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221 results on '"Mackay, Ian"'

3. The structure of hexahelicene and other molecules

Author

MacKay, Ian Renton

Subjects
540
Abstract

The first chapter of this thesis is concerned with an account of the structural analysis by X-ray diffraction methods of a molecular complex containing hexahelicene. The use of a complexing agent which contains a heavy atom has enabled the helical structure of this very interesting polycondensed aromatic hydrocarbon to be established and, although the atomic parameters which are presented are not fully refined, it is apparent that this conformation is achieved with very little distortion of the component benzene rings. The second chapter deals with the structure of the amino-sterol pancuronium bromide, and the relationship between its molecular geometry and clinical properties is discussed. The structure determination of the novel polyketide lactone portentol is described in the third chapter. This molecule exhibits a fairly high degree of molecular overcrowding and this is shown to result in a considerable distortion of the molecular framework. Finally, some theoretical and practical aspects of the correction of diffraction data for the effects of absorption of X-radiation by crystalline material are discussed and a description is given of a suite of data-reduction computer programs containing such a correction.

Published
1970

24. PREFACE

Author

GOLDSTEIN, GIDEON, primary and MACKAY, IAN R., additional

Published
1969
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39. THE "PEMPHIGUS" ANTIBODY AND IMMUNOPATHIES AFFECTING THE THYMUS.

Author

Whittingham, Senga and MacKay, Ian R.

Subjects
SKIN diseases, LYMPHOID tissue, ENDOCRINE glands, AUTOIMMUNE diseases, SYSTEMIC lupus erythematosus, VASCULAR diseases, LUPUS erythematosus
Abstract

Case studies of 2 patients with bullous skin lesions are reported, one of whom also had thyrotoxicosis and rheumaloid arthritis, and results of serological tests for the " pemphigus " antibody in 92 patients with other immunopathies. The "pemphigus" antibody, which reacts with the intercellular substance of squamous epithelium, was demonstrable in 1 case at low titre before the onset of widespread skin lesions; titres correlated with the activity of the skin lesions of pemphigus vulgaris; and the antibody was detected at low titre in diseases other than pemphigus vulgaris, including myasthenia gravis (2 cases) and systemic lupus erythematosus (1 case). The possible clinical and serological overlap between pemphigus vulgaris, myasthenia gravis and systemic lupus erythematosus was interpreted from the standpoint of thymic dysfunction. [ABSTRACT FROM AUTHOR]

Published
1971
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40. Fibrosing alveolitis and polymyositis.

Author

Thompson, Peter L., Mackay, Ian R., Thompson, P L, and Mackay, I R

Abstract

A case of fibrosing alveolitis and polymyositis is described. We think that this, in association with previously published reports, favours a real and not fortuitous association. The basis for the association may be an abnormality of immunity, but this could not be established in the present case nor from those previously published. [ABSTRACT FROM PUBLISHER]

Published
1970

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