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5 results on '"Sagnelli, E"'

2. Differential diagnosis between benign and malignant biliary tract obstruction: discriminative usefulness of some clinical and laboratory data

Author

Giusti G, Piccinino F, Evangelista Sagnelli, Pasquale G, Giusti, G, Piccinino, F, Sagnelli, E, and Pasquale, Giuseppe

Subjects
Cholestasis, Haptoglobins, Liver Neoplasms, Alanine Transaminase, Bilirubin, Blood Proteins, Blood Sedimentation, Alkaline Phosphatase, Blood Cell Count, Diagnosis, Differential, Pancreatic Neoplasms, Bile Duct Neoplasms, Cholelithiasis, Humans, Aspartate Aminotransferases, Serum Albumin
Abstract

The data of 26 patients with obstructive jaundice caused by biliary tract stones were compared to those of patients with malignant obstructive jaundice in order to evaluate the diagnostic effectiveness of some laboratory tests in the differential diagnosis between these two conditions. The Fisher's discriminant analysis was employed. The combined evaluation of serum albumin and haptoglobin appeared to have the most satisfactory discriminative effectiveness, yielding a 54% rate of correct diagnosis, with a safety margin of 95%.

Published
1975

3. The differential diagnosis between intrahepatic cholestatic jaundice and viral hepatitis during pregnancy.

Author

Piccinino F, Manzillo G, and Sagnelli E

Subjects
Alanine Transaminase blood, Aspartate Aminotransferases blood, Biopsy, Cholesterol blood, Diagnosis, Differential, Female, Hepatitis B Antigens analysis, Humans, Obstetric Labor, Premature etiology, Pregnancy, Pregnancy Complications, Infectious diagnosis, Pruritus, Vomiting, Cholestasis diagnosis, Hepatitis A diagnosis, Pregnancy Complications diagnosis
Abstract

Clinical and laboratory findings from 15 patients with icteric viral hepatitis during pregnancy (VHP) and from 22 patients with intrahepatic cholestasis during pregnancy (CJP) were evaluated statistically in order to find out which parameters might help in order to find out which parameters might help in differentiating the two diseases. Diagnosis was established by needle liver biopsy in all cases. The following data were considered: history, physical examination, erythrocyte sedimentation rate (ESR) serum cholesterol, prothrombin time, total serum bilirubin, SGOT, SGPT, serum alkaline phosphatase, serum protein, serum flocculation tests, BSP blood clearance and serum HB Ag. Vomiting, high GOT and GPT serum levels, and serum HB Ag positivity suggest VHP diagnosis. Otherwise a severe itching with scratching lesions, high ESR, elevated total cholesterol and serum alkaline phosphatase values mainly if occurring in the later stage of pregnancy are consistent with CJP diagnosis. When clinical and laboratory data from a jaundiced pregnant female do not allow diagnosis, this can be established only on the basis of needle liver biopsy.

Published
1975

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