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During the cytochemical investigation of human parotid mixed tumors, focal alkaline phosphatase activity was observed along the nuclear envelope of many neoplastic epithelial cells. Further investigation localized the enzyme reaction product within the nuclear pore and in relation to the pore-associated material. Commonly, the reaction product assumed a geometric pattern and measurements of the reaction product deposits (761 ± 8 Å) conformed to the size of the nuclear pore. The possible significance of the presence of the enzyme in the nuclear pore is discussed.

The technic of aspiration biopsy proved valuable in establishing a diagnosis of sarcoidosis of the parotid glands. Healing was prompt and uncomplicated and free of the danger of salivary gland fistula inherent in incisional biopsy of salivary gland tissue that has undergone pathologic change.

The metabolism of the submaxillary salivary gland tissue (particularly the content of protein and retention nitrogen, free protein and nonprotein sulfhydryl groups) is seen to change following the exclusion of the central parasympathetic effect by chorda tympani division. These changes develop gradually and are distinctly seen on the 20th–21st day after the operation. They are similar for unilateral and bilateral denervation, but each type of denervation has its characteristic features. With unilateral denervation the metabolism of the contralateral gland is also altered; however, these changes are not marked and differ qualitatively from those in the denervated glands.

A case of lingual mandibular bone cavity has been reported. Microscopically, it was composed of a mucocele which contained salivary gland tissue in its wall. Two explanations have been advanced to explain the presence of salivary gland tissue within the mandible, and a hypothesis has been presented to explain the development of this bony cavity. In view of the microscopic variance of this lesion and the fact that these lesions simply do not fit the definition of a cyst, it is hoped that the terms static, solitary, or latent bone cysts will be discarded in favor of the term lingual mandibular bone cavity , as advocated by Olech and Arora. 1

Homogenization of salivary gland tissue from the Macaca irus monkey showed an α-amylase content/g wet weight of parotid tissue about five times that of submandibular tissue. The sub

Cytomegalovirus was not detected in the salivary glands by virological or histopathological techniques during autopsies performed upon 100 subjects. It is hypothesized that the susceptible host acquires cytomegalovirus exogenously rather than from a latent focus in the salivary glands.

Intraoral acinic cell adenocarcinoma is a rare tumor, of which only six cases have previously been reported in the literature. In the present case the tumor appeared to be derived from minor salivary gland tissue.

After analyzing the confusion in terminology and previous interpretation of these lesions, the authors support their views with a report of a case.

Although salivary gland tissue inclusions in the mandible are no longer considered rare, inclusion of salivary gland tissue in the anterior portion of the mandible is very unusual. The case presented here brings to six the total number of cases reported in the literature.

131I-iodide and 99Tc-pertechnetate concentration in human salivary glands has been measured simultaneously in vivo by quantitative scintiscanning in 7 thyrotoxic subjects. The mid scan times were 5, 12 and 20 min. and the gland to plasma ratio (G/P) of 131I rose to 4.03±0.82 (s.e.) in the parotid and 10.7 ±3.1 (s.e.) in the submandibular glands. Corresponding values for G/P 99mTcO4-were 2.70 ±0.34 in the parotid and 5.3 ± 1.2 in the submandibular glands. Values obtained at parotidectomy 1 h after intravenous administration of a mixture containing 125I- and 99mTcO4- to 6 patients were 4.13 ± 0.85 for G/P 125I- and 2.50 ± 0.62 for G/P99mTcO4-. G/P131I- (or G/P125I-) and G/P 99mTeO4-, derived by both methods, were significantly correlated in parotid and submandibular glands. There was a significant correlation between G/P 131I-/G/P 99mTcO4- in the parotid glands and G/P131I-/G/P99mTcO4- in the submandibular glands. -It is concluded that 1. salivary gland values of 131I- and 99mTcO4,-as measured by scintiscanning are very close to values obtained by direct counting of excised human salivary gland tissue and 2. that the secretion processes in both glands are physiologically related.

Mycoplasmas were sought in the salivary secretions and minor salivary gland tissue of 26 patients with Sjögren's syndrome or the allied sicca complex. A mycoplasma (M. orale type 1) was recovered from the stimulated parotid saliva of only one case. Possible mechanisms of mycoplasmal cell damage in this and allied disorders are considered and some future lines of investigation are suggested.

Tumour material, collected by fine-needle aspiration according to Franzen (4) has been fixed and embedded for study with the transmission electron microscope (TEM). Different kinds of tumours, mainly from the head and neck region as well as experimental animal material (liver and salivary gland tissue from guinea-pigs) have been studied. It is possible to get material of good quality by careful processing of the specimens and the paper contains a number of micrographs showing such specimens. There is every reason to regard the results presented as an indication that electron microscopy can be used for more detailed studies in connection with fine-needle biopsy. It should be tried especially in those cases where it is of interest to follow a tumour during radiotherapy or treatment with antibiotics or cytotoxic drugs.

A case of aberrant salivary gland in the mandible has been reported. It appears that there is no way to diagnose this condition except by biopsy. Because of the paucity of literature on salivary gland tissue found within the mandible, this case has been reported. Only two other cases have been found in the literature.1, 2

Redundant labial mucosa with increased salivary gland tissue in the stroma corrected surgically.

In view of the recent embryologic studies of the middle ear, 1 it is logical that salivary gland tissue which normally would be present in the pharynx could also develop in the middle ear. Such "ectopic" salivary gland tissue has been observed in the oral cavity at other than the major salivary gland sites and occasionally has been observed in the nasal cavities, but rarely has it been observed elsewhere. 2-8 The present case is one of salivary gland tissue apparently primarily developing in the middle ear, a condition we have not seen reported elsewhere in the recent literature. Report of Case A white woman, aged 31, had had left unilateral deafness all her life, for which she was seen by several otologists who had advised no therapy. She was well adjusted to her impaired hearing and was rather unconcerned about it or about the occasional tinnitus she noted. Because of

THE rapid appearance of iodide in saliva following administration of iodide iodine-131 has been demonstrated1, and its measurement has proved useful in the evaluation of the thyroid status of clinical cases2. Recently, an experiment has been reported3 which suggested that the salivary glands may play an important part in thyroid metabolism, involving the removal of iodine-131 diiodotyrosine from the peripheral circulation. Dehalogenation processes by characteristic enzymes in the salivary gland tissue have been observed4.

Irradiation of salivary gland tissue during radiotherapy of head and neck cancer can cause severe xerostomia. The authors provide an artificial salivary flow using a continuous infusion pump and a subcutaneoustube.

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I am reporting this case because the microscopic changes and the location of the tumor are most unusual. Undoubtedly this was a congenital misplacement of tissue. A woman, aged 19, single, was troubled with occasional attacks of grand mal, tubotympanic catarrah and deafness. In making a routine examination of the nose and throat, I discovered a small tumor mass in the pharyngeal opening of the left eustachian tube. While the tumor mass was freely movable, it completely blocked the tube opening, acting like a ball valve. I discovered that it was attached well up in the tube on the posterior lip by a broad base. With the aid of a nasopharyngoscope, I was easily able to remove the tumor with a snare. Microscopic examination revealed that the sections consisted chiefly of lobules of salivary gland tissue, separated by wide bands of fibrous tissue and having a narrow layer of lymphoid