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Fifty histologically proved cases of eosinophilic granuloma of bone were studied. Male patients outnumbered females, 31 to 19. Ages ranged from 8 months to 53 years (average, 14 years). Only 9 patients thought that the onset was caused by trauma. Pathologic fractures occurred in 7. Eosinophilia was noted in only 5 cases. Treatment was by surgery, radiotherapy, and chemotherapy. Symptoms usually subsided within 2 weeks after treatment, and the average healing period for solitary lesions was 16 months.

One hundred one manifestly unreliable outpatients with active tuberulosis were given isoniazid orally, 14 mg/kg, and streptomycin sulfate intramuscularly, 27 mg/kg, in one dose twice weekly for periods from 3.4 to 22.0 months (mean, 13.0 months) following initial daily hospital treatment of 0 to 12 months (mean, 2.9 months). Outpatient treatment was given by a nurse at a place convenient to each patient. Failure to keep appointments occurred at a rate of 4.5%. One relapse occurred during treatment; 62 patients have completed treatment and have been followed up from 0.3 to 55.3 months (mean, 22.8 months) with no relapses to date.The major problem of antituberculosis treatment today is ensuring that patients take their medication. This study demonstrates that high-dose isoniazid and streptomycin therapy given by a nurse twice weekly is an effective, humane, and inexpensive solution.

Urinary stasis with attendant cystitis has been a problem in the long-term management of patients with the indwelling urethral catheter. Tidal drainage has been offered as a practical solution to this problem. It has been our experience that the instruments presently available fail to empty the bladder and only remove sufficient fluid to relieve excessive pressure. The ideal instrument should function in such a manner that it would completely empty the bladder at any desired time interval or pressure condition. Furthermore, such an instrument to be fully practical must be self-regulatory, requiring minimal professional attention.With these basic problems in mind, detailed experimentation has been applied toward the development of an instrument which would function to eliminate these problems.It can now be stated that after sufficient hospital trial the instrument described below fulfills these requirements of complete elimination, pressure and time interval control, and practical usability.This instrument can