross sections are obtained for the ( alpha ,n) and ( alpha ,3n) reactions. The ratios of higher spin states to lower spin states increases as the energies of alpha particles increase. The ratio is about twenty at 40 Mev for the ( alpha ,3n) reaction. (auth)

Transplantation assays were used to determine the fraction of clonogenic cells surviving in isologous transplanted squamous carcinomas after irradiation in vivo in mice breathing air, 5 per cent CO2 in O2, or O2 at three atmospheres absolute (OHP). The results of single-dose irradiation indicated that the percentages of cells which were severely hypoxic under the three conditions were, respectively: 13, 6·8 and 4·3. A series of experiments in which a first exposure of 1,000 R was given in air and a second exposure of 1,000 R, after 36 hours, in air or OHP failed to provide evidence either that hypoxic cells surviving the first dose of irradiation became “reoxygenated” during the 36 hour interval, or that the second dose in OHP was more effective than that in air. The findings are discussed in relation to other recently published data from experiments in which different tumours and techniques were used to seek evidence of “reoxygenation” or to study the influence on tumour response of the gas brea...

研究目的比較的簡単な方法で短時間のうちに運転中の経糸送出量を, 精度高く測定できる方法の確立を目的とする.研究結果1.カメラ, 度数計及び瞬間写真用クセノン放電管を使用して, 運転中にある一定のクランク角度において2回閃光をとばせ, その間の経糸変位量及び織機回転数を測定し, これによって1ピック当りの送出量を求めた.2.この測定法によれば, 測定値の誤差の生ずる割合は最大±0.3%, 1回の測定所要時間3min以内であって, 運転中簡単に, 精度高く送出量を測定することができる.

1) Leaves were collected for three years (1950-1952) from leading commercial apple orchards in Aomori Prefecture. Analysis records were taken of the dry matter per cent of nitrogen, phosphorus and potassium in the leaves.2) The leaves of Rall's Janet proved to have higher nitrogen and potassium content than Jonathan leaves, though the difference of phosphorus contents between varieties was not significant.3) Most productive orchards showed higher N content in leaves than the less productive orchards. The relation between P and K content and the productivity of orchards was not recognized.4) Generally, the lower N and the higher Kcontents of orchard leaves are apt to produce the better fruit color, and therefore the N/K values indicated rather clearly the fruit color of the harvest time, but much more investigations might be necessary on this subject.5) The trees on the alluvial soil orchards had rather higher N, P and lower K leaf contents than on the volcanic ash ones.6) Sod management of orchard soils was tend to make nitrogen content of leaves significantly lower than clean cultivation.7) Leaf compositions were highest in 1952 (an on-year after an off-year), lowest in 1950 (an on-year prior to an off-year) and intermediate in 1951 (an off-year).8) The age of trees seemed to decrease N content slightly, but not so clearly for the other two elements.9) From June to September, N and P in leaves decreased gradually, but the variation of K content was rather indistinct. The most adequate time for leaf sampling, in the case of nutrient diagnosis, was middle July in Aomori Prefecture.10) In this study, any correlation could not be found between the leaf content of N, P and K and the amount of fertilizers applied in the same year, because the variations of circumference were so large and not erasable.11) At the beginning of July, sampled leaves contained the elements as follows; Rall's Janet Jonathan (111 samples) (54 samples) max, mean. min. max, mean. min. N 2.49 3.25 3.98 2.30 3.00 3.84 P 0.115 0.170 0.247 0.096 0.167 0.244K 0.75 1.53 2.18 0.70 1.34 1.85 (dry matter per cent)12) The lowest level of leaf nitrogen in early July, to get the yield more than 800 bushel per acre, is 2.8 per cent (Rall's Janet) and 2.6 per cent (Jonathan). The relation between P and K contents and the yield was not clear.13) Hunger signs were not found, even when leaf K was below 1 per cent and P was less than 0.1 per cent.14) Japanese apple leaves have usually rather high N and low K contents. This might be due partly to the heavy bearing habit of the trees, though the further investigation may be needed on these problems.

The half-life of naturally occurring 176 Lu has been redetermined to be (3.79 ± 0.03) × 10 10 y from γ-ray measurements, using a Ge(Li) and a NaI(Tl) detector. Two independent lutetium sources were used: the oxide of isotopically enriched 176 Lu and the oxide of natural abundance.

A comparative study was made of the toxic properties of actinomycin D and X-rays using synchronized populations of Chinese hamster cells cultured in vitro. X-irradiated cells are most resistant in the latter half of the DNA synthetic period (late S). While cells treated with actinomycin D appear to go through a survival maximum at the same age, they are most resistant after the completion of DNA synthesis; i.e. in G2 (or G2-mitosis). In spite of these differences, we found that actinomycin D damage in late S cells interacts with X-ray damage. Thus, a common locus for the site of actions of both agents is suggested which may be in or around the genome of a cell in view of the well-known DNA binding properties of actinomycin D.

We have studied the combined effects of X-irradiation and nitrogen mustard treatment on the colony-forming ability of Chinese hamster cells. In contrast to X-irradiation, nitrogen mustard acting by itself yields an exponential dose-effect relationship. Moreover, whether delivered in immediate sequence or after varying intervals, nitrogen mustard treatment does not affect radiation survival and vice versa. These results, plus the lack of any indication of the repair of sublethal nitrogen mustard damage, are consistent with independent but different modes of action at the same site(s), or action at different sites.

The thermal exchange reaction between lutenium ion and its EDTA complex in aqueous solution was studied in a pH range of 4·0–6·0 and concentrations of Lutetium ion and complex of the order of 10−3–10−4 M. The rate was found to be proportional to [H+]1·0–1·5 and [LuY]1·0, and to be influenced slightly by the concentration of lutetium ion. Slight dependence on ionic strength was also observed in an ionic strength range of 0·02–0·2. Apparent activation energies 10·2 kcal mole−1 and 11·6 kcal mole−1 were obtained at pH 5·8 and 4·5, respectively. The rate of exchange in a pH value higher than 4·0 is expressed by: R mole 1. −1 min −1 =k1[ LuY ][ H + ]+k′ 2 [ LuY ][ H + ] 2 +k′ 4 [ LuY ][ H + ] 3 +k 5 [ LuY ][ Lu 3+ ]+k′ 6 [ LuY ]x[ H + ][ Lu 3+ ] where κ1, κ′2, κ′4, κ5 and τ'6 are 14 mole−1 min−1, 1·5 × 106 12 mole−2 min−1, 4·2 × 1010 13 mole−3 min−1, 2·2 × 10−2 1 mole−1 min−1 and 7·5 × 103 12 mole−2 min−1 at 25°C in 0·01 M ammonium acetate buffer solution. Under the conditions studied the reaction via the protonation process is predominant and the bimolecular collision process is minor. Spontaneous dissociation process can be ignored.

研究目的製織中のクランク1回転間に経糸張力がどのような変化をするかを知ることと, それによって張力変化の軽減を企図するために, 経糸張力の理論的解析を行った.研究結果経糸を完全弾性体と見なし, 経糸張力が送出し, 巻取り, 開口, イージングモーションおよびおさ打などの運動によって変化するものとして取扱い, ウエイトレバなどの運動方程式をラプラス変換を用いて解くことによって張力の変化をあらわす式を誘導した.また, これらの式の数値計算結果は実験結果と一致することが確かめられた.張力の変化を軽減させるためには開口運動とイージング運動との差をできるだけ小さくすることが最も重要であり, また, ウエイトレバ軸並びに経糸運動に関係する各部の摩擦はウエイトレバ系振動のダンパとして重要な役割を演じていることが痛感された.

Optical absorption and photoluminescence studies on AgBr1-aeClae show that the nature of relaxed exciton states changes discontinuously from free to self-trapped excition as the composition x exceeds ∼0.45. The transition can be explained by attainment of sufficiently strong exciton-phonon coupling wehn the alloy composition is varried.

The Ag109(α, n)In114(14.4 min) and In112m(20.8 min), Ag109(α, 2n)In111(2.8 d) and Ag109 (α, 3n)In110(66 min) and In110m(4.9 h) reaction cross sections have been measured up to an alpha particle energy of 40 MeV. The experimental excitation functions can be reproduced by the statistical calculation by use of a level density formula of the form either W 1 (E) = C exp [2{a 1 (E−δ)} 1 2 ] or W 2 (E) = C(E − δ) −2 exp [2{a 2 (E − δ)} 1 2 ] , if values of a1 between 1 and 4 MeV−1 or of a2 between 4 and 7 MeV−1 are used and Cameron's pairing energy P is taken as − δ. It seems very likely that other reasonable choices of δ give values of the parameters a1 or a2 which are close to the above mentioned values. Grover's theory, which takes into account the angular momentum effect and gamma competition, is discussed. The (α, n) isometric cross section ratios agree with the prediction of Bishop et al. The sums of the observed reaction cross sections are consistent with the capture cross sections calculated by Igo from the optical model.

The formation cross sections of 26 A1 and 22 Na from proton bombardment of natural Si, Al and Mg have been measured as a function of E p up to E p = 52 MeV. The maximum values for 26 A1 formation from natural Si, Al and Mg are 60 mb at 44 MeV, 169 mb at 23 MeV and 12.6 mb at 11.3 MeV, respectively. The excitation functions for the 22 Na formation have been compared with those of previous experiments.

An extremely low-level gamma-ray spectrometer has been used to measure gamma rays associated with the decay of naturally occurring 176 Lu and 180 Ta. For the half-life of 176 Lu, a new value of (5.0±0.3)×10 10 y was derived from single-crystal sum-coincidence spectra of high-purity lutetium oxide samples of natural isotopic abundance. A search was also made for possible cascade gamma rays following the electron capture of 180 Ta in a purified tantalum oxide by means of the usual gamma-gamma coincidence technique. Although the obtained spectra were slightly complicated by the presence of radioactive impurities in the sample, some positive evidence for 180 Ta decay was observed. The lower limit deduced for the half-life was (1.5±0.5)×10 13 y.

1. Transient increase in blood pressure followed by a secondary hypotensive response and bradycardia was observed after rapid injection of contrast material or saline into the subclavian artery in the dog. Peripheral vasodilatation was noted.2. The transient and prompt elevation of the blood pressure was due to local mechanical (hydraulic) factors following the rapid injection of a large bolus of fluid at high pressure.3. The carotid sinus reflex does not play a primary role in the production of the secondary hypotension. Section of the vagus nerves abolished the bradycardia and diminished the fall of blood pressure.4. Transection of the spinal cord at C1 abolished the fall of blood pressure. It was concluded that under the experimental conditions described, the hypotension following intra-arterial injection of a liquid bolus resulted from stimulation of central vasomotor centers by perfusion.

The production of high specific activities of tin, 113Sn and 117mSn, with a cyclotron had been studied. Thick target yields for the reactions (A) 113In(d,2n)113Sn, (B) 115In(α,pn)-117mSn and (C) 110Cd(α,n)113Sn+111Cd(α,2n)-113Sn+ 114Cd(α,n)117mSn were determined for several incident particle energies. The reactions A and B are available for the production of the single tin activity. Reaction C is preferable to the others in the total yields of tin activities for the energy range studied, i. e., up to the energy of about 5 MeV. per nucleon of the incident particle. A thick target yield for reaction B has also been obtained from the excitation function up to the alpha particle energy of 40 MeV. The procedures for the carrier-free isolation of the tin activity from indium and cadmium targets by coprecipitation and ion exchange have also been described.

Summary Two substances could be isolated from culture filtrate of B. mallei, of which one seems to be the nucleoprotein in nature and the other the specific substance analogous to that of pneumococcus, streptococcus etc. Preliminary chemical examination indicates that this specific substance may belong to carbohydrates. The former—the so-called N.P.—is relatively nonspecific and gives rise to nonspecific precipitation. The relative nonspecificity of the precipitation reaction with the culture filtrate (or mallein) seems to depend upon this substance. The latter substance is highly specific; it gives rise to precipitation only with sera of infected or artificially immunized animals, but not with those of animals neither infected nor immunized with B. mallei. Specific precipitation with this specific substance is closely related to the complement-fixation reaction. The precipitation test with this specific substance appears the most simple and reliable means for the practical diagnosis of glanders applicable as well to mules and donkeys, as to horses.

研究目的送出量制御式積極送出装置およびブロックチエーン式消極送出装置について, 製織条件を種々に変え, おのおのの場合における経糸の総張力の時間的平均値と比送出量とを測定し, これらの変化の状態およびそれらの相互関係を検討して, 設計並びに取扱いの参考資料とする.研究結果諸種の条件変化に対して経糸張力および送出量が受ける影響を調査し, つぎの結果が得られた.1.積極, 消極両送出装置とも重錘重量を増加すると, 経糸張力は比例的に増加し, 比送出量は二次曲線的に減少する.2.ヘルド一致時期を変化させると, おさ打時以外の張力―クランク角度曲線は変化させた角度だけ位相のずれをもって現われる.3.ガイドローラの位置が高いほど比送出量は減少する.4.イージングカムの取付けを正常状態よりずらした場合, ずらし角が大きいほど最低張力が低くなる.5.温度一定で湿度のみを増加させると比送出量は減少する.

With the use of the excitation functions for 26Al-producing reactions measured by us, the rates of 26Al production in interplanetary targets (lunar rocks 10017 and 12002 and cosmic dust) by solar-flare particles have been calculated. The same calculations have also been made for 53Mn with the estimated excitation functions. The energy spectrum of solar protons averaged over the 1956–1966 solar cycle was used as a guide for the unknown flux over the last few million years with the assumption that the ratio of H/He was 6. It is shown that the half-value of the average flux reproduces rather well the observed depth profiles of these nuclides in the lunar rocks and the observed limit of 26Al in marine sediment. A slight discrepancy between the calculated and the observed pattern of 53Mn at the top surface of lunar rocks is discussed in terms of surface erosion and other effects. The present calculations are compared with earlier ones.

研究目的製織中の経糸張力および経糸送出量の測定方法を確立し, これらの測定法を応用することによって送出装置の運転中の性能を定量的に判定することを目的とする.研究結果(1) カメラ, 度数計およびクセノン放電管を使用し, 製織中の経糸送出量を求める方法を確立した.この方法によれば最大誤差±0.3%, 1回の測定所要時間3min以内である.(2) 応力リング, 抵抗線ひずみ計および電磁オッシログラフを用い, 経糸径路を変更することなく総経糸張力を測定した.測定値の最大誤差は±5%程度と推定される.(3) 筆者の1人が考案した消極積極両送出装置について, 経糸層半径の五つの点において経糸張力および経糸送出量を測定した結果, 次のことがらが判明した.消極送出装置の場合, 経糸平均張力の平均値からの偏差は+9.1～-5.4%, 経糸比送出量には±1%程度の変動がある.これは主として実験中の温湿度の変化に起因すると考えられる.したがってサンフォライズ加工を行う布等の製織に当っては, 温湿度調整装置との併用が望ましい.積極送出装置の場合, 経糸張力および経糸比送出量の変動は, それぞれ+1.6～-3.7%, +0.1～-0.3%であって, 全経糸層にわたってほとんど一定に保たれている.

In der Mandschurei fand bis beute noch niemals Rotzquarantaene statt. Wir verhaengten dieselbe zum ersten Mal ueber 1419 mandschurische Pferde, welche als Zugtiere in Dairen und Ryojun dienten, und kamen auf Grund der dabei gemachten Erfahrungen zu nachstehenden Schluessen:1) Fuer die Rotzdiagnose gibt es verschiedene Verfahren. Wenn man aber im allgemeinen Pferde gleichzeitig der Quarantaene unterwerfen will, so glauben wir, dass fuer die Vorwahl verdaechtiger Pferde die Mallein-Ophthalmoreaktion und zur Enddiagnose die Komplementbindungsreaktion, welche wir angestellt haben, in jeder Hinsicht die zweckmaessigsten sind.1) An 125 verdaechtigen unter 1419 Pferden wurden serologische Reaktionen angestellt. Unter allen Reaktionen ist die Komplementbindungsreaktion vom groessten diagnostischen Wert. Die Agglutination steht der Praezipitation ein wenig an Erfolg nach.3) Was den diagnostischen Titer dieser drei Reaktionen betrifft, so belaeuft sich nach unserer Untersuchungen der Komplementbindungs- auf 0.05ccm. der Agglutinations- auf 2000 und der Praezipitationstiter auf 20 fach (Mallein-Verduennung).4) Wir nahmen an 18 von 1419 Pferden Sektion vor und fanden durch makroskopische Befunde, dass 9 von Rotz befallen waren, und durch histologische Untersuchung, dass 3 an dieser Krankheit gelitten haben. Aber die Morbilitaet muesste in Wirklichkeit noch groesser gewesen sein, erstens well es unter den Tieren solche gab, bei denen die Komplementbindungsreaktion positiv ist und dennoch unter den Druck der Umstaende keine Sektion vorgenommen wurde, und zweitens weil wir bei Quarantaene zur einmaligen Methode unsere Zuflucht nahmen.5) Bei 2 Faellen von 12 an echtem Rotz erkrankten Pferden konnten wir Bazillus mallei isolieren.6) Es duerfte wohl hervorgehoben werden, dass klinisch bei dieser Quarantaene kein rotzkrankes Pferd gefunden wurde.

1. 1. A wheat germ agglutinin receptor fraction isolated from surface membranes of leukemia cells failed to interact with concanavalin A but did interact to a lesser degree with two other agglutinins. 2. 2. A preparation of concanavalin A that was not multivalent but presumably monovalent and which blocked the agglutination of susceptible cells by intact concavalin A had no effect on the agglutinability of the same cells by wheat germ agglutinin. 3. 3. Antiserum against the isolated wheat germ agglutinin receptor fraction from leukemia cells did not react with the normal lymphocytes nor did it react with red blood cells of syngeneic mice. 4. 4. The same antiserum against the wheat germ agglutinin receptor fraction inhibited the agglutination of L1210 (leukemia), Py 3T3 and Py BHK cells by wheat germ agglutinin but had no effect on the agglutination by concanavalin A of Py 3T3 or Py BHK cells. 5. 5. It was concluded that at least some lectin receptors are chemically and topographically on the membrane distinct from each other.

研究目的織機用緯糸木管について、これを長大にすることの可否をしらべ、更に高級繊維用として製織の際、緯糸切れ緯糸崩れ等がなく、且つ解け初めと解け終りの張力差の最も少い理想的な緯糸木管の形状を見出すことを目的として、種々実験研究を行つたものである。研究結果1. 緯糸木管の形状が緯糸張力に及ぼす影響を実験と理論とによつて究明し、これによつてロングボビンが高級繊維用として不適であることを明らかにした。2. 上記研究を基礎として、高級繊維用木管を試作し解舒張力試験及び製織試験の結果これが高級繊維用として非常に優秀であることを明らかにした。

An extremely low-level coincidence gamma-ray spectrometer has been established with heavy mass and anticoincidence shieldings. The main detector consists of a pair of 7.6 cm dia. × 7.6 cm NaI(Tl) crystals. The crystal has a 5 mm thick quartz window and is mounted in a 0.8 mm thick oxygen-free copper. The crystal is matched to a quartz-faced photomultiplier DuMont KM 2559 and shielded laterally with a 1.1 cm thick purified mercury and a 1.5 cm thick oxygen-free copper. The detector system is set inside a 20 cm thick iron room, on which a plastic scintillator of 10 cm thick × 70 cm × 90 cm is placed as the anticoincidence guard. The whole assembly is built in an underground cell heavily shielded against major cosmic-ray components with a rock cover of at least 100 mwe. For a positron emitter, a 100 g source with specific activity of 1.6×10 −3 dpm/g can be measured with a coefficient of variation of 1 in a total counting time of 2×10 4 min.

Summary 1.Two substances could be isolated from culture filtrate of B. mallei , of which one seems to be the nucleoprotein in nature and the other the specific substance analogous to that of pneumococcus, streptococcus etc. Preliminary chemical examination indicates that this specific substance may belong to carbohydrates. 2.The former—the so-called N.P.—is relatively nonspecific and gives rise to nonspecific precipitation. The relative nonspecificity of the precipitation reaction with the culture filtrate (or mallein) seems to depend upon this substance. 3.The latter substance is highly specific; it gives rise to precipitation only with sera of infected or artificially immunized animals, but not with those of animals neither infected nor immunized with B. mallei . 4.Specific precipitation with this specific substance is closely related to the complement-fixation reaction. 5.The precipitation test with this specific substance appears the most simple and reliable means for the practical diagnosis of glanders applicable as well to mules and donkeys, as to horses.

T HE pathogenesis of cerebral concussion has long been debated. The present experiments were undertaken to clarify the nature of acute cerebral disorders resulting from head injury. Concussion was defined by Denny-Brown as a "transitory and reversible nervous reaction with immediate onset following physical stress of sufficient violence and brevity, and characterized by progressive recovery thereafter. ''~ There are two main theories concerning the pathogenesis of concussion: the excitation theory of Walker, e t al., 4a and the paralytic theory of Denny-Brown and Russell2 These two theories, which postulate opposite mechanisms, will be reviewed. Walker and his associates 43 observed the appearance of fast activity in the electroencephalogram (EEG) with little change in amplitude immediately after a compressive impact applied to the exposed dura and brain in experimental animals. This was followed by '"extinction." The EEG changes were frequently accompanied by tonic extension movements of the extremities. They suggested that this type of concussion resulted from excitation of the central nervous system. An opposite view was proposed by Denny-Brown and Russell. Based on experimental observations of concussion produced by a pendulum striking the freely moving head (acceleration concussion), they concluded that this type of concussion was due to temporary paralysis of nervous function. In man, concussion is characterized by transient loss of neural function, accompa

Chinese hamster cells V-79 were treated with neocarzinostatin. The survival curve was made up of two components, the first with D0 of 0·025 μg/ml and the second with D0 of 0·05 μg/ml. When a correction for cell multiplicity is made, the first component was an exponential dose relation curve. The dose fractionation for 1-hr intervals and 6-hr intervals did not increase the survival. This illustrates that recovery of the Elkind type did not exist for neocarzinostatin.

Neocarzinostatin is a polypeptide anti-tumour substance produced by Streptomyces carzinostatics. Neocarzinostatin has demonstrated a strong anti-tumour activity towards several experimental tumours and has also been tried clinically. However, there are no experimental data for the effect on squamous carcinomas. Therefore, we studied the effect of neocarzinostatin on a murine squamous carcinoma. The survival curve was a two component curve and D0 values were 1·1 mg/kg in the first part and 8·5 mg/kg in the second part. On the other hand, neocarzinostatin was quite toxic for the WHT/Ht mice used in the experiment; e.g. LD50 (30) was 2·4 ± 0·9 mg/kg. This dose level corresponds to the dose required to obtain a surviving fraction of 0·1 of tumour cells treated with the drug.

研究目的杼の速さの測定法については従来から雷気的接点法, 磁束変化法, 電気的容量変化法・光束を遮断する等の光学的な方法等が報告されている.筆者等はこれ等の欠点を除くよ弓な換言すれば織布条件を何等変更することなく, また精度の高い測定法を見出すことを日的とした.研究結果2個の瞬間写真を利用する方法によれば上記の目的, 即ち織布条件を何等変更することなく且つ精度高い好速の測定が可能であることが判明し, 実際の例について測定を行った.

Evidence was found for the presence of a (0.30 ± 0.03) % β − decay branch of 176 Lu to an 8+ state in 176 Hf.

Many previous reports testify to the effectiveness of bleomycin as a drug for the clinical treatment of squamous carcinomata, and some radiotherapists have considered the possibility that an improved therapeutic ratio might be obtained by combined treatment with bleomycin and radiation. This consideration has been stimulated by recent reports of the effects of combined treatment with bleomycin using mammalian cells in vitro. Experiments are described here in which a murine squamous carcinoma has been used to obtain a survival curve for cells of tumours treated in vivo with single doses of bleomycin alone or in combination with radiation given before or after the drug. The survival curve for drug alone was a multicomponent curve with D(0) values of 0·1, 0·75 and 2·7 mg/kg. However, the results of the experiments with combined treatment showed no evidence of potentiation.

An in vivo perfused preparation was developed and used to study the effect of drugs on the dog electroureterogram. function This method eliminated the secondary effects of changes in blood pressure and urine flow produced by the drugs. Using this method, norepinephrine, epinephrine and some concentrations of acetylcholine accelerated ureteral peristalsis. Isoproterenol decreased ureteral peristalsis. Phentolamine, propranclol, neostigmine, atropine, DMPP, hexame’honium, and TTX showed no effect. Also, the effects of catecholamines and acetylcholine were not aliened by the influence of TTX. The results indicate that these drugs exert their effect on ureterEl peristalsis locally and not through neural pathways.