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2. A gas chromatographic method for determining haloperidol. A sensitive procedure for studying serum concentration and pharmacokinetics of haloperidol in patients

Author

Ohman R, Nyberg G, Forsman A, and Erik Mårtensson

Subjects
Male, Chromatography, Gas, Pharmacology toxicology, Thioridazine, Pharmacology, Pharmacokinetics, medicine, Haloperidol, Methods, Distribution (pharmacology), Humans, In patient, Chromatography, Chemistry, General Medicine, Serum concentration, Middle Aged, Kinetics, Tranquilizing Agents, Female, Gas chromatography, Chromatography, Thin Layer, medicine.drug, Half-Life
Abstract

A quick, specific and precise method for determining haloperidol in serum is described. The method is based on gas chromatography and the use of a structurally similar internal standard. Serum concentrations of haloperidol determined in patients treated with haloperidol, were in the range of 0.5 to 10 ng/ml. The precision of the method was ±8.3%. Of the many drugs tested so far, only thioridazine and dibenzepim interfere with the determinations. Preliminary pharmacokinetic studies based on the intravenous injection of haloperidol demontrated typical apparent volumes of distribution as large as 2,000 l and serum half-lives of 12.6–22.0 hrs. Inter-individual differences in these parameters were demonstrated.

Published
1974

3. Cell layer assay.

Author

Walther B and Ohman R

Subjects
Acetates metabolism, Animals, Carbon Radioisotopes, Cell Line, Chelating Agents, Cricetinae, Edetic Acid, Kidney, Kinetics, Leucine metabolism, Palmitic Acids metabolism, Phosphorus Radioisotopes, Thymidine metabolism, Tritium, Uridine metabolism, Cell Aggregation, Culture Techniques methods
Published
1974

4. Galactosyltransferases catalyzing the formation of the galactosyl-galactosyl linkage in glycosphingolipids.

Author

Mårtensson E, Ohman R, Graves M, and Svennerholm L

Subjects
Aging, Animals, Brain enzymology, Carbon Radioisotopes, Cerebrosides metabolism, Chromatography, Detergents pharmacology, Galactose, Gangliosides metabolism, Humans, Hydrogen-Ion Concentration, Kidney enzymology, Kinetics, Liver enzymology, Lung enzymology, Microsomes enzymology, Oligosaccharides, Protein Denaturation, Rats, Rats, Inbred Strains, Spleen enzymology, Subcellular Fractions enzymology, Time Factors, Tritium, Glycolipids metabolism, Hexosyltransferases metabolism
Published
1974

6. Developmental profiles of gangliosides in human and rat brain.

Author

Vanier MT, Holm M, Ohman R, and Svennerholm L

Subjects
Age Factors, Animals, Animals, Newborn, Autopsy, Brain embryology, Cerebellar Cortex metabolism, Cerebral Cortex metabolism, Child, Child, Preschool, Chromatography, Thin Layer, Fetus, Frontal Lobe embryology, Frontal Lobe metabolism, Humans, In Vitro Techniques, Infant, Infant, Newborn, Nerve Tissue Proteins biosynthesis, Nervous System metabolism, Neuraminic Acids biosynthesis, Organ Size, Phospholipids biosynthesis, Rats, Species Specificity, Brain growth & development, Brain metabolism, Gangliosides biosynthesis
Published
1971
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7. The activity of ganglioside sialidase in different regions of the human brain.

Author

Ohman R

Subjects
Adolescent, Adult, Aged, Autopsy, Basal Ganglia enzymology, Caudate Nucleus enzymology, Cerebral Cortex enzymology, Child, Frontal Lobe enzymology, Gangliosides analysis, Hippocampus enzymology, Humans, Middle Aged, Nervous System enzymology, Occipital Lobe enzymology, Parietal Lobe enzymology, Temporal Lobe enzymology, Thalamus enzymology, Brain enzymology, Neuraminidase analysis
Published
1971
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8. The diagnosis of Tay-Sachs disease.

Author

Ohman R, Ekelund H, and Svennerholm L

Subjects
Adolescent, Adult, Brain enzymology, Brain Chemistry, Child, Child, Preschool, Diagnosis, Differential, Electrophoresis, Female, Gangliosides classification, Humans, Infant, Lipidoses enzymology, Male, Methods, Middle Aged, Neuraminidase analysis, Phospholipids analysis, Ultracentrifugation, Gangliosides analysis, Glucosidases analysis, Lipidoses diagnosis
Published
1971
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9. Human brain sialidase.

Author

Ohman R, Rosenberg A, and Svennerholm L

Subjects
Acetates, Cadmium, Detergents pharmacology, Edetic Acid, Enzyme Activation, Frontal Lobe drug effects, Galactose, Gangliosides, Glycolates, Glycoside Hydrolases analysis, Humans, Kinetics, Sulfates, Surface-Active Agents pharmacology, Zinc, Frontal Lobe enzymology, Neuraminidase antagonists & inhibitors, Neuraminidase isolation & purification
Published
1970
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10. CONGENITAL AMAUROTIC IDIOCY.

Author

HAGBERG B, HULTQUIST G, OHMAN R, and SVENNERHOLM L

Subjects
Humans, Infant, Brain Chemistry, Chromatography, Gangliosides, Histocytochemistry, Intellectual Disability, Lipidoses, Pathology, Tay-Sachs Disease
Published
1965
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11. The isolation of sialyllactosides with the aid of gel filtration.

Author

Ohman R and Hygstedt O

Subjects
Animals, Cattle, Chemical Phenomena, Chemical Precipitation, Chemistry, Chromatography, Gel, Chromatography, Ion Exchange, Chromatography, Paper, Drug Stability, Female, Hydrogen-Ion Concentration, Ion Exchange Resins, Neuraminidase, Pregnancy, Spectrophotometry, Colostrum analysis, Neuraminic Acids analysis, Oligosaccharides analysis
Published
1968
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13. Glycosyltransferases--cellular studies.

Author

Ohman R, Barker R, Hill R, and Roseman S

Subjects
Animals, Azides metabolism, Cell Adhesion, Cell Membrane metabolism, Chick Embryo, Cricetinae, Fibroblasts enzymology, Galactose metabolism, Genetic Code, Glucosyltransferases physiology, Glycolipids biosynthesis, Glycoproteins biosynthesis, Golgi Apparatus enzymology, Manganese metabolism, Mice, Models, Biological, Monosaccharides metabolism, Mucins biosynthesis, Nucleotides metabolism, Retina cytology, Teratoma enzymology, Cell Membrane enzymology, Glucosyltransferases metabolism
Published
1973

14. A quantitative assay for intercellular adhesion.

Author

Walther BT, Ohman R, and Roseman S

Subjects
Animals, Carbon Isotopes, Cell Count, Cell Transformation, Neoplastic, Cells, Cultured, Chickens, Clone Cells, Cricetinae, Culture Media, Cytological Techniques, Isotope Labeling, Kidney, Liver, Mice, Mice, Inbred Strains, Myocardium, Phosphorus Isotopes, Retina, Simian virus 40, Teratoma, Time Factors, Tritium, Cell Adhesion
Abstract

Intercellular adhesion is measured by a new method based on determination of the rates of attachment of single cells to confluent cell monolayers. The procedure is simple, rapid, and reproducible. Specific and nonspecific intercellular adhesions can be quantitated and distinguished from each other, and from the adhesion to glass (or plastic). The rate of adhesion of single cells to the monolayer is characteristic of more than 80% of the single-cell population. This method, therefore, provides a means for study of the molecular basis of intercellular adhesion.

Published
1973
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17. The activity of ganglioside sialidase in the developing human brain.

Author

Ohman R and Svennerholm L

Subjects
Acetates metabolism, Adult, Aged, Autopsy, Cerebral Cortex growth & development, Child, Child, Preschool, Fetus, Gangliosides metabolism, Glycoside Hydrolases metabolism, Humans, In Vitro Techniques, Infant, Infant, Newborn, Infant, Premature, Lactates metabolism, Spectrophotometry, Cerebral Cortex enzymology, Neuraminidase metabolism
Published
1971
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18. Subcellular fractionation of ganglioside sialidase from human brain.

Author

Ohman R

Subjects
Aged, Autopsy, Cell Nucleus enzymology, Centrifugation, Density Gradient, Child, Preschool, Female, Glycoside Hydrolases analysis, Histocytochemistry, Humans, In Vitro Techniques, Lysosomes enzymology, Male, Microscopy, Electron, Microsomes enzymology, Mitochondria enzymology, Myelin Sheath enzymology, Nerve Tissue Proteins analysis, Synaptic Membranes enzymology, Synaptic Vesicles enzymology, Cerebral Cortex enzymology, Nerve Endings enzymology, Neuraminidase analysis
Published
1971
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19. Serum thyrotropin and hypothyroidism during lithium therapy.

Author

Lindstedt G, Lundberg PA, Tofft M, Akesson HO, and Ohman R

Subjects
Adult, Aged, Animals, Chorionic Gonadotropin, Chromatography, Gel, Female, Humans, Hypothyroidism diagnosis, Iodine Radioisotopes, Lithium therapeutic use, Male, Middle Aged, Rabbits immunology, Radioimmunoassay, Thyroid Function Tests, Thyroxine blood, Bipolar Disorder drug therapy, Hypothyroidism chemically induced, Lithium adverse effects, Thyrotropin blood
Published
1973
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