1. Scianna Blood Group System
- Author
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Hiroko Kaita, B. Chown, and Marion Lewis
- Subjects
Male ,Recombination, Genetic ,Genetic Linkage ,Hematology ,General Medicine ,Biology ,Pyrin domain ,Molecular biology ,White People ,Transmembrane protein ,In vitro ,Phenotype ,Gene Frequency ,Biochemistry ,Antigen ,Butyrophilin ,Terminology as Topic ,Blood Group Antigens ,Immunogenetics ,Extracellular ,Humans ,Female ,Receptor ,Function (biology) - Abstract
Publisher Summary This chapter discusses the Scianna blood group system. The terminology, expression, database accession numbers, and the carrier molecule related to the Scianna blood group system are also reviewed. This blood group was established in 1974 and was named after the family of the first maker of anti-Sc1. The function of the Scianna blood group system is also discussed. Human erythroid membrane associated protein (ERMAP) is an erythroid transmembrane adhesion/receptor protein. The extracellular IgV domain of HERMAP is homologous with the butyrophilin family of milk proteins, autoantigens, and avian blood group antigens. The intracellular B30.2 domain is highly homologous with a similar domain in a diverse group of proteins, including butyrophilin, pyrin, and MID1. The chapter also reviews the effect of enzymes/chemicals on Sc1 antigen on intact RBCs, and the in vitro characteristics and clinical significance of alloanti-Sc1.
- Published
- 1974
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