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Partly purified guinea-pig brain pyruvate kinase is not activated by fructose 1,6-diphosphate and gives hyperbolic substrate-saturation curves with phosphoenolpyruvate. It is therefore different from the L-type pyruvate kinase of mammalian liver. Inhibition by MgATP2- was competitive for MgADP- but not for phosphoenolpyruvate, and the enzyme is therefore different from the M-type pyruvate kinase, which is said to be competitively inhibited by MgATP2- with respect to both substrates. The Ki(MgATP2-) value of approx. 8mm for the brain enzyme is higher than the values (about 2mm) reported for the muscle enzyme. Stimulation of enzymic activity was observed at low (1–2mm) concentrations of MgATP2-. Substrate kinetic constants were Km (MgADP-)=0.47mm, Km (phosphoenolpyruvate)=0.08mm. Free Mg2+ at very high concentrations (over 10mm) was inhibitory (Ki=20–32mm). Neither ADP3- nor 5′-AMP2- inhibited the activity. The brain enzyme was concluded to be different from both the M-type and the L-type of other mammalian organs such as muscle and liver.

There has been sustained interest in the shock therapies since 1932, when Sakel1 introduced insulin coma for schizophrenia. Its use for several years was rather empiric, and today it is used only in selected cases. In 1935 Meduna2 added metrazol convulsive therapy to the treatment of schizophrenia. It was soon found, however, to be most effective for the depressed states, particularly the reactive depressions. It was heralded as a specific for the depressions but was frowned on because of its orthopedic complications and the fears patients expressed toward it.It is five years since electric shock therapy was introduced by Cerletti and Bini.3 There are now available a sufficient number of reports on this therapy to permit some definite conclusions. Electric shock has been accepted with considerable enthusiasm; and, although most investigators have been disappointed by their results in the treatment of some psychoses, particularly schizophrenia, it

Cephanone, a new 3-heterocyclic-thiomethyl cephalosporin antibiotic, was found to have an antibacterial spectrum similar to that of cephalothin. The compound was active in vitro against a variety of gram-positive and gram-negative bacteria. All strains of Staphylococcus aureustested were inhibited by concentrations of 6.2 µg or less of cephanone per ml. Beta-hemolytic group A streptococci and pneumococci were exquisitely sensitive. Among strains of Escherichia coliand Klebsiellasp., 83 and 82%, respectively, were inhibited by 3.1 µg or less of cephanone per ml. Excellent serum concentrations of the antibiotic were obtained after parenteral administration. Peak concentrations of 38 and 81.2 µg/ml were achieved in the serum after intramuscular and intravenous doses of 1 g of cephanone, respectively. The serum concentrations of cephanone fell gradually during the 12 hr after administration. Very high concentrations of cephanone were found in the urine.

The article presents a humorous story about a wealthy man who enjoys to look up into his old college classmates to compare his success with his classmates. He visited one of his friend who was an art collector. After he saw the possession of his classmate, he described in details his own possessions. As he was about to depart, he accidentally broke a vase and apologized and attempted to pay the piece. His friend told him not to worry since the piece could be obtainde from the Metropolitan Museum.