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Information on families of 44 patients fulfilling strict criteria for the Dubin-Johnson-Sprinz (DJS) syndrome revealed parental consanguinity in at least 11 cases. Direct and total serum bilirubin levels and sulfobromophthalein retention levels were determined on siblings, parents, and children of these DJS patients. Conjugated hyperbilirubinemia and elevated, increasing serum sulfobromophthalein retention at 2 hr, characteristic of the DJS syndrome, were observed in 17 of 44 tested siblings of propositi. Results of these liver function tests on all of 20 parents and 64 children of DJS patients indicated that they were not affected. The high frequency of parental consanguinity, the incidence of the syndrome among siblings of propositi, the lack of involvement of more than one generation within each family, and consideration of other reports of familial DJS syndrome suggest that the DJS syndrome is inherited only as an autosomal recessive trait. Reports of cases inherited as a dominant trait are probably due to erroneous diagnosis of propositi or their relatives or to pseudodominant inheritance of the recessive trait. Appreciation of the mode of inheritance may be helpful in the differential diagnosis of the constitutional hyperbilirubinemias and in the elucidation of the nature of the hepatic excretory defect in the DJS syndrome and other constitutional hyperbilirubinemias.

The main theorem (2.1) says that if N is an abstract regular neighborhood of a polyhedron X with collapsible retraction r: N → X, dimX < dimN − 3, and if g: N → intN is an embedding such that rg is close to the inclusion map X↪N, then g is isotopic to the inclusion X↪N by an ambient isotopy which is limited by r. As a corollary two close PL embeddings of a polyhedron X into a PL manifold Q are equivalent by small PL ambient isotopy if dimX < dimQ − 3 and if the embeddings are sufficiently close to a given topological embedding of X into Q. Some related results using a slightly weaker dimension restriction are also discussed, and some other corollaries are presented.

A method for prediction and analysis of the spectrum of the signal from the Laser Doppler Velocimeter is presented. The results relate the heterodyne spectrum of the signal to the space‐time correlation fuction for the turbulent transport of tracer particles in the fluid and to the characteristics of the optical system.

On average, 5-6 follicles were found in human ovaries primed with gonadotrophins. This number was only slightly correlated with the amount of urinary oestrogen and the amount of hormone administered. The levels of oestrogen in urine were determined by the number of large follicles (1·5 cm. in diameter or larger), each one contributing on average 15·37 μg. per day shortly before ovulation, and not by the total number of follicles. Some exceptional patients with few large follicles excreted large amounts of urinary oestrogen. The concentrations of œstradiol-17β and progesterone in follicular fluids were closely correlated, but there was considerable variation between follicles. Concentrations of œstradiol were between

A first step in the study of this problem was an examination of temporal parameters. In this study, CS durations longer than 5 sec. were employed in order to explore the possibility that prolongation of the CS might facilitate acquisition in the Skinnex box. Although previous results obtained with the shuttle-box suggested that short CS durations are more favorable for avoidance acquisition (Solomon & Brush, 1956; Woodward, 1954), performance in the Skinner and shuttle-box is sufficiently cl~ss~m~lar to merit questioning the generality of the results obtained with the latrer. Moreover, Meyer, el al. (1960) reported that the use of a CS of less than 5 sec. failed to facilitate acquisition in the Skinner box. This finding suggested that, if CS duration has any relevance to acquisition, the effects must be related to a range of durations of longer than 5 sec. Two experiments are reported. In Exp. 1, rats were trained with varied CS durations. During testing the CS was constant for all animals in order to assess differences resulting from the previous training without biasing latency requirements of the avoidance response. In Exp. 2, the longest CS duration was decreased gradually in order to mitigate the disruptive effects of an abrupt change in latency requirements.

An intrauterine chamber has been designed for sampling human uterine secretions and for exposing spermatozoa to uterine secretions in utero. The chamber is made of nylon tubing, with windows covered by cellulose ester membranes of specific pore size, and it can be inserted and removed cleanly and simply. Chambers loaded with saline and then left in utero for 12 hours contained fluids with an ionic balance differing from that of serum and with many proteins similar to those found in serum. Many spermatozoa were motile after being loaded into the chambers, left in utero for periods up to 14 hours, and then maintained in vitro for a further 24 hours.

SUMMARY 1. The injection of 1 i.u. pregnant mares' serum (PMS) followed after 40 hr by 2 i.u. human chorionic gonadotrophin (HCG), or of 3 i.u. PMS followed by 3 i.u. HCG into mature female mice selected at random with regard to their oestrous cycle induces oestrus and mating in approximately 75%, and ovulation in 99% of them. 2. The induction of superovulation depends on the amount of PMS injected and on the strain of mice used. 3. Two types of egg are ovulated, one being normal and with a cumulus, the other degenerated and without cumulus. 93% of the normal eggs were fertilized and 98% of the pronucleate eggs possessed two pronuclei. 4. Approximately three-quarters of the females which mate in response to the injected gonadotrophins become pregnant, although this number was less than the number becoming pregnant after mating during natural oestrus. Many of the treated females carried their embryos to term and some gave birth to large litters, although resorptions, irregular distribution of embryos in the uterus, and difficulty during parturition occurred in some females. Mean litter size of the treated females was similar to that found after natural mating. 5. After more than one treatment with gonadotrophins, fewer females mated, ovulated, and became pregnant than after the first treatment. This reduction in response may have been due to the greater age of the females or to their decreased sensitivity to the hormones. 6. The value of the method as a technique for inducing oestrus, ovulation, and pregnancy in mature female mice is considered.

A decrease in the frequency of chiasmata, a change in their location on the chromosome and an increase in the frequency of univalents have been found in mouse oocytes with increasing maternal age. Many of the univalents displayed a non-chiasmate association, others were not associated. Several of these observations evidently apply to man and are perhaps relevant in the aetiology of Down's syndrome and infertility in older mothers.

(1940). Physical Fitness through Weight-Lifting. The Journal of Health and Physical Education: Vol. 11, No. 10, pp. 606-635.

Precipitation static, a result of electrification of aircraft in flight, can cause loss of radio communication for long periods of time. Electrification may consist of either of two types, “autogenous” or “exogenous” electrification; autogenous electrification occurs when pROLE> of snow, dust or rain strike the surface of the aircraft, while exogenous electrification results from an aircraft being placed in a pre-existing atmospheric electric field. Serious autogenous electrification occurs only in snow and dust storms; the electrification due to rain pROLE> is found to be small. Autogenous electrification is proportional to the snow density and to the cube of the air speed. Temperature, humidity, aircraft surface type, and particle size and type are found to be minor factors. Exogenous electrification was found to be accompanied by indications of convection, but no correlation data are available for the relation between the strength of the convective currents and the amount of electrification. T...

Of 75 alcoholics treated with lysergide, 23 were diagnosed as schizophrenics. The nonschizophrenics had better reactions to the drug and more of them were abstinent at a 1-year follow-up than the s...

The power spectrum of phototube current from a laser Doppler velocimeter operating in the heterodyne mode has been computed. The spectrum is obtained in terms of the space time correlation function of the fluid. The spectral width and shape predicted by the theory are in agreement with experiment. For normal operating parameters the time average spectrum contains information only for times shorter than the Lagrangian integral time scale of the turbulence. To examine the long time behavior, one must use either extremely small scattering angles, much longer wavelength radiation or a different mode of signal analysis, e.g., FM detection.

A close reading of the text of the twelfth-century Montecassino Passion suggests an important relationship between the language of the play and the stage directions which outline its performance. To a remarkable degree, language and rubrics attempt to convey the Passion as a series of visual images, while individual speeches and choral address often serve as glosses on dramatic action. Art historians such as Emile Mâlel and Otto Pacht have discussed the impact of liturgical drama on the visual arts. Pacht, for example, sees this impact in such developments as the substitution of a liturgical sepulchrum for the tomb mentioned in scriptural sources, in the expansion of figures to include midwives in the Nativity and in the "style of the narrative" in the Emmaus miniatures of the St. Albans

SUMMARY The effects of an injection of pregnant mares' serum (PMS), human chorionic gonadotrophin (HCG), or of superovulation treatment with both of these gonadotrophins on subsequent reproductive behaviour of adult mice and on their response to a second superovulation treatment given shortly afterwards have been studied. An injection of PMS had induced ovulation, but not superovulation, in dioestrous mice autopsied 24 hr later. The injection also induced oestrus and superovulation in many mice (c. 30%) 60–62 hr later, a positive correlation being found between mating and ovulation in these mice. The resumption of the natural oestrous cycle after an injection of PMS was delayed in some of the mice. HCG had induced ovulation in mice in metoestrus-II and dioestrus autopsied 24 hr later. Most mice quickly resumed their natural oestrous cycle after the injection of HCG. If mice were not paired with males after the full superovulation treatment with PMS and HCG, they resumed their natural oestrous cycle within 3–6 days. Ovulation, fertilization and pregnancy during or after this natural oestrus were quite normal. These mice were also capable of further induced oestrus and superovulation when given a second course 1–3 days after the first treatment, though the number of mice that ovulated was lower, and the variability between mice in the number of eggs ovulated was higher, if the second treatment was given 1–2 days after the first. The corpora lutea formed in mice that mated after a superovulation treatment were fully active. A second treatment induced superovulation in most mice, but failed to induce oestrus in the majority of them, especially when given during mid-pseudopregnancy. Fertilization and embryonic development were quite normal in the few mice that mated.

SUMMARY The effects of exogenous oestrogen and progesterone on implantation and foetal mortality were studied in mice following induced superovulation with gonadotrophins. Short-term treatment with progesterone during early pregnancy did not influence implantation or foetal mortality, but 2 mg daily from days 2 to 12 reduced the number of embryos that implanted and increased foetal mortality after implantation. These effects of progesterone were more severe when few embryos were implanted. Oestradiol benzoate (OB), given after mating, reduced fertility by decreasing the proportion of mice with implanted embryos, causing cornification of the vagina in many mice during pregnancy. Administration of progesterone with OB did not alleviate these effects. Administration of OB before superovulation, or lengthening the interval between the injections of PMS and HCG in order to extend the period of uterine stimulation by endogenous oestrogen, interfered with ovulation in some mice. Approx. one-quarter of the mice given oestrogen had cornified vaginal smears during early pregnancy. Both treatments decreased the numbers of mice with implanted embryos.

In the first of two groups of rabbits aged less than 7 weeks, the tibialis anterior muscle was permanently denervated by suturing the divided common peroneal (external popliteal) nerve into biceps femoris, while in the second it was temporarily denervated by crushing the nerve. Longitudinal growth of the muscle bellies was diminished so that, by the time the rabbits were almost fully grown, their lengths in the two groups were respectively about 85 and 95% of the normal. The diminution of growth following complete or partial nerve section (with the possibility of reinnervation) lay between these extremes, its extent apparently depending on the duration of denervation and on the extent of reinnervation. The shape of the isometric tetanic tension-length curves of those muscles which became well reinnervated did not differ appreciably from the normal. Small indian ink marks were placed at intervals along the muscle in some of the young rabbits and measurement of the distance between them at the beginning and end of the experiment showed that denervation did not significantly affect the site at which longitudinal growth occurred.

SUMMARY The innate oestrous cycle, the dose of hormone, and the strain of mouse used influence ovulation and implantation in adult mice treated with pregnant mares' serum (PMS) and human chorionic gonadotrophin (HCG). Almost all of the treated mice in some strains will mate, while those from other strains are less responsive. Excess of hormone reduced the mating response and also suppressed ovulation through the formation of atretic corpora lutea and atretic follicles. Provided that the amount of hormone was not excessive, ovulation was induced in almost all mice of all strains irrespective of age, body weight, or stage of the oestrous cycle when treatment began. In one strain more eggs were recovered from females in metoestrus than from those in oestrus or dioestrus at the beginning of treatment, but this effect of the oestrous cycle was only found with low doses of PMS. The proportion of mice with implanted embryos after treatment was influenced by the dose of hormone, strain differences, and the stage of the oestrous cycle when treatment began. This proportion was low after large amounts of PMS and HCG, and generally higher in strains of high natural fertility than in those of low fertility. Fewer of the mice in dioestrus, when injected with PMS, had implanted embryos than had those in oestrus or metoestrus. A strain of mice containing many acyclic females was least successful in implanting embryos. The proportion of embryos that implanted decreased with increasing doses of hormone, apparently because of the increased competition between them for uterine sites.

Recent field tests on motors in service on pipelines and powerhouse systems have shown that the switching surge voltage appearing at the motor terminals during initial energization for starting frequently reach magnitudes approaching 2.0 per unit normal crest line-to-ground operating voltage with time-to-crest as short as 0.2 As. This is more severe than normally believed and may endanger turn-to-turn insulation.

A method for prediction of the spectrum observed with the laser Doppler flowmeter (LDF) is developed. A detailed analysis of the spectrum observed with steady flows is presented. The effects of diffusive motion of the scattering centers, spatially varying velocities, finite transit time of the centers through the sample volume, and uncertainty in scattering vector are computed. The latter two effects are shown to be identical. A computation of the sample volume size and shape is made using the optical parameters of the system. The calculated linewidths and shapes are in good agreement with data taken on two independent LDF systems. The general formalism is also applicable to measurements made on turbulent fluids and diffusely reflecting solid objects. The special case of a static fluid (zero velocity) is considered in detail and the low angle correction to the conventional expressions used in laser ``beat‐frequency'' spectroscopy is developed.

In a series of ninety-four patients with proved perforated duodenal ulcer x-ray evidence of pneumoperitoneum was present in 66 per cent and absent in 34 per cent. The time interval between onset of symptoms and x-ray examination had no demonstrable effect on the presence or absence of free peritoneal air. The size of the perforation in the duodenal wall was not significantly different in patients with or without pneumoperitoneum. The demonstration of pneumoperitoneum in an atypical case of suspected perforated duodenal ulcer is an extremely helpful diagnostic aid; absence of pneumoperitoneum in such a case is of relatively little diagnostic significance.

Criticism of medieval drama has for the most part been Aristotelian. The categories of the Poetics as well as the structure Aristotle creates for them have shaped the manner in which not only scholars but the general audience view the plays. Implicit in E. K. Chambers' The Mediaeval Stage (1903) and Karl Young's The Drama of the Medieval Church (1933) is a belief that the plays imitate action and character, and even so radical a study as O. B. Hardison, Jr.'s Christian Rite and Christian Drama in the Middle Ages (1965) recurs to Aristotelian bases. Hardison maintains that "in the ninth century the boundary . . . between religious ritual (the services of the Church) and drama did not exist. Religious ritual was the drama of the early Middle Ages and had been ever since the decline of the classical theater." As the Mass comes to be viewed as a drama by commentators from the ninth century onwards, the framework of liturgy also becomes dramatic so that "in one sense, at least, the Easter liturgy is a transitional phase between the sacred drama of the Mass and liturgical drama." "Its descending action begins with Lent. The point of crisis is reached on Good Friday, and Holy Saturday and Easter Sunday are devoted to the entombment and Resurrection, respectively." The model for this larger structure is Gilbert Murray's concept of the ritual form of Greek tragedy whose Aristotelian orientation Hardison calls "obvious from its terms." 1

The fertility of two unrelated strains of mice (strainsNandC) which had both been selected for large and small body size has been studied.The fertility of pairs of mice in the large or small lines of strainCwas unimpaired by selection. In strainN, some of the pairs in the large and small lines, but not in the control line, were sterile. Sterility in the large line was due to the low libido of the males, and not to female infertility. Sterility in the small line was probably due to hypo-functioning of the anterior pituitary of some females: the oestrous cycle was delayed or absent, some mice failed to ovulate after mating, and a high proportion of those mating had no implanted embryos at 12 days' gestation. Oestrus and ovulation could be induced in mice of the small line of strainNby exogenous gonadotrophins, and the proportion of mice with implanted embryos was considerably increased by progesterone supplements.The number of eggs found after natural mating was considerably higher in large mice than in small mice, and was significantly correlated with body weight in the small line of strainConly. The egg-number/body-weight ratio was higher in the lines of strainCthan in those of strainN, though the ratios were similar when carcass fat was subtracted from total body weight.The amount of endogenous follicle-stimulating hormone secreted by the mice of the five lines was estimated by inducing ovulation with various amounts of exogenous gonadotrophins, and comparing the number of eggs found after each dose with the mean number ovulated after natural mating. Estimates of the amount of follicle-stimulating hormone secreted by mice of strainCwere higher than those for mice of strainN.Differences in the rates of growth and in the numbers of eggs ovulated after natural mating indicate a higher level of pituitary activity in strainCthan in strainN.

The mallophagan genus Aquanirmus, parasitic on grebes (Podicipidae), is revised. Four new species and one new subspecies are described: emersoni ex Podiceps grisegena, occidentalis ex Aechmophorus occidentalis, podilymbus ex Podilymbus podiceps, bucomfishi ex Podiceps auritus, and bahli chamberlini ex Poliocephalus dominicus. The geographic and host distributions of the parasites are discussed. It is pointed out that geography plays an important role in the distribution of the species of Aquanirmus.

In comparing the 4 cases, it is apparent that gasoline sniffing over a prolonged period need not necessarily produce serious organic damage. Pleasant hallucinations appear to be a reward for sniffing gasoline. In two cases, a feeling of omnipotence and omniscience was clearly reported to be an important effect of gasoline sniffing. Gasoline sniffing may tend to occur in a child with the psychodynamics of a manic.

A distinctive new species of Austromenopon from two species of shearwaters, Puffinus kuhlii (Scopoli) and Puffinus leucomelas (Temminick), is described herein. The new species is based on specimens collected from museum study skins and also from material lent to me by Dr. Theresa Clay, British Museum (Natural History) and the U.S. National Museum. I am indebted to Dr. Clay for the opportunity to examine material from the Meinertzhagen collection and to Dr. K. C. Emerson for reviewing this manuscript.

An important step forward has been made in controlling the sex of rabbits by sexing pre-implantation embryos and transferring the sexed embryos into recipient females. In the experiments, foetuses were surgically delivered and their sex was found to have been correctly predicted at the blastocyst stage.

SYSTEMIC heparinization of the dog is a commonplace procedure in surgical research laboratories. In spite of the wide experience with canine heparinization, detailed descriptions of the results obtained by various methods are sparse. In many instances the method utilized is chosen arbitrarily or on a “precedent” basis. Attempts by the authors to find reported data on results obtained by various methods of canine heparinization ended in frustration. Because of our inability to find adequate information regarding quantitative effects of systemic heparin on the clotting time in the dog, we undertook the study reported on here.

The Universal Transverse Mercator Grid is a rectangular grid system now used on all standard military maps. Archaeologists could use this system for site location, which would prove especially beneficial in areas where townships and range grids have not been drawn. The use of the series of numbers in the system would help eliminate duplication in state or regional site files.

To determine whether acquisition of an avoidance response with a trace conditioning procedure in the Skinner box could be facilitated by the use of long CS-US intervals, three groups of six rats each were trained at CS-US intervals of either 5, 20, or 60 sec. The CS was presented for 1 sec. unless it was ended beforehand by a lever press. The 5-sec. CS-US interval group made fewer avoidance responses and terminated the 1-sec. CS less often than each of the other groups. It was suggested that the differences in performance were due to initial differences in opportunity for making the appropriate response.

A controlled study of admission multiphasic screening (AMS) at a large general hospital showed that AMS had no significant effect on a variety of indices of inpatient progress. Owing to a 64% increase in estimated cost of investigations with AMS, the total hospital admission cost was increased by approximately 5%. Under the conditions of this study, AMS added to the cost of hospitalization without associated evidence of benefit to the patient.