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The ability of the transplanted pancreas to restore normal blood glucose levels in the pancreatectomized dog was demonstrated first by Gayet and Guillaumie 40 years ago.1 The first successful pancreatic homotransplants using vascular anastomosis were reported by De Jode and Howard in 1962.2 Within the past few years, several experimental studies have emphasized the technical problems related to pancreatic transplantation, the methods of detecting the onset of rejection and the difficulties of preventing this process with immunosuppressive agents.3-10The present study has two objectives: first, to evaluate the endocrine function of partial and total duodenopancreatic homotransplants at different postoperative stages, and secondly, to study the efficiency of immunosuppressive therapy on the survival of these homografts. METHODS Nonrelated mongrel dogs of both sexes were used, weighing 8.5 to 17 kg (19 to 38 lb). The anesthesia employed was pentobarbital sodium, supplemented with phencyclidine hydrochloride. Twenty-nine pancreatic homotransplantations were

Histologic examination of the liver in viral hepatitis concerns two main aspects: (1) the morphologic findings during the course of the disease and their prognostic value in severe jaundice; and (2) study of protracted forms ranging from simple persistent viral hepatitis to cirrhosis. Improved epidemiologic knowledge, the discovery of the Australia antigen (HAA) and, more recently, of epidemic-hepatitis-associated antigen (EHAA) by Costantino et al1 has provided a more precise etiological basis for study of the lesions. The results presented here concern the histological study of two homogeneous groups of patients: one of 28 patients with severe jaundice observed by Caroli and ourselves during an epidemic and another of 50 patients, with epidemic or serum hepatitis of variable duration, in a military hospital. SEVERE FORMS They represent 1% to 2% in most epidemics. Among 700 soldiers, most of them young adults, no deaths occurred. The classification into three main groups