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Infection of HeLa cells with herpes simplex virus leads to a large increase in a new DNA polymerase activity in the nucleus of infected cells. This herpes simplex virus-induced DNA polymerase has been purified 400- to 1300-fold from infected cells and shown to be different in its properties from the normal host cell DNA polymerases. The herpes simplex virus-induced DNA polymerase can be eluted as two peaks of activity on DEAE-cellulose in the presence of glycerol. However, these two DNA polymerase activities seem to have the same molecular weight (1.8 x 105) and exhibit similar properties after further purification on phosphocellulose. The herpes simplex virus-induced DNA polymerase is markedly different from the host DNA polymerases in its high salt requirement for maximal activity. It shows a strong preference for an oligomer-homopolymer template containing deoxyguanylate and deoxycytidylate. A nuclease activity which degrades the polydeoxyadenylate-deoxythymidylate copolymer and the deoxyguanylate-deoxycytidylate homopolymer pair is found to co-chromatograph with the herpes simplex virus-induced DNA polymerase.

Robert-Muller C. Saint-Malo - Saint-Servan : un port charbonnier. In: Annales de Geographie, t. 31, n°174, 1922. pp. 449-464.

Péguy Ch.-P., Robert-Muller Ch. Contribution à l'étude humaine des Alpes briançonnaises. In: Revue de géographie alpine, tome 32, n°1, 1944. pp. 59-98.

Robert-Muller C. Saint-Malo-Saint-Servan port charbonnier (fin). In: Annales de Bretagne. Tome 36, numéro 2, 1924. pp. 380-401.

Robert-Muller C. Deux " pêches au large " des cotes bretonnes de l'Atlantique, langouste et thon. In: L'information géographique, volume 4, n°1, 1939. pp. 1-4.

Robert-Muller Ch., Allix André. Un type d'émigration alpine : les colporteurs de l'Oisans. In: Revue de géographie alpine, tome 11, n°3, 1923. pp. 585-634.

Robert-Muller Charles. Statistiques charbonnières. In: Annales de Géographie, t. 38, n°213, 1929. pp. 221-229.

Robert-Muller Charles. La pêche et la conserve du thon dans la Bretagne de l'Atlantique. In: Annales de Géographie, t. 45, n°256, 1936. pp. 375-398.

Robert-Muller C. Saint-Malo - Saint-Servan : un port charbonnier. In: Annales de Géographie, t. 31, n°174, 1922. pp. 449-464.

Robert-Muller Ch. Questionnaire d'enquête sur l'émigration dans les Alpes françaises. In: Revue de géographie alpine, tome 11, n°3, 1923. pp. 577-584.

Robert-Muller Charles. Le nouveau port de pêche de Lorient. Chalutage et charbon. In: Annales de Géographie, t. 36, n°201, 1927. pp. 193-212.

Robert-Muller Charles, Capot-Rey Robert. Dans les mines de la Sarre. In: Annales de Géographie, t. 33, n°182, 1924. pp. 130-150.

Robert-Muller C. Saint-Malo-Saint-Servan, port charbonnier. In: Annales de Bretagne. Tome 35, numéro 3, 1921. pp. 402-421.

HeLa cell DNA-dependent DNA polymerase I, a low molecular weight enzyme of 40,000 to 50,000, has been compared to DNA-dependent DNA polymerase II, a high molecular weight enzyme. Inhibiting antiserum prepared against cytoplasmic DNA polymerase II does not inhibit DNA polymerase I. DNA polymerase II, whether isolated from the nucleus or cytoplasm, shows the same inhibition pattern by antiserum. A DNA polymerase II, obtained from cultured Chinese hamster cells, is also partially inhibited by the HeLa DNA polymerase II antiserum. HeLa DNA polymerase II sediments as one band of approximately 6.5 S (122,000 daltons) in 0.125 m (NH4)2SO4. At a lower salt concentration (0.01 m ), larger aggregates of 10.3 S and 11.7 S are seen. At neither salt concentration is there any DNA polymerase activity sedimenting in the 3 to 4 S region where DNA polymerase I is found.