1. Post-Exposure Prophylaxis of Murine Rabies with Polyinosinic-Polycytidylic Acid and Chlorite-Oxidized Amylose
- Author
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Burton Janis, Hilton B. Levy, and Maurice W. Harmon
- Subjects
Pharmacology ,Interferon inducer ,medicine.medical_treatment ,Stimulation ,Biology ,medicine.disease ,Virology ,Microbiology ,chemistry.chemical_compound ,Titer ,Infectious Diseases ,chemistry ,Interferon ,Amylose ,Polyinosinic:polycytidylic acid ,medicine ,Pharmacology (medical) ,Rabies ,Post-exposure prophylaxis ,medicine.drug - Abstract
Chlorite-oxidized amylose (COAM), polyinosinic-polycytidylic acid [poly(I:C)], and combinations of the two drugs were evaluated for their interferon-inducing properties and their ability to protect mice against rabies infection. Post-exposure administration of one or two doses (100 μg each) of poly(I:C) significantly protected mice against rabies infection. Pretreatment of mice with COAM 3 h before poly(I:C) stimulation resulted in an enhancement of the interferon response. However, the increased interferon titers were not reflected by increased protection against rabies infection over that achieved with poly(I:C) therapy alone. Therapy with COAM alone did not protect mice against rabies but, rather, was associated with enhanced mortality.
- Published
- 1974
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