1. LOCAL MAINTENANCE OF THE RABBIT CORPUS LUTEUM WITH OESTROGEN
- Author
-
J. Hammond and J. M. Robson
- Subjects
endocrine system ,medicine.medical_specialty ,Selective maintenance ,medicine.drug_class ,Diethylstilbestrol ,Ovary ,Biology ,Endocrinology ,Corpus Luteum ,Luteal Cells ,Internal medicine ,medicine ,Animals ,Humans ,skin and connective tissue diseases ,reproductive and urinary physiology ,Both ovaries ,urogenital system ,Estrogens ,medicine.anatomical_structure ,Estrogen ,Pituitary Gland ,Female ,Rabbits ,Corpus luteum ,hormones, hormone substitutes, and hormone antagonists ,medicine.drug - Abstract
IT HAS recently been shown (Hohn and Robson, 1950) that when small crystals of various oestrogens are implanted into the corpus luteum of pseudo-pregnant rabbits and the animals then hypophysectomised, there was no selective maintenance of the implanted corpus luteum. Depending on the oestrogen actually used and on the dose, the corpora lutea in both ovaries were either equally maintained or degenerated to the same extent. This suggested that oestrogens did not act directly on the luteal cells but through some indirect mechanism. However, evidence obtained by one of the authors of the present paper (J. H.) indicated quite clearly that the implantation of stilboestrol dipalmitate into the corpus luteum produced local maintenance in non-hypophysectomised animals. These results were privately communicated to J. M. R. and led him to perform the experiment with the same oestrogen in animals which were hypophysectomised after the implantation of the oestrogen.
- Published
- 1951